Mardon K, Patel JZ, Savinainen JR, Stimson DHR, Oyagawa CRM, Grimsey NL, Migotto MA, Njiru GFM, Hamilton BR, Cowin G, Yli-Kauhaluoma J, Vanduffel W, Blakey I, Bhalla R, Cawthorne C, Celen S, Bormans G, Thurecht KJ, Ahamed M (2022) <br />Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid alpha/beta-Hydrolase Domain 6 (ABHD6)<br /><i>Journal of Medicinal Chemistry</i> <br /><br />Della Pietra A, Giniatullin R, Savinainen JR (2021) <br />Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine<br /><i>Int J Mol Sci</i> <b>22</b>: <br /><br />Ahonen TJ, Savinainen JR, Yli-Kauhaluoma J, Kalso E, Laitinen JT, Moreira VM (2018) <br />Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A<br /><i>ACS Med Chem Lett</i> <b>9</b>: 1269<br /><br />Ahamed M, Attili B, van Veghel D, Ooms M, Berben P, Celen S, Koole M, Declercq L, Savinainen JR, Laitinen JT, Verbruggen A, Bormans G (2017) <br />Synthesis and preclinical evaluation of [(11)C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL)<br /><i>Eur Journal of Medicinal Chemistry</i> <b>136</b>: 104<br /><br />Aaltonen N, Kedzierska E, Orzelska-Gorka J, Lehtonen M, Navia-Paldanius D, Jakupovic H, Savinainen JR, Nevalainen T, Laitinen JT, Parkkari T, Gynther M (2016) <br />In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)m ethanone (JJKK-048)<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>359</b>: 62<br /><br />Navia-Paldanius D, Patel JZ, Lopez Navarro M, Jakupovic H, Goffart S, Pasonen-Seppanen S, Nevalainen TJ, Jaaskelainen T, Laitinen T, Laitinen JT, Savinainen JR (2016) <br />Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha/beta-hydrolase domain containing 11 (ABHD11)<br /><i>Eur J Pharm Sci</i> <b>93</b>: 253<br /><br />Savinainen JR, Navia-Paldanius D, Laitinen JT (2016) <br />A Sensitive and Versatile Fluorescent Activity Assay for ABHD6<br /><i>Methods Mol Biol</i> <b>1412</b>: 169<br /><br />Savinainen JR, Navia-Paldanius D, Laitinen JT (2016) <br />A Sensitive and Versatile Fluorescent Activity Assay for ABHD12<br /><i>Methods Mol Biol</i> <b>1412</b>: 179<br /><br />Navia-Paldanius D, Aaltonen N, Lehtonen M, Savinainen JR, Taschler U, Radner FP, Zimmermann R, Laitinen JT (2015) <br />Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase<br /><i>Eur J Pharm Sci</i> <b>77</b>: 180<br /><br />Patel JZ, Nevalainen TJ, Savinainen JR, Adams Y, Laitinen T, Runyon RS, Vaara M, Ahenkorah S, Kaczor AA, Navia-Paldanius D, Gynther M, Aaltonen N, Joharapurkar AA, Jain MR, Haka AS, Maxfield FR, Laitinen JT, Parkkari T (2015) <br />Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors<br /><i>ChemMedChem</i> <b>10</b>: 253<br /><br />Patel JZ, Ahenkorah S, Vaara M, Staszewski M, Adams Y, Laitinen T, Navia-Paldanius D, Parkkari T, Savinainen JR, Walczynski K, Laitinen JT, Nevalainen TJ (2015) <br />Loratadine analogues as MAGL inhibitors<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>25</b>: 1436<br /><br />Patel JZ, van Bruchem J, Laitinen T, Kaczor AA, Navia-Paldanius D, Parkkari T, Savinainen JR, Laitinen JT, Nevalainen TJ (2015) <br />Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors<br /><i>Bioorganic & Medicinal Chemistry</i> <b>23</b>: 6335<br /><br />Aaltonen N, Riera Ribas C, Lehtonen M, Savinainen JR, Laitinen JT (2014) <br />Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice<br /><i>Eur J Pharm Sci</i> <b>51</b>: 87<br /><br />Korhonen J, Kuusisto A, van Bruchem J, Patel JZ, Laitinen T, Navia-Paldanius D, Laitinen JT, Savinainen JR, Parkkari T, Nevalainen TJ (2014) <br />Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)<br /><i>Bioorganic & Medicinal Chemistry</i> <b>22</b>: 6694<br /><br />Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Karizkova J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR (2014) <br />Mutation of cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency<br /><i>Molecular Pharmacology</i> <b>85</b>: 510<br /><br />Parkkari T, Haavikko R, Laitinen T, Navia-Paldanius D, Rytilahti R, Vaara M, Lehtonen M, Alakurtti S, Yli-Kauhaluoma J, Nevalainen T, Savinainen JR, Laitinen JT (2014) <br />Discovery of Triterpenoids as Reversible Inhibitors of alpha/beta-hydrolase Domain Containing 12 (ABHD12)<br /><i>PLoS ONE</i> <b>9</b>: e98286<br /><br />Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT (2014) <br />Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL)<br /><i>Molecular Pharmacology</i> <b>86</b>: 522<br /><br />Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, Nevalainen T, Laitinen JT (2014) <br />Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)<br /><i>PLoS ONE</i> <b>9</b>: e109869<br /><br />Aaltonen N, Savinainen JR, Ribas CR, Ronkko J, Kuusisto A, Korhonen J, Navia-Paldanius D, Hayrinen J, Takabe P, Kasnanen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppanen S, Poso A, Nevalainen T, Laitinen JT (2013) <br />Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase<br /><i>Chemical Biology</i> <b>20</b>: 379<br /><br />Navia-Paldanius D, Savinainen JR, Laitinen JT (2012) <br />Biochemical and pharmacological characterization of human alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)<br /><i>J Lipid Res</i> <b>53</b>: 2413<br /><br />Savinainen JR, Saario SM, Laitinen JT (2012) <br />The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors<br /><i>Acta Physiol (Oxf)</i> <b>204</b>: 267<br /><br />Savinainen JR, Yoshino M, Minkkila A, Nevalainen T, Laitinen JT (2010) <br />Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique<br /><i>Analytical Biochemistry</i> <b>399</b>: 132<br /><br />Minkkila A, Savinainen JR, Kasnanen H, Xhaard H, Nevalainen T, Laitinen JT, Poso A, Leppanen J, Saario SM (2009) <br />Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors<br /><i>ChemMedChem</i> <b>4</b>: 1253<br /><br />Saario SM, Savinainen JR, Laitinen JT, Jarvinen T, Niemi R (2004) <br />Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes<br /><i>Biochemical Pharmacology</i> <b>67</b>: 1381<br /><br />