Rosenberg YJ, Garcia K, Diener J, Sullivan D, Donahue S, Mao L, Lees J, Jiang X, Urban LA, Momper JD, Ho KY, Taylor P (2023) <br />A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides<br /><i>Journal of Neurochemistry</i> <br /><br />Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radic Z (2021) <br />Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects<br /><i>Journal of Biological Chemistry</i> <br /><br />Shyong YJ, Sepulveda Y, Garcia A, Samskey NM, Radic Z, Sit R, Sharpless KB, Momper JD, Taylor P (2021) <br />Enhancing target tissue levels and diminishing plasma clearance of ionizing zwitterionic antidotes in organophosphate exposures<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <br /><br />Taylor P (2021) <br />Cholinergic Capsules and Academic Admonitions<br /><i>Annual Review of Pharmacology & Toxicology</i> <b>61</b>: 25<br /><br />Taylor P, Shong YJ, Samskey N, Ho KY, Radic Z, Fenical W, Sharpless KB, Kovarik Z, Andrea Camacho-Hernandez G (2021) <br />Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical<br /><i>Journal of Neurochemistry</i> <br /><br />Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z (2020) <br />Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>295</b>: 4079<br /><br />Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HD, Zinn KR, Taylor P, Gerdes JM, Thompson CM (2020) <br />Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[(18) F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [(18) F]-VXS<br /><i>Annals of the New York Academy of Sciences</i> <br /><br />Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radic Z (2019) <br />A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies<br /><i>Chemico-Biological Interactions</i> <br /><br />Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radic Z, Kovalevsky A (2019) <br />Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>294</b>: 10607<br /><br />Kovarik Z, Kalisiak J, Hrvat NM, Katalinic M, Zorbaz T, Zunec S, Green C, Radic Z, Fokin VV, Sharpless KB, Taylor P (2019) <br />Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase<br /><i>Chemistry</i> <b>25</b>: 4100<br /><br />Kovarik Z, Macek Hrvat N, Kalisiak J, Katalinic M, Sit RK, Zorbaz T, Radic Z, Fokin VV, Sharpless KB, Taylor P (2019) <br />Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase<br /><i>Toxicol Appl Pharmacol</i> <b>372</b>: 40<br /><br />Macek Hrvat N, Kalisiak J, Sinko G, Radic Z, Sharpless KB, Taylor P, Kovarik Z (2019) <br />Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases<br /><i>Toxicol Lett</i> <b>321</b>: 83<br /><br />Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic Z, Rosenberg YJ, Kovarik Z, Sit R, Sharpless KB (2019) <br />Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure<br /><i>Chemico-Biological Interactions</i> <b>308</b>: 194<br /><br />Hagstrom D, Zhang S, Ho A, Tsai ES, Radic Z, Jahromi A, Kaj KJ, He Y, Taylor P, Collins ES (2018) <br />Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity<br /><i>Archives of Toxicology</i> <b>92</b>: 1161<br /><br />Rosenberg YJ, Wang J, Ooms T, Rajendran N, Mao L, Jiang X, Lees J, Urban L, Romper J, Sepulveda Y, Shyong YJ, Taylor P (2017) <br />Post-exposure treatment with the oxime RS194B rapidly reactivates and reverses advanced symptoms of lethal inhaled paraoxon in macaques<br /><i>Toxicol Lett</i> <b>293</b>: 229<br /><br />Sit RK, Kovarik Z, Macek Hrvat N, Zunec S, Green C, Fokin VV, Sharpless KB, Radic Z, Taylor P (2018) <br />Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>367</b>: 363<br /><br />Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins ES (2016) <br />Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation<br /><i>Archives of Toxicology</i> <b>91</b>: 2837<br /><br />Mangas I, Radic Z, Taylor P, Ghassemian M, Candela H, Vilanova E, Estevez J (2017) <br />Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain<br /><i>Archives of Toxicology</i> <b>91</b>: 909<br /><br />Molgo J, Marchot P, Araoz R, Benoit E, Iorga BI, Zakarian A, Taylor P, Bourne Y, Servent D (2017) <br />Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors<br /><i>Journal of Neurochemistry</i> <b>142 Suppl 2</b>: 41<br /><br />Rosenberg YJ, Mao L, Jiang X, Lees J, Zhang L, Radic Z, Taylor P (2017) <br />Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor<br /><i>Chemico-Biological Interactions</i> <b>274</b>: 50<br /><br />Bourne Y, Sharpless KB, Taylor P, Marchot P (2016) <br />Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase<br /><i>Journal of the American Chemical Society</i> <b>138</b>: 1611<br /><br />Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radic Z (2016) <br />Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning<br /><i>Annals of the New York Academy of Sciences</i> <b>1378</b>: 41<br /><br />Macek Hrvat N, Zunec S, Taylor P, Radic Z, Kovarik Z (2016) <br />HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 148<br /><br />Mangas I, Taylor P, Vilanova E, Estevez J, Franca TCC, Komives E, Radic Z (2016) <br />Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches<br /><i>Archives of Toxicology</i> <b>90</b>: 603<br /><br />de Lima WE, Francisco A, da Cunha EFF, Radic Z, Taylor P, Franca TCC, Ramalho TC (2016) <br />Mechanistic studies of new oximes reactivators of human butyrylcholinesterase inhibited by cyclosarin and sarin<br /><i>J Biomol Struct Dyn</i> <br /><br />Arunrungvichian K, Boonyarat C, Fokin VV, Taylor P, Vajragupta O (2015) <br />Cognitive Improvements in a Mouse Model with Substituted 1,2,3-Triazole Agonists for Nicotinic Acetylcholine Receptors<br /><i>ACS Chem Neurosci</i> <b>6</b>: 1331<br /><br />Bourne Y, Sulzenbacher G, Radic Z, Araoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgo J, Taylor P, Marchot P (2015) <br />Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal alpha7 from Muscle alpha1(2)betagammadelta nAChRs<br /><i>Structure</i> <b>23</b>: 1106<br /><br />Kovarik Z, Macek Hrvat N, Katalinic M, Sit RK, Paradyse A, Zunec S, Musilek K, Fokin VV, Taylor P, Radic Z (2015) <br />Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes<br /><i>Chemical Research in Toxicology</i> <b>28</b>: 1036<br /><br />Schmidt HR, Radic Z, Taylor P, Fradinger EA (2015) <br />Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system<br /><i>Toxicol Appl Pharmacol</i> <b>284</b>: 197<br /><br />Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radic Z (2014) <br />Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 1378<br /><br />Kovarik Z, Macek Hrvat N, Sit RK, Radic Z, Fokin VV, Sharpless KB, Taylor P (2013) <br />Centrally acting oximes in reactivation of tabun-phosphoramidated AChE<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 77<br /><br />Morris GM, Green LG, Radic Z, Taylor P, Sharpless KB, Olson AJ, Grynszpan F (2013) <br />Automated docking with protein flexibility in the design of femtomolar click chemistry inhibitors of acetylcholinesterase<br /><i>J Chem Inf Model</i> <b>53</b>: 898<br /><br />Radic Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang LM, Amitai G, Green C, Radic B, Duggan BM, Ajami D, Rebek J, Taylor P (2013) <br />Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes<br /><i>Biochemical Journal</i> <b>450</b>: 231<br /><br />Radic Z, Sit RK, Garcia E, Zhang LM, Berend S, Kovarik Z, Amitai G, Fokin VV, Sharpless KB, Taylor P (2013) <br />Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 67<br /><br />Taylor P, De Jaco A, Comoletti D, Miller M, Camp S (2013) <br />Cholinesterase confabs and cousins: Approaching forty years<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 10<br /><br />De Jaco A, Dubi N, Camp S, Taylor P (2012) <br />Congenital hypothyroidism mutations affect common folding and trafficking in the alpha/beta-hydrolase fold proteins<br /><i>Febs J</i> <b>279</b>: 4293<br /><br />De Jaco A, Comoletti D, Dubi N, Camp S, Taylor P (2012) <br />Processing of cholinesterase-like alpha/beta-hydrolase fold proteins: alterations associated with congenital disorders<br /><i>Protein Pept Lett</i> <b>19</b>: 173<br /><br />Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz A, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV (2012) <br />Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template<br /><i>Journal of the American Chemical Society</i> <b>134</b>: 6732<br /><br />Radic Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Fokin VV, Sharpless KB, Taylor P (2012) <br />Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases<br /><i>Journal of Biological Chemistry</i> <b>287</b>: 11798<br /><br />Suckow AT, Zhang C, Egodage S, Comoletti D, Taylor P, Miller MT, Sweet IR, Chessler SD (2012) <br />Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function<br /><i>Journal of Biological Chemistry</i> <b>287</b>: 19816<br /><br />Yamauchi JG, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing JR, Ho KY, Talley TT, Sharpless KB, Fokin VV, Taylor P (2012) <br />Synthesis of selective agonists for the alpha7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates<br /><i>Molecular Pharmacology</i> <b>82</b>: 687<br /><br />Bernard V, Girard E, Hrabovska A, Camp S, Taylor P, Plaud B, Krejci E (2011) <br />Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction<br /><i>Molecular & Cellular Neurosciences</i> <b>46</b>: 272<br /><br />Cochran R, Kalisiak J, Kucukkilinc TT, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P (2011) <br />Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging<br /><i>Journal of Biological Chemistry</i> <b>286</b>: 29718<br /><br />Kombo DC, Mazurov A, Tallapragada K, Hammond PS, Chewning J, Hauser TA, Vasquez-Valdivieso M, Yohannes D, Talley TT, Taylor P, Caldwell WS (2011) <br />Docking studies of benzylidene anabaseine interactions with alpha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related alpha7 selective ligands<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 5625<br /><br />Sit RK, Radic Z, Gerardi V, Zhang L, Garcia E, Katalinic M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P (2011) <br />New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases<br /><i>Journal of Biological Chemistry</i> <b>286</b>: 19422<br /><br />Talley TT, Nemecz A, Yamauchi JG, Wu J, Ho KY, Sankaran B, Taylor P (2011) <br />Poster: Acetylcholine binding protein-nicotinic receptor chimeras for delineating structure and determinants of ligand selectivity<br /><i>Biochemical Pharmacology</i> <b>82</b>: 1028<br /><br />Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P (2011) <br />Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>338</b>: 125<br /><br />Yamauchi JG, Nemecz A, Nguyen QT, Muller A, Schroeder LF, Talley TT, Lindstrom JM, Kleinfeld D, Taylor P (2011) <br />Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors<br /><i>PLoS ONE</i> <b>6</b>: e16519<br /><br />Bourne Y, Radic Z, Araoz R, Talley TT, Benoit E, Servent D, Taylor P, Molgo J, Marchot P (2010) <br />Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism<br /><i>Proc Natl Acad Sci U S A</i> <b>107</b>: 6076<br /><br />Bourne Y, Radic Z, Taylor P, Marchot P (2010) <br />Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state<br /><i>Journal of the American Chemical Society</i> <b>132</b>: 18292<br /><br />Camp S, Zhang L, Krejci E, Dobbertin A, Bernard V, Girard E, Duysen EG, Lockridge O, De Jaco A, Taylor P (2010) <br />Contributions of selective knockout studies to understanding cholinesterase disposition and function<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 72<br /><br />De Jaco A, Dubi N, Comoletti D, Taylor P (2010) <br />Folding anomalies of neuroligin3 caused by a mutation in the alpha/beta-hydrolase fold domain<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 56<br /><br />De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman M, Butko MT, Tsien RY, Taylor P (2010) <br />Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family<br /><i>Journal of Biological Chemistry</i> <b>285</b>: 28674<br /><br />Kucukkilinc TT, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radic Z, Taylor P (2010) <br />Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 238<br /><br />Leone P, Comoletti D, Taylor P, Bourne Y, Marchot P (2010) <br />Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: a comparison with acetylcholinesterase<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 49<br /><br />Leone P, Comoletti D, Ferracci G, Conrod S, Garcia SU, Taylor P, Bourne Y, Marchot P (2010) <br />Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions<br /><i>EMBO Journal</i> <b>29</b>: 2461<br /><br />Radic Z, Kalisiak J, Fokin VV, Sharpless KB, Taylor P (2010) <br />Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 163<br /><br />Sine SM, Wang HL, Hansen S, Taylor P (2010) <br />On the origin of ion selectivity in the Cys-loop receptor family<br /><i>Journal of Molecular Neuroscience</i> <b>40</b>: 70<br /><br />Taylor P (2010) <br />From Split to Sibenik: The Tortuous Pathway in the Cholinesterase Field<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 3<br /><br />Wang X, Lee J, Di Jeso B, Treglia AS, Comoletti D, Dubi N, Taylor P, Arvan P (2010) <br />Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer<br /><i>Journal of Biological Chemistry</i> <b>285</b>: 17564<br /><br />Babakhani A, Talley TT, Taylor P, McCammon JA (2009) <br />A virtual screening study of the acetylcholine binding protein using a relaxed-complex approach<br /><i>Comput Biol Chem</i> <b>33</b>: 160<br /><br />Boudinot E, Bernard V, Camp S, Taylor P, Champagnat J, Krejci E, Foutz AS (2009) <br />Influence of differential expression of acetylcholinesterase in brain and muscle on respiration<br /><i>Respir Physiol Neurobiol</i> <b>165</b>: 40<br /><br />Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y (2009) <br />Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor<br /><i>EMBO Journal</i> <b>28</b>: 3040<br /><br />Rana BK, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen JR, Eskin E, Valle AM, Das M, Mahata SK, Taupenot L, Stridsberg M, Talley TT, Ziegler MG, Smith DW, Schork NJ, O'Connor DT, Taylor P (2009) <br />Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>331</b>: 419<br /><br />Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, Taylor P (2009) <br />Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 3735<br /><br />Camp S, De Jaco A, Zhang L, Marquez M, de la Torre B, Taylor P (2008) <br />Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron<br /><i>Journal of Neuroscience</i> <b>28</b>: 2459<br /><br />Comoletti D, Grishaev A, Whitten AE, Taylor P, Trewhella J (2008) <br />Characterization of the solution structure of a neuroligin/beta-neurexin complex<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 150<br /><br />De Jaco A, Comoletti D, King CC, Taylor P (2008) <br />Trafficking of cholinesterases and neuroligins mutant proteins. An association with autism<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 349<br /><br />Hansen SB, Wang HL, Taylor P, Sine SM (2008) <br />An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance<br /><i>Journal of Biological Chemistry</i> <b>283</b>: 36066<br /><br />Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P (2008) <br />Probing gorge dimensions of cholinesterases by freeze-frame click chemistry<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 161<br /><br />Suckow AT, Comoletti D, Waldrop MA, Mosedale M, Egodage S, Taylor P, Chessler SD (2008) <br />Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion<br /><i>Endocrinology</i> <b>149</b>: 6006<br /><br />Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P (2008) <br />Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore<br /><i>Proc Natl Acad Sci U S A</i> <b>105</b>: 7606<br /><br />Valle AM, Radic Z, Rana BK, Whitfield JB, O'Connor DT, Martin NG, Taylor P (2008) <br />The cholinesterases: analysis by pharmacogenomics in man<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 343<br /><br />Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM (2008) <br />Control of cation permeation through the nicotinic receptor channel<br /><i>PLoS Comput Biol</i> <b>4</b>: e41<br /><br />Comoletti D, Grishaev A, Whitten AE, Tsigelny I, Taylor P, Trewhella J (2007) <br />Synaptic arrangement of the neuroligin/beta-neurexin complex revealed by X-ray and neutron scattering<br /><i>Structure</i> <b>15</b>: 693<br /><br />Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P (2007) <br />Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion<br /><i>Neuron</i> <b>56</b>: 979<br /><br />Kovarik Z, Radic Z, Berman HA, Taylor P (2007) <br />Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates<br /><i>Toxicology</i> <b>233</b>: 79<br /><br />Taylor P, Talley TT, Radic Z, Hansen SB, Hibbs RE, Shi J (2007) <br />Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes<br /><i>Biochemical Pharmacology</i> <b>74</b>: 1164<br /><br />Taylor P, Reiner E, Kovarik Z, Radic Z (2007) <br />Application of recombinant DNA methods for production of cholinesterases as organophosphate antidotes and detectors<br /><i>Arh Hig Rada