Pang YP (2022) <br />How neocarcerand Octacid4 self-assembles with guests into irreversible noncovalent complexes and what accelerates the assembly<br /><i>Commun Chem</i> <b>5</b>: 9<br /><br />Cheng XJ, Gu JX, Pang YP, Liu J, Xu T, Li XR, Hua YZ, Newell KA, Huang XF, Yu Y, Liu Y (2019) <br />Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease<br /><i>ACS Chem Neurosci</i> <b>10</b>: 3500<br /><br />Darras FH, Pang YP (2017) <br />On the use of the experimentally determined enzyme inhibition constant as a measure of absolute binding affinity<br /><i>Biochemical & Biophysical Research Communications</i> <b>489</b>: 451<br /><br />Brimijoin S, Chen VP, Pang YP, Geng L, Gao Y (2016) <br />Physiological Roles for Butyrylcholinesterase: A BChE-Ghrelin Axis<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 271<br /><br />Chang L, Cui W, Yang Y, Xu S, Zhou WH, Fu HJ, Hu SQ, Mak SH, Hu JW, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang YP, Rowan MJ, Anwyl R, Han YF (2015) <br />Protection against beta-amyloid-induced synaptic and memory impairments via altering beta-amyloid assembly by bis(heptyl)-cognitin<br /><i>Sci Rep</i> <b>5</b>: 10256<br /><br />Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S (2015) <br />Plasma butyrylcholinesterase regulates ghrelin to control aggression<br /><i>Proc Natl Acad Sci U S A</i> <b>112</b>: 2251<br /><br />Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF (2015) <br />Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils<br /><i>CNS Neurosci Ther</i> <b>21</b>: 953<br /><br />Dou D, Park JG, Rana S, Madden BJ, Jiang H, Pang YP (2013) <br />Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases<br /><i>Sci Rep</i> <b>3</b>: 1068<br /><br />Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF (2013) <br />Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway<br /><i>CNS Neurosci Ther</i> <b>19</b>: 764<br /><br />Lu Y, Pang YP, Park Y, Gao X, Yao J, Zhang X, Zhu KY (2012) <br />Genome organization, phylogenies, expression patterns, and three-dimensional protein models of two acetylcholinesterase genes from the red flour beetle<br /><i>PLoS ONE</i> <b>7</b>: e32288<br /><br />Lu Y, Park Y, Gao X, Zhang X, Yao J, Pang YP, Jiang H, Zhu KY (2012) <br />Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum<br /><i>Sci Rep</i> <b>2</b>: 288<br /><br />Pang YP, Brimijoin S, Ragsdale DW, Zhu KY, Suranyi R (2012) <br />Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides<br /><i>Curr Drug Targets</i> <b>13</b>: 471<br /><br />Hornberg A, Artursson E, Warme R, Pang YP, Ekstrom F (2010) <br />Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad<br /><i>Biochemical Pharmacology</i> <b>79</b>: 507<br /><br />Polsinelli GA, Singh SK, Mishra RK, Suranyi R, Ragsdale DW, Pang YP, Brimijoin S (2010) <br />Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 142<br /><br />Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F (2010) <br />Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds<br /><i>Biochemical Pharmacology</i> <b>80</b>: 941<br /><br />Ekstrom F, Hornberg A, Artursson E, Hammarstrom LG, Schneider G, Pang YP (2009) <br />Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design<br /><i>PLoS ONE</i> <b>4</b>: e5957<br /><br />Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S (2009) <br />Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides<br /><i>PLoS ONE</i> <b>4</b>: e4349<br /><br />Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S (2009) <br />Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases<br /><i>PLoS ONE</i> <b>4</b>: e6851<br /><br />Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY (2009) <br />Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons<br /><i>Neuropharmacology</i> <b>57</b>: 33<br /><br />Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY (2008) <br />Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies<br /><i>Neuropharmacology</i> <b>54</b>: 1086<br /><br />Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF (2008) <br />The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine<br /><i>J Pharm Biomed Anal</i> <b>46</b>: 75<br /><br />Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF (2008) <br />Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry<br /><i>Biomedical Chromatography</i> <b>22</b>: 414<br /><br />Ekstrom F, Astot C, Pang YP (2007) <br />Novel nerve-agent antidote design based on crystallographic and mass spectrometric analyses of tabun-conjugated acetylcholinesterase in complex with antidotes<br /><i>Clinical Pharmacology & Therapeutics</i> <b>82</b>: 282<br /><br />Li WM, Kan KK, Carlier PR, Pang YP, Han YF (2007) <br />East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A<br /><i>Curr Alzheimer Res</i> <b>4</b>: 386<br /><br />Ekstrom F, Pang