Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM (2016) <br />Carboxylesterases: General detoxifying enzymes<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 327<br /><br />Wierdl M, Tsurkan L, Hatfield MJ, Potter PM (2016) <br />Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer<br /><i>British Journal of Pharmacology</i> <b>173</b>: 2811<br /><br />Hatfield MJ, Tsurkan L, Garrett M, Shaver TM, Hyatt JL, Edwards CC, Hicks LD, Potter PM (2011) <br />Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11<br /><i>Biochemical Pharmacology</i> <b>81</b>: 24<br /><br />Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR (2011) <br />Nerve agent hydrolysis activity designed into a human drug metabolism enzyme<br /><i>PLoS ONE</i> <b>6</b>: e17441<br /><br />Parkinson EI, Hatfield MJ, Tsurkan L, Hyatt JL, Edwards CC, Hicks LD, Yan B, Potter PM (2011) <br />Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones<br /><i>Bioorganic & Medicinal Chemistry</i> <b>19</b>: 4635<br /><br />Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM (2009) <br />Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 3742<br /><br />Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008) <br />An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11<br /><i>Cancer Gene Therapy</i> <b>15</b>: 183<br /><br />Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS (2007) <br />Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma<br /><i>Cancer Research</i> <b>67</b>: 22<br /><br />Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM (2007) <br />Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils<br /><i>Bioorganic & Medicinal Chemistry</i> <b>15</b>: 3801<br /><br />Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM (2007) <br />Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 5727<br /><br />Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM (2007) <br />Selective inhibition of carboxylesterases by isatins, indole-2,3-diones<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 1876<br /><br />Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM (2007) <br />Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds<br /><i>Molecular Pharmacology</i> <b>71</b>: 713<br /><br />Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM (2006) <br />Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity<br /><i>Mol Cancer Ther</i> <b>5</b>: 2281<br /><br />Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR (2005) <br />Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil<br /><i>Journal of Molecular Biology</i> <b>352</b>: 165<br /><br />Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM (2005) <br />Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 247<br /><br />