Toksikol</i> <b>58</b>: 339<br /><br />Taylor P, Kovarik Z, Reiner E, Radic Z (2007) <br />Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure<br /><i>Toxicology</i> <b>233</b>: 70<br /><br />Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, Casida JE (2007) <br />Defining nicotinic agonist binding surfaces through photoaffinity labeling<br /><i>Biochemistry</i> <b>46</b>: 8798<br /><br />Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE (2007) <br />Mapping the elusive neonicotinoid binding site<br /><i>Proc Natl Acad Sci U S A</i> <b>104</b>: 9075<br /><br />Bourne Y, Hansen SB, Sulzenbacher G, Talley TT, Huxford T, Taylor P, Marchot P (2006) <br />Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 103<br /><br />Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot P (2006) <br />Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding<br /><i>Journal of Biological Chemistry</i> <b>281</b>: 29256<br /><br />Bui JM, Radic Z, Taylor P, McCammon JA (2006) <br />Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase<br /><i>Biophysical Journal</i> <b>90</b>: 3280<br /><br />Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Sudhof TC, Taylor P (2006) <br />Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins<br /><i>Biochemistry</i> <b>45</b>: 12816<br /><br />De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radic Z, Lockridge O, Ellisman MH, Taylor P (2006) <br />A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family<br /><i>Journal of Biological Chemistry</i> <b>281</b>: 9667<br /><br />Gao F, Mer G, Tonelli M, Hansen SB, Burghardt TP, Taylor P, Sine SM (2006) <br />Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop<br /><i>Molecular Pharmacology</i> <b>70</b>: 1230<br /><br />Girard E, Barbier J, Camp S, Taylor P, Chatonnet A, Krejci E, Molgo J (2006) <br />Synaptic efficacy and remodeling at the neuromuscular junction of knockout mice deficient in acetylcholinesterase<br /><i>Journal de Physiologie (Paris)</i> <b>99</b>: 254<br /><br />Girard E, Bernard V, Camp S, Taylor P, Krejci E, Molgo J (2006) <br />Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 99<br /><br />Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Bourne Y, Taylor P (2006) <br />Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 101<br /><br />Hibbs RE, Johnson DA, Shi J, Taylor P (2006) <br />Structural dynamics of the acetylcholine binding protein: hydrodynamic and fluorescence anisotropy decay analyses<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 73<br /><br />Hibbs RE, Radic Z, Taylor P, Johnson DA (2006) <br />Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein<br /><i>Journal of Biological Chemistry</i> <b>281</b>: 39708<br /><br />Kovarik Z, Ciban N, Radic Z, Simeon-Rudolf V, Taylor P (2006) <br />Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP<br /><i>Biochemical & Biophysical Research Communications</i> <b>342</b>: 973<br /><br />Valle A, O'Connor DT, Taylor P, Zhu G, Montgomery GW, Slagboom PE, Martin NG, Whitfield JB (2006) <br />Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity<br /><i>Clinical Chemistry</i> <b>52</b>: 1014<br /><br />Boucard AA, Chubykin AA, Comoletti D, Taylor P, Sudhof TC (2005) <br />A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins<br /><i>Neuron</i> <b>48</b>: 229<br /><br />Bourne Y, Radic Z, Kolb HC, Sharpless KB, Taylor P, Marchot P (2005) <br />Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 159<br /><br />Camp S, Zhang L, Marquez M, de la Torre B, Long JM, Bucht G, Taylor P (2005) <br />Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 79<br /><br />Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Sudhof TC (2005) <br />Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism<br /><i>Journal of Biological Chemistry</i> <b>280</b>: 22365<br /><br />De Jaco A, Kovarik Z, Comoletti D, Jennings LL, Gaietta G, Ellisman MH, Taylor P (2005) <br />A single mutation near the C-terminus in alpha/beta hydrolase fold protein family causes a defect in protein processing<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 371<br /><br />De Jaco A, Camp S, Taylor P (2005) <br />Influence of the 5' intron in the control of acetylcholinesterase gene expression during myogenesis<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 372<br /><br />Gao F, Bren N, Burghardt TP, Hansen S, Henchman RH, Taylor P, McCammon JA, Sine SM (2005) <br />Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence<br /><i>Journal of Biological Chemistry</i> <b>280</b>: 8443<br /><br />Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA (2005) <br />Ligand-induced conformational change in the alpha7 nicotinic receptor ligand binding domain<br /><i>Biophysical Journal</i> <b>88</b>: 2564<br /><br />Hibbs RE, Johnson DA, Shi J, Hansen SB, Taylor P (2005) <br />Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: hydrodynamic and fluorescence anisotropy decay analyses<br /><i>Biochemistry</i> <b>44</b>: 16602<br /><br />Kovarik Z, Radic Z, Simeon-Rudolf V, Reiner E, Taylor P (2005) <br />Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 388<br /><br />Krasinski A, Radic Z, Manetsch R, Raushel J, Taylor P, Sharpless KB, Kolb HC (2005) <br />In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors<br /><i>Journal of the American Chemical Society</i> <b>127</b>: 6686<br /><br />Luo C, Dawson M, Chambers C, Chilukuri N, Radic Z, Taylor P, Doctor BP, Saxena A (2005) <br />Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 393<br /><br />Pezzementi L, Shi J, Johnson DA, Radic Z, Boyd A, Taylor P (2005) <br />Ligand-induced conformational changes in residues flanking the active site gorge of acetylcholinesterase<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 413<br /><br />Radic Z, Manetsch R, Krasinski A, Raushel J, Yamauchi J, Garcia C, Kolb HC, Sharpless KB, Taylor P (2005) <br />Molecular basis of interactions of cholinesterases with tight binding inhibitors<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 133<br /><br />Zhang D, Suen J, Zhang Y, Song Y, Radic Z, Taylor P, Holst MJ, Bajaj C, Baker NA, McCammon JA (2005) <br />Tetrameric mouse acetylcholinesterase: continuum diffusion rate calculations by solving the steady-state Smoluchowski equation using finite element methods<br /><i>Biophysical Journal</i> <b>88</b>: 1659<br /><br />Bourne Y, Kolb HC, Radic Z, Sharpless KB, Taylor P, Marchot P (2004) <br />Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation<br /><i>Proc Natl Acad Sci U S A</i> <b>101</b>: 1449<br /><br />Bourne Y, Taylor P, Radic Z, Berman HA, Marchot P (2004) <br />Poster (50) Insights into the interactions at the acetylcholinesterase peripheral anionic site.<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 347<br /><br />Bourne Y, Taylor P, Radic Z, Lewis WG, Grynszpan F, Finn MG, Sharpless KB, Marchot P (2004) <br />Poster (51) Novel compounds with distinctive interactions at the acetylcholinesterase peripheral anionic site<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 348<br /><br />Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, Sine SM (2004) <br />Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel<br /><i>Nature</i> <b>430</b>: 896<br /><br />Boyd AE, Dunlop CS, Wong L, Radic Z, Taylor P, Johnson DA (2004) <br />Nanosecond dynamics of acetylcholinesterase near the active center gorge<br /><i>Journal of Biological Chemistry</i> <b>279</b>: 26612<br /><br />Camp S, Zhang LM, Marquez M, de la Torre B, Taylor P (2004) <br />Knockout mice with deletions of alternatively spliced exons of acetylcholinesterase<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 43 <br /><br />Camp S, Zhang LM, Marquez M, Taylor P (2004) <br />Poster (10) Knockout mice with deletions of alternatively spliced exons of acetylcholinesterase.<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 326<br /><br />Comoletti D, Flynn RE, Jennings LL, Hoffman RC, Marchot P, Bourne Y, Sudhof TC, Taylor P (2004) <br />Interaction of recombinant soluble neuroligin-1 with neurexin-1-_.