Shi J, Xiao J, Wang X, Jung SM, Bleske BE, Markowitz JS, Patrick KS, Zhu HJ (2021)
Plasma carboxylesterase 1 predicts methylphenidate exposure: a proof-of-concept study using plasma protein biomarker for hepatic drug metabolism
Clinical Pharmacology & Therapeutics

Patrick KS, Radke JL, Raymond JR, Koller L, Nguyen LV, Rodriguez W, Straughn AB (2019)
Drug Regimen Individualization for Attention-Deficit/Hyperactivity Disorder: Guidance for Methylphenidate and Dexmethylphenidate Formulations
Pharmacotherapy 39: 677

Patrick KS, Rodriguez W (2019)
Potential for Underestimation of d-Methylphenidate Bioavailability Using Chiral Derivatization/Gas Chromatography
Drug Metabolism & Disposition: The Biological Fate of Chemicals 47: 764

Zhu HJ, Patrick KS, Straughn AB, Reeves OT, 3rd, Bernstein H, Shi J, Johnson HJ, Knight JM, Smith AT, Malcolm RJ, Markowitz JS (2017)
Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers
J Clin Psychopharmacol 37: 419

Patrick KS, Corbin TR, Murphy CE (2014)
Ethylphenidate as a Selective Dopaminergic Agonist and Methylphenidate-Ethanol Transesterification Biomarker
J Pharm Sci 103: 3834

Markowitz JS, Zhu HJ, Patrick KS (2013)
Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability
J Child Adolesc Psychopharmacol 23: 648

Patrick KS, Straughn AB, Reeves OT, 3rd, Bernstein H, Bell GH, Anderson ER, Malcolm RJ (2013)
Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans
Drug Metabolism & Disposition: The Biological Fate of Chemicals 41: 197

Zhu HJ, Patrick KS, Markowitz JS (2011)
Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: Application to human ethanol interactions
Journal of Chromatography B Analyt Technol Biomed Life Sciences 879: 783

LeVasseur NL, Zhu HJ, Markowitz JS, DeVane CL, Patrick KS (2008)
Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping
Journal of Chromatography B Analyt Technol Biomed Life Sciences 862: 140

Zhu HJ, Patrick KS, Yuan HJ, Wang JS, Donovan JL, DeVane CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS (2008)
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis
American Journal of Human Genetics 82: 1241