Codony S, Entrena JM, Calvo-Tusell C, Jora B, Gonzalez-Cano R, Osuna S, Corpas R, Morisseau C, Perez B, Barniol-Xicota M, Grinan-Ferre C, Perez C, Rodriguez-Franco MI, Martinez AL, Loza MI, Pallas M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vazquez S (2022) <br />Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>65</b>: 13660<br /><br />Gonzalez-Naranjo P, Perez C, Gonzalez-Sanchez M, Gironda-Martinez A, Ulzurrun E, Bartolome F, Rubio-Fernandez M, Martin-Requero A, Campillo NE, Paez JA (2022) <br />Multitarget drugs as potential therapeutic agents for alzheimer's disease. A new family of 5-substituted indazole derivatives as cholinergic and BACE1 inhibitors<br /><i>J Enzyme Inhib Med Chem</i> <b>37</b>: 2348<br /><br />Codony S, Calvo-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Perez C, Rodriguez-Franco MI, Pizarro-Delgado J, Corpas R, Grinan-Ferre C, Pallas M, Sanfeliu C, Vazquez-Carrera M, Hammock BD, Feixas F, Vazquez S (2021) <br />From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis<br /><i>Journal of Medicinal Chemistry</i> <br /><br />Jin N, Matter WF, Michael LF, Qian Y, Gheyi T, Cano L, Perez C, Lafuente C, Broughton HB, Espada A (2021) <br />The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage<br /><i>ACS Chemical Biology</i> <br /><br />Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza MI, Brea JM, Saez E, Oyarzabal J, Pineda-Lucena A, Perez B, Perez C, Rodriguez-Franco MI, Leiva R, Osuna S, Morisseau C, Hammock BD, Vazquez-Carrera M, Vazquez S (2020) <br />2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis<br /><i>Journal of Medicinal Chemistry</i> <b>63</b>: 9237<br /><br />Nunez-Borque E, Gonzalez-Naranjo P, Bartolome F, Alquezar C, Reinares-Sebastian A, Perez C, Ceballos ML, Paez JA, Campillo NE, Martin-Requero A (2020) <br />Targeting Cannabinoid Receptor Activation and BACE-1 Activity Counteracts TgAPP Mice Memory Impairment and Alzheimer's Disease Lymphoblast Alterations<br /><i>Molecular Neurobiology</i> <br /><br />Bermejo-Poza R, Fernandez-Muela M, de la Fuente J, Perez C, de Chavarri EG, Diaz MT, Torrent F, Villarroel M (2019) <br />Physio-metabolic response of rainbow trout during prolonged food deprivation before slaughter<br /><i>Fish Physiol Biochem</i> <b>45</b>: 253<br /><br />Estrada-Valencia M, Herrera-Arozamena C, Perez C, Vina D, Morales-Garcia JA, Perez-Castillo A, Ramos E, Romero A, Laurini E, Pricl S, Rodriguez-Franco MI (2019) <br />New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer s disease endowed with neurogenic properties<br /><i>J Enzyme Inhib Med Chem</i> <b>34</b>: 712<br /><br />Gonzalez-Naranjo P, Perez-Macias N, Perez C, Roca C, Vaca G, Giron R, Sanchez-Robles E, Martin-Fontelles MI, de Ceballos ML, Martin-Requero A, Campillo NE, Paez JA (2019) <br />Indazolylketones as new multitarget cannabinoid drugs<br /><i>Eur Journal of Medicinal Chemistry</i> <b>166</b>: 90<br /><br />de Andrade P, Mantoani SP, Goncalves Nunes PS, Magadan CR, Perez C, Xavier DJ, Hojo ETS, Campillo NE, Martinez A, Carvalho I (2019) <br />Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry</i> <b>27</b>: 931<br /><br />Chierrito TPC, Pedersoli-Mantoani S, Roca C, Sebastian-Perez V, Martinez-Gonzalez L, Perez DI, Perez C, Canales A, Canada FJ, Campillo NE, Carvalho I, Martinez A (2018) <br />Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>145</b>: 431<br /><br />Del Cerro P, Alquezar C, Bartolome F, Gonzalez-Naranjo P, Perez C, Carro E, Paez JA, Campillo NE, Martin-Requero A (2018) <br />Activation of the Cannabinoid Type 2 Receptor by a Novel Indazole Derivative Normalizes the Survival Pattern