Guo MSS, Wu Q, Dong TT, Tsim KWK (2022)
The UV-induced uptake of melanosome by skin keratinocyte is triggered by alpha7 nicotinic acetylcholine receptor-mediated phagocytosis
Febs J
Xia Y, Wu Q, Mak S, Liu EYL, Zheng BZY, Dong TTX, Pi R, Tsim KWK (2022)
Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells
FASEB Journal 36: e22189
Liu EYL, Mak S, Kong X, Xia Y, Kwan KKL, Xu ML, Tsim KWK (2021)
Tacrine induces endoplasmic reticulum-stressed apoptosis via disrupting the proper assembly of oligomeric acetylcholinesterase in cultured neuronal cells
Molecular Pharmacology
Xuan Z, Gu X, Yan S, Xie Y, Zhou Y, Zhang H, Jin H, Hu S, Mak MSH, Zhou D, Tsim KWK, Carlier PR, Han Y, Cui W (2021)
Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease
ACS Chem Neurosci 12: 2462
Hu WH, Mak SH, Zheng ZY, Xia YJ, Xu ML, Duan R, Dong TT, Li SP, Zhan CS, Shang XH, Tsim KWK (2020)
Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice
Front Pharmacol 11: 1045
Kong XP, Ren HQ, Liu EYL, Leung KW, Guo SC, Duan R, Dong TTX, Tsim KWK (2020)
The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix
Molecules 25:
Liu EYL, Xia Y, Kong X, Guo MSS, Yu AXD, Zheng BZY, Mak S, Xu ML, Tsim KWK (2020)
Interacting with alpha 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages
Acta Pharm Sin B 10: 1926
Wu Q, Bai P, Xia Y, Lai QWS, Guo MSS, Dai K, Zheng Z, Ling CSJ, Dong TTX, Pi R, Tsim KWK (2020)
Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor
Neurochem Int 141: 104861
Wu Q, Xia Y, Dai K, Bai P, Kwan KKL, Guo MSS, Dong TTX, Tsim KWK (2020)
Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis
FASEB Journal 34: 8941
Hu WH, Chan GK, Duan R, Wang HY, Kong XP, Dong TTX, Tsim KWK (2019)
Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer
Cancers (Basel) 11:
Hu WH, Duan R, Xia YT, Xiong QP, Wang HY, Chan GK, Liu SY, Dong TTX, Qin QW, Tsim KWK (2019)
Binding of Resveratrol to Vascular Endothelial Growth Factor Suppresses Angiogenesis by Inhibiting the Receptor Signaling
Journal of Agricultural and Food Chemistry 67: 1127
Hu WH, Wang HY, Kong XP, Xiong QP, Poon KK, Xu L, Duan R, Chan GK, Dong TTX, Tsim KWK (2019)
Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling
FASEB Journal 33: 532
Kong XP, Liu EYL, Chen ZC, Xu ML, Yu AXD, Wu KQY, Xia YJ, Duan R, Dong TTX, Tsim KWK (2019)
Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex
Molecules 24:
Lam KYC, Wu KQY, Hu WH, Yao P, Wang HY, Dong TTX, Tsim KWK (2019)
Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes
Neuroscience Letters 707: 134308
Liu EYL, Xu ML, Xia YJ, Kong XP, Wu KQY, Dong TTX, Tsim KWK (2019)
Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12cells
Chemico-Biological Interactions 306: 147
Luo Y, Xie HQ, Chen Y, Xia Y, Sha R, Liu YY, Ma Y, Xu T, Xu L, Tsim KWK, Zhao B (2019)
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells
Chemico-Biological Interactions 308: 164
Wang HY, Wang C, Guo LX, Zheng YF, Hu WH, Dong TTX, Wang TJ, Tsim KWK (2019)
Simultaneous determination of short-chain fatty acids in human feces by HPLC with ultraviolet detection following chemical derivatization and solid-phase extraction segmental elution
J Sep Sci 42: 2500
Xu ML, Luk WKW, Liu EYL, Kong XP, Wu KQY, Xia YJ, Dong TTX, Tsim KWK (2019)
Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor
Chemico-Biological Interactions 308: 317
Xu ML, Zheng ZY, Xia YJ, Liu EYL, Chan SK, Hu WH, Duan R, Dong TTX, Zhan CS, Shang XH, Tsim KWK (2019)
Shexiang Baoxin Pill, a Formulated Chinese Herbal Mixture, Induces Neuronal Differentiation of PC12 Cells: A Signaling Triggered by Activation of Protein Kinase A
Front Pharmacol 10: 1130
