Hayes TR, Chao CK, Blecha JE, Huynh TL, VanBrocklin HF, Zinn KR, Gerdes JM, Thompson CM (2023)
[(11)C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography (PET) Imaging in Rat
Journal of Pharmacology & Experimental Therapeutics

Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF (2021)
Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats
Chemical Research in Toxicology 34: 63

Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HD, Zinn KR, Taylor P, Gerdes JM, Thompson CM (2020)
Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[(18) F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [(18) F]-VXS
Annals of the New York Academy of Sciences

Talley TT, Chao CK, Berkman CE, Richardson RJ, Thompson CM (2020)
Inhibition of Acetylcholinesterases by Stereoisomeric Organophosphorus Compounds Containing Both Thioester and p-Nitrophenyl Leaving Groups
Chemical Research in Toxicology 33: 2455

Thompson CM, Gerdes JM, VanBrocklin HF (2020)
Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures
Neurobiol Dis 133: 104455

Bharate SB, Chao CK, Thompson CM (2019)
Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes
Environ Toxicol Pharmacol 71: 103218

Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF (2019)
Divergent synthesis of organophosphate [(11)C]VX- and [(11)C]Sarin-surrogates from a common set of starting materials
Appl Radiat Isot 151: 182

Chao CK, Balasubramanian N, Gerdes JM, Thompson CM (2018)
The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE
Chemico-Biological Interactions 291: 220

Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF (2018)
Radiosynthesis of O-(1-[(18) F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin
J Labelled Comp Radiopharm 61: 1089

Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM (2018)
Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [(11)C]2-Pyridinealdoxime Methiodide ([(11)C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication
ACS Chem Neurosci 9: 3007

Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF (2017)
An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer
J Labelled Comp Radiopharm 60: 337

Chao CK, Ahmed SK, Gerdes JM, Thompson CM (2016)
Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases
Chemical Research in Toxicology 29: 1810

James SL, Ahmed SK, Murphy S, Braden MR, Belabassi Y, VanBrocklin HF, Thompson CM, Gerdes JM (2014)
A Novel Fluorine-18 beta-Fluoroethoxy Organophosphate Positron Emission Tomography Imaging Tracer Targeted to Central Nervous System Acetylcholinesterase
ACS Chem Neurosci 5: 519

Kaleem Ahmed S, Belabassi Y, Sankaranarayanan L, Chao CK, Gerdes JM, Thompson CM (2013)
Synthesis and anti-acetylcholinesterase properties of novel beta- and gamma-substituted alkoxy organophosphonates
Bioorganic & Medicinal Chemistry Lett 23: 2048

Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM (2010)
Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase
Bioorganic & Medicinal Chemistry 18: 787

Guo L, Suarez AI, Braden MR, Gerdes JM, Thompson CM (2010)
Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates
Bioorganic & Medicinal Chemistry Lett 20: 1194

Guo L, Suarez AI, Thompson CM (2010)
Inactivation of acetylcholinesterase by various fluorophores
J Enzyme Inhib Med Chem 25: 116

Prins JM, George KM, Thompson CM (2010)
Paraoxon-induced protein expression changes to SH-SY5Y cells
Chemical Research in Toxicology 23: 1656

Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ (2010)
Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms
PLoS ONE 5: e10562

Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM (2009)
New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 19: 5101

Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O (2009)
Mass spectrometry identifies multiple organophosphorylated sites on tubulin
Toxicol Appl Pharmacol 240: 149

Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2009)
Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine
Toxicol Sci 107: 144

Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo OA, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2008)
Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin
Chemical Research in Toxicology 21: 1787

Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O (2008)
Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents
Chemico-Biological Interactions 175: 180

Spaulding RS, George KM, Thompson CM (2006)
Analysis and sequencing of the active-site peptide from native and organophosphate-inactivated acetylcholinesterase by electrospray ionization, quadrupole/time-of-flight (QTOF) mass spectrometry
Journal of Chromatography B Analyt Technol Biomed Life Sciences 830: 105

