Hayes TR, Chao CK, Blecha JE, Huynh TL, VanBrocklin HF, Zinn KR, Gerdes JM, Thompson CM (2023) <br />[(11)C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography (PET) Imaging in Rat<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <br /><br />Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF (2021) <br />Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats<br /><i>Chemical Research in Toxicology</i> <b>34</b>: 63<br /><br />Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HD, Zinn KR, Taylor P, Gerdes JM, Thompson CM (2020) <br />Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[(18) F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [(18) F]-VXS<br /><i>Annals of the New York Academy of Sciences</i> <br /><br />Talley TT, Chao CK, Berkman CE, Richardson RJ, Thompson CM (2020) <br />Inhibition of Acetylcholinesterases by Stereoisomeric Organophosphorus Compounds Containing Both Thioester and p-Nitrophenyl Leaving Groups<br /><i>Chemical Research in Toxicology</i> <b>33</b>: 2455<br /><br />Thompson CM, Gerdes JM, VanBrocklin HF (2020) <br />Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures<br /><i>Neurobiol Dis</i> <b>133</b>: 104455<br /><br />Bharate SB, Chao CK, Thompson CM (2019) <br />Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes<br /><i>Environ Toxicol Pharmacol</i> <b>71</b>: 103218<br /><br />Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF (2019) <br />Divergent synthesis of organophosphate [(11)C]VX- and [(11)C]Sarin-surrogates from a common set of starting materials<br /><i>Appl Radiat Isot</i> <b>151</b>: 182<br /><br />Chao CK, Balasubramanian N, Gerdes JM, Thompson CM (2018) <br />The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE<br /><i>Chemico-Biological Interactions</i> <b>291</b>: 220<br /><br />Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF (2018) <br />Radiosynthesis of O-(1-[(18) F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin<br /><i>J Labelled Comp Radiopharm</i> <b>61</b>: 1089<br /><br />Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM (2018) <br />Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [(11)C]2-Pyridinealdoxime Methiodide ([(11)C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication<br /><i>ACS Chem Neurosci</i> <b>9</b>: 3007<br /><br />Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF (2017) <br />An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer<br /><i>J Labelled Comp Radiopharm</i> <b>60</b>: 337<br /><br />Chao CK, Ahmed SK, Gerdes JM, Thompson CM (2016) <br />Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases<br /><i>Chemical Research in Toxicology</i> <b>29</b>: 1810<br /><br />James SL, Ahmed SK, Murphy S, Braden MR, Belabassi Y, VanBrocklin HF, Thompson CM, Gerdes JM (2014) <br />A Novel Fluorine-18 beta-Fluoroethoxy Organophosphate Positron Emission Tomography Imaging Tracer Targeted to Central Nervous System Acetylcholinesterase<br /><i>ACS Chem Neurosci</i> <b>5</b>: 519<br /><br />Kaleem Ahmed S, Belabassi Y, Sankaranarayanan L, Chao CK, Gerdes JM, Thompson CM (2013) <br />Synthesis and anti-acetylcholinesterase properties of novel beta- and gamma-substituted alkoxy organophosphonates<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>23</b>: 2048<br /><br />Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM (2010) <br />Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry</i> <b>18</b>: 787<br /><br />Guo L, Suarez AI, Braden MR, Gerdes JM, Thompson CM (2010) <br />Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>20</b>: 1194<br /><br />Guo L, Suarez AI, Thompson CM (2010) <br />Inactivation of acetylcholinesterase by various fluorophores<br /><i>J Enzyme Inhib Med Chem</i> <b>25</b>: 116<br /><br />Prins JM, George KM, Thompson CM (2010) <br />Paraoxon-induced protein expression changes to SH-SY5Y cells<br /><i>Chemical Research in Toxicology</i> <b>23</b>: 1656<br /><br />Proskocil BJ, Bruun DA, Thompson CM, Fryer AD, Lein PJ (2010) <br />Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms<br /><i>PLoS ONE</i> <b>5</b>: e10562<br /><br />Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM (2009) <br />New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>19</b>: 5101<br /><br />Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O (2009) <br />Mass spectrometry identifies multiple organophosphorylated sites on tubulin<br /><i>Toxicol Appl Pharmacol</i> <b>240</b>: 149<br /><br />Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2009) <br />Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine<br /><i>Toxicol Sci</i> <b>107</b>: 144<br /><br />Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo OA, Thompson CM, Hinrichs SH, Masson P, Lockridge O (2008) <br />Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin<br /><i>Chemical Research in Toxicology</i> <b>21</b>: 1787<br /><br />Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O (2008) <br />Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 180<br /><br />Spaulding RS, George KM, Thompson CM (2006) <br />Analysis and sequencing of the active-site peptide from native and organophosphate-inactivated acetylcholinesterase by electrospray ionization, quadrupole/time-of-flight (QTOF) mass spectrometry<br /><i>Journal of Chromatography B Analyt Technol Biomed Life Sciences</i> <b>830</b>: 105<br /><br />Li H, Schopfer LM, Spaulding R, Thompson CM, Lockridge O (2005) <br />Identification of organophosphate-reactive proteins by tandem mass spectrometry<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 383<br /><br />Lockridge O, Duysen EG, Voelker T, Thompson CM, Schopfer LM (2005) <br />Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice<br /><i>Environ Toxicol Pharmacol</i> <b>19</b>: 463<br /><br />Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O (2005) <br />Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry<br /><i>Toxicol Sci</i> <b>83</b>: 303<br /><br />Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O (2005) <br />Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)<br /><i>Analytical Biochemistry</i> <b>345</b>: 122<br /><br />Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O (2005) <br />Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase<br /><i>Chemical Research in Toxicology</i> <b>18</b>: 747<br /><br />Thullbery MD, Cox HD, Schule T, Thompson CM, George KM (2005) <br />Differential localization of acetylcholinesterase in neuronal and non-neuronal cells<br /><i>Journal of Cellular Biochemistry</i> <b>96</b>: 599<br /><br />Doorn JA, Thompson CM, Christner RB, Richardson RJ (2003) <br />Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms<br /><i>Chemical Research in Toxicology</i> <b>16</b>: 958<br /><br />George KM, Schule T, Sandoval LE, Jennings LL, Taylor P, Thompson CM (2003) <br />Differentiation between acetylcholinesterase and the organophosphate-inhibited form using antibodies and the correlation of antibody recognition with reactivation mechanism and rate<br /><i>Journal of Biological Chemistry</i> <b>278</b>: 45512<br /><br />George KM, Montgomery MA, Sandoval LE, Thompson CM (2002) <br />Examination of cross-antigenicity of acetylcholinesterase and butyrylcholinesterase using anti-acetylcholinesterase antibodies<br /><i>Toxicol Lett</i> <b>126</b>: 99<br /><br />Doorn JA, Talley TT, Thompson CM, Richardson RJ (2001) <br />Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase<br /><i>Chemical Research in Toxicology</i> <b>14</b>: 807<br /><br />Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ (2001) <br />Identification of Butyrylcholinesterase Adducts after Inhibition with Isomalathion Using Mass Spectrometry: Difference in Mechanism between (1R)- and (1S)-Stereoisomers<br /><i>Toxicol Appl Pharmacol</i> <b>176</b>: 73<br /><br />Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ (2000) <br />Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group<br /><i>Chemical Research in Toxicology</i> <b>13</b>: 1313<br /><br />Saltmarsh JR, Boyd AE, Rodriguez OP, Radic Z, Taylor P, Thompson CM (2000) <br />Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>10</b>: 1523<br /><br />Jianmongkol S, Marable BR, Berkman CE, Talley TT, Thompson CM, Richardson RJ (1999) <br />Kinetic Evidence for Different Mechanisms of Acetylcholinesterase Inhibition by (1R)- and (1S)-Stereoisomers of Isomalathion<br /><i>Toxicol Appl Pharmacol</i> <b>155</b>: 43<br /><br />Talley TT, Jianmongkol S, Richardson RJ, Radic Z, Thompson CM (1998) <br />Isomalathion Stereoisomers<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 531<br /><br />Rodriguez OP, Muth GW, Berkman CE, Kim K, Thompson CM (1997) <br />Inhibition of various cholinesterases with the enantiomers of malaoxon<br /><i>Bulletin of Environmental Contamination & Toxicology</i> <b>58</b>: 171<br /><br />Jianmongkol S, Berkman CE, Thompson CM, Richardson RJ (1996) <br />Relative potencies of the four stereoisomers of isomalathion for inhibition of hen brain acetylcholinesterase and neurotoxic esterase in vitro<br /><i>Toxicology & Applied Pharmacology</i> <b>139</b>: 342<br /><br />Thompson CM, Suarez AI, Rodriguez OP (1996) <br />Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates<br /><i>Chemical Research in Toxicology</i> <b>9</b>: 1325<br /><br />Berkman CE, Thompson CM, Perrin SR (1993) <br />Synthesis, absolute configuration, and analysis of malathion, malaoxon, and isomalathion enantiomers [published erratum appears in Chem Res Toxicol 1994 Mar-Apr;7(2):275]<br /><i>Chemical Research in Toxicology</i> <b>6</b>: 718<br /><br />Berkman CE, Quinn DA, Thompson CM (1993) <br />Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion<br /><i>Chemical Research in Toxicology</i> <b>6</b>: 724<br /><br />Berkman CE, Ryu S, Quinn DA, Thompson CM (1993) <br />Kinetics of the postinhibitory reactions of acetylcholinesterase poisoned by chiral isomalathion: a surprising nonreactivation induced by the RP stereoisomers<br /><i>Chemical Research in Toxicology</i> <b>6</b>: 28<br /><br />