Hu WH, Chan GK, Lou JS, Wu KQY, Wang HY, Duan R, Cheng MY, Dong TTX, Tsim KWK (2018)
The extract of Polygoni Cuspidati Rhizoma et Radix suppresses the vascular endothelial growth factor-induced angiogenesis
Phytomedicine 42: 135
Liu EYL, Xu ML, Jin Y, Wu KQY, Dong TTX, Tsim KWK (2018)
Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells
Front Mol Neurosci 11: 59
Wu KQY, Fung AHY, Xu ML, Poon K, Liu EYL, Kong XP, Yao P, Xiong QP, Dong TTX, Tsim KWK (2018)
Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells
Journal of Biological Chemistry 293: 14417
Xie HQ, Xia Y, Xu T, Chen Y, Fu H, Li Y, Luo Y, Xu L, Tsim KWK, Zhao B (2018)
2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells
Environ Pollut 235: 965
Xu ML, Luk WKW, Bi CWC, Liu EYL, Wu KQY, Yao P, Dong TTX, Tsim KWK (2018)
Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast
Journal of Neurochemistry 146: 390
Xu ML, Bi CWC, Liu EYL, Dong TTX, Tsim KWK (2017)
Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor
Journal of Biological Chemistry 292: 12667
Cui JD, Xu ML, Liu EYL, Dong TTX, Lin HQ, Tsim KWK, Bi CWC (2016)
Expression of globular form acetylcholinesterase is not altered in P2Y1R knock-out mouse brain
Chemico-Biological Interactions 259: 291
Lau KM, Gong AG, Xu ML, Lam CT, Zhang LM, Bi CWC, Cui D, Cheng AW, Dong TTX, Tsim KWK, Lin H (2016)
Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis
Brain Research 1642: 114
Lou JS, Yan L, Bi CWC, Chan GK, Wu KQY, Liu EYL, Huang Y, Yao P, Du CY, Dong TTX, Tsim KWK (2016)
Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling
Sci Rep 6: 31926
Xie HQ, Xu T, Chen Y, Li Y, Xia Y, Xu SL, Wang L, Tsim KWK, Zhao B (2016)
New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins
Chemico-Biological Interactions 259: 286
Xu ML, Bi CWC, Kong AY, Dong TTX, Wong YH, Tsim KWK (2016)
Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts
Chemico-Biological Interactions 259: 295
Xu L, Chen Y, Xie HQ, Xu T, Fu H, Zhang S, Tsim KWK, Bi CWC, Zhao B (2016)
2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells
Chemico-Biological Interactions 259: 282
Hu S, Wang R, Cui W, Zhang Z, Mak SH, Xu D, Choi C, Tsim KWK, Carlier PR, Lee M, Han Y (2015)
Inhibiting beta-Amyloid-Associated Alzheimer's Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue
Journal of Molecular Neuroscience 55: 1014
Xu ML, Bi CWC, Cheng LK, Mak SH, Yao P, Luk WK, Lau KK, Cheng AW, Tsim KWK (2015)
Reduced Expression of P2Y2 Receptor and Acetylcholinesterase at Neuromuscular Junction of P2Y1 Receptor Knock-out Mice
Journal of Molecular Neuroscience 57: 446
Xu ML, Luk WK, Lau KM, Bi CWC, Cheng AW, Gong AG, Lin H, Tsim KWK (2015)
Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition
Journal of Molecular Neuroscience 57: 486
Bi CWC, Luk WK, Campanari ML, Liu YH, Xu L, Lau KM, Xu ML, Choi RC, Saez-Valero J, Tsim KWK (2014)
Quantification of the Transcripts Encoding Different Forms of AChE in Various Cell Types: Real-Time PCR Coupled with Standards in Revealing the Copy Number
Journal of Molecular Neuroscience 53: 461
Campanari ML, Garcia-Ayllon MS, Blazquez-Llorca L, Luk WK, Tsim KWK, Saez-Valero J (2014)
Acetylcholinesterase protein level is preserved in the Alzheimer's brain
Journal of Molecular Neuroscience 53: 446
Chen J, Lam CT, Kong AY, Zhang WL, Zhan JY, Bi CWC, Chan GK, Lam KY, Yao P, Dong TTX, Tsim KWK (2014)
The Extract of Ziziphus jujuba Fruit (Jujube) Induces Expression of Erythropoietin Via Hypoxia-Inducible Factor-1alpha in Cultured Hep3B Cells
Planta Med 80: 1622
Garcia-Ayllon MS, Campanari ML, Montenegro MF, Cuchillo-Ibanez I, Belbin O, Lleo A, Tsim KWK, Vidal CJ, Saez-Valero J (2014)
Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA
Neurobiology of Aging 35: 1526
Mak SH, Luk WW, Cui W, Hu S, Tsim KWK, Han Y (2014)
Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from chinese medicinal herbs
Journal of Molecular Neuroscience 53: 511
Xin GZ, Lam YC, Maiwulanjiang M, Chan GK, Zhu KY, Tang WL, Dong TTX, Shi ZQ, Li P, Tsim KWK (2014)
Authentication of Bulbus Fritillariae Cirrhosae by RAPD-derived DNA markers
Molecules 19: 3450
Zhan JY, Yao P, Bi CWC, Zheng KY, Zhang WL, Chen JP, Dong TTX, Su ZR, Tsim KWK (2014)
The sulfur-fumigation reduces chemical composition and biological properties of Angelicae Sinensis Radix
Phytomedicine 21: 1318
Zhan JY, Zheng KY, Zhang WL, Chen JP, Yao P, Bi CWC, Dong TTX, Tsim KWK (2014)
Identification of Angelica oil as a suppressor for the biological properties of Danggui Buxue tang: a Chinese herbal decoction composes of Astragali Radix and Angelica Sinensis Radix
J Ethnopharmacol 154: 825
Zheng KY, Zhang ZX, Du CY, Zhang WL, Bi CWC, Choi RC, Dong TTX, Tsim KWK (2014)
Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction
Planta Med 80: 159
Zou XH, Xie HQ, Zha GC, Chen VP, Sun YJ, Zheng YZ, Tsim KWK, Dong TTX, Choi RC, Luk WK (2014)
Characterizations of Cholinesterases in Golden Apple Snail (Pomacea canaliculata)
Journal of Molecular Neuroscience 53: 424
Choi RC, Chen VP, Luk WK, Yung AW, Ng AH, Dong TTX, Tsim KWK (2013)
Expression of cAMP-responsive element binding proteins (CREBs) in fast- and slow-twitch muscles: A signaling pathway to account for the synaptic expression of collagen-tailed subunit (ColQ) of acetylcholinesterase at the rat neuromuscular junction
Chemico-Biological Interactions 203: 282
Choi RC, Zhu JT, Yung AW, Lee PS, Xu SL, Guo AJ, Zhu KY, Dong TTX, Tsim KWK (2013)
Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease
Evid Based Complement Alternat Med 2013: 635694
Choi RC, Chu GK, Siow NL, Yung AW, Yung LY, Lee PS, Lo CC, Simon J, Dong TTX, Barnard EA, Tsim KWK (2013)
Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation
Molecular Pharmacology 84: 50
Maiwulanjiang M, Zhu KY, Chen J, Miernisha A, Xu SL, Du CY, Lau KK, Choi RC, Dong TTX, Aisa HA, Tsim KWK (2013)
Song bu li decoction, a traditional uyghur medicine, protects cell death by regulation of oxidative stress and differentiation in cultured PC12 cells
Evid Based Complement Alternat Med 2013: 687958
Xu SL, Bi CWC, Choi RC, Zhu KY, Miernisha A, Dong TTX, Tsim KWK (2013)
Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor
Evid Based Complement Alternat Med 2013: 127075
Xu SL, Zhu KY, Bi CWC, Choi RC, Miernisha A, Yan AL, Maiwulanjiang M, Men SW, Dong TTX, Tsim KWK (2013)
Flavonoids induce the expression of synaptic proteins, synaptotagmin, and postsynaptic density protein-95 in cultured rat cortical neuron
Planta Med 79: 1710
Xu SL, Zhu KY, Bi CWC, Yan L, Men SW, Dong TTX, Tsim KWK (2013)
Flavonoids, derived from traditional Chinese medicines, show roles in the differentiation of neurons: possible targets in developing health food products
Birth Defects Res C Embryo Today 99: 292
Zha G, Chen VP, Luk WK, Zou XH, Choi RC, Tsim KWK (2013)
Characterization of acetylcholinesterase in Hong Kong oyster (Crassostrea hongkongensis) from South China Sea
Chemico-Biological Interactions 203: 277
Zhan JY, Zhang WL, Zheng KY, Zhu KY, Chen JP, Chan PH, Dong TTX, Choi RC, Lam H, Tsim KWK, Lau DT (2013)
Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry
Chin Med 8: 12
Zhan JY, Zheng KY, Zhu KY, Zhang WL, Bi CWC, Chen JP, Du CY, Dong TTX, Lau DT, Tsim KWK (2013)
Importance of wine-treated Angelica Sinensis Radix in Si Wu Tang, a traditional herbal formula for treating women's ailments
