Hu Z, Jiao L, Xie X, Xu L, Yan J, Yang M, Yan Y (2023) <br />Characterization of a New Thermostable and Organic Solution-Tolerant Lipase from Pseudomonas fluorescens and Its Application in the Enrichment of Polyunsaturated Fatty Acids<br /><i>Int J Mol Sci</i> <b>24</b>: 8924<br /><br />Huang J, Dai S, Chen X, Xu L, Yan J, Yang M, Yan Y (2023) <br />Alteration of Chain-Length Selectivity and Thermostability of Rhizopus oryzae Lipase via Virtual Saturation Mutagenesis Coupled with Disulfide Bond Design<br /><i>Applied Environmental Microbiology</i> <br /><br />Huang J, Xie X, Zheng Z, Ye L, Wang P, Xu L, Wu Y, Yan J, Yang M, Yan Y (2023) <br />De Novo Computational Design of a Lipase with Hydrolysis Activity towards Middle-Chained Fatty Acid Esters<br /><i>Int J Mol Sci</i> <b>24</b>: 8581<br /><br />Ghide MK, Li K, Wang J, Abdulmalek SA, Yan Y (2022) <br />Immobilization of Rhizomucor miehei lipase on magnetic multiwalled carbon nanotubes towards the synthesis of structured lipids rich in sn-2 palmitic acid and sn-1,3 oleic acid (OPO) for infant formula use<br /><i>Food Chem</i> <b>390</b>: 133171<br /><br />He W, Yuan G, Han Y, Yan Y, Li G, Zhao C, Shen J, Jiang X, Chen C, Ni L, Wang DW (2022) <br />Glimepiride Use is Associated with Reduced Cardiovascular Mortality in Patients with Type 2 Diabetes and Chronic Heart Failure: A Prospective Cohort Study<br /><i>Eur J Prev Cardiol</i> <br /><br />Jiao L, Li W, Li Y, Zhou Q, Zhu M, Zhao G, Zhang H, Yan Y (2022) <br />Employing Engineered Enolase Promoter for Efficient Expression of Thermomyces lanuginosus Lipase in Yarrowia lipolytica via a Self-Excisable Vector<br /><i>Int J Mol Sci</i> <b>24</b>: <br /><br />Ye QX, Huang JF, Xu ZJ, Yan YY, Yan Y, Liu LG (2022) <br />Short-term prognostic factors for hepatitis B virus-related acute-on-chronic liver failure<br /><i>World J Clin Cases</i> <b>10</b>: 8186<br /><br />Zhong G, Guo J, Pang C, Su D, Tang C, Jing L, Zhang F, He P, Yan Y, Chen Z, Liu J, Jiang N (2022) <br />Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation<br /><i>Bioorg Chem</i> <b>130</b>: 106224<br /><br />Zhou X, Zhong F, Yan Y, Wu S, Wang H, Liu J, Li F, Cui D, Xu M (2022) <br />Pancreatic Cancer Cell-Derived Exosomes Promote Lymphangiogenesis by Downregulating ABHD11-AS1 Expression<br /><i>Cancers (Basel)</i> <b>14</b>: <br /><br />Gao DW, Jamieson CS, Wang G, Yan Y, Zhou J, Houk KN, Tang Y (2021) <br />A Polyketide Cyclase That Forms Medium-Ring Lactones<br /><i>Journal of the American Chemical Society</i> <b>143</b>: 80<br /><br />Xia S, Zhu X, Yan Y, Zhang T, Chen G, Lei D, Wang G (2021) <br />Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish<br /><i>Ecotoxicology & Environmental Safety</i> <b>218</b>: 112308<br /><br />Xiao X, Qiao Y, Xu Z, Wu T, Wu Y, Ling Z, Yan Y, Huang J (2021) <br />Enzyme-Responsive Aqueous Two-Phase Systems in a Cationic-Anionic Surfactant Mixture<br /><i>Langmuir</i> <br /><br />Yan Y, Zhang N, Liu C, Wu X, Liu K, Yin Z, Zhou X, Xie L (2021) <br />A highly contiguous genome assembly of a polyphagous predatory mite Stratiolaelaps scimitus (Womersley) (Acari: Laelapidae)<br /><i>Genome Biol Evol</i> <br /><br />Li G, Xu L, Zhang H, Liu J, Yan J, Yan Y (2020) <br />A De Novo Designed Esterase with p-Nitrophenyl Acetate Hydrolysis Activity<br /><i>Molecules</i> <b>25</b>: 4658<br /><br />Liao Q, Li Q, Zhao Y, Jiang P, Yan Y, Sun H, Liu W, Feng