Acidic_Lipase
Relationship
Comment
This entry represents a family of eukaryotic lipases, including gastric triacylglycerol lipase (LIPF) lysosomal acid lipase (LIPA) and LIPJ, LIPK, LIPM, LIPN. Mutations in LIPA cause Wolman disease, Cholesterol Ester Storage Disease, CESD and mutation in LIPN causes Late-Onset Form of Autosomal-Recessive Congenital IchthyosisDatabase
Interpro : IPR039097 Gastric triacylglycerol lipase , IPR025483 Lipase, eukaryotic Lipase_euk , IPR000734 Lipase , IPR006693 AB-hydrolase-associated lipase region
PIRSF : PIRSF000862 lipase, eukaryotic type
Pdoc : PDOC00110
Pfam : PF04083 Abhydro_lipase
Prints : PR00821
EC Number : 3.1.1.3
References (20)
| Title : Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis - Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
| Author(s) : Duta-Mare M , Sachdev V , Leopold C , Kolb D , Vujic N , Korbelius M , Hofer DC , Xia W , Huber K , Auer M , Gottschalk B , Magnes C , Graier WF , Prokesch A , Radovic B , Bogner-Strauss JG , Kratky D |
| Ref : Biochimica & Biophysica Acta , 1863 :467 , 2018 |
| Abstract : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
| ESTHER : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
| PubMedSearch : Duta-Mare_2018_Biochim.Biophys.Acta_1863_467 |
| PubMedID: 29374543 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages - Schlager_2017_Oncotarget_8_40037 |
| Author(s) : Schlager S , Vujic N , Korbelius M , Duta-Mare M , Dorow J , Leopold C , Rainer S , Wegscheider M , Reicher H , Ceglarek U , Sattler W , Radovic B , Kratky D |
| Ref : Oncotarget , 8 :40037 , 2017 |
| Abstract : Schlager_2017_Oncotarget_8_40037 |
| ESTHER : Schlager_2017_Oncotarget_8_40037 |
| PubMedSearch : Schlager_2017_Oncotarget_8_40037 |
| PubMedID: 28402950 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase-deficient mice - Zhao_2017_J.Biol.Chem_292_19198 |
| Author(s) : Zhao T , Ding X , Yan C , Du H |
| Ref : Journal of Biological Chemistry , 292 :19198 , 2017 |
| Abstract : Zhao_2017_J.Biol.Chem_292_19198 |
| ESTHER : Zhao_2017_J.Biol.Chem_292_19198 |
| PubMedSearch : Zhao_2017_J.Biol.Chem_292_19198 |
| PubMedID: 28924047 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover - Grumet_2016_J.Biol.Chem_291_17977 |
| Author(s) : Grumet L , Eichmann TO , Taschler U , Zierler KA , Leopold C , Moustafa T , Radovic B , Romauch M , Yan C , Du H , Haemmerle G , Zechner R , Fickert P , Kratky D , Zimmermann R , Lass A |
| Ref : Journal of Biological Chemistry , 291 :17977 , 2016 |
| Abstract : Grumet_2016_J.Biol.Chem_291_17977 |
| ESTHER : Grumet_2016_J.Biol.Chem_291_17977 |
| PubMedSearch : Grumet_2016_J.Biol.Chem_291_17977 |
| PubMedID: 27354281 |
| Gene_locus related to this paper: human-LIPA , mouse-1llip |
| Title : Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-\/-) Mice - Du_2015_Am.J.Pathol_185_2379 |
| Author(s) : Du H , Zhao T , Ding X , Yan C |
| Ref : American Journal of Pathology , 185 :2379 , 2015 |
| Abstract : Du_2015_Am.J.Pathol_185_2379 |
| ESTHER : Du_2015_Am.J.Pathol_185_2379 |
| PubMedSearch : Du_2015_Am.J.Pathol_185_2379 |
| PubMedID: 26212911 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease - Sun_2014_Mol.Genet.Metab_112_229 |
| Author(s) : Sun Y , Xu YH , Du H , Quinn B , Liou B , Stanton L , Inskeep V , Ran H , Jakubowitz P , Grilliot N , Grabowski GA |
| Ref : Mol Genet Metab , 112 :229 , 2014 |
