Espinosa-Jimenez T, Cano A, Sanchez-Lopez E, Olloquequi J, Folch J, Bullo M, Verdaguer E, Auladell C, Pont C, Munoz-Torrero D, Parcerisas A, Camins A, Ettcheto M (2023) <br />A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet<br /><i>Cell Biosci</i> <b>13</b>: 52<br /><br />Codony S, Pont C, Grinan-Ferre C, Di Pede-Mattatelli A, Calvo-Tusell C, Feixas F, Osuna S, Jarne-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Perez B, Bartra C, Sanfeliu C, Juarez-Jimenez J, Morisseau C, Hammock BD, Pallas M, Vazquez S, Munoz-Torrero D (2022) <br />Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease<br /><i>Journal of Medicinal Chemistry</i> <b>65</b>: 4909<br /><br />Jarne-Ferrer J, Grinan-Ferre C, Bellver-Sanchis A, Vazquez S, Munoz-Torrero D, Pallas M (2022) <br />A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer's Disease Mice Models<br /><i>Pharmaceuticals (Basel)</i> <b>15</b>: <br /><br />Sampietro A, Perez-Areales FJ, Martinez P, Arce EM, Galdeano C, Munoz-Torrero D (2022) <br />Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis<br /><i>Pharmaceuticals (Basel)</i> <b>15</b>: <br /><br />Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021) <br />From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects<br /><i>Eur Journal of Medicinal Chemistry</i> <b>225</b>: 113779<br /><br />Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021) <br />Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 812<br /><br />Zambrano P, Suwalsky M, Jemiola-Rzeminska M, Gallardo-Nelson MJ, Strzalka K, Munoz-Torrero D (2021) <br />Protective Role of a Donepezil-Huprine Hybrid against the beta-Amyloid (1-42) Effect on Human Erythrocytes<br /><i>Int J Mol Sci</i> <b>22</b>: <br /><br />Perez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaro A, Ginex T, Sabate R, Perez B, Andrisano V, Puigoriol-Illamola D, Pallas M, Luque FJ, Loza MI, Brea J, Ferrer I, Ciruela F, Messeguer A, Munoz-Torrero D (2020) <br />Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6<br /><i>Journal of Medicinal Chemistry</i> <b>63</b>: 9360<br /><br />Perez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaro A, Bartolini M, De Simone A, Andrisano V, Perez B, Sabate R, Sureda FX, Vazquez S, Munoz-Torrero D (2019) <br />A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>180</b>: 613<br /><br />Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018) <br />Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis<br /><i>Molecules</i> <b>23</b>: <br /><br />Relat J, Perez B, Camps P, Munoz-Torrero D, Badia A, Victoria Clos M (2018) <br />Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation<br /><i>Basic Clin Pharmacol Toxicol</i> <b>122</b>: 94<br /><br />Relat J, Come J, Perez B, Camps P, Munoz-Torrero D, Badia A, Gimenez-Llort L, Clos MV (2018) <br />Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice<br /><i>Int J Mol Sci</i> <b>19</b>: <br /><br />Gimenez-Llort L, Ratia M, Perez B, Camps P, Munoz-Torrero D, Badia A, Clos MV (2017) <br />Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease<br /><i>Behav Pharmacol</i> <b>28</b>: 124<br /><br />Perez-Areales FJ, Betari N, Viayna A, Pont C, Espargaro A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Perez B, Sabate R, Lamuela-Raventos RM, Andrisano V, Luque FJ, Munoz-Torrero D (2017) <br />Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids<br /><i>Future Med Chem</i> <b>9</b>: 965<br /><br />Decker M, Munoz-Torrero D (2016) <br />Special Issue: Molecules against Alzheimer<br /><i>Molecules</i> <b>21</b>: <br /><br />Serrano FG, Tapia-Rojas C, Carvajal FJ, Cisternas P, Viayna E, Sola I, Munoz-Torrero D, Inestrosa NC (2016) <br />Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AbetaPPswe/PS-1 Mice of Different Ages<br /><i>Curr Alzheimer Res</i> <b>13</b>: 1017<br /><br />Di Pietro O, Vicente-Garcia E, Taylor MC, Berenguer D, Viayna E, Lanzoni A, Sola I, Sayago H, Riera C, Fisa R, Clos MV, Perez B, Kelly JM, Lavilla R, Munoz-Torrero D (2015) <br />Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity<br /><i>Eur Journal of Medicinal Chemistry</i> <b>105</b>: 120<br /><br />Gimenez-Llort L, Ratia M, Perez B, Camps P, Munoz-Torrero D, Badia A, Clos MV (2015) <br />AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice<br /><i>Behavioural Brain Research</i> <b>286</b>: 97<br /><br />Sola I, Aso E, Frattini D, Lopez-Gonzalez I, Espargaro A, Sabate R, Di Pietro O, Luque FJ, Clos MV, Ferrer I, Munoz-Torrero D (2015) <br />Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies<br /><i>Journal of Medicinal Chemistry</i> <b>58</b>: 6018<br /><br />Sola I, Castella S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Perez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Munoz-Torrero D (2015) <br />Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity<br /><i>Bioorganic & Medicinal Chemistry</i> <b>23</b>: 5156<br /><br />Torrent J, Vilchez-Acosta A, Munoz-Torrero D, Trovaslet M, Nachon F, Chatonnet A, Grznarova K, Acquatella-Tran Van Ba I, Le Goffic R, Herzog L, Beringue V, Rezaei H (2015) <br />Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases<br /><i>Acta Neuropathologica Commun</i> <b>3</b>: 18<br /><br />Di Pietro O, Perez-Areales FJ, Juarez-Jimenez J, Espargaro A, Clos MV, Perez B, Lavilla R, Sabate R, Luque FJ, Munoz-Torrero D (2014) <br />Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies<br /><i>Eur Journal of Medicinal Chemistry</i> <b>84C</b>: 107<br /><br />Perez-Areales FJ, Di Pietro O, Espargaro A, Vallverdu-Queralt A, Galdeano C, Ragusa IM, Viayna E, Guillou C, Clos MV, Perez B, Sabate R, Lamuela-Raventos RM, Luque FJ, Munoz-Torrero D (2014) <br />Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties<br /><i>Bioorganic & Medicinal Chemistry</i> <b>22</b>: 5298<br /><br />Sola I, Artigas A, Taylor MC, Gbedema SY, Perez B, Clos MV, Wright CW, Kelly JM, Munoz-Torrero D (2014) <br />Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>24</b>: 5435<br /><br />Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Munoz-Torrero D (2014) <br />Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 2549<br /><br />Di Pietro O, Viayna E, Vicente-Garcia E, Bartolini M, Ramon R, Juarez-Jimenez J, Clos MV, Perez B, Andrisano V, Luque FJ, Lavilla R, Munoz-Torrero D (2013) <br />1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies<br /><i>Eur Journal of Medicinal Chemistry</i> <b>73C</b>: 141<br /><br />Pera M, Camps P, Munoz-Torrero D, Perez B, Badia A, Clos Guillen MV (2013) <br />Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide<br /><i>PLoS ONE</i> <b>8</b>: e74344<br /><br />Ratia M, Gimenez-Llort L, Camps P, Munoz-Torrero D, Perez B, Clos MV, Badia A (2013) <br />Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD)<br /><i>Neurodegener Dis</i> <b>11</b>: 129<br /><br />Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillon C, Gonzalez-Munoz GC, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Munoz-Torrero D (2012) <br />Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 661<br /><br />Munoz-Torrero D, Pera M, Relat J, Ratia M, Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV (2012) <br />Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents<br /><i>Neurodegener Dis</i> <b>10</b>: 96<br /><br />Defaux J, Sala M, Formosa X, Galdeano C, Taylor MC, Alobaid WA, Kelly JM, Wright CW, Camps P, Munoz-Torrero D (2011) <br />Huprines as a new family of dual acting trypanocidal-antiplasmodial agents<br /><i>Bioorganic & Medicinal Chemistry</i> <b>19</b>: 1702<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Ramirez L, Viayna E, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, Luque FJ (2010) <br />Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 411<br /><br />Galdeano C, Viayna E, Arroyo P, Bidon-Chanal A, Blas JR, Munoz-Torrero D, Luque FJ (2010) <br />Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents<br /><i>Curr Pharm Des</i> <b>16</b>: 2818<br /><br />Hedberg MM, Clos MV, Ratia M, Gonzalez D, Lithner CU, Camps P, Munoz-Torrero D, Badia A, Gimenez-Llort L, Nordberg A (2010) <br />Effect of huprine X on beta-amyloid, synaptophysin and alpha7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice<br /><i>Neurodegener Dis</i> <b>7</b>: 