Lockridge O, Schopfer LM (2023) <br />Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates<br /><i>Chemico-Biological Interactions</i> <br /><br />Schopfer LM, David E, Hinrichs SH, Lockridge O (2023) <br />Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography step on Hupresin<br /><i>PLoS ONE</i> <b>18</b>: e0280380<br /><br />Onder S, Schopfer LM, Jiang W, Tacal O, Lockridge O (2022) <br />Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells<br /><i>Neurotoxicology</i> <br /><br />Onder S, Biberoglu K, Tacal O, Schopfer LM (2022) <br />Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer's disease<br /><i>Chemico-Biological Interactions</i> <b>363</b>: 110029<br /><br />Schopfer LM, Onder S, Lockridge O (2022) <br />Organophosphorus Pesticides Promote Protein Cross-Linking<br /><i>Chemical Research in Toxicology</i> <br /><br />Onder S, van Grol M, Fidder A, Xiao G, Noort D, Yerramalla U, Tacal O, Schopfer LM, Lockridge O (2021) <br />Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry<br /><i>J Proteome Res</i> <br /><br />Schopfer LM, Onder S, Lockridge O (2021) <br />Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides<br /><i>PLoS ONE</i> <b>16</b>: e0254450<br /><br />Biberoglu K, Tacal O, Schopfer LM, Lockridge O (2020) <br />Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase<br /><i>Molecules</i> <b>25</b>: <br /><br />Biberoglu K, Schopfer LM, Tacal O, Lockridge O (2020) <br />Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine<br /><i>Analytical Biochemistry</i> <br /><br />Schopfer LM, Lockridge O (2020) <br />Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine<br /><i>Molecules</i> <b>25</b>: <br /><br />Toker L, Silman I, Zeev-Ben-Mordehai T, Sussman JL, Schopfer LM, Lockridge O (2020) <br />Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers<br /><i>Chemico-Biological Interactions</i> <br /><br />Grigorenko BL, Novichkova DA, Lushchekina SV, Zueva IV, Schopfer LM, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P (2019) <br />Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad<br /><i>Chemico-Biological Interactions</i> <b>306</b>: 138<br /><br />Lockridge O, Verdier L, Schopfer LM (2019) <br />Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution<br /><i>Chemico-Biological Interactions</i> <br /><br />Schopfer LM, Lockridge O, David E, Hinrichs SH (2019) <br />Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography<br /><i>PLoS ONE</i> <b>14</b>: e0209795<br /><br />Schopfer LM, Lockridge O (2019) <br />Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon<br /><i>Chemical Research in Toxicology</i> <b>32</b>: 762<br /><br />Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T (2018) <br />Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly<br /><i>Proc Natl Acad Sci U S A</i> <b>115</b>: 13270<br /><br />Lockridge O, David E, Schopfer LM, Masson P, Brazzolotto X, Nachon F (2018) <br />Purification of recombinant human butyrylcholinesterase on Hupresin(R)<br /><i>Journal of Chromatography B Analyt Technol Biomed Life Sciences</i> <b>1102-1103</b>: 109<br /><br />Lushchekina SV, Schopfer LM, Grigorenko BL, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P (2018) <br />Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents<br /><i>Front Pharmacol</i> <b>9</b>: 211<br /><br />Onder S, Schopfer LM, Cashman JR, Tacal O, Johnson RC, Blake TA, Lockridge O (2018) <br />Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure<br /><i>Analytical Chemistry</i> <b>90</b>: 974<br /><br />Saxena A, Belinskaya T, Schopfer LM, Lockridge O (2018) <br />Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig (Sus scrofa)<br /><i>Data Brief</i> <b>20</b>: 1607<br /><br />Saxena A, Belinskaya T, Schopfer LM, Lockridge O (2018) <br />Characterization of butyrylcholinesterase from porcine milk<br /><i>Archives of Biochemistry & Biophysics</i> <b>652</b>: 38<br /><br />Schopfer LM, Lockridge O (2018) <br />Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity<br /><i>Journal of Biological Chemistry</i> <b>293</b>: 13566<br /><br />Dafferner AJ, Lushchekina SV, Masson P, Xiao G, Schopfer LM, Lockridge O (2017) <br />Characterization of butyrylcholinesterase in bovine serum<br /><i>Chemico-Biological Interactions</i> <b>266</b>: 17<br /><br />Dafferner AJ, Schopfer LM, Xiao G, Cashman JR, Yerramalla U, Johnson RC, Blake