Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: ABHD11-Acetyl_transferase

ABHD11-Acetyl_transferase



Relationship
Block X
Parent Family : Abhydrolase_6

Comment
ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al. published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis

Database
Sequences
Interpro
|
PIRSF
|
Pdoc
|
PFam
|
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
8 more
    Title: ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis
    Liu G, Ruan Y, Zhang J, Wang X, Wu W, He P, Wang J, Xiong J, Cheng Y and Jian R <3 more author(s)>
    Ref: Front Cell Developmental Biology, 8:570, 2020 : PubMed

            

    Title: Ethyl acetate production by the elusive alcohol acetyltransferase from yeast
    Kruis AJ, Levisson M, Mars AE, Van der Ploeg M, Garces Daza F, Ellena V, Kengen SWM, Van der Oost J, Weusthuis RA
    Ref: Metab Eng, 41:92, 2017 : PubMed

            

    Title: Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human alpha/beta-hydrolase domain containing 11 (ABHD11)
    Navia-Paldanius D, Patel JZ, Lopez Navarro M, Jakupovic H, Goffart S, Pasonen-Seppanen S, Nevalainen TJ, Jaaskelainen T, Laitinen T and Savinainen JR <1 more author(s)>
    Ref: Eur J Pharm Sci, 93:253, 2016 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in ABHD11-Acetyl_transferase family (3)

Genes Proteins in ABHD11-Acetyl_transferase family (423)

Fragments of genes in ABHD11-Acetyl_transferase family (31)

Substrates of some enzymes in the ABHD11-Acetyl_transferase family (7)

Inhibitors of some enzymes in the ABHD11-Acetyl_transferase family (6)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer