Steadman D, Atkinson BN, Zhao Y, Willis NJ, Frew S, Monaghan A, Patel C, Armstrong E, Costelloe K, Magno L, Bictash M, Jones EY, Fish PV, Svensson F (2022) <br />Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity<br /><i>Journal of Medicinal Chemistry</i> <b>65</b>: 562<br /><br />Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L, Ruza RR, Harlos K, Jeganathan F, Constantinou S, Costa A, Kjaer S, Bictash M, Salinas PC, Whiting P, Vincent JP, Fish PV, Jones EY (2022) <br />Structural Analysis and Development of Notum Fragment Screening Hits<br /><i>ACS Chem Neurosci</i> <b>13</b>: 2060<br /><br />Bayle ED, Svensson F, Atkinson BN, Steadman D, Willis NJ, Woodward HL, Whiting P, Vincent JP, Fish PV (2021) <br />Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling<br /><i>Journal of Medicinal Chemistry</i> <br /><br />Zhao Y, Svensson F, Steadman D, Frew S, Monaghan A, Bictash M, Moreira T, Chalk R, Lu W, Fish PV, Jones EY (2021) <br />Structural Insights into Notum Covalent Inhibition<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 11354<br /><br />Mahy W, Patel M, Steadman D, Woodward HL, Atkinson BN, Svensson F, Willis NJ, Flint A, Papatheodorou D, Zhao Y, Vecchia L, Ruza RR, Hillier J, Frew S, Monaghan A, Costa A, Bictash M, Walter MW, Jones EY, Fish PV (2020) <br />Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity<br /><i>Journal of Medicinal Chemistry</i> <b>63</b>: 9464<br /><br />Atkinson BN, Steadman D, Zhao YG, Sipthorp J, Vecchia L, Ruza RR, Jeganathan F, Lines G, Frew S, Monaghan A, Kjaer S, Bictash M, Jones Y, Fish PV, Zhao Y, Jones EY (2019) <br />Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen<br /><i>Medchemcomm</i> <b>10</b>: 1361<br /><br />Atkinson BN, Steadman D, Mahy W, Zhao Y, Sipthorp J, Bayle ED, Svensson F, Papageorgiou G, Jeganathan F, Frew S, Monaghan A, Bictash M, Jones EY, Fish PV (2019) <br />Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <br /><br />Willis NJ, Bayle ED, Papageorgiou G, Steadman D, Atkinson BN, Mahy W, Fish PV (2019) <br />An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent<br /><i>Beilstein J Org Chem</i> <b>15</b>: 2790<br /><br />