Gajic M, Knez D, Sosic I, Mravljak J, Meden A, Kosak U, Leitzbach L, George S, Hofmann B, Zivkovic A, Steinhilber D, Stark H, Gobec S, Smelcerovic A, Anderluh M (2022)
Repurposing of 8-Hydroxyquinoline-based Butyrylcholinesterase and Cathepsin B Ligands as Potent Non-peptidic Deoxyribonuclease I Inhibitors
ChemMedChem

Lillich FF, Willems S, Ni X, Kilu W, Borkowsky C, Brodsky M, Kramer JS, Brunst S, Hernandez-Olmos V, Heering J, Schierle S, Kestner RI, Mayser FM, Helmstadter M, Gobel T, Weizel L, Namgaladze D, Kaiser A, Steinhilber D, Pfeilschifter W, Kahnt AS, Proschak A, Chaikuad A, Knapp S, Merk D, Proschak E (2021)
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists/Soluble Epoxide Hydrolase Inhibitors
Journal of Medicinal Chemistry

Hiesinger K, Schott A, Kramer JS, Blocher R, Witt F, Wittmann SK, Steinhilber D, Pogoryelov D, Gerstmeier J, Werz O, Proschak E (2020)
Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase
ACS Med Chem Lett 11: 298

Hiesinger K, Kramer JS, Beyer S, Eckes T, Brunst S, Flauaus C, Wittmann SK, Weizel L, Kaiser A, Kretschmer SBM, George S, Angioni C, Heering J, Geisslinger G, Schubert-Zsilavecz M, Schmidtko A, Pogoryelov D, Pfeilschifter J, Hofmann B, Steinhilber D, Schwalm S, Proschak E (2020)
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase
Journal of Medicinal Chemistry 63: 11498

Gobel T, Diehl O, Heering J, Merk D, Angioni C, Wittmann SK, Buscato E, Kottke R, Weizel L, Schader T, Maier TJ, Geisslinger G, Schubert-Zsilavecz M, Steinhilber D, Proschak E, Kahnt AS (2019)
Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor gamma
Front Pharmacol 10: 263

Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, Hammock BD, Proschak E (2019)
Computer-Aided Selective Optimization of Side Activities of Talinolol
ACS Med Chem Lett 10: 899

Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knoll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E (2019)
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain
Journal of Medicinal Chemistry 62: 8443

Schmidt J, Rotter M, Weiser T, Wittmann S, Weizel L, Kaiser A, Heering J, Goebel T, Angioni C, Wurglics M, Paulke A, Geisslinger G, Kahnt A, Steinhilber D, Proschak E, Merk D (2017)
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis
Journal of Medicinal Chemistry 60: 7703

Blocher R, Lamers C, Wittmann SK, Merk D, Hartmann M, Weizel L, Diehl O, Bruggerhoff A, Boss M, Kaiser A, Schader T, Gobel T, Grundmann M, Angioni C, Heering J, Geisslinger G, Wurglics M, Kostenis E, Brune B, Steinhilber D, Schubert-Zsilavecz M, Kahnt AS, Proschak E (2016)
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor gamma Modulators
Journal of Medicinal Chemistry 59: 61

Meirer K, Glatzel D, Kretschmer S, Wittmann SK, Hartmann M, Blocher R, Angioni C, Geisslinger G, Steinhilber D, Hofmann B, Furst R, Proschak E (2016)
Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
Molecules 22:

Achenbach J, Klingler FM, Blocher R, Moser D, Hafner AK, Rodl CB, Kretschmer S, Kruger B, Lohr F, Stark H, Hofmann B, Steinhilber D, Proschak E (2013)
Exploring the chemical space of multitarget ligands using aligned self-organizing maps
ACS Med Chem Lett 4: 1169

Meirer K, Rodl CB, Wisniewska JM, George S, Hafner AK, Buscato EL, Klingler FM, Hahn S, Berressem D, Wittmann SK, Steinhilber D, Hofmann B, Proschak E (2013)
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase
Journal of Medicinal Chemistry 56: 1777