Takahashi M, Hirota I, Nakano T, Kotani T, Takani D, Shiratori K, Choi Y, Haba M, Hosokawa M (2021)
Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase
Drug Metab Pharmacokinet 38: 100391

Takahashi M, Takani D, Haba M, Hosokawa M (2020)
Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters
Chirality 32: 73

Takahashi M, Lee YJ, Kanayama T, Kondo Y, Nishio K, Mukai K, Haba M, Hosokawa M (2020)
Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1
Eur J Pharm Sci

Mizoi K, Takahashi M, Sakai S, Ogihara T, Haba M, Hosokawa M (2019)
Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases
Xenobiotica

Shirayama Y, Takahashi M, Oda Y, Yoshino K, Sato K, Okubo T, Iyo M (2019)
rCBF and cognitive impairment changes assessed by SPECT and ADAS-cog in late-onset Alzheimer's disease after 18 months of treatment with the cholinesterase inhibitors donepezil or galantamine
Brain Imaging Behav 13: 75

Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M (2019)
Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase
Eur J Pharm Sci 132: 125

Ueda K, Katayama S, Arai T, Furuta N, Ikebe S, Ishida Y, Kanaya K, Ouma S, Sakurai H, Sugitani M, Takahashi M, Tanaka T, Tsuno N, Wakutani Y, Shekhawat A, Das Gupta A, Kiyose K, Toriyama K, Nakamura Y (2019)
Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan
Dement Geriatr Cogn Dis Extra 9: 302

Yamazaki H, Takahashi M, Wakabayashi T, Sakai K, Yamamuro D, Takei A, Takei S, Nagashima S, Yagyu H, Sekiya M, Ebihara K, Ishibashi S (2019)
Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells
J Atheroscler Thromb 26: 246

Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M (2018)
Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
Bioorganic & Medicinal Chemistry Lett 28: 997

Takahashi M, Oda Y, Okubo T, Shirayama Y (2017)
Relationships between cognitive impairment on ADAS-cog and regional cerebral blood flow using SPECT in late-onset Alzheimer's disease
J Neural Transm (Vienna) 124: 1109

Hirano T, Yamashita S, Takahashi M, Hashimoto H, Mori Y, Goto M (2016)
Anagliptin, a dipeptidyl peptidase-4 inhibitor, decreases macrophage infiltration and suppresses atherosclerosis in aortic and coronary arteries in cholesterol-fed rabbits
Metabolism 65: 893

Matsumoto S, Murakami N, Koizumi H, Takahashi M, Izumi Y, Kaji R (2016)
Edrophonium Challenge Test for Blepharospasm
Front Neurosci 10: 226

Matsumoto Y, Kano M, Akutsu Y, Hanari N, Hoshino I, Murakami K, Usui A, Suito H, Takahashi M, Otsuka R, Xin H, Komatsu A, Iida K, Matsubara H (2016)
Quantification of plasma exosome is a potential prognostic marker for esophageal squamous cell carcinoma
Oncol Rep 36: 2535

Mizoi K, Takahashi M, Haba M, Hosokawa M (2016)
Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases
Bioorganic & Medicinal Chemistry Lett 26: 921

Ohnishi T, Sakiyama Y, Okuri Y, Kimura Y, Sugiyama N, Saito T, Takahashi M, Kobayashi T (2014)
The prediction of response to Galantamine treatment in Patients with mild to moderate Alzheimer's Disease
Curr Alzheimer Res 11: 110

Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, Enkhtuvshin B, Sekiya M, Okazaki H, Osuga J, Ishibashi S (2014)
Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages
J Lipid Res 55: 2033

Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, Sakai K, Nagashima S, Tomoda H, Igarashi M, Okazaki H, Yagyu H, Osuga J, Ishibashi S (2014)
Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages
J Lipid Res 55: 2082

Takahashi M, Yagyu H, Tazoe F, Nagashima S, Ohshiro T, Okada K, Osuga J, Goldberg IJ, Ishibashi S (2013)
Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity
J Lipid Res 54: 1124

Masai E, Kamimura N, Kasai D, Oguchi A, Ankai A, Fukui S, Takahashi M, Yashiro I, Sasaki H, Harada T, Nakamura S, Katano Y, Narita-Yamada S, Nakazawa H, Hara H, Katayama Y, Fukuda M, Yamazaki S, Fujita N (2012)
Complete genome sequence of Sphingobium sp. strain SYK-6, a degrader of lignin-derived biaryls and monoaryls
Journal of Bacteriology 194: 534