F, Qu W (2020) <br />Design, synthesis and biological evaluation of novel carboline-cinnamic acid hybrids as multifunctional agents for treatment of Alzheimer's disease<br /><i>Bioorg Chem</i> <b>99</b>: 103844<br /><br />Zhou Y, Wu X, Ye L, Bai Y, Zhang H, Xuan Z, Feng Y, Zhang P, Chen Y, Yan Y, Zhu B, Cui W (2020) <br />Edaravone at high concentrations attenuates cognitive dysfunctions induced by abdominal surgery under general anesthesia in aged mice<br /><i>Metabolic Brain Disease</i> <br /><br />Zou B, Zhang L, Xia J, Wang P, Yan Y, Wang X, Adesanya IO (2020) <br />Metal-Organic Frameworks Conjugated Lipase with Enhanced Bio-catalytic Activity and Stability<br /><i>Appl Biochem Biotechnol</i> <br /><br />Zou B, Yan Y, Xia J, Zhang L, Adesanya IO (2020) <br />Enhancing bio-catalytic activity and stability of lipase nanogel by functional ionic liquids modification<br /><i>Colloids Surf B Biointerfaces</i> <b>195</b>: 111275<br /><br />Wang Z, Miao H, Liu J, Xu B, Yao X, Xu C, Zhao S, Fang X, Jia C, Wang J, Zhang J, Li J, Xu Y, Ma W, Wu Z, Yu L, Yang Y, Liu C, Guo Y, Sun S, Baurens FC, Martin G, Salmon F, Garsmeur O, Yahiaoui N, Hervouet C, Rouard M, Laboureau N, Habas R, Ricci S, Peng M, Guo A, Xie J, Li Y, Ding Z, Yan Y, Tie W, D'Hont A, Hu W, Jin Z (2019) <br />Musa balbisiana genome reveals subgenome evolution and functional divergence<br /><i>Nat Plants</i> <b>5</b>: 810<br /><br />Zhang L, Zhou J, Yan Y, Zhou X, Zhou Q, Du R, Hu S, Ge W, Huang Y, Xu H, Kong Y, Zheng H, Ding Y, Shen Y, Wang W (2019) <br />Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts<br /><i>Cancer Letters</i> <b>465</b>: 36<br /><br />Fan S, Wang J, Yan Y, Jia Y (2018) <br />Excellent Degradation Performance of a Versatile Phthalic Acid Esters-Degrading Bacterium and Catalytic Mechanism of Monoalkyl Phthalate Hydrolase<br /><i>Int J Mol Sci</i> <b>19</b>: <br /><br />Fan S, Li K, Yan Y, Wang J, Qiao C, Yang T, Jia Y, Zhao B (2018) <br />A novel chlorpyrifos hydrolase CPD from Paracoccus sp. TRP: Molecular cloning, characterization and catalytic mechanism<br /><i>Electronic Journal of Biotechnology</i> <b>31</b>: 10<br /><br />Jiao L, Zhou Q, Su Z, Yan Y (2018) <br />Efficient Heterologous Production of Rhizopus oryzae Lipase via Optimization of Multiple Expression-Related Helper Proteins<br /><i>Int J Mol Sci</i> <b>19</b>: <br /><br />Li G, Fang X, Su F, Chen Y, Xu L, Yan Y (2018) <br />Enhancing the Thermostability of Rhizomucor miehei Lipase with a Limited Screening Library by Rational-Design Point Mutations and Disulfide Bonds<br /><i>Applied Environmental Microbiology</i> <b>84</b>: <br /><br />Lin B, Yan Y, Guo M, Cao Y, Yu Y, Zhang T, Huang Y, Wu D (2018) <br />Modification-free carbon dots as turn-on fluorescence probe for detection of organophosphorus pesticides<br /><i>Food Chem</i> <b>245</b>: 1176<br /><br />Zeng Z, Yan Y, Wang B, Liu N, Xu H (2017) <br />Discovery and identification of O, O-diethyl O-(4-(5-phenyl-4, 5-dihydroisoxazol-3-yl) phenyl) phosphorothioate (XP-1408) as a novel mode of action of organophosphorus insecticides<br /><i>Sci Rep</i> <b>7</b>: 3617<br /><br />Li J, Liu K, Han Y, Tang BZ, Huang J, Yan Y (2016) <br />Fabrication of Propeller-Shaped Supra-amphiphile for Construction of Enzyme-Responsive Fluorescent Vesicles<br /><i>ACS Appl Mater Interfaces</i> <b>8</b>: 27987<br /><br />Li X, Liu Z, Wang G, Pan D, Jiao L, Yan