TA, Lockridge O (2017) <br />Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure<br /><i>Chemical Research in Toxicology</i> <b>30</b>: 1897<br /><br />Onder S, David E, Tacal O, Schopfer LM, Lockridge O (2017) <br />Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide<br /><i>Front Pharmacol</i> <b>8</b>: 713<br /><br />Onder S, Dafferner AJ, Schopfer LM, Xiao G, Yerramalla U, Tacal O, Blake TA, Johnson RC, Lockridge O (2017) <br />Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids<br /><i>Chemical Research in Toxicology</i> <b>30</b>: 2218<br /><br />Schopfer LM, Delacour H, Masson P, Leroy J, Krejci E, Lockridge O (2017) <br />The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment<br /><i>Molecules</i> <b>22</b>: <br /><br />Peng H, Schopfer LM, Lockridge O (2016) <br />Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 63<br /><br />Schopfer LM, Lockridge O (2016) <br />Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers<br /><i>Biochimica & Biophysica Acta</i> <b>1864</b>: 706<br /><br />Schopfer LM, Lockridge O, Brimijoin S (2015) <br />Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin<br /><i>General & Comparative Endocrinology</i> <b>224</b>: 61<br /><br />Delacour H, Lushchekina SV, Mabboux I, Bousquet A, Ceppa F, Schopfer LM, Lockridge O, Masson P (2014) <br />Characterization of a Novel BCHE Silent Allele: Point Mutation (p.Val204Asp) Causes Loss of Activity and Prolonged Apnea with Suxamethonium<br /><i>PLoS ONE</i> <b>9</b>: e101552<br /><br />Delacour H, Lushchekina SV, Mabboux I, Ceppa F, Masson P, Schopfer LM, Lockridge O (2014) <br />Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), silent with mivacurium<br /><i>Biochemical Pharmacology</i> <b>92</b>: 476<br /><br />Schopfer LM, Masson P, Lamourette P, Simon S, Lockridge O (2014) <br />Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome<br /><i>Analytical Biochemistry</i> <b>461C</b>: 17<br /><br />Tacal O, Schopfer LM (2014) <br />Healthy F-16 pilots show no evidence of exposure to tri-ortho-cresyl phosphate through the on-board oxygen generating system<br /><i>Chemico-Biological Interactions</i> <b>215C</b>: 69<br /><br />Biberoglu K, Schopfer LM, Saxena A, Tacal O, Lockridge O (2013) <br />Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase<br /><i>Biochimica & Biophysica Acta</i> <b>1834</b>: 745<br /><br />Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M (2013) <br />Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry<br /><i>Chemical Research in Toxicology</i> <b>26</b>: 280<br /><br />Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O (2013) <br />Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond<br /><i>Toxicol Sci</i> <b>132</b>: 390<br /><br />Jiang W, Murashko EA, Dubrovskii YA, Podolskaya EP, Babakov VN, Mikler J, Nachon F, Masson P, Schopfer LM, Lockridge O (2013) <br />Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase<br /><i>Analytical Biochemistry</i> <b>439</b>: 132<br /><br />Jiang W, Dubrovskii YA, Podolskaya EP, Murashko EA, Babakov VN, Nachon F, Masson P, Schopfer LM, Lockridge O (2013) <br />PHOS-Select Iron Affinity Beads Enrich Peptides for the Detection of Organophosphorus Adducts on Albumin<br /><i>Chemical Research in Toxicology</i> <b>26</b>: 1917<br /><br />Li B, Duysen EG, Froment MT, Masson P, Nachon F, Jiang W, Schopfer LM, Thiele GM, Klassen LW, Cashman JR, Williams GR, Lockridge O (2013) <br />Polyclonal antibody to soman-tyrosine<br /><i>Chemical Research in Toxicology</i> <b>26</b>: 584<br /><br />Liyasova MS, Schopfer LM, Lockridge O (2013) <br />Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 103<br /><br />Liyasova MS, Schopfer LM, Kodani S, Lantz SR, Casida JE, Lockridge O (2013) <br />Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor<br /><i>Chemical Research in Toxicology</i> <b>26</b>: 422<br /><br />Masson P, Lushchekina SV, Schopfer LM, Lockridge O (2013) <br />Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies<br /><i>Biochemical Journal</i> <b>454</b>: 387<br /><br />Tacal O, Li B, Lockridge O, Schopfer LM (2013) <br />Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation; mass spectrometry analysis of oxidation products<br /><i>Photochem Photobiol</i> <b>89</b>: 336<br /><br />Biberoglu K, Schopfer LM, Tacal O, Lockridge O (2012) <br />The proline-rich tetramerization peptides in equine