Li H, Schopfer LM, Spaulding R, Thompson CM, Lockridge O (2005)
Identification of organophosphate-reactive proteins by tandem mass spectrometry
Chemico-Biological Interactions 157-158: 383

Lockridge O, Duysen EG, Voelker T, Thompson CM, Schopfer LM (2005)
Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice
Environ Toxicol Pharmacol 19: 463

Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O (2005)
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry
Toxicol Sci 83: 303

Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O (2005)
Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)
Analytical Biochemistry 345: 122

Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O (2005)
Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase
Chemical Research in Toxicology 18: 747

Thullbery MD, Cox HD, Schule T, Thompson CM, George KM (2005)
Differential localization of acetylcholinesterase in neuronal and non-neuronal cells
Journal of Cellular Biochemistry 96: 599

Doorn JA, Thompson CM, Christner RB, Richardson RJ (2003)
Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms
Chemical Research in Toxicology 16: 958

George KM, Schule T, Sandoval LE, Jennings LL, Taylor P, Thompson CM (2003)
Differentiation between acetylcholinesterase and the organophosphate-inhibited form using antibodies and the correlation of antibody recognition with reactivation mechanism and rate
Journal of Biological Chemistry 278: 45512

George KM, Montgomery MA, Sandoval LE, Thompson CM (2002)
Examination of cross-antigenicity of acetylcholinesterase and butyrylcholinesterase using anti-acetylcholinesterase antibodies
Toxicol Lett 126: 99

Doorn JA, Talley TT, Thompson CM, Richardson RJ (2001)
Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase
Chemical Research in Toxicology 14: 807

Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ (2001)
Identification of Butyrylcholinesterase Adducts after Inhibition with Isomalathion Using Mass Spectrometry: Difference in Mechanism between (1R)- and (1S)-Stereoisomers
Toxicol Appl Pharmacol 176: 73

Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ (2000)
Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group
Chemical Research in Toxicology 13: 1313

Saltmarsh JR, Boyd AE, Rodriguez OP, Radic Z, Taylor P, Thompson CM (2000)
Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 10: 1523

Jianmongkol S, Marable BR, Berkman CE, Talley TT, Thompson CM, Richardson RJ (1999)
Kinetic Evidence for Different Mechanisms of Acetylcholinesterase Inhibition by (1R)- and (1S)-Stereoisomers of Isomalathion
Toxicol Appl Pharmacol 155: 43

Talley TT, Jianmongkol S, Richardson RJ, Radic Z, Thompson CM (1998)
Isomalathion Stereoisomers
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 531

Rodriguez OP, Muth GW, Berkman CE, Kim K, Thompson CM (1997)
Inhibition of various cholinesterases with the enantiomers of malaoxon
Bulletin of Environmental Contamination & Toxicology 58: 171

Jianmongkol S, Berkman CE, Thompson CM, Richardson RJ (1996)
Relative potencies of the four stereoisomers of isomalathion for inhibition of hen brain acetylcholinesterase and neurotoxic esterase in vitro
Toxicology & Applied Pharmacology 139: 342

Thompson CM, Suarez AI, Rodriguez OP (1996)
Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates
Chemical Research in Toxicology 9: 1325

Berkman CE, Thompson CM, Perrin SR (1993)
Synthesis, absolute configuration, and analysis of malathion, malaoxon, and isomalathion enantiomers [published erratum appears in Chem Res Toxicol 1994 Mar-Apr;7(2):275]
Chemical Research in Toxicology 6: 718

Berkman CE, Quinn DA, Thompson CM (1993)
Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion
Chemical Research in Toxicology 6: 724

Berkman CE, Ryu S, Quinn DA, Thompson CM (1993)
Kinetics of the postinhibitory reactions of acetylcholinesterase poisoned by chiral isomalathion: a surprising nonreactivation induced by the RP stereoisomers
Chemical Research in Toxicology 6: 28