Y (2016) <br />Overexpression of Candida rugosa lipase Lip1 via combined strategies in Pichia pastoris<br /><i>Enzyme Microb Technol</i> <b>82</b>: 115<br /><br />Su F, Li G, Fan Y, Yan Y (2016) <br />Enhanced performance of lipase via microcapsulation and its application in biodiesel preparation<br /><i>Sci Rep</i> <b>6</b>: 29670<br /><br />Duan S, Guan X, Lin R, Liu X, Yan Y, Zhang T, Chen X, Huang J, Sun X, Li Q, Fang S, Xu J, Yao Z, Gu H (2015) <br />Silibinin inhibits acetylcholinesterase activity and amyloid beta peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease<br /><i>Neurobiology of Aging</i> <b>36</b>: 1792<br /><br />Huang S, Li X, Xu L, Ke C, Zhang R, Yan Y (2015) <br />Protein-Coated Microcrystals from Candida rugosa Lipase: Its Immobilization, Characterization, and Application in Resolution of Racemic Ibuprofen<br /><i>Appl Biochem Biotechnol</i> <b>177</b>: 36<br /><br />Wang G, Liu Z, Xu L, Zhang H, Yan Y (2015) <br />Probing role of key residues in the divergent evolution of Yarrowia lipolytica lipase 2 and Aspergillus niger eruloyl esterase A<br /><i>Microbiol Res</i> <b>178</b>: 27<br /><br />Yang W, Xu L, Zhang H, Yan Y (2015) <br />Characterizing LipR from Pseudomonas sp. R0-14 and Applying in Enrichment of Polyunsaturated Fatty Acids from Algal Oil<br /><i>J Microbiol Biotechnol</i> <b>25</b>: 1880<br /><br />Yang W, Cao H, Xu L, Zhang H, Yan Y (2015) <br />A novel eurythermic and thermostale lipase LipM from Pseudomonas moraviensis M9 and its application in the partial hydrolysis of algal oil<br /><i>BMC Biotechnol</i> <b>15</b>: 94<br /><br />Biftu T, Sinha-Roy R, Chen P, Qian X, Feng D, Kuethe JT, Scapin G, Gao YD, Yan Y, Krueger D, Bak A, Eiermann G, He J, Cox J, Hicks J, Lyons K, He H, Salituro G, Tong S, Patel S, Doss G, Petrov A, Wu J, Xu SS, Sewall C, Zhang X, Zhang B, Thornberry NA, Weber AE (2014) <br />Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 3205<br /><br />Shao H, Xu L, Yan Y (2014) <br />Biochemical Characterization of a Carboxylesterase from the Archaeon Pyrobaculum sp. 1860 and a Rational Explanation of Its Substrate Specificity and Thermostability<br /><i>Int J Mol Sci</i> <b>15</b>: 16885<br /><br />Wang G, Liu Z, Xu L, Yan Y (2014) <br />Aromatic Amino Acid Mutagenesis at the Substrate Binding Pocket of Yarrowia lipolytica Lipase Lip2 Affects Its Activity and Thermostability<br /><i>ScientificWorldJournal</i> <b>2014</b>: 382581<br /><br />Zha D, Zhang H, Xu L, Yan Y (2014) <br />N-terminal transmembrane domain of lipase LipA from Pseudomonas protegens Pf-5: A must for its efficient folding into an active conformation<br /><i>Biochimie</i> <b>105</b>: 165<br /><br />Chen D, Peng C, Zhang H, Yan Y (2013) <br />Assessment of activities and conformation of lipases treated with sub- and supercritical carbon dioxide<br /><i>Appl Biochem Biotechnol</i> <b>169</b>: 2189<br /><br />Li X, Huang S, Xu L, Yan Y (2013) <br />Improving activity and enantioselectivity of lipase via immobilization on macroporous resin for resolution of racemic 1- phenylethanol in non-aqueous medium<br /><i>BMC Biotechnol</i> <b>13</b>: 92<br /><br />Li X, Huang S, Xu L, Yan Y (2013) <br />Conformation and Catalytic Properties Studies of Candida rugosa Lip7 via Enantioselective Esterification of Ibuprofen in Organic Solvents and Ionic Liquids<br /><i>ScientificWorldJournal</i> <b>2013</b>: 364730<br /><br />Liu