Planta Med 79: 533
Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CWC, Chen JP, Dong TTX, Choi RC, Lau DT, Tsim KWK (2013)
Chemical and biological assessment of angelica roots from different cultivated regions in a chinese herbal decoction danggui buxue tang
Evid Based Complement Alternat Med 2013: 483286
Zhu KY, Xu SL, Choi RC, Yan AL, Dong TTX, Tsim KWK (2013)
Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes
Evid Based Complement Alternat Med 2013: 731385
Bi CWC, Xu L, Tian XY, Liu J, Zheng KY, Lau CW, Lau DT, Choi RC, Dong TTX, Huang Y, Tsim KWK (2012)
Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity
PLoS ONE 7: e51670
Bi CWC, Xu L, Zhang WL, Zhan JY, Fu Q, Zheng KY, Chen VP, Lau DT, Choi RC, Wang TJ, Dong TTX, Tsim KWK (2012)
Fo shou san, an ancient herbal decoction prepared from angelicae sinensis radix and chuanxiong rhizoma, induces erythropoietin expression: a signaling mediated by the reduced degradation of hypoxia-inducible factor in cultured liver cells
Planta Med 78: 122
Chan WK, Chen VP, Luk WK, Choi RC, Tsim KWK (2012)
N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase
Neuroscience Letters 523: 71
Luk WK, Chen VP, Choi RC, Tsim KWK (2012)
N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting
Febs J 279: 3229
Tsim KWK, Soreq H (2012)
Acetylcholinesterase: old questions and new developments
Front Mol Neurosci 5: 101
Wang T, Choi RC, Li J, Bi CWC, Ran W, Chen X, Dong TTX, Bi K, Tsim KWK (2012)
Trillin, a steroidal saponin isolated from the rhizomes of Dioscorea nipponica, exerts protective effects against hyperlipidemia and oxidative stress
J Ethnopharmacol 139: 214
Xu H, Su ZR, Huang W, Choi RC, Zheng YZ, Lau DT, Dong TTX, Wang ZT, Tsim KWK (2012)
Er Zhi Wan, an ancient herbal decoction for woman menopausal syndrome, activates the estrogenic response in cultured MCF-7 cells: an evaluation of compatibility in defining the optimized preparation method
J Ethnopharmacol 143: 109
Xu SL, Choi RC, Zhu KY, Leung KW, Guo AJ, Bi D, Xu H, Lau DT, Dong TTX, Tsim KWK (2012)
Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor
Evid Based Complement Alternat Med 2012: 278273
Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CWC, Chen JP, Du CY, Zhao KJ, Lau DT, Dong TTX, Tsim KWK (2012)
Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications
Phytomedicine 19: 1042
Zheng KY, Choi RC, Guo AJ, Bi CWC, Zhu KY, Du CY, Zhang ZX, Lau DT, Dong TTX, Tsim KWK (2012)
The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang
J Pharm Biomed Anal 70: 671
Zheng KY, Zhang ZX, Guo AJ, Bi CWC, Zhu KY, Xu SL, Zhan JY, Lau DT, Dong TTX, Choi RC, Tsim KWK (2012)
Salidroside stimulates the accumulation of HIF-1alpha protein resulted in the induction of EPO expression: a signaling via blocking the degradation pathway in kidney and liver cells
European Journal of Pharmacology 679: 34
Zhu KY, Mao QQ, Ip SP, Choi RC, Dong TTX, Lau DT, Tsim KWK (2012)
A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats
Evid Based Complement Alternat Med 2012: 149256
Chen VP, Luk WK, Chan WK, Leung KW, Guo AJ, Chan GK, Xu SL, Choi RC, Tsim KWK (2011)
Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation
Front Mol Neurosci 4: 36
Zhan JY, Zheng KY, Zhu KY, Bi CWC, Zhang WL, Du CY, Fu Q, Dong TTX, Choi RC, Tsim KWK, Lau DT (2011)
Chemical and biological assessment of Angelicae Sinensis Radix after processing with wine: an orthogonal array design to reveal the optimized conditions
Journal of Agricultural and Food Chemistry 59: 6091
Zheng KY, Choi RC, Cheung AW, Guo AJ, Bi CWC, Zhu KY, Fu Q, Du Y, Zhang WL, Zhan JY, Duan R, Lau DT, Dong TTX, Tsim KWK (2011)
Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1alpha