379<br /><br />Viayna E, Gomez T, Galdeano C, Ramirez L, Ratia M, Badia A, Clos MV, Verdaguer E, Junyent F, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Camps P, Munoz-Torrero D (2010) <br />Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates<br /><i>ChemMedChem</i> <b>5</b>: 1855<br /><br />Camps P, Formosa X, Galdeano C, Munoz-Torrero D, Ramirez L, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Huertas O, Dafni T, Luque FJ (2009) <br />Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 5365<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ (2008) <br />Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 3588<br /><br />Munoz-Torrero D (2008) <br />Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease<br /><i>Curr Med Chem</i> <b>15</b>: 2433<br /><br />Camps P, Gomez E, Munoz-Torrero D, Badia A, Clos MV, Curutchet C, Munoz-Muriedas J, Luque FJ (2006) <br />Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 6833<br /><br />Clos MV, Pera M, Ratia M, Roman S, Camps P, Munoz-Torrero D, Colombo L, Salmona M, Badia A (2006) <br />Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 89<br /><br />Munoz-Torrero D, Camps P (2006) <br />Dimeric and hybrid anti-Alzheimer drug candidates<br /><i>Curr Med Chem</i> <b>13</b>: 399<br /><br />Pera M, Roman S, Ratia M, Camps P, Munoz-Torrero D, Colombo L, Manzoni C, Salmona M, Badia A, Clos MV (2006) <br />Acetylcholinesterase triggers the aggregation of PrP 106-126<br /><i>Biochemical & Biophysical Research Communications</i> <b>346</b>: 89<br /><br />Camps P, Formosa X, Munoz-Torrero D, Petrignet J, Badia A, Clos MV (2005) <br />Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 1701<br /><br />Roman S, Badia A, Camps P, Munoz-Torrero D, Clos MV (2005) <br />Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors<br /><i>Brain Research</i> <b>1061</b>: 73<br /><br />Jorda EG, Verdaguer E, Jimenez A, Canudas AM, Rimbau V, Camps P, Munoz-Torrero D, Camins A, Pallas M (2004) <br />(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration<br /><i>J Alzheimers Dis</i> <b>6</b>: 577<br /><br />Alcala Mdel M, Vivas NM, Hospital S, Camps P, Munoz-Torrero D, Badia A (2003) <br />Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids<br /><i>Neuropharmacology</i> <b>44</b>: 749<br /><br />Camps P, Munoz-Torrero D (2002) <br />Cholinergic drugs in pharmacotherapy of Alzheimer's disease<br /><i>Mini Rev Med Chem</i> <b>2</b>: 11<br /><br />Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Munoz-Torrero D, Camps P, Rosenberry TL, Silman I, Sussman JL (2002) <br />3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates<br /><i>Biochemistry</i> <b>41</b>: 2970<br /><br />Camps P, Gomez E, Munoz-Torrero D, Badia A, Vivas NM, Barril X, Orozco M, Luque FJ (2001) <br />Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 4733<br /><br />Camps P, Munoz-Torrero D (2001) <br />Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease<br /><i>Mini Rev Med Chem</i> <b>1</b>: 163<br /><br />Ros E, Aleu J, Gomez de Aranda I, Munoz-Torrero D, Camps P, Badia A, Marsal J, Solsona C (2001) <br />The pharmacology of novel acetylcholinesterase inhibitors, (+/-)- huprines Y and X, on the Torpedo electric organ<br /><i>European Journal of Pharmacology</i> <b>421</b>: 77<br /><br />Camps P, Cusack B, Mallender WD, Achab RE, Morral J, Munoz-Torrero D, Rosenberry TL (2000) <br />Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease<br /><i>Molecular Pharmacology</i> <b>57</b>: 409<br /><br />Camps P, El Achab R, Morral J, Munoz-Torrero D, Badia A, Banos JE, Vivas NM, Barril X, Orozco M, Luque FJ (2000) <br />New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>43</b>: 4657<br /><br />Camps P, El Achab R, Gorbig DM, Morral J, Munoz-Torrero D, Badia A, Eladi Banos J, Vivas NM, Barril X, Orozco M, Luque FJ (1999) <br />Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>42</b>: 3227<br /><br />Badia A, Banos JE, Camps P, Contreras J, Gorbig DM, Munoz-Torrero D, Simon M, Vivas NM (1998) <br />Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry</i> <b>6</b>: 427<br /><br />