Cristancho Ortiz CJ, de Freitas Silva M, Pruccoli L, Fonseca Nadur N, de Azevedo LL, Kummerle AE, Guedes IA, Dardenne LE, Leomil Coelho LF, Guimaraes MJ, da Silva FMR, Castro N, Gontijo VS, Rojas VCT, de Oliveira MK, Vilela FC, Giusti-Paiva A, Barbosa G, Lima LM, Pinheiro GB, Veras LG, Mortari MR, Tarozzi A, Viegas C, Jr. (2022)
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation
RSC Med Chem 13: 568

Macedo Vaz S, de Freitas Silva M, Dos Reis Rosa Franco G, Jorge RGM, Motta RdSF, Goncalves Castro N, Alvim Guedes I, Dardenne LE, Amaral Alves M, Garrett da Costa R, Beserra Pinheiro G, Germino Veras L, Renata Mortari M, Pruccoli L, Tarozzi A, Viegas C, Jr. (2022)
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease
Bioorganic & Medicinal Chemistry 71: 116952

Bellozi PMQ, Campos AC, Viegas FPD, Silva MF, Machado RP, Vaz SM, Riquiel MM, Carneiro-Junior WO, Lima IVA, Saliba SW, Vaz GN, Viegas C, Jr., de Oliveira ACP (2020)
New multifunctional AChE inhibitor drug prototypes protect against Abeta-induced memory deficit
Neurol Sci 41: 451

Morroni F, Sita G, Graziosi A, Ravegnini G, Molteni R, Paladini MS, Dias KST, Dos Santos AF, Viegas C, Jr., Camps I, Pruccoli L, Tarozzi A, Hrelia P (2019)
PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease
Front Pharmacol 10: 658

Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simoes de Lima LM, Mancini KC, Marques de Oliveira PC, Morais EP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Pecanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GA, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C, Jr. (2018)
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates
Eur Journal of Medicinal Chemistry 147: 48

Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimaraes MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C, Jr. (2017)
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 130: 440

Rodrigues Simoes MC, Dias Viegas FP, Moreira MS, Freitas Silva M, Riquiel MM, da Rosa PM, Castelli MR, Dos Santos MH, Soares MG, Viegas C, de Freitas Silva M, Viegas C, Jr. (2014)
Donepezil: an important prototype to the design of new drug candidates for Alzheimer's disease
Mini Rev Med Chem 14: 2

Valli M, Danuello A, Pivatto M, Saldana JC, Heinzen H, Dominguez L, Campos VP, Marqui SR, Young MC, Viegas C, Jr., Silva DH, Bolzani VS (2011)
Anticholinesterasic, nematostatic and anthelmintic activities of pyridinic and pyrazinic compounds
Curr Med Chem 18: 3423

Castro NG, Costa RS, Pimentel LS, Danuello A, Romeiro NC, Viegas C, Jr., Barreiro EJ, Fraga CA, Bolzani VS, Rocha MS (2008)
CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline
European Journal of Pharmacology 580: 339

Viegas C, Jr., Bolzani VS, Pimentel LS, Castro NG, Cabral RF, Costa RS, Floyd C, Rocha MS, Young MC, Barreiro EJ, Fraga CA (2005)
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids
Bioorganic & Medicinal Chemistry 13: 4184

Viegas C, Jr., Bolzani Vda S, Barreiro EJ, Fraga CA (2005)
New anti-Alzheimer drugs from biodiversity: the role of the natural acetylcholinesterase inhibitors
Mini Rev Med Chem 5: 915

Viegas C, Jr., da SBV, Furlan M, Barreiro EJ, Young MC, Tomazela D, Eberlin MN (2004)
Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis
Journal of Natural Products 67: 908