Sekizuka T, Yamamoto A, Komiya T, Kenri T, Takeuchi F, Shibayama K, Takahashi M, Kuroda M, Iwaki M (2012)
Corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the C. diphtheriae NCTC 13129 prophage
BMC Microbiol 12: 72

Prakash T, Oshima K, Morita H, Fukuda S, Imaoka A, Kumar N, Sharma VK, Kim SW, Takahashi M, Saitou N, Taylor TD, Ohno H, Umesaki Y, Hattori M (2011)
Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation
Cell Host Microbe 10: 273

Takahashi M, Ubukata S, Sato E, Shoji M, Morikawa N, Watanabe H, Takahashi H (2011)
[Acute respiratory failure associated with cholinergic crisis: report of five cases and review of the literature]
Nihon Kokyuki Gakkai Zasshi 49: 877

Wang XL, Osuga J, Tazoe F, Okada K, Nagashima S, Takahashi M, Ohshiro T, Bayasgalan T, Yagyu H, Ishibashi S (2011)
Molecular analysis of a novel LCAT mutation (Gly179 --> Arg) found in a patient with complete LCAT deficiency
J Atheroscler Thromb 18: 713

Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S (2010)
The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages
Circulation Research 107: 1387

Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T (2010)
Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia
Neuropsychopharmacology 35: 1155

Koyama K, Takahashi M, Oitate M, Nakai N, Takakusa H, Miura S, Okazaki O (2009)
CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract
Antimicrobial Agents & Chemotherapy 53: 4845

Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, Takahashi M, Tazoe F, Wada T, Ohta K, Takanashi M, Kumagai M, Nishi M, Takase S, Yahagi N, Yagyu H, Ohashi K, Nagai R, Kadowaki T, Furukawa Y, Ishibashi S (2009)
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis
Cell Metab 10: 219

Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga J, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I (2009)
Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding
American Journal of Physiology Endocrinol Metab 297: E1115

Fukushima H, Hiratate A, Takahashi M, Saito-Hori M, Munetomo E, Kitano K, Saito H, Takaoka Y, Yamamoto K (2008)
Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Chem Pharm Bull (Tokyo) 56: 1110

Fukushima H, Hiratate A, Takahashi M, Mikami A, Saito-Hori M, Munetomo E, Kitano K, Chonan S, Saito H, Suzuki A, Takaoka Y, Yamamoto K (2008)
Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry 16: 4093

Hitsumoto T, Takahashi M, Iizuka T, Shirai K (2008)
Effect of the angiotensin II receptor antagonist telmisartan on lipoprotein lipase mass in preheparin serum
J Atheroscler Thromb 15: 138

Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W (2008)
Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning
Development 135: 1957

Takahashi M, Hiyama Y, Yokoyama M, Yu S, Hu Y, Melford K, Bensadoun A, Goldberg IJ (2008)
In vivo arterial lipoprotein lipase expression augments inflammatory responses and impairs vascular dilatation
Arterioscler Thromb Vasc Biol 28: 455

Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL (2007)
Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
Anesthesiology 107: 621

Hikage T, Saitoh Y, Tanaka-Saito C, Hagami H, Satou F, Shimotai Y, Nakano Y, Takahashi M, Takahata Y, Tsutsumi K (2007)
Structure and allele-specific expression variation of novel alpha/beta hydrolase fold proteins in gentian plants
Mol Genet Genomics 278: 95

Kamimura M, Takahashi M, Kikuchi K, Reza AM, Kiuchi M (2007)
Tissue-specific regulation of juvenile hormone esterase gene expression by 20-hydroxyecdysone and juvenile hormone in Bombyx mori
Archives of Insect Biochemistry & Physiology 65: 143

Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K, Arima T, Akita O, Kashiwagi Y, Abe K, Gomi K, Horiuchi H, Kitamoto K, Kobayashi T, Takeuchi M, Denning DW, Galagan JE, Nierman WC, Yu J, Archer DB, Bennett JW, Bhatnagar D, Cleveland TE, Fedorova ND, Gotoh O, Horikawa H, Hosoyama A, Ichinomiya M, Igarashi R, Iwashita K, Juvvadi PR, Kato M, Kato Y, Kin T, Kokubun A, Maeda H, Maeyama N, Maruyama J, Nagasaki H, Nakajima T, Oda K, Okada K, Paulsen I, Sakamoto K, Sawano T, Takahashi M, Takase K, Terabayashi Y, Wortman JR, Yamada O, Yamagata Y, Anazawa H, Hata Y, Koide Y, Komori T, Koyama Y, Minetoki T, Suharnan S, Tanaka A, Isono K, Kuhara S, Ogasawara N, Kikuchi H (2005)
Genome sequencing and analysis of Aspergillus oryzae
Nature 438: 1157