| Abstract : Sun_2014_Mol.Genet.Metab_112_229 |
| ESTHER : Sun_2014_Mol.Genet.Metab_112_229 |
| PubMedSearch : Sun_2014_Mol.Genet.Metab_112_229 |
| PubMedID: 24837159 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations - Ramirez_2011_J.Lipid.Res_52_688 |
| Author(s) : Ramirez CM , Liu B , Aqul A , Taylor AM , Repa JJ , Turley SD , Dietschy JM |
| Ref : J Lipid Res , 52 :688 , 2011 |
| Abstract : Ramirez_2011_J.Lipid.Res_52_688 |
| ESTHER : Ramirez_2011_J.Lipid.Res_52_688 |
| PubMedSearch : Ramirez_2011_J.Lipid.Res_52_688 |
| PubMedID: 21289032 |
| Gene_locus related to this paper: mouse-1llip |
| Title : A mutation in LIPN, encoding epidermal lipase N, causes a late-onset form of autosomal-recessive congenital ichthyosis - Israeli_2011_Am.J.Hum.Genet_88_482 |
| Author(s) : Israeli S , Khamaysi Z , Fuchs-Telem D , Nousbeck J , Bergman R , Sarig O , Sprecher E |
| Ref : American Journal of Human Genetics , 88 :482 , 2011 |
| Abstract : Israeli_2011_Am.J.Hum.Genet_88_482 |
| ESTHER : Israeli_2011_Am.J.Hum.Genet_88_482 |
| PubMedSearch : Israeli_2011_Am.J.Hum.Genet_88_482 |
| PubMedID: 21439540 |
| Gene_locus related to this paper: human-LIPN |
| Title : Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo) - Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| Author(s) : Holmes RS , Cox LA , Vandeberg JL |
| Ref : Comparative Biochemistry & Physiology Part D Genomics Proteomics , 5 :217 , 2010 |
| Abstract : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| ESTHER : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| PubMedSearch : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| PubMedID: 20598663 |
| Gene_locus related to this paper: human-LIPF , human-LIPJ , human-LIPK , human-LIPM , human-LIPN , mouse-LIPK |
| Title : Critical roles of lysosomal acid lipase in myelopoiesis - Qu_2010_Am.J.Pathol_176_2394 |
| Author(s) : Qu P , Shelley WC , Yoder MC , Wu L , Du H , Yan C |
| Ref : American Journal of Pathology , 176 :2394 , 2010 |
| Abstract : Qu_2010_Am.J.Pathol_176_2394 |
| ESTHER : Qu_2010_Am.J.Pathol_176_2394 |
| PubMedSearch : Qu_2010_Am.J.Pathol_176_2394 |
| PubMedID: 20348241 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Critical roles of lysosomal acid lipase in T cell development and function - Qu_2009_Am.J.Pathol_174_944 |
| Author(s) : Qu P , Du H , Wilkes DS , Yan C |
| Ref : American Journal of Pathology , 174 :944 , 2009 |
| Abstract : Qu_2009_Am.J.Pathol_174_944 |
| ESTHER : Qu_2009_Am.J.Pathol_174_944 |
| PubMedSearch : Qu_2009_Am.J.Pathol_174_944 |
| PubMedID: 19179613 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung - Li_2007_Int.J.Exp.Pathol_88_427 |
| Author(s) : Li Y , Qin Y , Li H , Wu R , Yan C , Du H |
| Ref : International Journal of Experimental Pathology , 88 :427 , 2007 |
| Abstract : Li_2007_Int.J.Exp.Pathol_88_427 |
| ESTHER : Li_2007_Int.J.Exp.Pathol_88_427 |
| PubMedSearch : Li_2007_Int.J.Exp.Pathol_88_427 |
| PubMedID: 18039279 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice - Lian_2005_Am.J.Pathol_167_813 |
| Author(s) : Lian X , Yan C , Qin Y , Knox L , Li T , Du H |
| Ref : American Journal of Pathology , 167 :813 , 2005 |
| Abstract : Lian_2005_Am.J.Pathol_167_813 |
| ESTHER : Lian_2005_Am.J.Pathol_167_813 |
| PubMedSearch : Lian_2005_Am.J.Pathol_167_813 |
