Liu P, Cheng M, Guo J, Cao D, Luo J, Wan Y, Fang Y, Jin Y, Xie SS, Liu J (2023) <br />Dual functional antioxidant and butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of novel melatonin-alkylbenzylamine hybrids<br /><i>Bioorganic & Medicinal Chemistry</i> <b>78</b>: 117146<br /><br />Guo J, Xu A, Cheng M, Wan Y, Wang R, Fang Y, Jin Y, Xie SS, Liu J (2022) <br />Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease<br /><i>Drug Des Devel Ther</i> <b>16</b>: 1495<br /><br />Guo J, Cheng M, Liu P, Cao D, Luo J, Wan Y, Fang Y, Jin Y, Xie SS, Liu J (2022) <br />A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator<br /><i>Eur Journal of Medicinal Chemistry</i> <b>242</b>: 114630<br /><br />Zhang Z, Guo J, Cheng M, Zhou W, Wan Y, Wang R, Fang Y, Jin Y, Liu J, Xie SS (2021) <br />Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>213</b>: 113154<br /><br />Fu J, Bao F, Gu M, Liu J, Zhang Z, Ding J, Xie SS (2020) <br />Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer's disease<br /><i>J Enzyme Inhib Med Chem</i> <b>35</b>: 118<br /><br />Jiang N, Ding J, Liu J, Sun X, Zhang Z, Mo Z, Li X, Yin H, Tang W, Xie SS (2019) <br />Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with beta-amyloid anti-aggregation properties for the treatment of Alzheimer's disease<br /><i>Bioorg Chem</i> <b>89</b>: 103027<br /><br />Lan JS, Zeng RF, Jiang XY, Hou JW, Liu Y, Hu ZH, Li HX, Li Y, Xie SS, Ding Y, Zhang T (2019) <br />Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease<br /><i>Bioorg Chem</i> <br /><br />He Q, Liu J, Lan JS, Ding J, Sun Y, Fang Y, Jiang N, Yang Z, Sun L, Jin Y, Xie SS (2018) <br />Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation<br /><i>Bioorg Chem</i> <b>81</b>: 512<br /><br />Jiang N, Huang Q, Liu J, Liang N, Li Q, Xie SS (2018) <br />Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>146</b>: 287<br /><br />Lan JS, Zhang T, Liu Y, Yang J, Xie SS, Liu J, Miao ZY, Ding Y (2017) <br />Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>133</b>: 184<br /><br />Lan JS, Ding Y, Liu Y, Kang P, Hou JW, Zhang XY, Xie SS, Zhang T (2017) <br />Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>139</b>: 48<br /><br />Li F, Wang ZM, Wu JJ, Wang J, Xie SS, Lan JS, Xu W, Kong LY, Wang XB (2016) <br />Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease<br /><i>J Enzyme Inhib Med Chem</i> <br /><br />Xie SS, Lan JS, Wang X, Wang ZM, Jiang N, Li F, Wu JJ, Wang J, Kong LY (2016) <br />Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry</i> <b>24</b>: 1528<br /><br />Xie SS, Lan JS, Wang XB, Jiang N, Dong G, Li ZR, Wang KD, Guo PP, Kong LY (2015) <br />Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties<br /><i>Eur Journal of Medicinal Chemistry</i> <b>93C</b>: 42<br /><br />Xie SS, Wang X, Jiang N, Yu W, Wang KD, Lan JS, Li ZR, Kong LY (2015) <br />Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>95</b>: 153<br /><br />Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY (2014) <br />Design, synthesis and evaluation of novel tacrine-(beta-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry</i> <b>22</b>: 6089<br /><br />Xu ZC, Wang XB, Yu WY, Xie SS, Li SY, Kong LY (2014) <br />Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>24</b>: 2368<br /><br />Li SY, Wang XB, Xie SS, Jiang N, Wang KD, Yao HQ, Sun HB, Kong LY (2013) <br />Multifunctional tacrine-flavonoid hybrids with cholinergic, beta-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>69C</b>: 632<br /><br />Xie SS, Wang XB, Li JY, Yang L, Kong LY (2013) <br />Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>64C</b>: 540<br /><br />