serum butyrylcholinesterase<br /><i>Febs J</i> <b>279</b>: 3844<br /><br />Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O (2012) <br />Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran<br /><i>Chemico-Biological Interactions</i> <b>195</b>: 189<br /><br />Liyasova MS, Schopfer LM, Lockridge O (2012) <br />Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin<br /><i>Chemical Research in Toxicology</i> <b>25</b>: 1752<br /><br />Schopfer LM, Lockridge O (2012) <br />Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts<br /><i>Drug Test Anal</i> <b>4</b>: 246<br /><br />Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P (2011) <br />Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis<br /><i>Chemical Research in Toxicology</i> <b>24</b>: 797<br /><br />Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O (2011) <br />Production of ES1 plasma carboxylesterase knockout mice for toxicity studies<br /><i>Chemical Research in Toxicology</i> <b>24</b>: 1891<br /><br />Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O (2011) <br />Exposure to tri-o-cresyl phosphate detected in jet airplane passengers<br /><i>Toxicol Appl Pharmacol</i> <b>256</b>: 337<br /><br />Marsillach J, Richter RJ, Kim JH, Stevens RC, Maccoss MJ, Tomazela D, Suzuki SM, Schopfer LM, Lockridge O, Furlong CE (2011) <br />Biomarkers of organophosphorus (OP) exposures in humans<br /><i>Neurotoxicology</i> <b>32</b>: 656<br /><br />Nachon F, Carletti E, Wandhammer M, Nicolet Y, Schopfer LM, Masson P, Lockridge O (2011) <br />X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger<br /><i>Biochemical Journal</i> <b>434</b>: 73<br /><br />Jiang W, Duysen EG, Hansen H, Shlyakhtenko L, Schopfer LM, Lockridge O (2010) <br />Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents<br /><i>Toxicol Sci</i> <b>115</b>: 183<br /><br />Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Masson P, Lockridge O (2010) <br />Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose<br /><i>J Appl Toxicol</i> <b>30</b>: 559<br /><br />Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Nachon F, Masson P, Lockridge O (2010) <br />Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos<br /><i>Toxicol Sci</i> <b>116</b>: 23<br /><br />Liyasova MS, Schopfer LM, Lockridge O (2010) <br />Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545<br /><i>Biochemical Pharmacology</i> <b>79</b>: 784<br /><br />Lockridge O, Schopfer LM (2010) <br />Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 344<br /><br />Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O (2010) <br />Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates<br /><i>Journal of Chromatography B Analyt Technol Biomed Life Sciences</i> <b>878</b>: 1297<br /><br />Schopfer LM, Furlong CE, Lockridge O (2010) <br />Development of diagnostics in the search for an explanation of aerotoxic syndrome<br /><i>Analytical Biochemistry</i> <b>404</b>: 64<br /><br />Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O (2009) <br />Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase<br /><i>Chemical Research in Toxicology</i> <b>22</b>: 1680<br /><br />Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O (2009) <br />Mass spectral characterization of organophosphate-labeled lysine in peptides.<br /><i>Analytical Biochemistry</i> <b>394</b>: 92<br /><br />Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O (2009) <br />Mass spectrometry identifies multiple organophosphorylated sites on tubulin<br /><i>Toxicol Appl Pharmacol</i> <b>240</b>: 149<br /><br />Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM (2009) <br />Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine<br /><i>Chemico-Biological Interactions</i> <b>180</b>: 492<br /><br />Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2009) <br />Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine<br /><i>Toxicol Sci</i> <b>107</b>: 144<br /><br />Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O (2009) <br />Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum<br /><i>J Appl Toxicol</i> <b>29</b>: 149<br /><br />Carletti E, Li H, Li B, Ekstrom F, Nicolet Y, Loiodice M, Gillon E, Froment MT, Lockridge O, Schopfer LM, Masson P, Nachon F (2008) <br />Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation<br /><i>Journal of the American Chemical Society</i> <b>130</b>: 16011<br /><br />Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo OA, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2008) <br />Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin<br /><i>Chemical Research in Toxicology</i> <b>21</b>: 1787<br /><br />Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O (2008) <br />Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 180<br /><br />Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, Masson P (2008) <br />Binding and hydrolysis of soman by human serum albumin<br /><i>Chemical Research in Toxicology</i> <b>21</b>: 421<br /><br />Li H, Schopfer LM, Masson P, Lockridge O (2008) <br />Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers<br /><i>Biochemical Journal</i> <b>411</b>: 425<br /><br />Li H, Tong L, Schopfer LM, Masson P, Lockridge O (2008) <br />Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 68<br /><br />Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P (2008) <br />Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines<br /><i>Journal of Biological Chemistry</i> <b>283</b>: 22582<br /><br />Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O (2008) <br />A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 273<br /><br />Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM (2008) <br />Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters<br /><i>Febs J</i> <b>275</b>: 2617<br /><br />Mikami LR, Wieseler S, Souza RL, Schopfer LM, Nachon F, Lockridge O, Chautard-Freire-Maia EA (2008) <br />Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population<br /><i>Pharmacogenet Genomics</i> <b>18</b>: 213<br /><br />Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O (2007) <br />Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411<br /><i>Analytical Biochemistry</i> <b>361</b>: 263<br /><br />Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O (2007) <br />Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry<br /><i>Toxicol Sci</i> <b>100</b>: 136<br /><br />Masson P, Froment MT, Darvesh S, Schopfer LM, Lockridge O (2007) <br />Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate<br /><i>J Enzyme Inhib Med Chem</i> <b>22</b>: 463<br /><br />Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM (2007) <br />Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase<br /><i>Biochimica & Biophysica Acta</i> <b>1774</b>: 16<br /><br />Masson P, Froment MT, Gillon E, Nachon F, Darvesh S, Schopfer LM (2007) <br />Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides<br /><i>Biochimica & Biophysica Acta</i> <b>1774</b>: 1139<br /><br />Mikami LR, Wieseler S, Souza RL, Schopfer LM, Lockridge O, Chautard-Freire-Maia EA (2007) <br />Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase<br /><i>Pharmacogenet Genomics</i> <b>17</b>: 681<br /><br />Poyot T, Nachon F, Froment MT, Loiodice M, Wieseler S, Schopfer LM, Lockridge O, Masson P (2006) <br />Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters<br /><i>Biochimica & Biophysica Acta</i> <b>1764</b>: 1470<br /><br />Wieseler S, Schopfer LM, Lockridge O (2006) <br />Markers of organophosphate exposure in human serum<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 93<br /><br />Li H, Schopfer LM, Spaulding R, Thompson CM, Lockridge O (2005) <br />Identification of organophosphate-reactive proteins by tandem mass spectrometry<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 383<br /><br />Lockridge O, Duysen EG, Voelker T, Thompson CM, Schopfer LM (2005) <br />Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice<br /><i>Environ Toxicol Pharmacol</i> <b>19</b>: 463<br /><br />Lockridge O, Schopfer LM, Winger G, Woods JH (2005) <br />Large scale purification of butyrylcholinesterase from human plasma suitable for injection into monkeys; A potential new therapeutic for protection against cocaine end nerve agent toxicity<br /><i>Journal of Medicinal Chemistryical Biology Radiol Def</i> <b>3</b>: nihms5095<br /><br />Masson P, Schopfer LM, Froment MT, Debouzy JC, Nachon F, Gillon E, Lockridge O, Hrabovska A, Goldstein BN (2005) <br />Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 143<br /><br />Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O (2005) <br />Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry<br /><i>Toxicol Sci</i> <b>83</b>: 303<br /><br />Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O (2005) <br />Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)<br /><i>Analytical Biochemistry</i> <b>345</b>: 122<br /><br />Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O (2005) <br />Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase<br /><i>Chemical Research in Toxicology</i> <b>18</b>: 747<br /><br />Masson P, Goldstein BN, Debouzy JC, Froment MT, Lockridge O, Schopfer LM (2004) <br />Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate<br /><i>European Journal of Biochemistry</i> <b>271</b>: 220<br /><br />Masson P, Froment MT, Nachon F, Schopfer LM (2004) <br />Hysteresis in butyrylcholinesterase catalysis.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Masson P, Froment MT, Nachon F, Lockridge O, Schopfer LM (2004) <br />Hysteretic behavior of butyrylcholinesterase: Kinetic curiosity or catalytically and physiologicaly significant?<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 191 <br /><br />Masson P, Bec N, Froment MT, Nachon F, Balny C, Lockridge O, Schopfer LM (2004) <br />Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior<br /><i>European Journal of Biochemistry</i> <b>271</b>: 1980<br /><br />Masson P, Froment MT, Nachon F, Lockridge O, Schopfer LM (2004) <br />Poster (20) Hysteretic behavior of butyrylcholinesterase : kinetic curiosity or catalytically and physiologically significant?<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 331<br /><br />Schopfer LM, Boeck AT, Broomfield CA, Lockridge O (2004) <br />Mutants of human butyrylcholinesterase with organophosphate hydrolase activity; evidence that His117 is a general base catalyst for hydrolysis of echothiophate<br /><i>Journal of Medicinal Chemistryical Biology Radiol Def</i> <b>2</b>: 1<br /><br />Wang Y, Schopfer LM, Duysen EG, Nachon F, Masson P, Lockridge O (2004) <br />Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants<br /><i>Analytical Biochemistry</i> <b>329</b>: 131<br /><br />Boeck AT, Schopfer LM, Lockridge O (2002) <br />DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase<br /><i>Biochemical Pharmacology</i> <b>63</b>: 2101<br /><br />Masson P, Froment MT, Fort S, Ribes F, Bec N, Balny C, Schopfer LM (2002) <br />Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior<br /><i>Biochimica & Biophysica Acta</i> <b>1597</b>: 229<br /><br />Masson P, Schopfer LM, Bartels CF, Froment MT, Ribes F, Nachon F, Lockridge O (2002) <br />Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite<br /><i>Biochimica & Biophysica Acta</i> <b>1594</b>: 313<br /><br />Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O (2001) <br />Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to vx lethality<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>299</b>: 528<br /><br />Josse D, Lockridge O, Xie W, Bartels CF, Schopfer LM, Masson P (2001) <br />The active site of human paraoxonase (PON1)<br /><i>J Appl Toxicol</i> <b>21 Suppl 1</b>: S7<br /><br />Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP (2001) <br />Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.<br /><i>Journal of Biological Chemistry</i> <b>276</b>: 9330<br /><br />Bartels CF, Xie W, Miller-Lindholm AK, Schopfer LM, Lockridge O (2000) <br />Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma<br /><i>Biochemical Pharmacology</i> <b>60</b>: 479<br /><br />Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, Hammond P, Brimijoin S, Hinrichs SH, Lockridge O (2000) <br />Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse<br /><i>Journal of Neurochemistry</i> <b>75</b>: 1320<br /><br />Josse D, Xie W, Renault F, Rochu D, Schopfer LM, Masson P, Lockridge O (1999) <br />Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities<br /><i>Biochemistry</i> <b>38</b>: 2816<br /><br />Josse D, Xie W, Masson P, Schopfer LM, Lockridge O (1999) <br />Tryptophan residue(s) as major components of the human serum paraoxonase active site<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 79<br /><br />Masson P, Legrand P, Bartels CF, Froment MT, Schopfer LM, Lockridge O (1997) <br />Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase<br /><i>Biochemistry</i> <b>36</b>: 2266<br /><br />Reiner E, Davis CS, Schwab BW, Schopfer LM, Richardson RJ (1987) <br />Kinetics of heat inactivation of phenyl valerate hydrolases from hen and rat brain<br /><i>Biochemical Pharmacology</i> <b>36</b>: 3181<br /><br />