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, Taylor P (2004) <br />The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing<br /><i>Journal of Neuroscience</i> <b>24</b>: 4889<br /><br />Hibbs RE, Talley TT, Taylor P (2004) <br />Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein<br /><i>Journal of Biological Chemistry</i> <b>279</b>: 28483<br /><br />Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor P (2004) <br />Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry<br /><i>Biochemistry</i> <b>43</b>: 1496<br /><br />Jennings LL, Komives EA, Taylor P (2004) <br />Organophosphate modifications of mouse acetylcholinesterase: Detection of exposure by Maldi-Tof mass spectrometry<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 265 <br /><br />Jennings LL, Komives EA, Taylor P (2004) <br />Poster (85) Organophosphate modifications of mouse acetylcholinesterase: detection of exposure by maldi-tof mass spectrometry<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 365<br /><br />Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P (2004) <br />Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates<br /><i>Biochemistry</i> <b>43</b>: 3222<br /><br />Kovarik Z, Wong L, Radic Z, Taylor P (2004) <br />Phosphorylation of mouse cholinesterases and mutants by DDVP and reactivation of conjugates by HI-6 and 2-PAM<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 219 <br /><br />Kovarik Z, Wong L, Radic Z, Taylor P (2004) <br />Poster (89) Phosphorylation of mouse cholinesterases and mutants by ddvp and reactivation of conjugates by Hi-6 and 2-PAM<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 367<br /><br />Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A (2004) <br />Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Manetsch R, Krasinski A, Radic Z, Raushel J, Taylor P, Sharpless KB, Kolb HC (2004) <br />In situ click chemistry: enzyme inhibitors made to their own specifications<br /><i>Journal of the American Chemical Society</i> <b>126</b>: 12809<br /><br />Radic Z, Kim E, Taylor P (2004) <br />Intrinsic tryptophan fluorescence of cholinesterases.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Radic Z, Kim E, Taylor P (2004) <br />Monitoring cholinesterase - ligand interactions<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 201 <br /><br />Radic Z, Taylor P (2004) <br />Poster (22) Monitoring cholinesterase-ligand interactions<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 332<br /><br />Reiner E, Sinko G, Radic Z, Taylor P, Simeon-Rudolf V (2004) <br />Kinetics of interaction of ethopropazine enantiomers with butyrylcholinesterase and acetylcholinesterase.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Reiner E, Sinko G, Bosak A, Simeon-Rudolf V, Radic Z, Taylor P, Stojan J, Golicnik M (2004) <br />Kinetics of ethopropazine binding to butyrylcholinesterase in the absence and presence of acetylthiocholine<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 187 <br /><br />Reiner E, Sinko G, Stuglin A, Simeon-Rudolf V, Radic Z, Taylor P, Stojan J, Golicnik M (2004) <br />Poster (19) Kinetics of ethopropazine binding to butyrylcholinesterase in the absence and presence of acetylthiocholine.<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 330<br /><br />Shi J, Radic Z, Boyd AE, Johnson DA, Taylor P (2004) <br />Ligand-induced conformational changes in the omega loop of acetylcholinesterase revealed by fluorescence spectroscopy.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Shi J, Radic Z, Johnson DA, Taylor P (2004) <br />Analysis of acetylcholinesterase structure and dynamics by steady state and time-resolved fluorescence<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 225 <br /><br />Shi J, Radic Z, Johnson DA, Taylor P (2004) <br />Poster (105) Analysis of acetylcholinesterase structure and dynamics by steady state and time-resolved fluorescence<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 375<br /><br />Taylor P, Hansen SB, Talley TT, Hibbs RE, Radic Z (2004) <br />Contemporary paradigms for cholinergic ligand design guided by biological structure<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>14</b>: 1875<br /><br />Taylor P (2004) <br />Rene Couteaux Lecture.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Taylor P, Shi J, Radic Z, Boyd AE, Johnson DA (2004) <br />Spectroscopic approaches to the study of acetylcholinesterase structure and function<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 177 <br /><br />Taylor P, Shi J, Johnson DA, Boyd AE, Radic Z (2004) <br />Poster (13) Conformational dynamics accompanying substrate and inhibitor binding to acetylcholinesterase.<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 327<br /><br />Kovarik Z, Radic Z, Berman HA, Taylor P (2004) <br />Phosphonylation of acetylcholinesterase and the propensity for reactivation analysed by chirality and mutagenesis.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Bourne Y, Taylor P, Radic Z, Marchot P (2003) <br />Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site<br /><i>EMBO Journal</i> <b>22</b>: 1<br /><br />Comoletti D, Flynn RE, Jennings LL, Chubykin AA, Matsumura T, Hasegawa H, Sudhof TC, Taylor P (2003) <br />Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta<br /><i>Journal of Biological Chemistry</i> <b>278</b>: 50497<br /><br />Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, Sine SM (2003) <br />Curariform antagonists bind in different orientations to acetylcholine-binding protein<br /><i>Journal of Biological Chemistry</i> <b>278</b>: 23020<br /><br />George KM, Schule T, Sandoval LE, Jennings LL, Taylor P, Thompson CM (2003) <br />Differentiation between acetylcholinesterase and the organophosphate-inhibited form using antibodies and the correlation of antibody recognition with reactivation mechanism and rate<br /><i>Journal of Biological Chemistry</i> <b>278</b>: 45512<br /><br />Henchman RH, Wang HL, Sine SM, Taylor P, McCammon JA (2003) <br />Asymmetric structural motions of the homomeric alpha7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation<br /><i>Biophysical Journal</i> <b>85</b>: 3007<br /><br />Jennings LL, Malecki M, Komives EA, Taylor P (2003) <br />Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry<br /><i>Biochemistry</i> <b>42</b>: 11083<br /><br />Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P (2003) <br />Acetylcholinesterase active centre and gorge conformations analyzed by combinatorial mutations and enantiomeric phosphonates<br /><i>Biochemical Journal</i> <b>31</b>: 33<br /><br />Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A (2003) <br />Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase<br /><i>Biochemical Pharmacology</i> <b>66</b>: 387<br /><br />Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radic Z, Taylor P, Lockridge O, Doctor BP (2003) <br />Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases<br /><i>European Journal of Biochemistry</i> <b>270</b>: 4447<br /><br />Shi J, Tai K, McCammon JA, Taylor P, Johnson DA (2003) <br />Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop<br /><i>Journal of Biological Chemistry</i> <b>278</b>: 30905<br /><br />Hansen SB, Radic Z, Talley TT, Molles BE, Deerinck TJ, Tsigelny I, Taylor P (2002) <br />Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein<br /><i>Journal of Biological Chemistry</i> <b>277</b>: 41299<br /><br />Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB (2002) <br />Cover picture: angew. Chem. Int. Ed. 6/2002<br /><i>Angew Chem Int Ed Engl</i> <b>41</b>: 875<br /><br />Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB (2002) <br />Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks<br /><i>Angew Chem Int Ed Engl</i> <b>41</b>: 1053<br /><br />Molles BE, Rezai P, Kline EF, McArdle JJ, Sine SM, Taylor P (2002) <br />Identification of residues at the alpha and epsilon subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors<br /><i>Journal of Biological Chemistry</i> <b>277</b>: 5433<br /><br />Molles BE, Tsigelny I, Nguyen PD, Gao SX, Sine SM, Taylor P (2002) <br />Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site<br /><i>Biochemistry</i> <b>41</b>: 7895<br /><br />Satoh T, Taylor P, Bosron WF, Sanghani SP, Hosokawa M, La Du BN (2002) <br />Current progress on esterases: from molecular structure to function<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>30</b>: 488<br /><br />Shi J, Radic Z, Taylor P (2002) <br />Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys 69- Cys 96, of mouse acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>277</b>: 43301<br /><br />Sinchaikul S, Tyndall JD, Fothergill-Gilmore LA, Taylor P, Phutrakul S, Chen ST, Walkinshaw MD (2002) <br />Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1<br /><i>Acta Crystallographica D Biol Crystallogr</i> <b>58</b>: 182<br /><br />Tyndall JD, Sinchaikul S, Fothergill-Gilmore LA, Taylor P, Walkinshaw MD (2002) <br />Crystal Structure of a Thermostable Lipase from Bacillus stearothermophilus P1<br /><i>Journal of Molecular Biology</i> <b>323</b>: 859<br /><br />Radic Z, Taylor P (2001) <br />Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates<br /><i>J Appl Toxicol</i> <b>21 Suppl 1</b>: S13<br /><br />Shi J, Boyd AE, Radic Z, Taylor P (2001) <br />Reversibly bound and covalently attached ligands induce conformational changes in the Omega loop, Cys 69-Cys 96, of mouse acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>276</b>: 42196<br /><br />Boyd AE, Marnett AB, Wong L, Taylor P (2000) <br />Probing the active center Gorge of acetylcholinesterase by fluorophores Linked to substituted cysteines<br /><i>Journal of Biological Chemistry</i> <b>275</b>: 22401<br /><br />Kraut D, Goff H, Pai RK, Hosea NA, Silman I, Sussman JL, Taylor P, Voet JG (2000) <br />Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride<br /><i>Molecular Pharmacology</i> <b>57</b>: 1243<br /><br />Malany S, Osaka H, Sine SM, Taylor P (2000) <br />Orientation of alpha-neurotoxin at the subunit interfaces of the nicotinic acetylcholine receptor<br /><i>Biochemistry</i> <b>39</b>: 15388<br /><br />Osaka H, Malany S, Molles BE, Sine SM, Taylor P (2000) <br />Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>275</b>: 5478<br /><br />Saltmarsh JR, Boyd AE, Rodriguez OP, Radic Z, Taylor P, Thompson CM (2000) <br />Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>10</b>: 1523<br /><br />Taylor P, Osaka H, Molles BE, Keller SH, Malany S (2000) <br />Contributions of Studies of the Nicotinic Receptor from Muscle to Defining Structural and Functional Properties of Ligand-Gated Ion Channels<br /><i>Handbook of Experimental Pharmacology</i> <b>144</b>: 79<br /><br />Taylor P, Malanz S, Molles BE, Osaka H, Tsigelny I (2000) <br />Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure<br /><i>Pflugers Arch</i> <b>440</b>: R115<br /><br />Tsigelny I, Shindyalov IN, Bourne PE, Sudhof TC, Taylor P (2000) <br />Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations<br /><i>Protein Science</i> <b>9</b>: 180<br /><br />Wong L, Radic Z, Bruggemann RJ, Hosea NA, Berman HA, Taylor P (2000) <br />Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis<br /><i>Biochemistry</i> <b>39</b>: 5750<br /><br />Xie W, Stribley JA, Chatonnet A, Wilder PJ, Rizzino A, McComb RD, Taylor P, Hinrichs SH, Lockridge O (2000) <br />Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>293</b>: 896<br /><br />Bourne Y, Taylor P, Bougis PE, Marchot P (1999) <br />Crystal structure of mouse acetylcholinesterase. A peripheral site- occluding loop in a tetrameric assembly<br /><i>Journal of Biological Chemistry</i> <b>274</b>: 2963<br /><br />Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PB, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor P, Wonnacott S (1999) <br />International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits<br /><i>Pharmacol Rev</i> <b>51</b>: 397<br /><br />Luo ZD, Wang Y, Werlen G, Camp S, Chien KR, Taylor P (1999) <br />Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation<br /><i>Molecular Pharmacology</i> <b>56</b>: 886<br /><br />Luo C, Saxena A, Ashani Y, Leader H, Radic Z, Taylor P, Doctor BP (1999) <br />Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 129<br /><br />Luo C, Saxena A, Smith M, Garcia GE, Radic Z, Taylor P, Doctor BP (1999) <br />Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium<br /><i>Biochemistry</i> <b>38</b>: 9937<br /><br />Osaka H, Malany S, Kanter J, Sine SM, Taylor P (1999) <br />Subunit interface selectivity of the alpha-neurotoxins for the nicotinic acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>274</b>: 9581<br /><br />Radic Z, Taylor P (1999) <br />The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 111<br /><br />Taylor P, Wong L, Radic Z, Tsigelny I, Bruggemann R, Hosea NA, Berman HA (1999) <br />Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 3<br /><br />Xie W, Wilder PJ, Stribley J, Chatonnet A, Rizzino A, Taylor P, Hinrichs SH, Lockridge O (1999) <br />Knockout of one acetylcholinesterase allele in the mouse<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 289<br /><br />Bougis PE, Taylor P, Marchot P (1998) <br />Biotinylation of the tyrosine residues of fasciculin<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 416<br /><br />Bourne Y, Taylor P, Kanter J, Bougis PE, Marchot P (1998) <br />Crystal Structure of Mouse Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 315<br /><br />Boyd AE, Wong L, Taylor P (1998) <br />Acetylcholinesterase Structural Perturbations Examined Through Cysteine Substitution Mutagenesis<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 452<br /><br />Bruggemann RJ, Radic Z, Tsigelny I, Taylor P (1998) <br />Oxime Reactivation of Acetylcholinesterase Inhibited by Enantiomeric Organophosphates<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 377<br /><br />Camp S, Taylor P (1998) <br />Intronic Elements Appear Essential for the Differentiation-Specific Expression of Acetylcholinesterase in C2C12 Myotubes<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 51<br /><br />Kanter J, Eads J, Camp S, Marchot P, Taylor P (1998) <br />Expression and Purification of Recombinant Mutants of Fasciculin from Mammalian Cells<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 240<br /><br />Keller SH, Taylor P (1998) <br />Mechanisms regulating expression of nicotinic acetylcholine receptor subunits<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 446<br /><br />Lockridge O, Xie W, Chatonnet A, Taylor P, Bartels CF (1998) <br />ACHE Knockout Mouse; Cat AChE and Cat BChE Sequences; Tetramers of BChE<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 41<br /><br />Luo ZD, Camp S, Mutero A, Taylor P (1998) <br />Splicing of 5' introns dictates alternative splice selection of acetylcholinesterase pre-mRNA and specific expression during myogenesis<br /><i>Journal of Biological Chemistry</i> <b>273</b>: 28486<br /><br />Luo ZD, Camp S, Mutero A, Taylor P (1998) <br />Intronic Sequences Influence Pre-mRNA Splicing of Acetylcholinesterase During Muscle Differentiation<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 121<br /><br />Luo ZD, Wang Y, Taylor P (1998) <br />Calcineurin Enhances mRNA Stability of Acetylcholinesterase During Muscle Differentiation in C2-C12 Cells<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 123<br /><br />Luo C, Ashani Y, Saxena A, Leader H, Maxwell DM, Taylor P, Doctor BP (1998) <br />Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 215<br /><br />Malany S, Ackermann EJ, Osaka H, Taylor P (1998) <br />Complementary binding studies between alpha-neurotoxin and the nicotinic acetylcholine receptor<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 462<br /><br />Malany S, Taylor P, Quinn DM, Sawai M, Shafferman A, Velan B, Kronman C (1998) <br />Correlation of Isotope and Viscosity Effects<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 232<br /><br />Marchot P, Taylor P, Kanter J, Bougis PE, Bourne Y (1998) <br />Tetrameric assembly and peripheral site-occluding loop of mouse acetylcholinesterase<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 465<br /><br />Marchot P, Bourne Y, Prowse CN, Kanter J, Eads J, Bougis PE, Taylor P (1998) <br />Fasciculin Inhibition of Mouse Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 331<br /><br />Marchot P, Bourne Y, Prowse CN, Bougis PE, Taylor P (1998) <br />Inhibition of mouse acetylcholinesterase by fasciculin: crystal structure of the complex and mutagenesis of fasciculin<br /><i>Toxicon</i> <b>36</b>: 1613<br /><br />Molles BE, Kline EF, Sine SM, McArdle JJ, Taylor P (1998) <br />Probing the structure of the ligand binding site on the muscle nicotinic receptor with Waglerin peptides<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 470<br /><br />Osaka H, Ackermann EJ, Kanter J, Tsigelny I, Sine SM, Taylor P (1998) <br />Binding orientation of thealpha-neurotoxins with the nicotinic acetylcholine receptor<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 476<br /><br />Radic Z, Taylor P (1998) <br />The Effect of Peripheral Site Ligands on the Reaction Kinetics of Phosphyl and Carboxyl Esters with Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 211<br /><br />Sugiyama N, Marchot P, Kawanishi C, Osaka H, Molles BE, Sine SM, Taylor P (1998) <br />Residues at the subunit interfaces of the nicotinic acetylcholine receptor that contribute to alpha-conotoxin M1 binding<br /><i>Molecular Pharmacology</i> <b>53</b>: 787<br /><br />Tara S, Elcock AH, Kirchhoff PD, Briggs JM, Radic Z, Taylor P, McCammon JA (1998) <br />Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge<br /><i>Biopolymers</i> <b>46</b>: 465<br /><br />Taylor P, Osaka H, Molles BE, Sugiyama N, Marchot P, Ackermann EJ, Malany S, McArdle JJ, Sine SM, Tsigelny I (1998) <br />Toxins selective for subunit interfaces as probes of nicotinic acetylcholine receptor structure<br /><i>Journal de Physiologie (Paris)</i> <b>92</b>: 79<br /><br />Taylor P (1998) <br />Development of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease<br /><i>Neurology</i> <b>51</b>: S65<br /><br />Tsigelny I, Matsumura T, Sudhof TC, Taylor P (1998) <br />Metal Binding Motifs in Cholinesterases and Neuroligins<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 407<br /><br />Wong L, Radic Z, Hosea NA, Berman HA, Taylor P (1998) <br />Reactivation of Enantiomeric Organophosphonyl Conjugates of Acetylcholinesterase Mutants, F295L and F297I by Mono- and Bis-Quarternary Oximes<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 250<br /><br />Marchot P, Prowse CN, Kanter J, Camp S, Ackermann EJ, Radic Z, Bougis PE, Taylor P (1997) <br />Expression and activity of mutants of fasciculin, a peptidic acetylcholinesterase inhibitor from mamba venom<br /><i>Journal of Biological Chemistry</i> <b>272</b>: 3502<br /><br />Radic Z, Kirchhoff PD, Quinn DM, McCammon JA, Taylor P (1997) <br />Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin<br /><i>Journal of Biological Chemistry</i> <b>272</b>: 23265<br /><br />Saxena A, Maxwell DM, Quinn DM, Radic Z, Taylor P, Doctor BP (1997) <br />Mutant acetylcholinesterases as potential detoxification agents for organophosphate poisoning<br /><i>Biochemical Pharmacology</i> <b>54</b>: 269<br /><br />Taylor P (1997) <br />Metrifonate. A viewpoint<br /><i>Drugs & Aging</i> <b>11</b>: 497<br /><br />Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA (1997) <br />Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis<br /><i>Enantiomer</i> <b>2</b>: 249<br /><br />Tsigelny I, Sugiyama N, Sine SM, Taylor P (1997) <br />A model of the nicotinic receptor extracellular domain based on sequence identity and residue location<br /><i>Biophysical Journal</i> <b>73</b>: 52<br /><br />Coleman BA, Taylor P (1996) <br />Regulation of acetylcholinesterase expression during neuronal differentiation<br /><i>Journal of Biological Chemistry</i> <b>271</b>: 4410<br /><br />Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P (1996) <br />Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates<br /><i>Biochemistry</i> <b>35</b>: 10995<br /><br />Luo ZD, Pincon-Raymond M, Taylor P (1996) <br />Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channel<br /><i>Journal of Neurochemistry</i> <b>67</b>: 111<br /><br />Marchot P, Ravelli RB, Raves ML, Bourne Y, Vellom DC, Kanter J, Camp S, Sussman JL, Taylor P (1996) <br />Soluble monomeric acetylcholinesterase from mouse: expression, purification, and crystallization in complex with fasciculin<br /><i>Protein Science</i> <b>5</b>: 672<br /><br />Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P (1995) <br />Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes<br /><i>Journal of Biological Chemistry</i> <b>270</b>: 6370<br /><br />Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P (1995) <br />Amino Acid Residues that Control Mono- and Bisquaternary Oxime-Induced Reactivation of O-Ethyl Methylphosphonylated Cholinesterases<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 133<br /><br />Bourne Y, Taylor P, Marchot P (1995) <br />Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex<br /><i>Cell</i> <b>83</b>: 503<br /><br />Camp S, Engel AG, Getman DK, Bon S, Massoulie J, Taylor P (1995) <br />Mutations in the Catalytic Subunit of Acetylcholinesterase do not Appear Responsible for Congenital Myasthenic Syndrome Associated with End-Plate Acetylcholinesterase Deficiency<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 51<br /><br />Camp S, Bon S, Li Y, Getman DK, Engel AG, Massoulie J, Taylor P (1995) <br />Patients with congenital myasthenia associated with end-plate acetylcholinesterase deficiency show normal sequence, mRNA splicing, and assembly of catalytic subunits<br /><i>Journal of Clinical Investigation</i> <b>95</b>: 333<br /><br />Coleman BA, Taylor P (1995) <br />Regulation of AChE Gene Expression in Neuronally Induced Mouse P19 Cells<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 55<br /><br />Getman DK, Mutero A, Inoue K, Taylor P (1995) <br />Transcription factor repression and activation of the human acetylcholinesterase gene<br /><i>Journal of Biological Chemistry</i> <b>270</b>: 23511<br /><br />Getman DK, Inoue K, Taylor P (1995) <br />Regulation of Human Acetylcholinesterase Gene Expression<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 56<br /><br />Hosea NA, Berman HA, Taylor P (1995) <br />Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases<br /><i>Biochemistry</i> <b>34</b>: 11528<br /><br />Kreienkamp HJ, Maeda RK, Sine SM, Taylor P (1995) <br />Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor<br /><i>Neuron</i> <b>14</b>: 635<br /><br />Luo ZD, Pincon-Raymond M, Taylor P (1995) <br />Regulation of Acetylcholinesterase (AChE) mRNA by Ryanodine-Sensitive and L-Type Calcium Channels during Myogenesis in Vitro and Muscle Development in Vivo<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 53<br /><br />Marchot P, Camp S, Radic Z, Bougis PE, Taylor P (1995) <br />Structural Determinants of Fasciculin Specificity for Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 197<br /><br />Maxwell DM, Brecht KM, Saxena A, Taylor P, Doctor BP (1995) <br />Comparison of Acetylcholinesterase, Pyridostigmine, and HI-6 as Antidotes against Organophosphorus Compounds<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 353<br /><br />Mutero A, Camp S, Taylor P (1995) <br />Promoter elements of the mouse acetylcholinesterase gene. Transcriptional regulation during muscle differentiation<br /><i>Journal of Biological Chemistry</i> <b>270</b>: 1866<br /><br />Mutero A, Taylor P (1995) <br />Promoter Elements of the Mouse Acetylcholinesterase Gene<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 57<br /><br />Pickering NA, Taylor P, Berman HA (1995) <br />Organophosphate Specificity of Acyl Pocket Cholinesterase Mutants<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 227<br /><br />Quinn DM, Seravalli J, Nair HK, Medhekar R, Husseini B, Radic Z, Vellom DC, Pickering NA, Taylor P (1995) <br />The Function of Electrostatics in Acetylcholinesterase Catalysis<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 203<br /><br />Quinn DM, Nair HK, Seravalli J, Lee K, Arbuckle T, Radic Z, Vellom DC, Pickering NA, Taylor P (1995) <br />London Dispersion Interactions in Molecular Recognition by Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 228<br /><br />Radic Z, Quinn DM, Vellom DC, Camp S, Taylor P (1995) <br />Allosteric control of acetylcholinesterase catalysis by fasciculin<br /><i>Journal of Biological Chemistry</i> <b>270</b>: 20391<br /><br />Radic Z, Quinn DM, Vellom DC, Camp S, Taylor P (1995) <br />Amino Acid Residues in Acetylcholinesterase which Influence Fasciculin Inhibition<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 183<br /><br />Sine SM, Kreienkamp HJ, Bren N, Maeda RK, Taylor P (1995) <br />Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity<br /><i>Neuron</i> <b>15</b>: 205<br /><br />Taylor P, Radic Z, Kreienkamp HJ, Luo ZD, Pickering NA, Camp S (1995) <br />Ligand Specificity and Gene Expression in the Cholinergic Synapse<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 15<br /><br />Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA (1995) <br />Structural bases for the specificity of cholinesterase catalysis and inhibition.