Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008)
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
Cancer Gene Therapy 15: 183

Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR (2006)
Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
Journal of Molecular Biology 363: 201

Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR (2005)
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil
Journal of Molecular Biology 352: 165

Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Molecular Pharmacology 67: 1874

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase
Chemico-Biological Interactions 157-158: 153

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM (2005)
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11
Chemico-Biological Interactions 157-158: 247

Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM (2005)
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice
Cancer Chemother Pharmacol 56: 629

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM (2005)
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases
Journal of Medicinal Chemistry 48: 2906

Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM (2004)
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity
Molecular Pharmacology 65: 1336

Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM (2004)
Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model
Biochemistry 43: 1874

Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK (2004)
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application
Mol Cancer Ther 3: 903

Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR (2003)
Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
Nat Struct Biol 10: 349

Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR (2003)
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
Chemical Biology 10: 341

Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM (2003)
p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
Journal of Pharmacology & Experimental Therapeutics 304: 699

Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM (2003)
Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance
Molecular Pharmacology 64: 279

Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK (2003)
Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies
Mol Cancer Ther 2: 1171

Yoon KJ, Morton CL, Potter PM, Danks MK, Lee RE (2003)
Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism
Bioorganic & Medicinal Chemistry 11: 3237

Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR (2002)
Structural insights into CPT-11 activation by mammalian carboxylesterases
Nat Struct Biol 9: 337

Wagner LM, Guichard SM, Burger RA, Morton CL, Straign CM, Ashmun RA, Harris LC, Houghton PJ, Potter PM, Danks MK (2002)
Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients
Cancer Research 62: 5001

Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM (2001)
Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases
Molecular Pharmacology 60: 355

Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM (2001)
Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
Cancer Research 61: 5078

Khanna R, Morton CL, Danks MK, Potter PM (2000)
Proficient metabolism of irinotecan by a human intestinal carboxylesterase
Cancer Research 60: 4725

Morton CL, Potter PM (2000)
Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase
Mol Biotechnol 16: 193

Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM (2000)
Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase
Cancer Research 60: 4206

Potter PM, McKenzie PP, Hussain N, Noonberg S, Morton CL, Harris LC (2000)
Construction of adenovirus for high level expression of small RNAs in mammalian cells. Application to a Bcl-2 ribozyme
Mol Biotechnol 15: 105

Wierdl M, Morton CL, Danks MK, Potter PM (2000)
Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
Biochemical Pharmacology 59: 773

Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, Potter PM (1999)
Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy
Clin Cancer Research 5: 917

Morton CL, Wadkins RM, Danks MK, Potter PM (1999)
The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase
Cancer Research 59: 1458

Danks MK, Morton CL, Pawlik CA, Potter PM (1998)
Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11
Cancer Research 58: 20

Guichard SM, Morton CL, Krull EJ, Stewart CF, Danks MK, Potter PM (1998)
Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase
Clin Cancer Research 4: 3089

Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK (1998)
Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme
Cancer Research 58: 3627

Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK (1998)
Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11)
Cancer Research 58: 2646

Potter PM, Wolverton JS, Morton CL, Whipple DO, Danks MK (1998)
In situ subcellular localization of epitope-tagged human and rabbit carboxylesterases
Cytometry 32: 223