Pang YP (2022)
How neocarcerand Octacid4 self-assembles with guests into irreversible noncovalent complexes and what accelerates the assembly
Commun Chem 5: 9

Cheng XJ, Gu JX, Pang YP, Liu J, Xu T, Li XR, Hua YZ, Newell KA, Huang XF, Yu Y, Liu Y (2019)
Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease
ACS Chem Neurosci 10: 3500

Darras FH, Pang YP (2017)
On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity
Biochemical & Biophysical Research Communications 489: 451

Brimijoin S, Chen VP, Pang YP, Geng L, Gao Y (2016)
Physiological Roles for Butyrylcholinesterase: A BChE-Ghrelin Axis
Chemico-Biological Interactions 259: 271

Chang L, Cui W, Yang Y, Xu S, Zhou WH, Fu HJ, Hu SQ, Mak SH, Hu JW, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang YP, Rowan MJ, Anwyl R, Han YF (2015)
Protection against beta-amyloid-induced synaptic and memory impairments via altering beta-amyloid assembly by bis(heptyl)-cognitin
Sci Rep 5: 10256

Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S (2015)
Plasma butyrylcholinesterase regulates ghrelin to control aggression
Proc Natl Acad Sci U S A 112: 2251

Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF (2015)
Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils
CNS Neurosci Ther 21: 953

Dou D, Park JG, Rana S, Madden BJ, Jiang H, Pang YP (2013)
Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases
Sci Rep 3: 1068

Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF (2013)
Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway
CNS Neurosci Ther 19: 764

Lu Y, Pang YP, Park Y, Gao X, Yao J, Zhang X, Zhu KY (2012)
Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle
PLoS ONE 7: e32288

Lu Y, Park Y, Gao X, Zhang X, Yao J, Pang YP, Jiang H, Zhu KY (2012)
Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum
Sci Rep 2: 288

Pang YP, Brimijoin S, Ragsdale DW, Zhu KY, Suranyi R (2012)
Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides
Curr Drug Targets 13: 471

Hornberg A, Artursson E, Warme R, Pang YP, Ekstrom F (2010)
Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad
Biochemical Pharmacology 79: 507

Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S (2010)
Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle
Chemico-Biological Interactions 187: 142

Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F (2010)
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds
Biochemical Pharmacology 80: 941

Ekstrom F, Hornberg A, Artursson E, Hammarstrom LG, Schneider G, Pang YP (2009)
Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design
PLoS ONE 4: e5957

Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S (2009)
Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides
PLoS ONE 4: e4349

Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S (2009)
Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases
PLoS ONE 4: e6851

Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY (2009)
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons
Neuropharmacology 57: 33

Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY (2008)
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies
Neuropharmacology 54: 1086

Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF (2008)
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine
J Pharm Biomed Anal 46: 75

Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF (2008)
Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry
Biomedical Chromatography 22: 414

Ekstrom F, Astot C, Pang YP (2007)
Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes
Clinical Pharmacology & Therapeutics 82: 282

Li WM, Kan KK, Carlier PR, Pang YP, Han YF (2007)
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A
Curr Alzheimer Res 4: 386

Ekstrom F, Pang YP, Boman M, Artursson E, Akfur C, Borjegren S (2006)
Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates
Biochemical Pharmacology 72: 597

Pang YP (2006)
Novel acetylcholinesterase target site for malaria mosquito control
PLoS ONE 1: e58

Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL (2006)
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
Journal of Medicinal Chemistry 49: 5491

Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL (2005)
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase
Journal of the American Chemical Society 127: 11029

Patani GA, Pang YP, Chien YW (2005)
A potent and selective tacrine analog--biomembrane permeation and physicochemical characterization
Pharm Dev Technol 10: 525

Hammond PI, Kern C, Hong F, Kollmeyer TM, Pang YP, Brimijoin S (2003)
Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design
Journal of Pharmacology & Experimental Therapeutics 307: 190

Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S (2003)
Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators
Chemical Biology 10: 491

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003)
Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J Am Chem Soc 125: 363

Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S (2002)
Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase
Journal of Pharmacology & Experimental Therapeutics 302: 710

Sun H, Pang YP, Lockridge O, Brimijoin S (2002)
Re-engineering butyrylcholinesterase as a cocaine hydrolase
Molecular Pharmacology 62: 220

Ros E, Aleu J, Gomez de Aranda I, Canti C, Pang YP, Marsal J, Solsona C (2001)
Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ
Journal of Neurophysiology 86: 183

Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP (2001)
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
Journal of Biological Chemistry 276: 9330

Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP (2000)
Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
Angew Chem Int Ed Engl 39: 1775

Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF (2000)
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]
Neuroscience Letters 288: 95

Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP (1999)
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis
Bioorganic & Medicinal Chemistry 7: 351

Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP (1999)
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions
Journal of Medicinal Chemistry 42: 4225

Carlier PR, Du DM, Han Y, Liu J, Pang YP (1999)
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 9: 2335

Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR (1999)
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities
Bioorganic & Medicinal Chemistry 7: 2569

Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF (1999)
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist
Neuroreport 10: 795

Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF (1999)
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE
Neuroreport 10: 789

Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF (1999)
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor
Zhongguo Yao Li Xue Bao 20: 211

Hammond P, Kern C, Pang YP, Brimijoin S (1998)
Improved Acetylcholinesterase Reactivation with Bis-Oximes Modeled on Crystal Structure
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 252

Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL (1997)
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
Nat Struct Biol 4: 57

Pang YP, Quiram P, Jelacic T, Hong F, Brimijoin S (1996)
Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease
Journal of Biological Chemistry 271: 23646

Pang YP, Kozikowski AP (1994)
Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies
J Comput Aided Mol Des 8: 669

Pang YP, Kozikowski AP (1994)
Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program
J Comput Aided Mol Des 8: 683

Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn DM, Taylor P, Doctor BP (1994)
Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases
Protein Science 3: 1770