<br /><i>Toxicology Letters</i> <b>83</b>: 453<br /><br />van den Born HK, Radic Z, Marchot P, Taylor P, Tsigelny I (1995) <br />Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase<br /><i>Protein Science</i> <b>4</b>: 703<br /><br />Kreienkamp HJ, Sine SM, Maeda RK, Taylor P (1994) <br />Glycosylation sites selectively interfere with alpha-toxin binding to the nicotinic acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 8108<br /><br />Radic Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P (1994) <br />Site of fasciculin interaction with acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 11233<br /><br />Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn DM, Taylor P, Doctor BP (1994) <br />Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases<br /><i>Protein Science</i> <b>3</b>: 1770<br /><br />Sine SM, Quiram P, Papanikolaou F, Kreienkamp HJ, Taylor P (1994) <br />Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 8808<br /><br />Taylor P, Radic Z, Kreienkamp HJ, Maeda RK, Luo ZD, Fuentes ME, Vellom DC, Pickering NA (1994) <br />Expression and ligand specificity of acetylcholinesterase and the nicotinic receptor: a tale of two cholinergic sites<br /><i>Biochemical Society Transactions</i> <b>22</b>: 740<br /><br />Taylor P, Radic Z (1994) <br />The cholinesterases: from genes to proteins<br /><i>Annual Review of Pharmacology & Toxicology</i> <b>34</b>: 281<br /><br />Ekstrom TJ, Klump WM, Getman DK, Karin M, Taylor P (1993) <br />Promoter elements and transcriptional regulation of the acetylcholinesterase gene<br /><i>DNA & Cell Biology</i> <b>12</b>: 63<br /><br />Fuentes ME, Taylor P (1993) <br />Control of acetylcholinesterase gene expression during myogenesis<br /><i>Neuron</i> <b>10</b>: 679<br /><br />Hutchinson DO, Walls TJ, Nakano S, Camp S, Taylor P, Harper CM, Groover RV, Peterson HA, Jamieson DG, Engel AG (1993) <br />Congenital endplate acetylcholinesterase deficiency<br /><i>Brain</i> <b>116</b>: 633<br /><br />Hutchinson DO, Engel AG, Walls TJ, Nakano S, Camp S, Taylor P, Harper CM, Brengman JM (1993) <br />The spectrum of congenital end-plate acetylcholinesterase deficiency<br /><i>Annals of the New York Academy of Sciences</i> <b>681</b>: 469<br /><br />Li Y, Camp S, Rachinsky TL, Bongiorno C, Taylor P (1993) <br />Promoter elements and transcriptional control of the mouse acetylcholinesterase gene<br /><i>Journal of Biological Chemistry</i> <b>268</b>: 3563<br /><br />Li Y, Camp S, Taylor P (1993) <br />Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene<br /><i>Journal of Biological Chemistry</i> <b>268</b>: 5790<br /><br />Radic Z, Pickering NA, Vellom DC, Camp S, Taylor P (1993) <br />Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors<br /><i>Biochemistry</i> <b>32</b>: 12074<br /><br />Saxena A, Doctor BP, Maxwell DM, Lenz DE, Radic Z, Taylor P (1993) <br />The role of glutamate-199 in the aging of cholinesterase<br /><i>Biochemical & Biophysical Research Communications</i> <b>197</b>: 343<br /><br />Taylor P, Li Y, Camp S, Rachinsky TL, Ekstrom TJ, Getman DK, Fuentes ME, Vellom DC, Radic Z (1993) <br />Structure and regulation of expression of the acetylcholinesterase gene<br /><i>Chemico-Biological Interactions</i> <b>87</b>: 199<br /><br />Vellom DC, Radic Z, Li Y, Pickering NA, Camp S, Taylor P (1993) <br />Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity<br /><i>Biochemistry</i> <b>32</b>: 12<br /><br />Wasserman L, Doctor BP, Gentry MK, Taylor P (1993) <br />Epitope mapping of form-specific and nonspecific antibodies to acetylcholinesterase<br /><i>Journal of Neurochemistry</i> <b>61</b>: 2124<br /><br />Getman DK, Eubanks JH, Camp S, Evans GA, Taylor P (1992) <br />The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7<br /><i>American Journal of Human Genetics</i> <b>51</b>: 170<br /><br />Rachinsky TL, Crenshaw EBd, Taylor P (1992) <br />Assignment of the gene for acetylcholinesterase to distal mouse chromosome 5<br /><i>Genomics</i> <b>14</b>: 511<br /><br />Radic Z, Gibney G, Kawamoto S, MacPhee-Quigley K, Bongiorno C, Taylor P (1992) <br />Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants<br /><i>Biochemistry</i> <b>31</b>: 9760<br /><br />Taylor P (1992) <br />Impact of Recombinant DNA Technology and Protein Structure Determination on Past and Future Studies on Acetylcholinesterase<br /><i>In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases</i> <b>(Shafferman, A. and Velan, B., Eds) Plenum Press, New York</b>: 1<br /><br />Abramson SN, Radic Z, Manker D, Faulkner DJ, Taylor P (1991) <br />Poster: Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 296<br /><br />Amitai G, Taylor P (1991) <br />Poster: Characterization of peripheral anionic site peptides of AChE by photoaffinity labeling with monoazidopropidium (MAP)<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 285<br /><br />Arpagaus M, Vaughan TA, La Du BN, Lockridge O, Masson P, Chatonnet A, Newton M, Taylor P (1991) <br />Poster: Use of the polymerase chain reaction for homology probing of butyrylchoIinesterase (BCHE) in several animal species<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 194<br /><br />Aslanian D, Grof P, Masson P, Taylor P, Bon S, Chatel JM, Massoulie J (1991) <br />Poster: A comparative raman spectroscopic study of cholinesterases<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 56<br /><br />Aslanian D, Grof P, Bon S, Masson P, Negrerie M, Chatel JM, Balkanski M, Taylor P, Massoulie J (1991) <br />A comparative Raman spectroscopic study of cholinesterases<br /><i>Biochimie</i> <b>73</b>: 1375<br /><br />Friboulet A, Taylor P, Rieger F (1991) <br />Poster: Interaction of reversible and irreversible inhibitors with a peripheral site on acetylcholinesterase<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 286<br /><br />Li Y, Camp S, Rachinsky TL, Getman DK, Taylor P (1991) <br />Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression<br /><i>Journal of Biological Chemistry</i> <b>266</b>: 23083<br /><br />Radic Z, Reiner E, Taylor P (1991) <br />Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives<br /><i>Molecular Pharmacology</i> <b>39</b>: 98<br /><br />Reiner E, Aldridge WN, Simeon-Rudolf V, Radic Z, Taylor P (1991) <br />Mechanism of Substrate Inhibition of Acetylcholinesterase<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 227<br /><br />Taylor P, Gibney G, Camp S, Maulet Y, Ekstrom TJ, Rachinsky TL, Li Y (1991) <br />Features of Acetylcholinesterase Structure and Gene Expression Emerging from Recent Recombinant DNA Studies<br /><i>In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology</i> <b>(Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC</b>: 179<br /><br />Taylor P (1991) <br />The cholinesterases.<br /><i>Journal of Biological Chemistry</i> <b>266</b>: 4025<br /><br />Friboulet A, Rieger F, Goudou D, Amitai G, Taylor P (1990) <br />Interaction of an organophosphate with a peripheral site on acetylcholinesterase<br /><i>Biochemistry</i> <b>29</b>: 914<br /><br />Gibney G, Camp S, Dionne M, MacPhee-Quigley K, Taylor P (1990) <br />Mutagenesis of essential functional residues in acetylcholinesterase<br /><i>Proceedings of the National Academy of Sciences of the United States of America</i> <b>87</b>: 7546<br /><br />Gibney G, Taylor P (1990) <br />Biosynthesis of Torpedo acetylcholinesterase in mammalian cells. Functional expression and mutagenesis of the glycophospholipid-anchored form [published erratum appears in J Biol Chem 1990 Nov 15;265(32):20051]<br /><i>Journal of Biological Chemistry</i> <b>265</b>: 12576<br /><br />Maulet Y, Camp S, Gibney G, Rachinsky TL, Ekstrom TJ, Taylor P (1990) <br />Single gene encodes glycophospholipid-anchored and asymmetric acetylcholinesterase forms: alternative coding exons contain inverted repeat sequences<br /><i>Neuron</i> <b>4</b>: 289<br /><br />Ogert RA, Gentry MK, Richardson EC, Deal CD, Abramson SN, Alving CR, Taylor P, Doctor BP (1990) <br />Studies on the topography of the catalytic site of acetylcholinesterase using polyclonal and monoclonal antibodies<br /><i>Journal of Neurochemistry</i> <b>55</b>: 756<br /><br />Rachinsky TL, Camp S, Li Y, Ekstrom TJ, Newton M, Taylor P (1990) <br />Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species<br /><i>Neuron</i> <b>5</b>: 317<br /><br />Abramson SN, Ellisman MH, Deerinck TJ, Maulet Y, Gentry MK, Doctor BP, Taylor P (1989) <br />Differences in structure and distribution of the molecular forms of acetylcholinesterase<br /><i>Journal of Cell Biology</i> <b>108</b>: 2301<br /><br />Abramson SN, Radic Z, Manker D, Faulkner DJ, Taylor P (1989) <br />Onchidal: a naturally occurring irreversible inhibitor of acetylcholinesterase with a novel mechanism of action<br /><i>Molecular Pharmacology</i> <b>36</b>: 349<br /><br />Ludgate M, Dong Q, Dreyfus PA, Zakut H, Taylor P, Vassart G, Soreq H (1989) <br />Definition, at the molecular level, of a thyroglobulin- acetylcholinesterase shared epitope: study of its pathophysiological significance in patients with Graves' ophthalmopathy<br /><i>Autoimmunity</i> <b>3</b>: 167<br /><br />Gibney G, MacPhee-Quigley K, Thompson B, Vedvick TS, Low MG, Taylor SS, Taylor P (1988) <br />Divergence in primary structure between the molecular forms of acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>263</b>: 1140<br /><br />Schumacher M, Maulet Y, Camp S, Taylor P (1988) <br />Multiple messenger RNA species give rise to the structural diversity in acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>263</b>: 18979<br /><br />Aslanian D, Grof P, Negrerie M, Balkanski M, Taylor P (1987) <br />Raman spectroscopic study on the conformation of 11 S form acetylcholinesterase from Torpedo californica<br /><i>FEBS Letters</i> <b>219</b>: 202<br /><br />Berman HA, Decker MM, Nowak MW, Leonard KJ, McCauley M, Baker WM, Taylor P (1987) <br />Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase<br /><i>Molecular Pharmacology</i> <b>31</b>: 610<br /><br />Friboulet A, Goudou D, Taylor P, Rieger F (1987) <br />Evidence for the interaction of acetylcholinesterase inhibitors with catalytic and extra-catalytic sites on the insolubilized enzyme<br /><i>Progress in Clinical & Biological Research</i> <b>253</b>: 277<br /><br />Johnson DA, Brown RD, Herz JM, Berman HA, Andreasen GL, Taylor P (1987) <br />Decidium. A novel fluorescent probe of the agonist/antagonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>262</b>: 14022<br /><br />Edery H, Geyer MA, Taylor P, Berman HA (1986) <br />Target sites for anticholinesterases on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorus agents<br /><i>Journal of Autonomic Pharmacology</i> <b>6</b>: 195<br /><br />MacPhee-Quigley K, Vedvick TS, Taylor P, Taylor SS (1986) <br />Profile of the disulfide bonds in acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>261</b>: 13565<br /><br />Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P (1986) <br />Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence<br /><i>Nature</i> <b>319</b>: 407<br /><br />Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P (1986) <br />Primary structure of acetylcholinesterase: implications for regulation and function.<br /><i>Federation Proceedings</i> <b>45</b>: 2976<br /><br />Berman HA, Yguerabide J, Taylor P (1985) <br />Flexibility of the molecular forms of acetylcholinesterase measured with steady-state and time-correlated fluorescence polarization spectroscopy<br /><i>Biochemistry</i> <b>24</b>: 7140<br /><br />MacPhee-Quigley K, Taylor P, Taylor SS (1985) <br />Primary structures of the catalytic subunits from two molecular forms of acetylcholinesterase. A comparison of NH2-terminal and active center sequences<br /><i>Journal of Biological Chemistry</i> <b>260</b>: 12185<br /><br />Manavalan P, Taylor P, Johnson WC, Jr. (1985) <br />Circular dichroism studies of acetylcholinesterase conformation. Comparison of the 11 S and 5.6 S species and the differences induced by inhibitory ligands<br /><i>Biochimica & Biophysica Acta</i> <b>829</b>: 365<br /><br />Amitai G, Brown RD, Taylor P (1984) <br />The relationship between alpha 1-adrenergic receptor occupation and the mobilization of intracellular calcium<br /><i>Journal of Biological Chemistry</i> <b>259</b>: 12519<br /><br />Bolger MB, Dionne V, Chrivia J, Johnson DA, Taylor P (1984) <br />Interaction of a fluorescent acyldicholine with the nicotinic acetylcholine receptor and acetylcholinesterase<br /><i>Molecular Pharmacology</i> <b>26</b>: 57<br /><br />Doctor BP, Taylor P (1984) <br />Poster 8. Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase<br /><i>In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases</i> <b>(Brzin M, Barnard EA, Sket D, Eds) De Gruyter</b>: <br /><br />Taylor P, Camp S, Lee SL, Amitai G, Taylor SS, Doctor BP (1984) <br />Molecular aspects of the biosynthesis and disposition of multiple forms of acetylcholinesterase<br /><i>In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases</i> <b>(Brzin M, Barnard EA, Sket D, Eds) De Gruyter</b>: 145<br /><br />Doctor BP, Camp S, Gentry MK, Taylor SS, Taylor P (1983) <br />Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase<br /><i>Proceedings of the National Academy of Sciences of the United States of America</i> <b>80</b>: 5767<br /><br />Lee SL, Heinemann SF, Taylor P (1982) <br />Structural characterization of the asymmetric (17 + 13) S forms of acetylcholinesterase from Torpedo. I. Analysis of subunit composition<br /><i>Journal of Biological Chemistry</i> <b>257</b>: 12282<br /><br />Lee SL, Taylor P (1982) <br />Structural characterization of the asymmetric (17 + 13) S species of acetylcholinesterase from Torpedo. II. Component peptides obtained by selective proteolysis and disulfide bond reduction<br /><i>Journal of Biological Chemistry</i> <b>257</b>: 12292<br /><br />Lee SL, Camp S, Taylor P (1982) <br />Characterization of a hydrophobic, dimeric form of acetylcholinesterase from Torpedo<br /><i>Journal of Biological Chemistry</i> <b>257</b>: 12302<br /><br />Sine SM, Taylor P (1982) <br />Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells<br /><i>Journal of Biological Chemistry</i> <b>257</b>: 8106<br /><br />Berman HA, Becktel W, Taylor P (1981) <br />Spectroscopic studies on acetylcholinesterase: influence of peripheral- site occupation on active-center conformation<br /><i>Biochemistry</i> <b>20</b>: 4803<br /><br />Sine SM, Taylor P (1981) <br />Relationship between reversible antagonist occupancy and the functional capacity of the acetylcholine receptor<br /><i>Journal of Biological Chemistry</i> <b>256</b>: 6692<br /><br />Berman HA, Yguerabide J, Taylor P (1980) <br />Fluorescence energy transfer on acetylcholinesterase: spatial relationship between peripheral site and active center<br /><i>Biochemistry</i> <b>19</b>: 2226<br /><br />Sine SM, Taylor P (1980) <br />The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin<br /><i>Journal of Biological Chemistry</i> <b>255</b>: 10144<br /><br />Taylor P, Rieger F, Greene LA (1980) <br />Development of the multiple molecular forms of acetylcholinesterase in chick paravertebral sympathetic ganglia: an in vivo and in vitro study<br /><i>Brain Research</i> <b>182</b>: 383<br /><br />Bolger MB, Taylor P (1979) <br />Kinetics of association between bisquaternary ammonium ligands and acetylcholinesterase. Evidence for two conformational states of the enzyme from stopped-flow measurements of fluorescence<br /><i>Biochemistry</i> <b>18</b>: 3622<br /><br />Epstein DJ, Berman HA, Taylor P (1979) <br />Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates<br /><i>Biochemistry</i> <b>18</b>: 4749<br /><br />Berman HA, Taylor P (1978) <br />Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase<br /><i>Biochemistry</i> <b>17</b>: 1704<br /><br />Taylor P, Lwebuga-Mukasa JS, Lappi S, Berman HA (1978) <br />Structure of Acetylcholinesterase: Its Relationship to the Postsynaptic Membrane<br /><i>Advances in Behavioral Biology</i> <b>24</b>: 239<br /><br />Flanagan SD, Barondes SH, Taylor P (1976) <br />Affinity partitioning of membranes. Cholinergic receptor-containing membranes from Torpedo californica<br /><i>Journal of Biological Chemistry</i> <b>251</b>: 858<br /><br />Lwebuga-Mukasa JS, Lappi S, Taylor P (1976) <br />Molecular forms of acetylcholinesterase from Torpedo californica: their relationship to synaptic membranes<br /><i>Biochemistry</i> <b>15</b>: 1425<br /><br />Flanagan SD, Taylor P, Barondes SH (1975) <br />Affinity partitioning of acetylcholine receptor enriched membranes and their purification<br /><i>Nature</i> <b>254</b>: 441<br /><br />Flanagan SD, Taylor P, Barondes SH (1975) <br />Purification of acetylcholine receptor enriched membranes by use of affinity partitioning<br /><i>Croatica Chemica Acta</i> <b>47</b>: 449<br /><br />Reiner E, Aldridge WN, Hopff WH, Taylor P, Krupka RM, Rosenberry TL, Augustinsson KB, Mooser G, O'Brien RD, Brodbeck U, Massoulie J, Maricic S, Eldefrawi ME, Silman I (1975) <br />General discussion on models for the ligand binding sites of cholinesterase<br /><i>Croatica Chemica Acta</i> <b>47</b>: 499<br /><br />Taylor P, Lwebuga-Mukasa JS, Berman HA, Lappi S (1975) <br />Spectroscopic studies of ligand interactions with acetylcholinesterase<br /><i>Croatica Chemica Acta</i> <b>47</b>: 251<br /><br />Taylor P, Lappi S (1975) <br />Interaction of fluorescence probes with acetylcholinesterase. The site and specificity of propidium binding<br /><i>Biochemistry</i> <b>14</b>: 1989<br /><br />Taylor P, Jones JW, Jacobs NM (1974) <br />Acetylcholinesterase from Torpedo: characterization of an enzyme species isolated by lytic procedures<br /><i>Molecular Pharmacology</i> <b>10</b>: 78<br /><br />Taylor P, Jacobs NM (1974) <br />Interaction between bisquaternary ammonium ligands and acetylcholinesterase: complex formation studied by fluorescence quenching<br /><i>Molecular Pharmacology</i> <b>10</b>: 93<br /><br />