Panek D, Pasieka A, Latacz G, Zareba P, Szczech M, Godyn J, Chantegreil F, Nachon F, Brazzolotto X, Skrzypczak-Wiercioch A, Walczak M, Smolik M, Salat K, Hofner G, Wanner K, Wieckowska A, Malawska B (2023)
Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies
Eur Journal of Medicinal Chemistry 249: 115135

Pasieka A, Panek D, Zareba P, Slugocka E, Gucwa N, Espargaro A, Latacz G, Khan N, Bucki A, Sabate R, Wieckowska A, Malawska B (2023)
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and beta-amyloid inhibitors for the treatment of Alzheimer's disease
Bioorganic & Medicinal Chemistry 88-89: 117333

Pasieka A, Diamanti E, Uliassi E, Laura Bolognesi M (2023)
Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?
ChemMedChem

Zareba P, Ltka K, Mazur G, Gryzlo B, Pasieka A, Godyn J, Panek D, Skrzypczak-Wiercioch A, Hofner GC, Latacz G, Maj M, Espargaro A, Sabate R, Jozwiak K, Wanner KT, Salat K, Malawska B, Kulig K, Bajda M (2023)
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, beta-secretase, and amyloid beta aggregation as potential treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 261: 115832

Pasieka A, Panek D, Jonczyk J, Godyn J, Szalaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F, Dias J, Knez D, Lu J, Pi R, Korabecny J, Brazzolotto X, Gobec S, Hofner G, Wanner K, Wieckowska Q, Malawska B (2021)
Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters
Eur Journal of Medicinal Chemistry 218: 113397

Wichur T, Pasieka A, Godyn J, Panek D, Goral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A, Gluch-Lutwin M, Knez D, Brazzolotto X, Gobec S, Kolaczkowski M, Sabate R, Malawska B, Wieckowska A (2021)
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau
Eur Journal of Medicinal Chemistry 225: 113783

Szalaj N, Godyn J, Jonczyk J, Pasieka A, Panek D, Wichur T, Wieckowski K, Zareba P, Bajda M, Pislar A, Malawska B, Sabate R, Wieckowska A (2020)
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease
J Enzyme Inhib Med Chem 35: 1944

Wichur T, Wieckowska A, Wieckowski K, Godyn J, Jonczyk J, Valdivieso ADR, Panek D, Pasieka A, Sabate R, Knez D, Gobec S, Malawska B (2019)
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease
Eur Journal of Medicinal Chemistry 187: 111916

Panek D, Wieckowska A, Pasieka A, Godyn J, Jonczyk J, Bajda M, Knez D, Gobec S, Malawska B (2018)
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents
Molecules 23:

Panek D, Wieckowska A, Jonczyk J, Godyn J, Bajda M, Wichur T, Pasieka A, Knez D, Pislar A, Korabecny J, Soukup O, Sepsova V, Sabate R, Kos J, Gobec S, Malawska B (2018)
Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents
ACS Chem Neurosci 9: 1074

Panek D, Wichur T, Godyn J, Pasieka A, Malawska B (2017)
Advances toward multifunctional cholinesterase and beta-amyloid aggregation inhibitors
Future Med Chem 9: 1835

Hebda M, Bajda M, Wieckowska A, Szalaj N, Pasieka A, Panek D, Godyn J, Wichur T, Knez D, Gobec S, Malawska B (2016)
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
Molecules 21: