Anglister L, Silman I, Soreq H (2021)
Preface: Cholinergic mechanisms: This is the Preface for the special issue Cholinergic Mechanisms
Journal of Neurochemistry

Silman I, Shnyrov VL, Ashani Y, Roth E, Nicolas A, Sussman JL, Weiner L (2021)
Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif
Protein Science

Silman I (2021)
The multiple biological roles of the cholinesterases
Prog Biophys Mol Biol 162: 41

Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021)
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Journal of Medicinal Chemistry 64: 812

Catto M, Pisani L, De la Mora E, Belviso BD, Mangiatordi GF, Pinto A, Palma A, Denora N, Caliandro R, Colletier JP, Silman I, Nicolotti O, Altomare CD (2020)
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor
ACS Med Chem Lett 11: 869

Nachon F, Rosenberry TL, Silman I, Sussman JL (2020)
A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides
Molecules 25: 1198

Sussman JL, Silman I (2020)
Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function
Neuropharmacology

Toker L, Silman I, Zeev-Ben-Mordehai T, Sussman JL, Schopfer LM, Lockridge O (2020)
Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers
Chemico-Biological Interactions

Chandar NB, Efremenko I, Silman I, Martin JML, Sussman JL (2019)
Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design
Chemico-Biological Interactions 310: 108715

Dighe SN, De la Mora E, Chan S, Kantham S, McColl G, Miles JA, Veliyath SK, Sreenivas BY, Nassar ZD, Silman I, Sussman JL, Weik M, McGeary RP, Parat MO, Brazzolotto X, Ross BP (2019)
Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.
Communications chemistry 2: 35

Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman JL, Weik M, Maurice T, Dallemagne P, Rochais C (2019)
Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
Eur Journal of Medicinal Chemistry 162: 234

Novichkova DA, Lushchekina SV, Dym O, Masson P, Silman I, Sussman JL (2019)
The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability
Chemico-Biological Interactions 309: 108699

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY (2019)
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
Eur Journal of Medicinal Chemistry 168: 58

Bilkis I, Silman I, Weiner L (2018)
Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins
Curr Med Chem 25: 5528

Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018)
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis
Molecules 23:

Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T (2018)
Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly
Proc Natl Acad Sci U S A 115: 13270

Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F (2018)
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Journal of Medicinal Chemistry 61: 7630

Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Perez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY (2018)
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration
Chemistry 24: 9675

Haronen H, Zainul Z, Tu H, Naumenko N, Sormunen R, Miinalainen I, Shakirzyanova A, Oikarainen T, Abdullin A, Martin P, Santoleri S, Koistinaho J, Silman I, Giniatullin R, Fox MA, Heikkinen A, Pihlajaniemi T (2017)
Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse
Hum Mol Genet 26: 2076

Prado MAM, Marchot P, Silman I (2017)
Preface: Cholinergic Mechanisms
Journal of Neurochemistry 142 Suppl 2: 3

Silman I, Sussman JL (2017)
Recent developments in structural studies on acetylcholinesterase
Journal of Neurochemistry 142 Suppl 2: 19

Soreq H, Silman I (2017)
Alexander George Karczmar (1917-2017)
Journal of Neurochemistry 143: 609

Xu Y, Cheng S, Sussman JL, Silman I, Jiang H (2017)
Computational Studies on Acetylcholinesterases
Molecules 22:

Ashani Y, Leader H, Aggarwal N, Silman I, Worek F, Sussman JL, Goldsmith M (2016)
In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications
Chemico-Biological Interactions 259: 252

Dym O, Song W, Felder CE, Roth E, Shnyrov V, Ashani Y, Xu Y, Joosten RP, Weiner L, Sussman JL, Silman I (2016)
The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue/Acetylcholinesterase Complex
Protein Science 25: 1096

Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, Fleishman SJ (2016)
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
Mol Cell 63: 337

Ben-David M, Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS (2013)
Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme
Journal of Molecular Biology 425: 1028

Silman I, Roth E, Paz A, Triquigneaux MM, Ehrenshaft M, Xu Y, Shnyrov VL, Sussman JL, Deterding LJ, Ashani Y, Mason RP, Weiner L (2013)
The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy
Chemico-Biological Interactions 203: 63

Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS (2012)
Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1
Journal of Molecular Biology 418: 181

Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS (2012)
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification
Chemical Biology 19: 456

Khare SD, Kipnis Y, Greisen P, Jr., Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H, Sussman JL, Stoddard BL, Tawfik DS, Baker D (2012)
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
Nat Chemical Biology 8: 294

Paz A, Roth E, Ashani Y, Xu Y, Shnyrov VL, Sussman JL, Silman I, Weiner L (2012)
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase
Protein Science 21: 1138

Triquigneaux MM, Ehrenshaft M, Roth E, Silman I, Ashani Y, Mason RP, Weiner L, Deterding LJ (2012)
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer Methylene Blue
Biochemical Journal 448: 83

Wood K, Paz A, Dijkstra K, Scheek RM, Otten R, Silman I, Sussman JL, Mulder FA (2012)
Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3
Biomol NMR Assign 6: 15

Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS (2011)
In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases
Toxicol Lett 206: 24

Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS (2011)
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
Nat Chemical Biology 7: 120

Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M (2011)
Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations
Protein Science 20: 1114

Weiner L, Roth E, Silman I (2011)
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen
Photochem Photobiol 87: 308

Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H (2010)
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers
Chemico-Biological Interactions 187: 362

Dvir H, Silman I, Harel M, Rosenberry TL, Sussman JL (2010)
Acetylcholinesterase: from 3D structure to function
Chemico-Biological Interactions 187: 10

Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL (2010)
Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase
Biophysical Journal 99: 4003

Gabel F, Masson P, Froment MT, Doctor BP, Saxena A, Silman I, Zaccai G, Weik M (2009)
Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its aged soman conjugate
Biophysical Journal 96: 1489

Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS (2009)
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization
Biochemistry 48: 6644

Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL (2009)
The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad
Journal of Medicinal Chemistry 52: 2543

Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M (2009)
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime
Journal of Medicinal Chemistry 52: 7593

Weiner L, Shnyrov VL, Konstantinovskii L, Roth E, Ashani Y, Silman I (2009)
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors
Biochemistry 48: 563

Zeev-Ben-Mordehai T, Paz A, Peleg Y, Toker L, Wolf SG, Rydberg EH, Sussman JL, Silman I (2009)
Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization
Protein Expr Purif 63: 147

Zeev-Ben-Mordehai T, Mylonas E, Paz A, Peleg Y, Toker L, Silman I, Svergun DI, Sussman JL (2009)
The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties
Biophysical Journal 97: 2316

Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M (2008)
Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography
Proc Natl Acad Sci U S A 105: 11742

Harel M, Sonoda LK, Silman I, Sussman JL, Rosenberry TL (2008)
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site
Journal of the American Chemical Society 130: 7856

Paz A, Zeev-Ben-Mordehai T, Lundqvist M, Sherman E, Mylonas E, Weiner L, Haran G, Svergun DI, Mulder FA, Sussman JL, Silman I (2008)
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3
Biophysical Journal 95: 1928

Silman I, Sussman JL (2008)
Acetylcholinesterase: how is structure related to function?
Chemico-Biological Interactions 175: 3

Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M (2008)
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design
Protein Science 17: 601

Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL (2008)
Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics
Biophysical Journal 95: 2500

Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I, Bourgeois D, Weik M (2007)
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography
Acta Crystallographica D Biol Crystallogr 63: 1115

Haviv H, Wong DM, Silman I, Sussman JL (2007)
Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors
Curr Top Med Chem 7: 375

Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M (2006)
Structural insights into substrate traffic and inhibition in acetylcholinesterase
EMBO Journal 25: 2746

Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL (2006)
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
Journal of Medicinal Chemistry 49: 5491

Gabel F, Weik M, Masson P, Renault F, Fournier D, Brochier L, Doctor BP, Saxena A, Silman I, Zaccai G (2005)
Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study
Biophysical Journal 89: 3303

Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Molecular Pharmacology 67: 1874

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase
Chemico-Biological Interactions 157-158: 153

Hasin Y, Avidan N, Bercovich D, Korczyn AD, Silman I, Beckmann JS, Sussman JL (2005)
Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations
Curr Alzheimer Res 2: 207

Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL (2005)
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase
Journal of the American Chemical Society 127: 11029

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM (2005)
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11
Chemico-Biological Interactions 157-158: 247

Niu C, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, Jiang H (2005)
Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation
J Phys Chem B 109: 23730

Parnas H, Slutsky I, Rashkovan G, Silman I, Wess J, Parnas I (2005)
Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors
Journal of Neurophysiology 93: 3257

Silman I, Sussman JL (2005)
Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology
Curr Opin Pharmacol 5: 293

Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS (2004)
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
Proc Natl Acad Sci U S A 101: 482

Colletier JP, Fournier D, Greenblatt HM, Sussman JL, Zaccai G, Silman I, Weik M (2004)
Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 359

Dvir H, Jiang H, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL (2004)
Poster (79) X-ray structures of TcAChE complexed with (+)-huperzine a and (-)-huperzine b: structural evidence for an active-site rearrangement
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 362

Dvir H, Harel M, Bon S, Liu WQ, Vidal M, Garbay C, Sussman JL, Massoulie J, Silman I (2004)
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix
EMBO Journal 23: 4394

Gabel F, Weik M, Doctor BP, Saxena A, Fournier D, Brochier L, Renault F, Masson P, Silman I, Zaccai G (2004)
The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study
Biophysical Journal 86: 3152

Greenblatt HM, Guillou C, Guenard D, Argaman A, Botti SA, Badet B, Thal C, Silman I, Sussman JL (2004)
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design
Journal of the American Chemical Society 126: 15405

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS (2004)
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
Nat Struct Mol Biol 11: 412

Harel M, Dvir H, Bon S, Liu WQ, Garbay C, Sussman JL, Massoulie J, Silman I (2004)
Crystal structure of the tetramerization domain of acetylcholinesterase at 2.
Cholinergic Mechanisms, CRC Press

Harel M, Dvir H, Bon S, Liu WQ, Garbay C, Sussman JL, Massoulie J, Silman I (2004)
Poster (48) Crystal structure of the tetramerization domain of acetylcholinesterase reveals a model of the AChE tetramer
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 347

Hasin Y, Avidan N, Bercovich D, Korczyn A, Silman I, Beckmann JS, Sussman JL (2004)
A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene
Hum Mutat 24: 408

Rydberg EH, Macion R, Zeev-Ben-Mordehai T, Solomon A, Rees DM, Toker L, Botti SA, Auld VJ, Silman I, Sussman JL (2004)
Overexpression of the extracellular and cytoplasmic domains of the Drosophila adhesion protein, gliotactin.
Cholinergic Mechanisms, CRC Press

Silman I, Greenblatt HM, Zeev-Ben-Mordehai T, Sussman JL (2004)
Poster (47) Conformational plasticity of acetylcholinesterase
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 346

Sussman JL, Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Botti SA, Auld VJ, Silman I (2004)
Poster (31) Natively unstructured proteins: a case study of cholinesterase-like adhesion molecules (clams)
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 337

Toutant JP, Massoulie J, Fournier D, Marty JL, Schmid RD, Pfeiffer D, Selkirk ME, Sussman JL, Silman I, Talesa V, Wodak SJ, Stojan J, Magearu V (2004)
New biosensors for improved detection of environmental and food contamination by anticholinesterase pesticides
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 233

Toutant JP, Massoulie J, Fournier D, Schmid RD, Pfeiffer D, Selkirk ME, Sussman JL, Silman I, Talesa V, Wodak SJ (2004)
Poster (24) New biosensors for improved detection of environmental contamination by anticholinesterase pesticides
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 333

Zeev-Ben-Mordehai T, Silman I, Sussman JL (2004)
Use of the morphing graphics technique to visualize conformational differences between acetylcholinesterases from different species and inhibitor-induced conformational changes.
Cholinergic Mechanisms, CRC Press

Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Silman I, Sussman JL (2004)
Poster (104) Biophysical and bioinformatic analysis of the cytoplasmic portion of gliotactin
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 375

Greenblatt HM, Dvir H, Silman I, Sussman JL (2003)
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease
Journal of Molecular Neuroscience 20: 369

Millard CB, Shnyrov VL, Newstead S, Shin I, Roth E, Silman I, Weiner L (2003)
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones
Protein Science 12: 2337

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003)
Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J Am Chem Soc 125: 363

Xu Y, Shen J, Luo X, Silman I, Sussman JL, Chen K, Jiang H (2003)
How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations
Journal of the American Chemical Society 125: 11340

Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Auld VJ, Silman I, Botti SA, Sussman JL (2003)
The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded
Proteins 53: 758

Zeev-Ben-Mordehai T, Silman I, Sussman JL (2003)
Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure
Biopolymers 68: 395

Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I (2002)
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine
Biochemistry 41: 3555

Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Munoz-Torrero D, Camps P, Rosenberry TL, Silman I, Sussman JL (2002)
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates
Biochemistry 41: 2970

Dvir H, Jiang H, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL (2002)
X-ray Structures of Torpedo californica Acetylcholinesterase Complexed with (+)-Huperzine A and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement
Biochemistry 41: 10810

Felder CE, Harel M, Silman I, Sussman JL (2002)
Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase
Acta Crystallographica D Biol Crystallogr 58: 1765

Koellner G, Steiner T, Millard CB, Silman I, Sussman JL (2002)
A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica
Journal of Molecular Biology 320: 721

Shin I, Wachtel E, Roth E, Bon C, Silman I, Weiner L (2002)
Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?
Protein Science 11: 2022

Weik M, Berges J, Raves ML, Gros P, McSweeney S, Silman I, Sussman JL, Houee-Levin C, Ravelli RB (2002)
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation
J Synchrotron Radiat 9: 342

De Ferrari GV, Canales MA, Shin I, Weiner L, Silman I, Inestrosa NC (2001)
A Structural Motif of Acetylcholinesterase That Promotes Amyloid beta-Peptide Fibril Formation
Biochemistry 40: 10447

Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J, Viner R, Silman I, Sussman JL, Greenblatt HM, Lewis T (2001)
A structure-based design approach to the development of novel, reversible AChE inhibitors
Journal of Medicinal Chemistry 44: 3203

Nicolas A, Ferron F, Toker L, Sussman JL, Silman I (2001)
Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase
Acta Crystallographica D Biol Crystallogr 57: 1348

Slutsky I, Silman I, Parnas I, Parnas H (2001)
Presynaptic M(2) muscarinic receptors are involved in controlling the kinetics of ACh release at the frog neuromuscular junction
The Journal of Physiology 536: 717

Weik M, Ravelli RB, Silman I, Sussman JL, Gros P, Kroon J (2001)
Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes
Protein Science 10: 1953

Harel M, Kryger G, Rosenberry TL, Mallender WD, Lewis T, Fletcher RJ, Guss JM, Silman I, Sussman JL (2000)
Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors
Protein Science 9: 1063

Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, Steiner T (2000)
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica
Journal of Molecular Biology 296: 713

Kraut D, Goff H, Pai RK, Hosea NA, Silman I, Sussman JL, Taylor P, Voet JG (2000)
Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride
Molecular Pharmacology 57: 1243

Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL (2000)
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
Acta Crystallographica D Biol Crystallogr 56: 1385

Weik M, Ravelli RB, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL (2000)
Specific chemical and structural damage to proteins produced by synchrotron radiation
Proceedings of the National Academy of Sciences of the United States of America 97: 623

Arnon R, Silman I, Tarrab-Hazdai R (1999)
Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday
Protein Science 8: 2553

Botti SA, Felder CE, Lifson S, Sussman JL, Silman I (1999)
A modular treatment of molecular traffic through the active site of cholinesterase
Biophysical Journal 77: 2430

Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL (1999)
Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution
FEBS Letters 463: 321

Kryger G, Silman I, Sussman JL (1999)
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs
Structure 7: 297

Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1999)
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level
Biochemistry 38: 7032

Millard CB, Koellner G, Ordentlich A, Shafferman A, Silman I, Sussman JL (1999)
Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad
Journal of the American Chemical Society 121: 9883

Morel N, Bon S, Greenblatt HM, Van Belle D, Wodak SJ, Sussman JL, Massoulie J, Silman I (1999)
Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase
Molecular Pharmacology 55: 982

Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL (1999)
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase
Chemico-Biological Interactions 119-120: 43

Tarrab-Hazdai R, Toker L, Silman I, Arnon R (1999)
Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin
Biochemical Journal 344 Pt 3: 945

Weiner L, Roth E, Mazur Y, Silman I (1999)
Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin
Biochemistry 38: 11401

Bar-On P, Harel M, Millard CB, Enz A, Sussman JL, Silman I (1998)
Kinetic and structural studies on the interaction of the anti-Alzheimer drug, ENA-713, with Torpedo californica acetylcholinesterase
Journal de Physiologie (Paris) 92: 406

Bar-On P, Harel M, Millard CB, Enz A, Sussman JL, Silman I (1998)
Kinetic and X-Ray Crystallographic Studies of the Binding of ENA-713 to Torpedo Californica Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 373

Botti SA, Felder CE, Sussman JL, Silman I (1998)
Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs
Protein Engineering 11: 415

Botti SA, Felder CE, Sussman JL, Silman I (1998)
Electrostatic homology modelling of a set of ChE-like neural adhesion proteins identifies a shared annular motif with ChEs. Structural implications for a cell-recognition role of ChEs
Journal de Physiologie (Paris) 92: 414

Botti SA, Felder CE, Lifson S, Sussman JL, Silman I (1998)
An Integrated Model for the Molecular Traffic through the Active Site of Cholinesterases
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 227

Botti SA, Felder CE, Sussman JL, Silman I (1998)
The Conjunction of a Conserved Electrostatic Motif and a Common Cholinesterase Fold Defines a Class of Adhesion Proteins
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 448

Giles K, Ben-Yohanan R, Velan B, Shafferman A, Sussman JL, Silman I (1998)
Assembly of Acetylcholinesterase Subunits in vitro
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 442

Giles K, Silman I, Sussman JL (1998)
Expression and Tissue Distribution of Cholinesterases Via EST Analysis
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 450

Greenblatt HM, Kryger G, Harel M, Lewis T, Taylor J, Silman I, Sussman JL (1998)
Crystal Structures of Complexes of E2020-Related Compounds with Torpedo Californica Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 371-371

Kryger G, Silman I, Sussman JL (1998)
Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica
Journal de Physiologie Paris 92: 191

Kryger G, Giles K, Harel M, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL (1998)
3D Structure at 2.7 Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 323

Kryger G, Giles K, Harel M, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL (1998)
3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7 Resolution
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 370

Kryger G, Silman I, Sussman JL (1998)
3D Structure of a Complex of the Anti-Alzheimer Drug, E2020, with Acetylcholinesterase at 2.5 Resolution
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 469

Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1998)
Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase
In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 425

Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1998)
Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 425

Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1998)
Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 454

Morel N, Bon S, Sussman JL, Massoulie J, Silman I (1998)
Surface Residues Near the Peripheral Site Affect the Stability of Torpedo Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 435

Nicolas A, Millard CB, Raves ML, Ravelli RB, Kroon J, Silman I, Sussman JL (1998)
Activity of Torpedo Californica Acetylcholinesterase in the Crystalline State
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 230

Ravelli RB, Raves ML, Ren Z, Bourgeois D, Roth M, Kroon J, Silman I, Sussman JL (1998)
Static laue diffraction studies on acetylcholinesterase
Acta Crystallographica D Biol Crystallogr 54: 1359

Raves ML, Giles K, Schrag JD, Schmid MF, Phillips JN, Jr., Chiu W, Howard AJ, Silman I, Sussman JL (1998)
Quaternary Structure of Tetrameric Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 351

Raves ML, Greenblatt HM, Kryger G, Nicolas A, Ravelli RB, Harel M, Kroon J, Silman I, Sussman JL (1998)
Alternative Crystal Forms of Torpedo Californica Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 372

Shin I, Silman I, Bon C, Weiner L (1998)
Membrane-Promoted Unfolding of Torpedo Californica and Bungarus Fasciatus Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 438

Shin I, Silman I, Bon C, Weiner L (1998)
Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus
Biochemistry 37: 4310

Silman I, Sussman JL (1998)
Irwin B. Wilson Plenary Lecture Structural and Functional Studies on Acetylcholinesterase
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 25

Tarrab-Hazdai R, Silman I, Toker L, Schechtman D, Arnon R (1998)
Acetylcholinesterase of S. mansoni (Trematode). Interaction of globular species with glycosaminoglycans
Journal de Physiologie (Paris) 92: 501

Felder CE, Botti SA, Lifson S, Silman I, Sussman JL (1997)
External and internal electrostatic potentials of cholinesterase models
J Mol Graph Model 15: 318

Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL (1997)
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
Nat Struct Biol 4: 57

Shin I, Kreimer DI, Silman I, Weiner L (1997)
Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer
Proceedings of the National Academy of Sciences of the United States of America 94: 2848

Faerman C, Ripoll D, Bon S, Le Feuvre Y, Morel N, Massoulie J, Sussman JL, Silman I (1996)
Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function
FEBS Letters 386: 65

Harel M, Quinn DM, Nair HK, Silman I, Sussman JL (1996)
The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.
Journal of the American Chemical Society 118: 2340

Kreimer DI, Shin I, Shnyrov VL, Villar E, Silman I, Weiner L (1996)
Two partially unfolded states of Torpedo californica acetylcholinesterase
Protein Science 5: 1852

Peng L, Silman I, Sussman JL, Goeldner M (1996)
Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases
Biochemistry 35: 10854

Porschke D, Creminon C, Cousin X, Bon C, Sussman JL, Silman I (1996)
Electrooptical measurements demonstrate a large permanent dipole moment associated with acetylcholinesterase
Biophysical Journal 70: 1603

Shin I, Silman I, Weiner L (1996)
Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes
Protein Science 5: 42

Eichler J, Silman I (1995)
The activity of an endoplasmic reticulum-localized pool of acetylcholinesterase is modulated by heat shock
Journal of Biological Chemistry 270: 4466

Harel M, Kleywegt GJ, Ravelli RB, Silman I, Sussman JL (1995)
Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target
Structure 3: 1355

Kreimer DI, Shnyrov VL, Villar E, Silman I, Weiner L (1995)
Irreversible thermal denaturation of Torpedo californica acetylcholinesterase
Protein Science 4: 2349

Ripoll DR, Faerman CH, Gillilan R, Silman I, Sussman JL (1995)
Electrostatic Properties of Human Acetylcholinesterase
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 67

Silman I, Kreimer DI, Shin I, Dolginova EA, Roth E, Goldfarb D, Szosenfogel R, Raves ML, Sussman JL, Borochov N, Weiner L (1995)
Studies on Partially Unfolded States of Torpedo californica Acetylcholinesterase
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 77

Sussman JL, Harel M, Raves ML, Quinn DM, Nair HK, Silman I (1995)
Structures of Complexes of Acetylcholinesterase with Covalently and Non-Covalently Bound Inhibitors
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 59

Axelsen PH, Harel M, Silman I, Sussman JL (1994)
Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography
Protein Science 3: 188

Eichler J, Kreimer DI, Varon L, Silman I, Weiner L (1994)
A molten globule of Torpedo acetylcholinesterase undergoes thiol-disulfide exchange
Journal of Biological Chemistry 269: 30093

Eichler J, Anselmet A, Sussman JL, Massoulie J, Silman I (1994)
Differential effects of peripheral site ligands on Torpedo and chicken acetylcholinesterase
Molecular Pharmacology 45: 335

Gilson MK, Straatsma TP, McCammon JA, Ripoll DR, Faerman CH, Axelsen PH, Silman I, Sussman JL (1994)
Open back door in a molecular dynamics simulation of acetylcholinesterase
Science 263: 1276

Kreimer DI, Szosenfogel R, Goldfarb D, Silman I, Weiner L (1994)
Two-state transition between molten globule and unfolded states of acetylcholinesterase as monitored by electron paramagnetic resonance spectroscopy
Proceedings of the National Academy of Sciences of the United States of America 91: 12145

Kreimer DI, Dolginova EA, Raves ML, Sussman JL, Silman I, Weiner L (1994)
A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials
Biochemistry 33: 14407

Mehlert A, Varon L, Silman I, Homans SW, Ferguson MA (1994)
Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica
Brazilian Journal of Medical & Biological Research 27: 243

Silman I, Harel M, Axelsen PH, Raves ML, Sussman JL (1994)
Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents
Biochemical Society Transactions 22: 745

Weiner L, Kreimer D, Roth E, Silman I (1994)
Oxidative stress transforms acetylcholinesterase to a molten-globule-like state
Biochemical & Biophysical Research Communications 198: 915

Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK, Doctor BP (1993)
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins
Protein Science 2: 366

Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL (1993)
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase
Proceedings of the National Academy of Sciences of the United States of America 90: 9031

Massoulie J, Sussman JL, Bon S, Silman I (1993)
Structure and functions of acetylcholinesterase and butyrylcholinesterase
Prog Brain Res 98: 139

Mehlert A, Silman I, Homans SW, Ferguson MA (1993)
The structure of the glycosylphosphatidylinositol anchor from Torpedo californica acetylcholinesterase
Biochemical Society Transactions 21:

Mehlert A, Varon L, Silman I, Homans SW, Ferguson MA (1993)
Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica
Biochemical Journal 296: 473

Ripoll DR, Faerman CH, Axelsen PH, Silman I, Sussman JL (1993)
An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase
Proceedings of the National Academy of Sciences of the United States of America 90: 5128

Sussman JL, Harel M, Silman I (1993)
Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs
Chemico-Biological Interactions 87: 187

Dolginova EA, Roth E, Silman I, Weiner L (1992)
Chemical modification of Torpedo acetylcholinesterase by disulfides: appearance of a molten globule state
Biochemistry 31: 12248

Duval N, Bon S, Silman I, Sussman JL, Massoulie J (1992)
Site-directed mutagenesis of active-site-related residues in Torpedo acetylcholinesterase. Presence of a glutamic acid in the catalytic triad
FEBS Letters 309: 421

Eichler J, Silman I, Anglister L (1992)
G2-acetylcholinesterase is presynaptically localized in Torpedo electric organ
Journal of Neurocytology 21: 707

Harel M, Sussman JL, Krejci E, Bon S, Chanal P, Massoulie J, Silman I (1992)
Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis
Proceedings of the National Academy of Sciences of the United States of America 89: 10827

Harel M, Silman I, Sussman JL (1992)
A Model of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase Indicates Differences in Specificity
In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases (Shafferman, A. and Velan, B., Eds) Plenum Press, New York: 189

Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag JD, Sussman JL, Verschueren KHG, Goldman A (1992)
The alpha/beta hydrolase fold
Protein Engineering 5: 197

Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N, Barak D, Harel M, Silman I, Sussman JL, Velan B (1992)
Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding
Journal of Biological Chemistry 267: 17640

Silman I, Krejci E, Duval N (1992)
Site-Directed Mutagenesis of Functional Residues in Torpedo Acetylcholinesterase
In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases (Shafferman, A. and Velan, B., Eds) Plenum Press, New York: 177

Sussman JL, Harel M, Silman I (1992)
Three Dimensional Structure of Acetylcholinesterase
In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases (Shafferman, A. and Velan, B., Eds) Plenum Press, New York: 95

Eichler J, Silman I, Gentry MK, Anglister L (1991)
Poster: Immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable membranes of Torpedo ocellata
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 49

Eichler J, Toker L, Silman I (1991)
Effect of heat shock on acetylcholinesterase activity in chick muscle cultures
FEBS Letters 293: 16

Espinoza B, Silman I, Arnon R, Tarrab-Hazdai R (1991)
Poster: Effects of exposure to PIPL-C on AChE activity of Schistosoma mansoni
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 50

Espinoza B, Silman I, Arnon R, Tarrab-Hazdai R (1991)
Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni
European Journal of Biochemistry 195: 863

Harel M, Su CT, Frolow F, Ashani Y, Silman I, Sussman JL (1991)
Refined crystal structures of aged and non-aged organophosphoryl conjugates of gamma-chymotrypsin
Journal of Molecular Biology 221: 909

Su CT, Steinberg N, Silman I, Harel M, Sussman JL, Grunwald J, Ashani Y (1991)
Poster: Physicochemical and crystallographic studies on the stability and structure of aged and nonaged organophosphoryl conjugates of chymotrypsin
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 274

Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I (1991)
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
Science 253: 872

Sussman JL, Harel M, Frolow F, Oefner C, Toker L, Silman I (1991)
Structural Studies on Acetylcholinesterase from Torpedo californica
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 7

Eichler J, Silman I, Gentry MK, Anglister L (1990)
Immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable membranes of Torpedo ocellata
Brain Research Mol Brain Res 8: 213

Steinberg N, Roth E, Silman I (1990)
Torpedo acetylcholinesterase is inactivated by thiol reagents
Biochemistry International 21: 1043

Steinberg N, Grunwald J, Roth E, August R, Haas E, Ashani Y, Silman I (1989)
Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin
Prog Clin Biol Res 289: 293

Steinberg N, van der Drift AC, Grunwald J, Segall Y, Shirin E, Haas E, Ashani Y, Silman I (1989)
Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy
Biochemistry 28: 1248

Eghbali M, Silman I, Robinson TF, Seifter S (1988)
Visualization of collagenase-sensitive acetylcholinesterase in isolated cardiomyocytes and in heart tissue
Cell & Tissue Research 253: 281

Espinoza B, Tarrab-Hazdai R, Silman I, Arnon R (1988)
Acetylcholinesterase in Schistosoma mansoni is anchored to the membrane via covalently attached phosphatidylinositol
Molecular & Biochemical Parasitology 29: 171

Inestrosa NC, Fuentes ME, Anglister L, Futerman AH, Silman I (1988)
A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C
Neuroscience Letters 90: 186

Sussman JL, Harel M, Frolow F, Varon L, Toker L, Futerman AH, Silman I (1988)
Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C
Journal of Molecular Biology 203: 821

Doctor BP, Toker L, Roth E, Silman I (1987)
Microtiter assay for acetylcholinesterase
Analytical Biochemistry 166: 399

Futerman AH, Raviv D, Michaelson DM, Silman I (1987)
Differential susceptibility to phosphatidylinositol-specific phospholipase C of acetylcholinesterase in excitable tissues of embryonic and adult Torpedo ocellata
Brain Research 388: 105

Low MG, Futerman AH, Ackermann KE, Sherman WR, Silman I (1987)
Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Evidence for a common membrane-anchoring structure
Biochemical Journal 241: 615

Silman I, Futerman AH (1987)
Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface
Biopolymers 26: S241

Silman I, Futerman AH (1987)
Modes of attachment of acetylcholinesterase to the surface membrane.
European Journal of Biochemistry 170: 11

Goldlust A, Arnon R, Silman I, Tarrab-Hazdai R (1986)
Acetylcholinesterase of Schistosoma mansoni: purification and characterization
Journal of Neuroscience Research 15: 569

Barton PL, Futerman AH, Silman I (1985)
Arrhenius plots of acetylcholinesterase activity in mammalian erythrocytes and in Torpedo electric organ. Effect of solubilization by proteinases and by a phosphatidylinositol-specific phospholipase C
Biochemical Journal 231: 237

Futerman AH, Fiorini RM, Roth E, Low MG, Silman I (1985)
Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C
Biochemical Journal 226: 369

Futerman AH, Low MG, Ackermann KE, Sherman WR, Silman I (1985)
Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase
Biochemical & Biophysical Research Communications 129: 312

Futerman AH, Low MG, Michaelson DM, Silman I (1985)
Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C
Journal of Neurochemistry 45: 1487

Page JD, Wilson IB, Silman I (1985)
Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding
Molecular Pharmacology 27: 437

Futerman AH, Fiorini RM, Roth E, Michaelson DM, Low MG, Silman I (1984)
Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C: enzymatic and physicochemical studies
In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases (Brzin M, Barnard EA, Sket D, Eds) De Gruyter: 99

Futerman AH, Low MG, Silman I (1984)
Poster 9. Solubilisation of acetylchoinesterase from Torpedo electric organ by a phosphatidylinositol-specific phospholipase C
In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:

Jedrzejczyk J, Silman I, Barnard EA (1984)
Poster 19. Molecular forms of the cholinesterases Inside and outside endplates in. slow-tonic chicken muscle fibers
In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:

Jedrzejczyk J, Silman I, Lai J, Barnard EA (1984)
Molecular forms of acetylcholinesterase in synaptic and extrasynaptic regions of avian tonic muscle
Neuroscience Letters 46: 283

Parvari R, Silman I, Soreq H (1984)
Ontogenic and agranulation-induced alterations in cholinesterases and in cholinesterase mRNA in the rodent cerebellum
In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases (Brzin M, Barnard EA, Sket D, Eds) De Gruyter: 219

Razon N, Soreq H, Roth E, Bartal A, Silman I (1984)
Characterization of activities and forms of cholinesterases in human primary brain tumors
Experimental Neurology 84: 681

Futerman AH, Low MG, Silman I (1983)
A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C
Neuroscience Letters 40: 85

Soreq H, Parvari R, Silman I (1983)
Biosynthesis of acetylcholinesterase in rat brain and Torpedo electric organ is directed by scarce mRNA species
Progress in Brain Research 58: 107

Amitai G, Ashani Y, Gafni A, Silman I (1982)
Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase
Biochemistry 21: 2060

Barnard EA, Lyles JM, Silman I, Jedrzejczyk J, Barnard PJ (1982)
Molecular forms of acetylcholinesterase and pseudocholinesterase in chicken skeletal muscles: their distribution and change with muscular dystrophy
Reproduction, Nutrition, Developpement 22: 261

Lyles JM, Silman I, Di Giamberardino L, Couraud JY, Barnard EA (1982)
Comparison of the molecular forms of the cholinesterases in tissues of normal and dystrophic chickens
Journal of Neurochemistry 38: 1007

Soreq H, Parvari R, Silman I (1982)
Biosynthesis and secretion of catalytically active acetylcholinesterase in Xenopus oocytes microinjected with mRNA from rat brain and from Torpedo electric organ
Proceedings of the National Academy of Sciences of the United States of America 79: 830

Ben-Barak J, Gazit H, Silman I, Dudai Y (1981)
In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands
European Journal of Pharmacology 74: 73

Jedrzejczyk J, Silman I, Lyles JM, Barnard EA (1981)
Molecular forms of the cholinesterases inside and outside muscle endplates
Bioscience Reports 1: 45

Amitai G, Ashani Y, Gafni A, Silman I (1980)
New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase
Neurochem Int 2C: 199

Amitai G, Ashani Y, Shahar A, Gafni A, Silman I (1980)
Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue
Monographs in Neural Sciences 7: 70

Kaufmann K, Silman I (1980)
The induction of ion channels through excitable membranes by acetylcholinesterase
Naturwissenschaften 67: 608

Lyles JM, Barnard EA, Silman I (1980)
Changes in the levels and forms of cholinesterases in the blood plasma of normal and dystrophic chickens
Journal of Neurochemistry 34: 978

Silman I, Anglister L (1980)
Electric eel acetylcholinesterase: a multisubunit enzyme containing a collagen tail
Monographs in Neural Sciences 7: 55

Anglister L, Tarrab-Hazdai R, Fuchs S, Silman I (1979)
Immunological cross-reactivity between electric-eel acetylcholinesterase and rat-tail-tendon collagen
European Journal of Biochemistry 94: 25

Gazit H, Silman I, Dudai Y (1979)
Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain
Brain Research 174: 351

Lyles JM, Silman I, Barnard EA (1979)
Developmental changes in levels and forms of cholinesterases in muscles of normal and dystrophic chickens
Journal of Neurochemistry 33: 727

Silman I, Di Giamberardino L, Lyles L, Couraud JY, Barnard EA (1979)
Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle
Nature 280: 160

Anglister L, Silman I (1978)
Molecular structure of elongated forms of electric eel acetylcholinesterase
Journal of Molecular Biology 125: 293

Blumberg S, Silman I (1978)
Inactivation of electric eel acetylcholinesterase by acylation with N-hydroxysuccinimide esters of amino acid derivatives
Biochemistry 17: 1125

Silman I, Lyles JM, Barnard EA (1978)
Intrinsic forms of acetylcholinesterase in skeletal muscle
FEBS Letters 94: 166

Rosenberg P, Silman I, Ben-David E, De Vries A, Condrea E (1977)
Characterization of membranes obtained from electric organ of the electric eel by sucrose gradient fractionation and by microdissection
Journal of Neurochemistry 29: 561

Silman I, Dudai Y (1977)
Acetylcholinesterase: structure and activity of a membrane-bound enzyme
Advances in Biological & Medical Physics 16: 223

Wilson IB, Silman I (1977)
Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite
Biochemistry 16: 2701

Anglister L, Rogozinski S, Silman I (1976)
Detection of hydroxyproline in preparations of acetylcholinesterase from the electric organ of the electric eel
FEBS Letters 69: 129

Prives J, Silman I, Amsterdam A (1976)
Appearance and disappearance of acetycholine receptor during differentiation of chick skeletal muscle in vitro
Cell 7: 543

Aharonov A, Tarrab-Hazdai R, Abramsky O, Silman I, Fuchs S (1975)
Proceedings: Thymus, acetylcholine receptor and myasthenia gravis
Isr J Med Sci 11: 1390

Kalderon N, Silman I (1975)
Proceedings: A water-soluble acetylcholine receptor fraction from electric organ tissue of the electric eel Electrophorus electricus
Isr J Med Sci 11: 1192

Prives J, Silman I, Amsterdam A (1975)
Proceedings: Appearance and disappearance of acetylcholine receptor during differentiation of embryonic chick skeletal muscle in vitro
Isr J Med Sci 11: 1192

Reiner E, Aldridge WN, Hopff WH, Taylor P, Krupka RM, Rosenberry TL, Augustinsson KB, Mooser G, O'Brien RD, Brodbeck U, Massoulie J, Maricic S, Eldefrawi ME, Silman I (1975)
General discussion on models for the ligand binding sites of cholinesterase
Croatica Chemica Acta 47: 499

Silman I, Dudai Y (1975)
Molecular structure and catalytic activity of membrane-bound acetylcholinesterase from Electric Organ Tissue of the Electric Eel
Croatica Chemica Acta 47: 181

Tarrab-Hazdai R, Aharonov A, Abramsky O, Silman I, Fuchs S (1975)
Proceedings: Animal model for myasthenia gravis: acetylcholine receptor-induced myasthenia in rabbits, guinea pigs and monkeys
Isr J Med Sci 11: 1390

Dudai Y, Silman I (1974)
Affinity chromatography of acetylcholinesterase
Methods Enzymol 34: 571

Dudai Y, Silman I (1974)
The effects of solubilization procedures on the release and molecular state of acetylcholinesterase from electric organ tissue
Journal of Neurochemistry 23: 1177

Dudai Y, Silman I (1974)
The molecular weight and subunit structure of acetylcholinesterase preparations from the electric organ of the electric eel
Biochemical & Biophysical Research Communications 59: 117

Fuchs S, Gurari D, Silman I (1974)
Chemical modification of electric eel acetylcholinesterase by tetranitromethane
Archives of Biochemistry & Biophysics 165: 90

Gurari D, Silman I, Fuchs S (1974)
Immunochemical and enzymic properties of the electric eel acetylcholinesterase-antiacetylcholinesterase system
European Journal of Biochemistry 43: 179

Dudai Y, Silman I (1973)
The effect of Ca(2+) on interaction of acetylcholinesterase with subcellular fractions of electric organ tissue from the electric eel
FEBS Letters 30: 49

Dudai Y, Herzberg M, Silman I (1973)
Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel
Proceedings of the National Academy of Sciences of the United States of America 70: 2473

Giberman E, Silman I, Edery H (1973)
Effect of cholinesterase inhibitors on active potassium influx in monkey erythrocytes
Biochemical Pharmacology 22: 271

Shinitzky M, Dudai Y, Silman I (1973)
Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase
FEBS Letters 30: 125

Dudai Y, Silman I, Kalderon N, Blumberg S (1972)
Purification by affinity chromatography of acetylcholinesterase from electric organ tissue of the electric eel subsequent to tryptic treatment
Biochimica & Biophysica Acta 268: 138

Dudai Y, Silman I, Shinitzky M, Blumberg S (1972)
Purification by affinity chromatography of the molecular forms of acetylcholinesterase present in fresh electric-organ tissue of electric eel
Proceedings of the National Academy of Sciences of the United States of America 69: 2400

Dudai Y, Silman I (1971)
The subunits of an acetylcholinesterase preparation purified from trypsin-treated electric eel tissue
FEBS Letters 16: 324

Kalderon N, Silman I, Blumberg S, Dudai Y (1970)
A method for the purification of acetylcholinesterase by affinity chromatography
Biochimica & Biophysica Acta 207: 560

Silman I, Karlin A (1969)
Acetylcholine receptor: covalent attachment of depolarizing groups at the active site
Science 164: 1420

Silman I (1969)
Microenvironmental effects on enzyme activity
Journal of General Physiology 54: 50

Goldman R, Kedem O, Silman I, Caplan SR, Katchalski E (1968)
Papain-collodion membranes. I. Preparation and properties
Biochemistry 7: 486

Silman I, Karlin A (1967)
Effect of local pH change caused by substrate hydrolysis on the activity of membrane-bound acetylcholinesterase
Proceedings of the National Academy of Sciences of the United States of America 58: 1664

Silman I, Katchalski E (1966)
Water-insoluble derivatives of enzymes, antigens, and antibodies
Annual Review of Biochemistry 35: 873

Silman I, Albu-Weissenberg M, Katchalski E (1966)
Some water-insoluble papain derivatives
Biopolymers 4: 441