YP, Boman M, Artursson E, Akfur C, Borjegren S (2006) <br />Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates<br /><i>Biochemical Pharmacology</i> <b>72</b>: 597<br /><br />Pang YP (2006) <br />Novel acetylcholinesterase target site for malaria mosquito control<br /><i>PLoS ONE</i> <b>1</b>: e58<br /><br />Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL (2006) <br />Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 5491<br /><br />Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL (2005) <br />Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase<br /><i>Journal of the American Chemical Society</i> <b>127</b>: 11029<br /><br />Patani GA, Pang YP, Chien YW (2005) <br />A potent and selective tacrine analog--biomembrane permeation and physicochemical characterization<br /><i>Pharm Dev Technol</i> <b>10</b>: 525<br /><br />Hammond PI, Kern C, Hong F, Kollmeyer TM, Pang YP, Brimijoin S (2003) <br />Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>307</b>: 190<br /><br />Pang YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S (2003) <br />Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators<br /><i>Chemical Biology</i> <b>10</b>: 491<br /><br />Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003) <br />Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity<br /><i>J Am Chem Soc</i> <b>125</b>: 363<br /><br />Sun H, Shen ML, Pang YP, Lockridge O, Brimijoin S (2002) <br />Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>302</b>: 710<br /><br />Sun H, Pang YP, Lockridge O, Brimijoin S (2002) <br />Re-engineering butyrylcholinesterase as a cocaine hydrolase<br /><i>Molecular Pharmacology</i> <b>62</b>: 220<br /><br />Ros E, Aleu J, Gomez de Aranda I, Canti C, Pang YP, Marsal J, Solsona C (2001) <br />Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ<br /><i>Journal of Neurophysiology</i> <b>86</b>: 183<br /><br />Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP (2001) <br />Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.<br /><i>Journal of Biological Chemistry</i> <b>276</b>: 9330<br /><br />Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP (2000) <br />Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product<br /><i>Angew Chem Int Ed Engl</i> <b>39</b>: 1775<br /><br />Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF (2000) <br />Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]<br /><i>Neuroscience Letters</i> <b>288</b>: 95<br /><br />Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP (1999) <br />Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis<br /><i>Bioorganic & Medicinal Chemistry</i> <b>7</b>: 351<br /><br />Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP (1999) <br />Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions<br /><i>Journal of Medicinal Chemistry</i> <b>42</b>: 4225<br /><br />Carlier PR, Du DM, Han Y, Liu J, Pang YP (1999) <br />Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>9</b>: 2335<br /><br />Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR (1999) <br />Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities<br /><i>Bioorganic & Medicinal Chemistry</i> <b>7</b>: 2569<br /><br />Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF (1999) <br />Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist<br /><i>Neuroreport</i> <b>10</b>: 795<br /><br />Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF (1999) <br />Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE<br /><i>Neuroreport</i> <b>10</b>: 789<br /><br />Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF (1999) <br />Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor<br /><i>Zhongguo Yao Li Xue Bao</i> <b>20</b>: 211<br /><br />Hammond P, Kern C, Pang YP, Brimijoin S (1998) <br />Improved Acetylcholinesterase Reactivation with Bis-Oximes Modeled on Crystal Structure<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 252<br /><br />Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL (1997) <br />Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A<br /><i>Nat Struct Biol</i> <b>4</b>: 57<br /><br />Pang YP, Quiram P, Jelacic T, Hong F, Brimijoin S (1996) <br />Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease<br /><i>Journal of Biological Chemistry</i> <b>271</b>: 23646<br /><br />Pang YP, Kozikowski AP (1994) <br />Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies<br /><i>J Comput Aided Mol Des</i> <b>8</b>: 669<br /><br />Pang YP, Kozikowski AP (1994) <br />Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program<br /><i>J Comput Aided Mol Des</i> <b>8</b>: 683<br /><br />Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn DM, Taylor P, Doctor BP (1994) <br />Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases<br /><i>Protein Science</i> <b>3</b>: 1770<br /><br />