Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008) <br />An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11<br /><i>Cancer Gene Therapy</i> <b>15</b>: 183<br /><br />Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR (2006) <br />Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1<br /><i>Journal of Molecular Biology</i> <b>363</b>: 201<br /><br />Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR (2005) <br />Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil<br /><i>Journal of Molecular Biology</i> <b>352</b>: 165<br /><br />Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM (2005) <br />The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action<br /><i>Molecular Pharmacology</i> <b>67</b>: 1874<br /><br />Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM (2005) <br />The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 153<br /><br />Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM (2005) <br />Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 247<br /><br />Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM (2005) <br />Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice<br /><i>Cancer Chemother Pharmacol</i> <b>56</b>: 629<br /><br />Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM (2005) <br />Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 2906<br /><br />Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM (2004) <br />Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity<br /><i>Molecular Pharmacology</i> <b>65</b>: 1336<br /><br />Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM (2004) <br />Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model<br /><i>Biochemistry</i> <b>43</b>: 1874<br /><br />Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK (2004) <br />Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application<br /><i>Mol Cancer Ther</i> <b>3</b>: 903<br /><br />Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR (2003) <br />Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme<br /><i>Nat Struct Biol</i> <b>10</b>: 349<br /><br />Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR (2003) <br />Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition<br /><i>Chemical Biology</i> <b>10</b>: 341<br /><br />Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM (2003) <br />p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>304</b>: 699<br /><br />Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM (2003) <br />Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance<br /><i>Molecular Pharmacology</i> <b>64</b>: 279<br /><br />Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK (2003) <br />Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies<br /><i>Mol Cancer Ther</i> <b>2</b>: 1171<br /><br />Yoon KJ, Morton CL, Potter PM, Danks MK, Lee RE (2003) <br />Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism<br /><i>Bioorganic & Medicinal Chemistry</i> <b>11</b>: 3237<br /><br />Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR (2002) <br />Structural insights into CPT-11 activation by mammalian carboxylesterases<br /><i>Nat Struct Biol</i> <b>9</b>: 337<br /><br />Wagner LM, Guichard SM, Burger RA, Morton CL, Straign CM, Ashmun RA, Harris LC, Houghton PJ, Potter PM, Danks MK (2002) <br />Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients<br /><i>Cancer Research</i> <b>62</b>: 5001<br /><br />Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM (2001) <br />Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases<br /><i>Molecular Pharmacology</i> <b>60</b>: 355<br /><br />Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM (2001) <br />Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase<br /><i>Cancer Research</i> <b>61</b>: 5078<br /><br />Khanna R, Morton CL, Danks MK, Potter PM (2000) <br />Proficient metabolism of irinotecan by a human intestinal carboxylesterase<br /><i>Cancer Research</i> <b>60</b>: 4725<br /><br />Morton CL, Potter PM (2000) <br />Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase<br /><i>Mol Biotechnol</i> <b>16</b>: 193<br /><br />Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM (2000) <br />Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase<br /><i>Cancer Research</i> <b>60</b>: 4206<br /><br />Potter PM, McKenzie PP, Hussain N, Noonberg S, Morton CL, Harris LC (2000) <br />Construction of adenovirus for high level expression of small RNAs in mammalian cells. Application to a Bcl-2 ribozyme<br /><i>Mol Biotechnol</i> <b>15</b>: 105<br /><br />Wierdl M, Morton CL, Danks MK, Potter PM (2000) <br />Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation<br /><i>Biochemical Pharmacology</i> <b>59</b>: 773<br /><br />Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, Potter PM (1999) <br />Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy<br /><i>Clin Cancer Research</i> <b>5</b>: 917<br /><br />Morton CL, Wadkins RM, Danks MK, Potter PM (1999) <br />The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase<br /><i>Cancer Research</i> <b>59</b>: 1458<br /><br />Danks MK, Morton CL, Pawlik CA, Potter PM (1998) <br />Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11<br /><i>Cancer Research</i> <b>58</b>: 20<br /><br />Guichard SM, Morton CL, Krull EJ, Stewart CF, Danks MK, Potter PM (1998) <br />Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase<br /><i>Clin Cancer Research</i> <b>4</b>: 3089<br /><br />Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK (1998) <br />Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme<br /><i>Cancer Research</i> <b>58</b>: 3627<br /><br />Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK (1998) <br />Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11)<br /><i>Cancer Research</i> <b>58</b>: 2646<br /><br />Potter PM, Wolverton JS, Morton CL, Whipple DO, Danks MK (1998) <br />In situ subcellular localization of epitope-tagged human and rabbit carboxylesterases<br /><i>Cytometry</i> <b>32</b>: 223<br /><br />