Menyhard DK, Kiss-Szeman A, Tichy-Racs E, Hornung B, Radi K, Szeltner Z, Domokos K, Szamosi I, Naray-Szabo G, Polgar L, Harmat V (2013) <br />A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization<br /><i>Journal of Biological Chemistry</i> <b>288</b>: 17884<br /><br />Szeltner Z, Juhasz T, Szamosi I, Rea D, Fulop V, Modos K, Juliano L, Polgar L (2012) <br />The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity<br /><i>Biochimica & Biophysica Acta</i> <b>1834</b>: 98<br /><br />Harmat V, Domokos K, Menyhard DK, Pallo A, Szeltner Z, Szamosi I, Beke-Somfai T, Naray-Szabo G, Polgar L (2011) <br />Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase<br /><i>Journal of Biological Chemistry</i> <b>286</b>: 1987<br /><br />Szeltner Z, Morawski M, Juhasz T, Szamosi I, Liliom K, Csizmok V, Tolgyesi F, Polgar L (2010) <br />GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase<br /><i>Biochimica & Biophysica Acta</i> <b>1804</b>: 2162<br /><br />Szeltner Z, Kiss AL, Domokos K, Harmat V, Naray-Szabo G, Polgar L (2009) <br />Characterization of a novel acylaminoacyl peptidase with hexameric structure and endopeptidase activity<br /><i>Biochimica & Biophysica Acta</i> <b>1794</b>: 1204<br /><br />Kiss AL, Pallo A, Naray-Szabo G, Harmat V, Polgar L (2008) <br />Structural and kinetic contributions of the oxyanion binding site to the catalytic activity of acylaminoacyl peptidase<br /><i>J Struct Biol</i> <b>162</b>: 312<br /><br />Szeltner Z, Polgar L (2008) <br />Structure, function and biological relevance of prolyl oligopeptidase<br /><i>Curr Protein Pept Sci</i> <b>9</b>: 96<br /><br />Gorrao SS, Hemerly JP, Lima AR, Melo RL, Szeltner Z, Polgar L, Juliano MA, Juliano L (2007) <br />Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase<br /><i>Peptides</i> <b>28</b>: 2146<br /><br />Juhasz T, Szeltner Z, Polgar L (2007) <br />Truncated prolyl oligopeptidase from Pyrococcus furiosus<br /><i>Proteins</i> <b>69</b>: 633<br /><br />Kiss AL, Hornung B, Radi K, Gengeliczki Z, Sztaray B, Juhasz T, Szeltner Z, Harmat V, Polgar L (2007) <br />The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity<br /><i>Journal of Molecular Biology</i> <b>368</b>: 509<br /><br />Juhasz T, Szeltner Z, Polgar L (2006) <br />Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus<br /><i>FEBS Letters</i> <b>580</b>: 3493<br /><br />Fuxreiter M, Magyar C, Juhasz T, Szeltner Z, Polgar L, Simon I (2005) <br />Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways<br /><i>Proteins</i> <b>60</b>: 504<br /><br />Juhasz T, Szeltner Z, Fulop V, Polgar L (2005) <br />Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase<br /><i>Journal of Molecular Biology</i> <b>346</b>: 907<br /><br />Szeltner Z, Alshafee I, Juhasz T, Parvari R, Polgar L (2005) <br />The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity<br /><i>Cell Mol Life Sciences</i> <b>62</b>: 2376<br /><br />Wright H, Kiss AL, Szeltner Z, Polgar L, Fulop V (2005) <br />Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase<br /><i>Acta Crystallographica Sect F Struct Biol Cryst Commun</i> <b>61</b>: 942<br /><br />Szeltner Z, Rea D, Juhasz T, Renner V, Fulop V, Polgar L (2004) <br />Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding<br /><i>Journal of Molecular Biology</i> <b>340</b>: 627<br /><br />Szeltner Z, Rea D, Renner V, Juliano L, Fulop V, Polgar L (2003) <br />Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding<br /><i>Journal of Biological Chemistry</i> <b>278</b>: 48786<br /><br />Polgar L (2002) <br />The prolyl oligopeptidase family<br /><i>Cell Mol Life Sciences</i> <b>59</b>: 349<br /><br />Szeltner Z, Rea D, Renner V, Fulop V, Polgar L (2002) <br />Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site<br /><i>Journal of Biological Chemistry</i> <b>277</b>: 42613<br /><br />Szeltner Z, Rea D, Juhasz T, Renner V, Mucsi Z, Orosz G, Fulop V, Polgar L (2002) <br />Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase<br /><i>Journal of Biological Chemistry</i> <b>277</b>: 44597<br /><br />Fulop V, Szeltner Z, Renner V, Polgar L (2001) <br />Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue<br /><i>Journal of Biological Chemistry</i> <b>276</b>: 1262<br /><br />Fulop V, Szeltner Z, Polgar L (2000) <br />Catalysis of serine oligopeptidases is controlled by a gating filter mechanism<br /><i>EMBO Rep</i> <b>1</b>: 277<br /><br />Szeltner Z, Renner V, Polgar L (2000) <br />The noncatalytic beta-propeller domain of prolyl oligopeptidase enhances the catalytic capability of the peptidase domain<br /><i>Journal of Biological Chemistry</i> <b>275</b>: 15000<br /><br />Fulop V, Bocskei Z, Polgar L (1998) <br />Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis<br /><i>Cell</i> <b>94</b>: 161<br /><br />Kahyaoglu A, Haghjoo K, Guo F, Jordan F, Kettner C, Felfoldi F, Polgar L (1997) <br />Low barrier hydrogen bond is absent in the catalytic triads in the ground state but Is present in a transition-state complex in the prolyl oligopeptidase family of serine proteases<br /><i>Journal of Biological Chemistry</i> <b>272</b>: 25547<br /><br />Polgar L (1995) <br />Effects of ionic strength on the catalysis and stability of prolyl oligopeptidase<br /><i>Biochemical Journal</i> <b>312</b>: 267<br /><br />Polgar L (1994) <br />Prolyl oligopeptidases<br /><i>Methods Enzymol</i> <b>244</b>: 188<br /><br />Polgar L (1992) <br />Structural relationship between lipases and peptidases of the prolyl oligopeptidase family<br /><i>FEBS Letters</i> <b>311</b>: 281<br /><br />Rawlings ND, Polgar L, Barrett AJ (1991) <br />A new family of serine-type peptidases related to prolyl oligopeptidase [letter]<br /><i>Biochemical Journal</i> <b>279</b>: 907<br /><br />