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Family Report for: ACHE

AChE



Relationship
Family ACHE
Block C
Parent Family : Cholinesterase

Comment
Acetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.
1 Xenobiotic(s) sensitivity


Database
Sequences
Interpro
|
IPR000997 (Cholinesterase), IPR002018 (Carboxylesterase, type B)
PIRSF
|
Pdoc
|
PFam
|
PF00135 (COesterase), PF08674 (AChE_tetra)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
2 more
    Title: Old and new questions about cholinesterases
    Massoulie J, Perrier N, Noureddine H, Liang D, Bon S
    Ref: Chemico-Biological Interactions, 175:30, 2008 : PubMed

            

    Title: The cholinesterases: from genes to proteins
    Taylor P, Radic Z
    Ref: Annual Review of Pharmacology & Toxicology, 34:281, 1994 : PubMed

            

    Title: Molecular and cellular biology of cholinesterases
    Massoulie J, Pezzementi L, Bon S, Krejci E, Vallette FM
    Ref: Prog Neurobiol, 41:31, 1993 : PubMed

            

Other Papers


Structure scheme for ACHE

Structures in ACHE family (315)

Genes Proteins in ACHE family (538)

Fragments of genes in ACHE family (365)

Substrates of some enzymes in the ACHE family (46)

Inhibitors of some enzymes in the ACHE family (539)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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AcePerl Lincoln Stein Home Page
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