Matheeussen V, Waumans Y, Martinet W, Van Goethem S, Van der Veken P, Scharpe S, Augustyns K, De Meyer GR, De Meester I (2013)
Dipeptidyl peptidases in atherosclerosis: expression and role in macrophage differentiation, activation and apoptosis
Basic Res Cardiol 108: 350
Matheeussen V, Lambeir AM, Jungraithmayr W, Gomez N, Mc Entee K, Van der Veken P, Scharpe S, De Meester I (2012)
Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors
Clinica Chimica Acta 413: 456
Matheeussen V, Baerts L, De Meyer G, De Keulenaer G, Van der Veken P, Augustyns K, Dubois V, Scharpe S, De Meester I (2011)
Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries
Biol Chem 392: 189
Dubois V, Lambeir AM, Vandamme S, Matheeussen V, Guisez Y, Scharpe S, De Meester I (2010)
Dipeptidyl peptidase 9 (DPP9) from bovine testes: identification and characterization as the short form by mass spectrometry
Biochimica & Biophysica Acta 1804: 781
De Meester I, Scharpe S, Lambeir AM (2009)
Dipeptidyl peptidases and related proteins: multifaceted markers and therapeutic targets
Clinical Chemistry & Laboratory Medicine 47: 245
Dubois V, Van Ginneken C, De Cock H, Lambeir AM, Van der Veken P, Augustyns K, Chen X, Scharpe S, De Meester I (2009)
Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues
Journal of Histochemistry & Cytochemistry 57: 531
Jost MM, Lamerz J, Tammen H, Menzel C, De Meester I, Lambeir AM, Augustyns K, Scharpe S, Zucht HD, Rose H, Jurgens M, Schulz-Knappe P, Budde P (2009)
In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma
Biochemical Pharmacology 77: 228
Vanderheyden M, Bartunek J, Goethals M, Verstreken S, Lambeir AM, De Meester I, Scharpe S (2009)
Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
Clinical Chemistry & Laboratory Medicine 47: 248
Brandt I, Gerard M, Sergeant K, Devreese B, Baekelandt V, Augustyns K, Scharpe S, Engelborghs Y, Lambeir AM (2008)
Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein
Peptides 29: 1472
Dubois V, Lambeir AM, Van der Veken P, Augustyns K, Creemers J, Chen X, Scharpe S, De Meester I (2008)
Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes
Front Biosci 13: 3558
Lambeir AM, Scharpe S, De Meester I (2008)
DPP4 inhibitors for diabetes--what next?
Biochemical Pharmacology 76: 1637
Van Goethem S, Van der Veken P, Dubois V, Soroka A, Lambeir AM, Chen X, Haemers A, Scharpe S, De Meester I, Augustyns K (2008)
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors
Bioorganic & Medicinal Chemistry Lett 18: 4159
Van der Veken P, De Meester I, Dubois V, Soroka A, Van Goethem S, Maes MB, Brandt I, Lambeir AM, Chen X, Haemers A, Scharpe S, Augustyns K (2008)
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads
Bioorganic & Medicinal Chemistry Lett 18: 4154
Maes MB, Dubois V, Brandt I, Lambeir AM, Van der Veken P, Augustyns K, Cheng JD, Chen X, Scharpe S, De Meester I (2007)
Dipeptidyl peptidase 8/9-like activity in human leukocytes
J Leukoc Biol 81: 1252
Van der Veken P, Soroka A, Brandt I, Chen YS, Maes MB, Lambeir AM, Chen X, Haemers A, Scharpe S, Augustyns K, De Meester I (2007)
Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates
Journal of Medicinal Chemistry 50: 5568
Brandt I, Lambeir AM, Ketelslegers JM, Vanderheyden M, Scharpe S, De Meester I (2006)
Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form
Clinical Chemistry 52: 82
Brandt I, Lambeir AM, Maes MB, Scharpe S, De Meester I (2006)
Peptide substrates of dipeptidyl peptidases
Advances in Experimental Medicine & Biology 575: 3
Maes MB, Martinet W, Schrijvers DM, Van der Veken P, De Meyer GR, Augustyns K, Lambeir AM, Scharpe S, De Meester I (2006)
Dipeptidyl peptidase II and leukocyte cell death
Biochemical Pharmacology 72: 70
Maes MB, Lambeir AM, Van der Veken P, De Winter B, Augustyns K, Scharpe S, De Meester I (2006)
In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII
Advances in Experimental Medicine & Biology 575: 73
Soroka A, Van der Veken P, De Meester I, Lambeir AM, Maes MB, Scharpe S, Haemers A, Augustyns K (2006)
Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines
Bioorganic & Medicinal Chemistry Lett 16: 4777
Zhai W, Cardell M, De Meester I, Augustyns K, Hillinger S, Inci I, Arni S, Jungraithmayr W, Scharpe S, Weder W, Korom S (2006)
Ischemia/reperfusion injury: The role of CD26/dipeptidyl-peptidase-IV-inhibition in lung transplantation
Transplant Proc 38: 3369
Brandt I, De Vriendt K, Devreese B, Van Beeumen J, Van Dongen W, Augustyns K, De Meester I, Scharpe S, Lambeir AM (2005)
Search for substrates for prolyl oligopeptidase in porcine brain
Peptides 26: 2536
Brandt I, Joossens J, Chen X, Maes MB, Scharpe S, De Meester I, Lambeir AM (2005)
Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile)
Biochemical Pharmacology 70: 134
Maes MB, Lambeir AM, Gilany K, Senten K, Van der Veken P, Leiting B, Augustyns K, Scharpe S, De Meester I (2005)
Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7)
Biochemical Journal 386: 315
Van der Veken P, Senten K, Kertesz I, De Meester I, Lambeir AM, Maes MB, Scharpe S, Haemers A, Augustyns K (2005)
Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases
Journal of Medicinal Chemistry 48: 1768
Rea D, Lambeir AM, Kumagai Y, De Meester I, Scharpe S, Fulop V (2004)
Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis
Acta Crystallographica D Biol Crystallogr 60: 1871
Senten K, Van der Veken P, De Meester I, Lambeir AM, Scharpe S, Haemers A, Augustyns K (2004)
Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors
Journal of Medicinal Chemistry 47: 2906
De Meester I, Lambeir AM, Proost P, Scharpe S (2003)
Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV
Advances in Experimental Medicine & Biology 524: 3
Lambeir AM, Durinx C, Scharpe S, De Meester I (2003)
Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV
Crit Rev Clin Lab Sci 40: 209
Lambeir AM, Rea D, Fulop V, Kumagai Y, Augustyns K, De Meester I, Haemers A, Scharpe S (2003)
Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme
Advances in Experimental Medicine & Biology 524: 29
Senten K, Daniels L, Van der Veken P, De Meester I, Lambeir AM, Scharpe S, Haemers A, Augustyns K (2003)
Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases
J Comb Chem 5: 336
Senten K, Van der Veken P, De Meester I, Lambeir AM, Scharpe S, Haemers A, Augustyns K (2003)
Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases
Journal of Medicinal Chemistry 46: 5005
Depreitere J, Durinx C, Wang Z, Coen E, Lambeir AM, Scharpe S, De Potter W, Nouwen EJ (2002)
Presence and release of SR-17 (chromogranin B(586-602)) in the porcine splenic nerve and its enzymatic degradation by CD26/dipeptidyl peptidase IV
Regul Pept 106: 71
Lambeir AM, Proost P, Durinx C, Bal G, Senten K, Augustyns K, Scharpe S, Van Damme J, De Meester I (2001)
Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
Journal of Biological Chemistry 276: 29839
Lambeir AM, Durinx C, Proost P, Van Damme J, Scharpe S, De Meester I (2001)
Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion
FEBS Letters 507: 327
Durinx C, Lambeir AM, Bosmans E, Falmagne JB, Berghmans R, Haemers A, Scharpe S, De Meester I (2000)
Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides
European Journal of Biochemistry 267: 5608
Belyaev A, Zhang X, Augustyns K, Lambeir AM, De Meester I, Vedernikova I, Scharpe S, Haemers A (1999)
Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors
Journal of Medicinal Chemistry 42: 1041
De Meester I, Belyaev A, Lambeir AM, De Meyer GR, Van Osselaer N, Haemers A, Scharpe S (1997)
In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (Prodipine)
Biochemical Pharmacology 54: 173
Goossens F, Vanhoof G, De Meester I, Augustyns K, Borloo M, Tourwe D, Haemers A, Scharpe S (1997)
Development and evaluation of peptide-based prolyl oligopeptidase inhibitors--introduction of N-benzyloxycarbonyl-prolyl-3- fluoropyrrolidine as a lead in inhibitor design
European Journal of Biochemistry 250: 177
Lambeir AM, Diaz Pereira JF, Chacon P, Vermeulen G, Heremans K, Devreese B, Van Beeumen J, De Meester I, Scharpe S (1997)
A prediction of DPP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma
Biochimica & Biophysica Acta 1340: 215
Lambeir AM, Borloo M, De Meester I, Belyaev A, Augustyns K, Hendriks D, Scharpe S, Haemers A (1996)
Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV
Biochimica & Biophysica Acta 1290: 76
De Meester I, Vanhoof G, Lambeir AM, Scharpe S (1996)
Use of immobilized adenosine deaminase (EC 3.5.4.4) for the rapid purification of native human CD26/dipeptidyl peptidase IV (EC 3.4.14.5)
Journal of Immunological Methodsods 189: 99
Goossens F, De Meester I, Vanhoof G, Hendriks D, Vriend G, Scharpe S (1995)
The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family
European Journal of Biochemistry 233: 432
Scharpe S, De Meester I (1994)
Purified and cell-bound CD26: enzymatic inhibition, antibody binding profile, and expression on T cells in relation to other surface markers
Verh K Acad Geneeskd Belg 56: 537
Vanhoof G, Goossens F, Hendriks L, De Meester I, Hendriks D, Vriend G, Van Broeckhoven C, Scharpe S (1994)
Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase
Gene 149: 363
Uyttenbroeck W, Hendriks D, Vriend G, De Baere I, Moens L, Scharpe S (1993)
Molecular characterization of an extracellular acid-resistant lipase produced by Rhizopus javanicus
Biol Chem Hoppe Seyler 374: 245