Bakker AT, Kotsogianni I, Mirenda L, Straub VM, Avalos M, van den Berg R, Florea BI, van Wezel GP, Janssen APA, Martin NI, van der Stelt M (2023)
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA
Journal of the American Chemical Society 145: 1136

Berger N, van der Wel T, Hirschmugl B, Baernthaler T, Gindlhuber J, Fawzy N, Eichmann T, Birner-Gruenberger R, Zimmermann R, van der Stelt M, Wadsack C (2023)
Inhibition of diacylglycerol lipase beta modulates lipid and endocannabinoid levels in the ex vivo human placenta
Front Endocrinol (Lausanne) 14: 1092024

Fellner M, Walsh A, Dela Ahator S, Aftab N, Sutherland B, Tan EW, Bakker AT, Martin NI, van der Stelt M, Lentz CS (2023)
Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response
ACS Infect Dis

Jiang M, Huizenga MCW, Wirt JL, Paloczi J, Amedi A, van den Berg R, Benz J, Collin L, Deng H, Di X, Driever WF, Florea BI, Grether U, Janssen APA, Hankemeier T, Heitman LH, Lam TW, Mohr F, Pavlovic A, Ruf I, van den Hurk H, Stevens AF, van der Vliet D, van der Wel T, Wittwer MB, van Boeckel CAA, Pacher P, Hohmann AG, van der Stelt M (2023)
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
Nat Commun 14: 8039

van Zadelhoff G, van der Stelt M (2023)
Oxygenation of Anandamide by Lipoxygenases
Methods Mol Biol 2576: 307

He Y, Grether U, Taddio MF, Meier C, Keller C, Edelmann MR, Honer M, Huber S, Wittwer MB, Heer D, Richter H, Collin L, Hug MN, Hilbert M, Postmus AGJ, Stevens AF, van der Stelt M, Kramer SD, Schibli R, Mu L, Gobbi LC (2022)
Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain
Eur Journal of Medicinal Chemistry 243: 114750

van Egmond N, Straub VM, van der Stelt M (2021)
Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors
Annual Review of Pharmacology & Toxicology 61: 441

Baggelaar MP, den Dulk H, Florea BI, Fazio D, Perruzza D, Bernabo N, Raspa M, Janssen APA, Scavizzi F, Barboni B, Overkleeft HS, Maccarrone M, van der Stelt M (2019)
ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction
ACS Chemical Biology 14: 2295

Zhou J, Mock ED, Martella A, Kantae V, Di X, Burggraaff L, Baggelaar MP, Al-Ayed K, Bakker A, Florea BI, Grimm SH, den Dulk H, Li CT, Mulder L, Overkleeft HS, Hankemeier T, van Westen GJP, van der Stelt M (2019)
Activity-Based Protein Profiling Identifies alpha-Ketoamides as Inhibitors for Phospholipase A2 Group XVI
ACS Chemical Biology 14: 164

van Esbroeck ACM, Kantae V, Di X, van der Wel T, den Dulk H, Stevens AF, Singh S, Bakker AT, Florea BI, Stella N, Overkleeft HS, Hankemeier T, van der Stelt M (2019)
Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells
Front Mol Neurosci 12: 286

Janssen APA, van der Vliet D, Bakker AT, Jiang M, Grimm SH, Campiani G, Butini S, van der Stelt M (2018)
Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors
ACS Chemical Biology 13: 2406

Jiang M, van der Stelt M (2018)
Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders
Journal of Medicinal Chemistry 61: 9059

van Rooden EJ, van Esbroeck ACM, Baggelaar MP, Deng H, Florea BI, Marques ARA, Ottenhoff R, Boot RG, Overkleeft HS, Aerts J, van der Stelt M (2018)
Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain
Front Neurosci 12: 440

van Rooden EJ, Kohsiek M, Kreekel R, van Esbroeck ACM, van den Nieuwendijk A, Janssen APA, van den Berg R, Overkleeft HS, van der Stelt M (2018)
Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and alpha,beta-Hydrolase Domain Containing Protein 6
Chem Asian J 13: 3491

van Rooden EJ, Florea BI, Deng H, Baggelaar MP, van Esbroeck ACM, Zhou J, Overkleeft HS, van der Stelt M (2018)
Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification
Nat Protoc 13: 752

Baggelaar MP, van der Stelt M (2017)
Competitive ABPP of Serine Hydrolases: A Case Study on DAGL-Alpha
Methods Mol Biol 1491: 161

Baggelaar MP, van Esbroeck AC, van Rooden EJ, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M (2017)
Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases
ACS Chemical Biology 12: 852

Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M (2017)
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding
Journal of Medicinal Chemistry 60: 428

Deng H, van der Wel T, van den Berg R, van den Nieuwendijk A, Janssen FJ, Baggelaar MP, Overkleeft HS, van der Stelt M (2017)
Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors
Medchemcomm 8: 982

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, De Petrocellis L, Ullmer C, Rothenhausler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M (2017)
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Nat Commun 8: 13958

van Esbroeck ACM, Janssen APA, Cognetta AB, 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allara M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M (2017)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Science 356: 1084

Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, Soethoudt M, van der Wel T, Zhou J, Overkleeft HS, Sanchez-Alavez M, Mori S, Nguyen W, Conti B, Liu X, Chen Y, Liu QS, Cravatt BF, van der Stelt M (2016)
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
Proc Natl Acad Sci U S A 113: 26

van Zadelhoff G, van der Stelt M (2016)
Oxygenation of Anandamide by Lipoxygenases
Methods Mol Biol 1412: 217

Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allara M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, Overkleeft HS, Hankemeier T, Werkman TR, Cravatt BF, van der Stelt M (2015)
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons
Journal of the American Chemical Society 137: 8851

Janssen FJ, Baggelaar MP, Hummel JJ, Overkleeft HS, Cravatt BF, Boger DL, van der Stelt M (2015)
Comprehensive Analysis of Structure-Activity Relationships of alpha-Ketoheterocycles as sn-1-Diacylglycerol Lipase alpha Inhibitors
Journal of Medicinal Chemistry 58: 9742

van der Wel T, Janssen FJ, Baggelaar MP, Deng H, den Dulk H, Overkleeft HS, van der Stelt M (2015)
A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase alpha
J Lipid Res 56: 927

Janssen FJ, Deng H, Baggelaar MP, Allara M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M (2014)
Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase alpha and alpha/beta-Hydrolase Domain 6
Journal of Medicinal Chemistry 57: 6610

Baggelaar MP, Janssen FJ, van Esbroeck AC, den Dulk H, Allara M, Hoogendoorn S, McGuire R, Florea BI, Meeuwenoord N, van den Elst H, van der Marel GA, Brouwer J, Di Marzo V, Overkleeft HS, van der Stelt M (2013)
Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-alpha in brain
Angew Chem Int Ed Engl 52: 12081