of Lymphoblasts from Patients with Late-Onset Alzheimer's Disease<br /><i>CNS Drugs</i> <b>32</b>: 579<br /><br />Estrada Valencia M, Herrera-Arozamena C, de Andres L, Perez C, Morales-Garcia JA, Perez-Castillo A, Ramos E, Romero A, Vina D, Yanez M, Laurini E, Pricl S, Rodriguez-Franco MI (2018) <br />Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>156</b>: 534<br /><br />Reis J, Cagide F, Valencia ME, Teixeira J, Bagetta D, Perez C, Uriarte E, Oliveira PJ, Ortuso F, Alcaro S, Rodriguez-Franco MI, Borges F (2018) <br />Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>158</b>: 781<br /><br />Roca C, Requena C, Sebastian-Perez V, Malhotra S, Radoux C, Perez C, Martinez A, Antonio Paez J, Blundell TL, Campillo NE (2018) <br />Identification of new allosteric sites and modulators of AChE through computational and experimental tools<br /><i>J Enzyme Inhib Med Chem</i> <b>33</b>: 1034<br /><br />Chierrito TPC, Mantoani SP, Roca C, Requena C, Sebastian-Perez V, Castillo WO, Moreira NCS, Perez C, Sakamoto-Hojo ET, Takahashi CS, Jimenez-Barbero J, Canada FJ, Campillo NE, Martinez A, Carvalho I (2017) <br />From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>139</b>: 773<br /><br />Fernandez S, Giglio J, Reyes AL, Damian A, Perez C, Perez DI, Gonzalez M, Oliver P, Rey A, Engler H, Cerecetto H (2017) <br />3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain<br /><i>Future Med Chem</i> <b>9</b>: 983<br /><br />Monjas L, Arce MP, Leon R, Egea J, Perez C, Villarroya M, Lopez MG, Gil C, Conde S, Rodriguez-Franco MI (2017) <br />Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia<br /><i>Eur Journal of Medicinal Chemistry</i> <b>130</b>: 60<br /><br />Chlebek J, De Simone A, Hostalkova A, Opletal L, Perez C, Perez DI, Havlikova L, Cahlikova L, Andrisano V (2016) <br />Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets<br /><i>Fitoterapia</i> <b>109</b>: 241<br /><br />Estrada M, Herrera-Arozamena C, Perez C, Vina D, Romero A, Morales-Garcia JA, Perez-Castillo A, Rodriguez-Franco MI (2016) <br />New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties<br /><i>Eur Journal of Medicinal Chemistry</i> <b>121</b>: 376<br /><br />Estrada M, Perez C, Soriano E, Laurini E, Romano M, Pricl S, Morales-Garcia JA, Perez-Castillo A, Rodriguez-Franco MI (2016) <br />New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with sigma-1 agonism and beta-secretase inhibition<br /><i>Future Med Chem</i> <b>8</b>: 1191<br /><br />Gonzalez-Naranjo P, Perez-Macias N, Campillo NE, Perez C, Aran VJ, Giron R, Sanchez-Robles E, Martin MI, Gomez-Canas M, Garcia-Arencibia M, Fernandez-Ruiz J, Paez JA (2014) <br />Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>73</b>: 56<br /><br />Lopez-Iglesias B, Perez C, Morales-Garcia JA, Alonso-Gil S, Perez-Castillo A, Romero A, Lopez MG, Villarroya M, Conde S, Rodriguez-Franco MI (2014) <br />New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 3773<br /><br />Bolea I, Gella A, Monjas L, Perez C, Rodriguez-Franco MI, Marco-Contelles J, Samadi A, Unzeta M (2013) <br />Multipotent, permeable drug ASS234 inhibits Abeta aggregation, possesses antioxidant properties and protects from Abeta-induced apoptosis in vitro<br /><i>Curr Alzheimer Res</i> <b>10</b>: 797<br /><br />Gonzalez-Naranjo P, Campillo NE, Perez C, Paez JA (2013) <br />Multitarget cannabinoids as novel strategy for Alzheimer disease<br /><i>Curr Alzheimer Res</i> <b>10</b>: 229<br /><br />Samadi A, de la Fuente Revenga M, Perez C, Iriepa I, Moraleda I, Rodriguez-Franco MI, Marco-Contelles J (2013) <br />Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>67</b>: 64<br /><br />Silva D, Chioua M, Samadi A, Agostinho P, Garcao P, Lajarin-Cuesta R, de los Rios C, Iriepa I, Moraleda I, Gonzalez-Lafuente L, Mendes E, Perez C, Rodriguez-Franco MI, Marco-Contelles J, Carmo Carreiras M (2013) <br />Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity<br /><i>ACS Chem Neurosci</i> <b>4</b>: 547<br /><br />Fernandez-Bachiller MI, Perez C, Monjas L, Rademann J, Rodriguez-Franco MI (2012) <br />New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and beta-amyloid-reducing properties<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 1303<br /><br />Samadi A, Estrada M, Perez C, Rodriguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Marco-Contelles J (2012) <br />Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling<br /><i>Eur Journal of Medicinal Chemistry</i> <b>57C</b>: 296<br /><br />Gonzalez-Munoz GC, Arce MP, Lopez B, Perez C, Romero A, Del Barrio L, Martin-de-Saavedra MD, Egea J, Leon R, Villarroya M, Lopez MG, Garcia AG, Conde S, Rodriguez-Franco MI (2011) <br />N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 2224<br /><br />Fernandez-Bachiller MI, Perez C, Gonzalez-Munoz GC, Conde S, Lopez MG, Villarroya M, Garcia AG, Rodriguez-Franco MI (2010) <br />Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties<br /><i>Journal of Medicinal Chemistry</i> <b>53</b>: 4927<br /><br />Gonzalez-Munoz GC, Arce MP, Lopez B, Perez C, Villarroya M, Lopez MG, Garcia AG, Conde S, Rodriguez-Franco MI (2010) <br />Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases<br /><i>Eur Journal of Medicinal Chemistry</i> <b>45</b>: 6152<br /><br />Arce MP, Rodriguez-Franco MI, Gonzalez-Munoz GC, Perez C, Lopez B, Villarroya M, Lopez MG, Garcia AG, Conde S (2009) <br />Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 7249<br /><br />Fernandez-Bachiller MI, Perez C, Campillo NE, Paez JA, Gonzalez-Munoz GC, Usan P, Garcia-Palomero E, Lopez MG, Villarroya M, Garcia AG, Martinez A, Rodriguez-Franco MI (2009) <br />Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties<br /><i>ChemMedChem</i> <b>4</b>: 828<br /><br />Rodriguez-Franco MI, Fernandez-Bachiller MI, Perez C, Hernandez-Ledesma B, Bartolome B (2006) <br />Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 459<br /><br />Rodriguez-Franco MI, Fernandez-Bachiller MI, Perez C, Castro A, Martinez A (2005) <br />Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry</i> <b>13</b>: 6795<br /><br />Martinez A, Lanot C, Perez C, Castro A, Lopez-Serrano P, Conde S (2000) <br />Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives<br /><i>Bioorganic & Medicinal Chemistry</i> <b>8</b>: 731<br /><br />Rodriguez-Franco MI, Dorronsoro I, Martinez A, Perez C, Badia A, Banos JE (2000) <br />Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties<br /><i>Arch Pharm (Weinheim)</i> <b>333</b>: 118<br /><br />Servin-Gonzalez L, Castro C, Perez C, Rubio M, Valdez F (1997) <br />bldA-dependent expression of the Streptomyces exfoliatus M11 lipase gene (lipA) is mediated by the product of a contiguous gene, lipR, encoding a putative transcriptional activator<br /><i>Journal of Bacteriology</i> <b>179</b>: 7816<br /><br />Cruz H, Perez C, Wellington E, Castro C, Servin-Gonzalez L (1994) <br />Sequence of the Streptomyces albus G lipase-encoding gene reveals the presence of a prokaryotic lipase family<br /><i>Gene</i> <b>144</b>: 141<br /><br />Perez C, Juarez K, Garcia-Castells E, Soberon G, Servin-Gonzalez L (1993) <br />Cloning, characterization, and expression in Streptomyces lividans 66 of an extracellular lipase-encoding gene from Streptomyces sp. M11<br /><i>Gene</i> <b>123</b>: 109<br /><br />