Journal of Agricultural and Food Chemistry 59: 1697
Zheng KY, Guo AJ, Bi CWC, Zhu KY, Chan GK, Fu Q, Xu SL, Zhan JY, Lau DT, Dong TTX, Choi RC, Tsim KWK (2011)
The extract of Rhodiolae Crenulatae Radix et Rhizoma induces the accumulation of HIF-1alpha via blocking the degradation pathway in cultured kidney fibroblasts
Planta Med 77: 894
Bi CWC, Xie HQ, Xu L, Li J, Cheung AW, Zhu JT, Zheng YZ, Chen VP, Lau DT, Choi RC, Wang TJ, Dong TTX, Tsim KWK (2010)
Fo shou san, an ancient herbal decoction prepared from rhizoma chuanxiong and radix angelicae sinensis, stimulates the production of hemoglobin and erythropoietin in cultured cells
Planta Med 76: 1525
Chen VP, Xie HQ, Chan WK, Leung KW, Choi RC, Tsim KWK (2010)
An induction effect of heat shock on the transcript of globular acetylcholinesterase in NG108-15 cells
Chemico-Biological Interactions 187: 106
Chen VP, Xie HQ, Chan WK, Leung KW, Chan GK, Choi RC, Bon S, Massoulie J, Tsim KWK (2010)
The PRiMA-linked cholinesterase tetramers are assembled from homodimers: hybrid molecules composed of acetylcholinesterase and butyrylcholinesterase dimers are up-regulated during development of chicken brain
Journal of Biological Chemistry 285: 27265
Guo AJ, Xie HQ, Choi RC, Zheng KY, Bi CWC, Xu SL, Dong TTX, Tsim KWK (2010)
Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro
Chemico-Biological Interactions 187: 246
Lin HQ, Choi R, Chan KL, Ip D, Tsim KWK, Wan DC (2010)
Differential gene expression profiling on the muscle of acetylcholinesterase knockout mice: a preliminary analysis
Chemico-Biological Interactions 187: 120
Siow NL, Choi RC, Xie HQ, Kong LW, Chu GK, Chan GK, Simon J, Barnard EA, Tsim KWK (2010)
ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors
Molecular Pharmacology 78: 1059
Tsim KWK, Leung KW, Mok KW, Chen VP, Zhu KY, Zhu JT, Guo AJ, Bi CWC, Zheng KY, Lau DT, Xie HQ, Choi RC (2010)
Expression and Localization of PRiMA-linked globular form acetylcholinesterase in vertebrate neuromuscular junctions
Journal of Molecular Neuroscience 40: 40
Wang T, Choi RC, Li J, Bi CWC, Zang L, Liu Z, Dong TTX, Bi K, Tsim KWK (2010)
Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica
Planta Med 76: 1642
Xie HQ, Leung KW, Chen VP, Chan GK, Xu SL, Guo AJ, Zhu KY, Zheng KY, Bi CWC, Zhan JY, Chan WK, Choi RC, Tsim KWK (2010)
PRiMA directs a restricted localization of tetrameric AChE at synapses
Chemico-Biological Interactions 187: 78
Xie HQ, Liang D, Leung KW, Chen VP, Zhu KY, Chan WK, Choi RC, Massoulie J, Tsim KWK (2010)
Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons
Journal of Biological Chemistry 285: 11537
Zheng KY, Choi RC, Xie HQ, Cheung AW, Guo AJ, Leung KW, Chen VP, Bi CWC, Zhu KY, Chan GK, Fu Q, Lau DT, Dong TTX, Zhao KJ, Tsim KWK (2010)
The expression of erythropoietin triggered by danggui buxue tang, a Chinese herbal decoction prepared from radix Astragali and radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells
J Ethnopharmacol 132: 259
Zheng YZ, Choi RC, Li J, Xie HQ, Cheung AW, Duan R, Guo AJ, Zhu JT, Chen VP, Bi CWC, Zhu Y, Lau DD, Dong TTX, Lau BW, Tsim KWK (2010)
Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis
Planta Med 76: 439
Zhu KY, Fu Q, Xie HQ, Xu SL, Cheung AW, Zheng KY, Luk WK, Choi RC, Lau DT, Dong TTX, Jiang ZY, Chen JJ, Tsim KWK (2010)
Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae
J Sep Sci 33: 3666
Cheung JK, Li J, Cheung AW, Zhu Y, Zheng KY, Bi CWC, Duan R, Choi RC, Lau DT, Dong TTX, Lau BW, Tsim KWK (2009)
Cordysinocan, a polysaccharide isolated from cultured Cordyceps, activates immune responses in cultured T-lymphocytes and macrophages: signaling cascade and induction of cytokines
