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Family Report for: A85-Mycolyl-transferase

A85-Mycolyl-transferase



Relationship
Block X
Parent Family : Antigen85c

Comment
This family contains Antigen85 responsible for high affinity of mycobacteria for fibronectin. Proteins of the antigen 85 possess a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. Mycobacterium tuberculosis MPT51 (FbpC1) is a non-catalytic alpha/beta hydrolases member of this family. This family corresponds to a subset of the the Carbohydrate Esterase family CE1 in CAZy - Carbohydrate-Active enZYmes database (CE_1)

Database
Sequences
Interpro
|
IPR000801 (Esterase_put)
PIRSF
|
Pdoc
|
PFam
|
PF00756 (Esterase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
2 more
    Title: Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales
    Dautin N, de Sousa-D'Auria C, Constantinesco-Becker F, Labarre C, Oberto J, de la Sierra-Gallay IL, Dietrich C, Issa H, Houssin C, Bayan N
    Ref: Biochimica & Biophysica Acta, 1861:3581, 2017 : PubMed

            

    Title: An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase.
    Anderson DH, Harth G, Horwitz MA, Eisenberg D
    Ref: Journal of Molecular Biology, 307:671", 2001 : PubMed

            

    Title: Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines
    Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC
    Ref: Nat Struct Biol, 7:141, 2000 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in A85-Mycolyl-transferase family (26)

Genes Proteins in A85-Mycolyl-transferase family (194)

Fragments of genes in A85-Mycolyl-transferase family (8)

Substrates of some enzymes in the A85-Mycolyl-transferase family (4)

Inhibitors of some enzymes in the A85-Mycolyl-transferase family (17)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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