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Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation
RSC Med Chem 13: 568

Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge RGM, Motta RdSF, Goncalves Castro N, Alvim Guedes I, Dardenne LE, Amaral Alves M, Garrett da Costa R, Beserra Pinheiro G, Germino Veras L, Renata Mortari M, Pruccoli L, Tarozzi A, Viegas C, Jr. (2022)
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease
Bioorganic & Medicinal Chemistry 71: 116952

Campos HM, da Costa M, da Silva Moreira LK, da Silva Neri HF, Branco da Silva CR, Pruccoli L, Dos Santos FCA, Costa EA, Tarozzi A, Ghedini PC (2021)
Protective Effects of Chrysin against the Neurotoxicity Induced by Aluminium: In Vitro and In Vivo Studies
Toxicology

de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimares MJR, F MRdS, Fonseca Nadur N, de Azevedo LL, Kummerle AE, Guedes IA, Dardenne LE, Gontijo VS, Tarozzi A, Viegas C (2020)
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease
Molecules 25:

Montanari S, Mahmoud AM, Pruccoli L, Rabbito A, Naldi M, Petralla S, Moraleda I, Bartolini M, Monti B, Iriepa I, Belluti F, Gobbi S, Di Marzo V, Bisi A, Tarozzi A, Ligresti A, Rampa A (2019)
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
Eur Journal of Medicinal Chemistry 178: 243

Morroni F, Sita G, Graziosi A, Ravegnini G, Molteni R, Paladini MS, Dias KST, Dos Santos AF, Viegas C, Jr., Camps I, Pruccoli L, Tarozzi A, Hrelia P (2019)
PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease
Front Pharmacol 10: 658

Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simoes de Lima LM, Mancini KC, Marques de Oliveira PC, Morais EP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Pecanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GA, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C, Jr. (2018)
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates
Eur Journal of Medicinal Chemistry 147: 48

Rampa A, Bartolini M, Pruccoli L, Naldi M, Iriepa I, Moraleda I, Belluti F, Gobbi S, Tarozzi A, Bisi A (2018)
Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease
Molecules 23:

Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimaraes MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C, Jr. (2017)
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 130: 440

Rampa A, Montanari S, Pruccoli L, Bartolini M, Falchi F, Feoli A, Cavalli A, Belluti F, Gobbi S, Tarozzi A, Bisi A (2017)
Chalcone-based carbamates for Alzheimer's disease treatment
Future Med Chem 9: 749

Montanari S, Bartolini M, Neviani P, Belluti F, Gobbi S, Pruccoli L, Tarozzi A, Falchi F, Andrisano V, Miszta P, Cavalli A, Filipek S, Bisi A, Rampa A (2016)
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives
ChemMedChem 11: 1296