Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM (2016) <br />Carboxylesterases: General detoxifying enzymes<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 327<br /><br />Wierdl M, Tsurkan L, Hatfield MJ, Potter PM (2016) <br />Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer<br /><i>British Journal of Pharmacology</i> <b>173</b>: 2811<br /><br />Yu X, Sigler SC, Hossain D, Wierdl M, Gwaltney SR, Potter PM, Wadkins RM (2012) <br />Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism<br /><i>J Mol Model</i> <b>18</b>: 2869<br /><br />Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR (2011) <br />Nerve agent hydrolysis activity designed into a human drug metabolism enzyme<br /><i>PLoS ONE</i> <b>6</b>: e17441<br /><br />Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR (2010) <br />Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin<br /><i>Molecular Pharmacology</i> <b>77</b>: 508<br /><br />Hatfield JM, Wierdl M, Wadkins RM, Potter PM (2008) <br />Modifications of human carboxylesterase for improved prodrug activation<br /><i>Expert Opin Drug Metab Toxicol</i> <b>4</b>: 1153<br /><br />Streit TM, Borazjani A, Lentz SE, Wierdl M, Potter PM, Gwaltney SR, Ross MK (2008) <br />Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition<br /><i>Biol Chem</i> <b>389</b>: 149<br /><br />Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008) <br />An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11<br /><i>Cancer Gene Therapy</i> <b>15</b>: 183<br /><br />Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS (2007) <br />Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma<br /><i>Cancer Research</i> <b>67</b>: 22<br /><br />Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM (2007) <br />Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils<br /><i>Bioorganic & Medicinal Chemistry</i> <b>15</b>: 3801<br /><br />Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM (2007) <br />Selective inhibition of carboxylesterases by isatins, indole-2,3-diones<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 1876<br /><br />Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM (2006) <br />Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity<br /><i>Mol Cancer Ther</i> <b>5</b>: 2281<br /><br />Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM (2005) <br />Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 5543<br /><br />Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM (2005) <br />Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 2906<br /><br />Wierdl M, Potter PM (2005) <br />Update on gene therapy approaches for cancer<br /><i>Curr Hematol Rep</i> <b>4</b>: 294<br /><br />Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM (2004) <br />Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model<br /><i>Biochemistry</i> <b>43</b>: 1874<br /><br />Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM (2003) <br />p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>304</b>: 699<br /><br />Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM (2003) <br />Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance<br /><i>Molecular Pharmacology</i> <b>64</b>: 279<br /><br />Meck MM, Wierdl M, Wagner LM, Burger RA, Guichard SM, Krull EJ, Harris LC, Potter PM, Danks MK (2001) <br />A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11<br /><i>Cancer Research</i> <b>61</b>: 5083<br /><br />Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM (2001) <br />Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases<br /><i>Molecular Pharmacology</i> <b>60</b>: 355<br /><br />Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM (2001) <br />Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase<br /><i>Cancer Research</i> <b>61</b>: 5078<br /><br />Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM (2000) <br />Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase<br /><i>Cancer Research</i> <b>60</b>: 4206<br /><br />Wierdl M, Morton CL, Danks MK, Potter PM (2000) <br />Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation<br /><i>Biochemical Pharmacology</i> <b>59</b>: 773<br /><br />Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK (1998) <br />Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme<br /><i>Cancer Research</i> <b>58</b>: 3627<br /><br />