J Ethnopharmacol 124: 61
Leung KW, Xie HQ, Chen VP, Mok MK, Chu GK, Choi RC, Tsim KWK (2009)
Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions--contribution and expression from motor neurons
Febs J 276: 3031
Li J, Li WZ, Huang W, Cheung AW, Bi CWC, Duan R, Guo AJ, Dong TTX, Tsim KWK (2009)
Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry
Journal of Chromatography A 1216: 2071
Li WZ, Li J, Bi CWC, Cheung AW, Huang W, Duan R, Choi RC, Chen IS, Zhao KJ, Dong TTX, Duan JA, Tsim KWK (2009)
Can rhizoma chuanxiong replace radix Angelica sinensis in the traditional Chinese herbal decoction danggui buxue tang?
Planta Med 75: 602
Mok MK, Leung KW, Xie HQ, Guo AJ, Chen VP, Zhu JT, Choi RC, Tsim KWK (2009)
A new variant of proline-rich membrane anchor (PRiMA) of acetylcholinesterase in chicken: expression in different muscle fiber types
Neuroscience Letters 461: 202
Zhu JT, Choi RC, Li J, Xie HQ, Bi CWC, Cheung AW, Dong TTX, Jiang ZY, Chen JJ, Tsim KWK (2009)
Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease
Planta Med 75: 1489
Zhu JT, Choi RC, Xie HQ, Zheng KY, Guo AJ, Bi CWC, Lau DT, Li J, Dong TTX, Lau BW, Chen JJ, Tsim KWK (2009)
Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons
Neuroscience Letters 461: 172
Choi RC, Simon J, Tsim KWK, Barnard EA (2008)
Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding
Journal of Biological Chemistry 283: 11050
Choi RC, Mok MK, Cheung AW, Siow NL, Xie HQ, Tsim KWK (2008)
Regulation of PRiMA-linked G(4) AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocyoma PC12 cells
Chemico-Biological Interactions 175: 76
Doctor BP, Tsim KWK, Siow NL (2008)
The IXth International Meeting on Cholinesterases, Suzhou, People's Republic of China, 6 to 10 May 2007
Chemico-Biological Interactions 175: 1
Lau FT, Choi RC, Xie HQ, Leung KW, Chen VP, Zhu JT, Bi CWC, Chu GK, Tsim KWK (2008)
Myocyte enhancer factor 2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes
Molecular & Cellular Neurosciences 39: 429
Tsim KWK, Choi RC, Xie HQ, Zhu JT, Leung KW, Lau FT, Chu GK, Chen VP, Mok MK, Cheung AW, Bi CWC (2008)
Transcriptional control of different subunits of AChE in muscles: signals triggered by the motor nerve-derived factors
Chemico-Biological Interactions 175: 58
Xie HQ, Leung KW, Chen VP, Lau FT, Liu LS, Choi RC, Tsim KWK (2008)
The promoter activity of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in muscle: suppressive roles of myogenesis and innervating nerve
Chemico-Biological Interactions 175: 79
Choi RC, Ting AK, Lau FT, Xie HQ, Leung KW, Chen VP, Siow NL, Tsim KWK (2007)
Calcitonin gene-related peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle: a distinction in driving two different promoters between fast- and slow-twitch muscle fibers
Journal of Neurochemistry 102: 1316
Fu H, Li W, Liu Y, Lao Y, Liu W, Chen C, Yu H, Lee NT, Chang DC, Li P, Pang Y, Tsim KWK, Li M, Han Y (2007)
Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons
J Proteome Res 6: 2435
Xie HQ, Choi RC, Leung KW, Siow NL, Kong LW, Lau FT, Peng HB, Tsim KWK (2007)
Regulation of a transcript encoding the proline-rich membrane anchor of globular muscle acetylcholinesterase. The suppressive roles of myogenesis and innervating nerves
Journal of Biological Chemistry 282: 11765
Zhu H, Gao W, Jiang H, Jin QH, Shi YF, Tsim KWK, Zhang XJ (2007)
Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis
International Journal of Biochemistryistry & Cell Biology 39: 93
Fu H, Li W, Lao Y, Luo J, Lee NT, Kan KK, Tsang HW, Tsim KWK, Pang Y, Li Z, Chang DC, Li M, Han Y (2006)
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels
Journal of Neurochemistry 98: 1400
Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KWK, Li X, Han Y (2006)
Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine
Neuroreport 17: 471
Tsim KWK, Xie HQ, Ting AK, Siow NL, Ling KK, Kong LW (2006)
Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions
Journal of Molecular Neuroscience 30: 189
Wan DC, Zhang X, Siow NL, Xie HQ, Tsim KWK (2006)
Chick acetylcholinesterase promoter regulation
Journal of Molecular Neuroscience 30: 33
Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, Tsim KWK, Li M, Han Y (2005)
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors
Journal of Biological Chemistry 280: 18179
Ting AK, Siow NL, Kong LW, Tsim KWK (2005)
Transcriptional regulation of acetylcholinesterase-associated collagen ColQ in fast- and slow-twitch muscle fibers
Chemico-Biological Interactions 157-158: 63
Xie HQ, Siow NL, Peng HB, Massoulie J, Tsim KWK (2005)
Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle
Chemico-Biological Interactions 157-158: 432
Choi RC, Siow NL, Cheng AW, Kong LW, Zhang X, Wan DC, Tsim KWK (2004)
NFKB regulates the promoter activity of human acetylcholinesterase in muscle.
Cholinergic Mechanisms, CRC Press
Lee HH, Choi RC, Ting AK, Siow NL, Jiang JX, Massoulie J, Tsim KWK (2004)
Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters
Journal of Biological Chemistry 279: 27098
Tsim KWK, Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Kong LW, Barnard EA (2004)
The role of P2Y1 nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junctions.
Cholinergic Mechanisms, CRC Press
Tung EK, Choi RC, Siow NL, Jiang JX, Ling KK, Simon J, Barnard EA, Tsim KWK (2004)
P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions
Molecular Pharmacology 66: 794
Xiao XQ, Wu DC, Gao Y, Fu Y, Lee NT, Ho WL, Tsim KWK, Han YF (2004)
Huperzine A, a promising anti-Alzheimer?s agent, reduces staurosporine-induced apoptosis in NG108-15 cells.
Cholinergic Mechanisms, CRC Press
Zhang X, Choi RC, Tsim KWK, Wan DC (2004)
Cloning and characterization of the acetylcholinesterase gene in the chicken.
Cholinergic Mechanisms, CRC Press
Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Simon J, Barnard EA, Tsim KWK (2003)
ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control
Journal of Neuroscience 23: 4445
Jiang JX, Choi RC, Siow NL, Lee HH, Wan DC, Tsim KWK (2003)
Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture: transcriptional regulation mediated by cAMP-dependent signaling
Journal of Biological Chemistry 278: 45435
Siow NL, Choi RC, Cheng AW, Jiang JX, Wan DC, Zhu SQ, Tsim KWK (2002)
A cyclic AMP-dependent pathway regulates the expression of acetylcholinesterase during myogenic differentiation of C2C12 cells
Journal of Biological Chemistry 277: 36129
Tsim KWK, Barnard EA (2002)
The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction
Neurosignals 11: 58
Choi RC, Siow NL, Zhu SQ, Wan DC, Wong YH, Tsim KWK (2001)
The cyclic AMP-mediated expression of acetylcholinesterase in myotubes shows contrasting activation and repression between avian and mammalian enzymes
Molecular & Cellular Neurosciences 17: 732
Choi RC, Man ML, Ling KK, Ip NY, Simon J, Barnard EA, Tsim KWK (2001)
Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor
Journal of Neuroscience 21: 9224
Wan DC, Choi RC, Siow NL, Tsim KWK (2000)
The promoter of human acetylcholinesterase is activated by a cyclic adenosine 3',5'-monophosphate-dependent pathway in cultured NG108-15 neuroblastoma cells
Neuroscience Letters 288: 81
Yang JF, Zhou H, Choi RC, Ip NY, Peng HB, Tsim KWK (1999)
A cysteine-rich form of Xenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes
Molecular & Cellular Neurosciences 13: 415
Choi RC, Yam SC, Hui B, Wan DC, Tsim KWK (1998)
Over-expression of acetylcholinesterase stimulates the expression of agrin in NG108-15 cells
Neuroscience Letters 248: 17
Choi RC, Yung LY, Dong TTX, Wan DC, Wong YH, Tsim KWK (1998)
The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotubes is mediated by cyclic AMP
Journal of Neurochemistry 71: 152
Tsim KWK (1998)
The signaling pathway of calcitonin gene-related peptide-induced acetylcholinesterase expression in muscle is mediated by cyclic AMP
Journal de Physiologie (Paris) 92: 505
Yang JF, Zhou H, Pun S, Ip NY, Peng HB, Tsim KWK (1998)
Cloning of cDNAs encoding xenopus neuregulin: expression in myotomal muscle during embryo development
Brain Research Mol Brain Res 58: 59
Pun S, Ng YP, Yang JF, Ip NY, Tsim KWK (1997)
Agrin-deficient myotube retains its acetylcholine receptor aggregation ability when challenged with agrin
Journal of Neurochemistry 69: 2555
Tsim KWK, Choi RC, Dong TTX, Wan DC (1997)
A globular, not asymmetric, form of acetylcholinesterase is expressed in chick motor neurons: down-regulation toward maturity and after denervation
Journal of Neurochemistry 68: 479
Wan DC, Ng YP, Choi RC, Cheung PW, Dong TTX, Tsim KWK (1997)
Denervation decreases the ipsilateral expression of AChE in chick lumbaric motor neurons
Neuroscience Letters 232: 83
Zhou H, Muramatsu T, Halfter W, Tsim KWK, Peng HB (1997)
A role of midkine in the development of the neuromuscular junction
Molecular & Cellular Neurosciences 10: 56
Reiss Y, Kroger S, Grassi J, Tsim KWK, Willbold E, Layer PG (1996)
Extracellular and asymmetric forms of acetylcholinesterase are expressed on cholinergic and noncholinergic terminal neuropil of the developing chick retina
Cell & Tissue Research 286: 13
Pun S, Tsim KWK (1995)
Truncated form of pro-acetylcholine receptor-inducing activity (ARIA) induces AChR alpha-subunit but not AChE transcripts in cultured chick myotubes
Neuroscience Letters 198: 107
Ruegg MA, Tsim KWK, Horton SE, Kroger S, Escher G, Gensch EM, McMahan UJ (1992)
The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
Neuron 8: 691
Tsim KWK, Greenberg I, Rimer M, Randall WR, Salpeter MM (1992)
Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells
Journal of Cell Biology 118: 1201
Tsim KWK, Ruegg MA, Escher G, Kroger S, McMahan UJ (1992)
cDNA that encodes active agrin [published erratum appears in Neuron 1992 Aug;9(2):following 381]
Neuron 8: 677
Tsim KWK, Randall WR, Barnard EA (1988)
An asymmetric form of muscle acetylcholinesterase contains three subunit types and two enzymic activities in one molecule
Proceedings of the National Academy of Sciences of the United States of America 85: 1262
Tsim KWK, Randall WR, Barnard EA (1988)
Identification of a 17 S asymmetric butyrylcholinesterase in chick muscle by monoclonal antibodies
Neuroscience Letters 86: 245
Tsim KWK, Randall WR, Barnard EA (1988)
Monoclonal antibodies specific for the different subunits of asymmetric acetylcholinesterase from chick muscle
Journal of Neurochemistry 51: 95
Tsim KWK, Randall WR, Barnard EA (1988)
Synaptic acetylcholinesterase of chicken muscle changes during development from a hybrid to a homogeneous enzyme
EMBO Journal 7: 2451
Weetman AP, Tse CK, Randall WR, Tsim KWK, Barnard EA (1988)
Acetylcholinesterase antibodies and thyroid autoimmunity
Clinical & Experimental Immunology 71: 96
Randall WR, Tsim KWK, Lai J, Barnard EA (1987)
Monoclonal antibodies against chicken brain acetylcholinesterase. Their use in immunopurification and immunochemistry to demonstrate allelic variants of the enzyme
European Journal of Biochemistry 164: 95