T, Zhao Y, Wang X, Li X, Yan Y (2013) <br />A novel oriented immobilized lipase on magnetic nanoparticles in reverse micelles system and its application in the enrichment of polyunsaturated fatty acids<br /><i>Bioresour Technol</i> <b>132C</b>: 99<br /><br />Ruan Z, Zhai Y, Song J, Shi Y, Li K, Zhao B, Yan Y (2013) <br />Molecular cloning and characterization of a newly isolated pyrethroid-degrading esterase gene from a genomic library of Ochrobactrum anthropi YZ-1<br /><i>PLoS ONE</i> <b>8</b>: e77329<br /><br />Shao H, Xu L, Yan Y (2013) <br />Isolation and characterization of a thermostable esterase from a metagenomic library<br /><i>J Ind Microbiol Biotechnol</i> <b>40</b>: 1211<br /><br />Pushparaj A, Pryslawsky Y, Forget B, Yan Y, Le Foll B (2012) <br />Extinction bursts in rats trained to self-administer nicotine or food in 1-h daily sessions<br /><i>Am J Transl Res</i> <b>4</b>: 422<br /><br />Wang X, Sun Y, Ke F, Zhao H, Liu T, Xu L, Liu Y, Yan Y (2012) <br />Constitutive expression of Yarrowia lipolytica lipase LIP2 in Pichia pastoris using GAP as promoter<br /><i>Appl Biochem Biotechnol</i> <b>166</b>: 1355<br /><br />Yan Y, Pushparaj A, Gamaleddin I, Steiner RC, Picciotto MR, Roder J, Le Foll B (2012) <br />Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction<br /><i>Behavioural Brain Research</i> <b>230</b>: 34<br /><br />Yuan M, Chen M, Zhang W, Lu W, Wang J, Yang M, Zhao P, Tang R, Li X, Hao Y, Zhou Z, Zhan Y, Yu H, Teng C, Yan Y, Ping S, Wang Y, Lin M (2012) <br />Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations<br /><i>PLoS ONE</i> <b>7</b>: e34458<br /><br />Zhai Y, Li K, Song J, Shi Y, Yan Y (2012) <br />Molecular cloning, purification and biochemical characterization of a novel pyrethroid-hydrolyzing carboxylesterase gene from Ochrobactrum anthropi YZ-1<br /><i>J Hazard Mater</i> <b>221-222</b>: 206<br /><br />Zheng J, Xu L, Liu Y, Zhang X, Yan Y (2012) <br />Lipase-coated K2SO4 micro-crystals: preparation, characterization, and application in biodiesel production using various oil feedstocks<br /><i>Bioresour Technol</i> <b>110</b>: 224<br /><br />Liu Y, Chen D, Yan Y, Peng C, Xu L (2011) <br />Biodiesel synthesis and conformation of lipase from Burkholderia cepacia in room temperature ionic liquids and organic solvents<br /><i>Bioresour Technol</i> <b>102</b>: 10414<br /><br />Yu H, Yuan M, Lu W, Yang J, Dai S, Li Q, Yang Z, Dong J, Sun L, Deng Z, Zhang W, Chen M, Ping S, Han Y, Zhan Y, Yan Y, Jin Q, Lin M (2011) <br />Complete genome sequence of the nitrogen-fixing and rhizosphere-associated bacterium Pseudomonas stutzeri strain DSM4166<br /><i>Journal of Bacteriology</i> <b>193</b>: 3422<br /><br />Zhan Y, Yan Y, Zhang W, Yu H, Chen M, Lu W, Ping S, Peng Z, Yuan M, Zhou Z, Elmerich C, Lin M (2011) <br />Genome sequence of Acinetobacter calcoaceticus PHEA-2, isolated from industry wastewater<br /><i>Journal of Bacteriology</i> <b>193</b>: 2672<br /><br />Zhao H, Xiao X, Xu L, Liu Y, Yan Y (2011) <br />[Heterologous expression and characterization of Yarrowia lipolytica lipase 4 and lipase 5 in Pichia pastoris]<br /><i>Wei Sheng Wu Xue Bao</i> <b>51</b>: 1374<br /><br />Huang Y, Zheng H, Yan Y (2010) <br />Optimization of lipase-catalyzed transesterification of lard for biodiesel production using response surface methodology<br /><i>Appl Biochem Biotechnol</i> <b>160</b>: 504<br /><br />Liu W, Zhao H, Jia