Niho N, Mutoh M, Takahashi M, Tsutsumi K, Sugimura T, Wakabayashi K (2005)
Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice
Proc Natl Acad Sci U S A 102: 2970

Takahashi M, Kamei Y, Ezaki O (2005)
Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size
American Journal of Physiology Endocrinol Metab 288: E117

Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K (2005)
Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species
Journal of Bacteriology 187: 7292

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Ohara O, Isogai T, Sugano S (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Nat Genet 36: 40

Saika Y, Sakai N, Takahashi M, Maruyama T, Kihara S, Ouchi N, Ishigami M, Hiraoka H, Nakamura T, Yamashita S, Matsuzawa Y (2003)
Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis
European Journal of Clinical Investigation 33: 216

Takahashi M, Saibara T, Nemoto Y, Ono M, Akisawa N, Iwasaki S, Toda K, Ogawa Y, Wakatsuki A, Inagaki S, Onishi S (2003)
A novel type hypertriglyceridemia observed in FLS mice
Lipids 38: 687

Mima J, Suzuki H, Takahashi M, Hayashi R (2002)
Overexpression and functional characterization of a serine carboxypeptidase inhibitor (I(C)) from Saccharomyces cerevisiae
J Biochem 132: 967

Ishii K, Kondo K, Takahashi M, Kimura M, Endoh M (2001)
An amino acid residue whose change by mutation affects drug binding to the HERG channel
FEBS Letters 506: 191

Kawarabayasi Y, Hino Y, Horikawa H, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A, Kosugi H, Hosoyama A, Fukui S, Nagai Y, Nishijima K, Otsuka R, Nakazawa H, Takamiya M, Kato Y, Yoshizawa T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Aoki K, Masuda S, Yanagii M, Nishimura M, Yamagishi A, Oshima T, Kikuchi H (2001)
Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7
DNA Research 8: 123

Tojima T, Yamane Y, Takahashi M, Ito E (2000)
Acquisition of neuronal proteins during differentiation of NG108-15 cells
Neurosci Res 37: 153

Kawarabayasi Y, Hino Y, Horikawa H, Yamazaki S, Haikawa Y, Jin-no K, Takahashi M, Sekine M, Baba S, Ankai A, Kosugi H, Hosoyama A, Fukui S, Nagai Y, Nishijima K, Nakazawa H, Takamiya M, Masuda S, Funahashi T, Tanaka T, Kudoh Y, Yamazaki J, Kushida N, Oguchi A, Aoki KI, Kubota K, Nakamura Y, Nomura N, Sako Y, Kikuchi H (1999)
Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1
DNA Research 6: 83

Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T (1994)
Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues
Brain Research 658: 163

Morinobu S, Kuwayama N, Kawanami T, Okuyama N, Takahashi M, Totsuka S, Endoh M (1992)
Influence of the acute stress on agonist-stimulated phosphoinositide hydrolysis in the rat cerebral cortex
Prog Neuropsychopharmacol Biological Psychiatry 16: 561

Catterall WA, Seagar MJ, Takahashi M, Nunoki K (1989)
Molecular properties of dihydropyridine-sensitive calcium channels
Annals of the New York Academy of Sciences 560: 1

Seagar MJ, Takahashi M, Catterall WA (1988)
Molecular properties of dihydropyridine-sensitive calcium channels
Annals of the New York Academy of Sciences 522: 162

Takahashi M, Catterall WA (1987)
Identification of an alpha subunit of dihydropyridine-sensitive brain calcium channels
Science 236: 88

Nakamura K, Koide M, Imanaga T, Ogasawara H, Takahashi M, Yoshikawa M (1980)
Prolonged neuromuscular blockade following trimetaphan infusion. A case report and in vitro study of cholinesterase inhibition
Anaesthesia 35: 1202

Yamamoto A, Adachi S, Kawamura S, Takahashi M, Kitani T (1974)
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Archives of Internal Medicine 134: 627