B, Xu L, Yan Y (2010) <br />Surface display of active lipase in Saccharomyces cerevisiae using Cwp2 as an anchor protein<br /><i>Biotechnol Lett</i> <b>32</b>: 255<br /><br />Pan S, Liu X, Xie Y, Yi Y, Li C, Yan Y, Liu Y (2010) <br />Esterification activity and conformation studies of Burkholderia cepacia lipase in conventional organic solvents, ionic liquids and their co-solvent mixture media<br /><i>Bioresour Technol</i> <b>101</b>: 9822<br /><br />Xu L, Jiang X, Yang J, Liu Y, Yan Y (2010) <br />Cloning of a novel lipase gene, lipJ08, from Candida rugosa and expression in Pichia pastoris by codon optimization<br /><i>Biotechnol Lett</i> <b>32</b>: 269<br /><br />Yang J, Sun J, Yan Y (2010) <br />lip2, a novel lipase gene cloned from Aspergillus niger exhibits enzymatic characteristics distinct from its previously identified family member<br /><i>Biotechnol Lett</i> <b>32</b>: 951<br /><br />Jia B, Yang J, Yan Y (2009) <br />[Homologous expression of Burkholderia cepacia G63 lipase gene based on T7 RNA polymerase expression system]<br /><i>Sheng Wu Gong Cheng Xue Bao</i> <b>25</b>: 215<br /><br />Shu Z, Duan M, Yang J, Xu L, Yan Y (2009) <br />Aspergillus niger lipase: Heterologous expression in Pichia pastoris, molecular modeling prediction and the importance of the hinge domains at both sides of the lid domain to interfacial activation<br /><i>Biotechnol Prog</i> <b>25</b>: 409<br /><br />Yang J, Zhang B, Yan Y (2009) <br />Cloning and expression of Pseudomonas fluorescens 26-2 lipase gene in Pichia pastoris and characterizing for transesterification<br /><i>Appl Biochem Biotechnol</i> <b>159</b>: 355<br /><br />Yang J, Zhang Z, Liu L, Yan Y (2009) <br />[Cloning, expression and characterization of a novel lipase gene lipB from Aspergillus niger F044]<br /><i>Wei Sheng Wu Xue Bao</i> <b>49</b>: 1095<br /><br />Huang Y, Cai Y, Yang J, Yan Y (2008) <br />[Directed evolution of lipase of Bacillus pumilus YZ02 by error-prone PCR]<br /><i>Sheng Wu Gong Cheng Xue Bao</i> <b>24</b>: 445<br /><br />Huang Y, Yan Y (2008) <br />Lipase-catalyzed biodiesel production with methyl acetate as acyl acceptor<br /><i>Z Naturforsch C</i> <b>63</b>: 297<br /><br />Liu W, Xu L, Zhao H, Yang J, Yan Y (2008) <br />[Cell surface display of Yarrowia lipolytica lipase Lip2 in Saccharomyces cerevisiae with a-agglutinin as carrier protein]<br /><i>Wei Sheng Wu Xue Bao</i> <b>48</b>: 1543<br /><br />Peng J, Yang L, Yang F, Yang J, Yan Y, Nie H, Zhang X, Xiong Z, Jiang Y, Cheng F, Xu X, Chen S, Sun L, Li W, Shen Y, Shao Z, Liang X, Xu J, Jin Q (2008) <br />Characterization of ST-4821 complex, a unique Neisseria meningitidis clone<br /><i>Genomics</i> <b>91</b>: 78<br /><br />Yan J, Yang J, Xu L, Yan Y (2008) <br />[Cloning and overexpression of lipase gene from Geotrichum candidum Y162]<br /><i>Wei Sheng Wu Xue Bao</i> <b>48</b>: 184<br /><br />Yang F, Yang J, Zhang X, Chen L, Jiang Y, Yan Y, Tang X, Wang J, Xiong Z, Dong J, Xue Y, Zhu Y, Xu X, Sun L, Chen S, Nie H, Peng J, Xu J, Wang Y, Yuan Z, Wen Y, Yao Z, Shen Y, Qiang B, Hou Y, Yu J, Jin Q (2005) <br />Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery<br /><i>Nucleic Acids Research</i> <b>33</b>: 6445<br /><br />Yan Y, Bornscheuer UT, Schmid RD (2002) <br />Efficient water removal in lipase-catalyzed esterifications using a low-boiling-point azeotrope<br /><i>Biotechnol Bioeng</i> <b>78</b>: 31<br /><br />