| PubMedID: 16127159 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Identification and characterization of a triacylglycerol lipase in Arabidopsis homologous to mammalian acid lipases - El-Kouhen_2005_FEBS.Lett_579_6067 |
| Author(s) : El-Kouhen K , Blangy S , Ortiz E , Gardies AM , Ferte N , Arondel V |
| Ref : FEBS Letters , 579 :6067 , 2005 |
| Abstract : El-Kouhen_2005_FEBS.Lett_579_6067 |
| ESTHER : El-Kouhen_2005_FEBS.Lett_579_6067 |
| PubMedSearch : El-Kouhen_2005_FEBS.Lett_579_6067 |
| PubMedID: 16226259 |
| Gene_locus related to this paper: arath-At2g15230 |
| Title : Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung - Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
| Author(s) : Lian X , Yan C , Yang L , Xu Y , Du H |
| Ref : American Journal of Physiology Lung Cell Mol Physiol , 286 :L801 , 2004 |
| Abstract : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
| ESTHER : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
| PubMedSearch : Lian_2004_Am.J.Physiol.Lung.Cell.Mol.Physiol_286_L801 |
| PubMedID: 14644759 |
| Gene_locus related to this paper: mouse-1llip |
| Title : Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor - Roussel_2002_J.Biol.Chem_277_2266 |
| Author(s) : Roussel A , Miled N , Berti-Dupuis L , Riviere M , Spinelli S , Berna P , Gruber V , Verger R , Cambillau C |
| Ref : Journal of Biological Chemistry , 277 :2266 , 2002 |
| Abstract : Roussel_2002_J.Biol.Chem_277_2266 |
| ESTHER : Roussel_2002_J.Biol.Chem_277_2266 |
| PubMedSearch : Roussel_2002_J.Biol.Chem_277_2266 |
| PubMedID: 11689574 |
| Gene_locus related to this paper: canfa-1lipg |
| Title : Gastric lipase: crystal structure and activity - Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| Author(s) : Canaan S , Roussel A , Verger R , Cambillau C |
| Ref : Biochimica & Biophysica Acta , 1441 :197 , 1999 |
| Abstract : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| ESTHER : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| PubMedSearch : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| PubMedID: 10570247 |
| Gene_locus related to this paper: human-LIPF |
| Title : Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest - Roussel_1999_J.Biol.Chem_274_16995 |
| Author(s) : Roussel A , Canaan S , Egloff MP , Riviere M , Dupuis L , Verger R , Cambillau C |
| Ref : Journal of Biological Chemistry , 274 :16995 , 1999 |
| Abstract : Roussel_1999_J.Biol.Chem_274_16995 |
| ESTHER : Roussel_1999_J.Biol.Chem_274_16995 |
| PubMedSearch : Roussel_1999_J.Biol.Chem_274_16995 |
| PubMedID: 10358049 |
| Gene_locus related to this paper: human-LIPF |
| Title : Occurrence of a mutation associated with Wolman disease in a family with cholesteryl ester storage disease - Maslen_1995_J.Inherit.Metab.Dis_18_620 |
| Author(s) : Maslen CL , Babcock D , Illingworth DR |
| Ref : J Inherit Metab Dis , 18 :620 , 1995 |
| Abstract : Maslen_1995_J.Inherit.Metab.Dis_18_620 |
| ESTHER : Maslen_1995_J.Inherit.Metab.Dis_18_620 |
| PubMedSearch : Maslen_1995_J.Inherit.Metab.Dis_18_620 |
| PubMedID: 8598644 |
| Title : Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease - Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
| Author(s) : Anderson RA , Byrum RS , Coates PM , Sando GN |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :2718 , 1994 |
| Abstract : Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
| ESTHER : Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
| PubMedSearch : Anderson_1994_Proc.Natl.Acad.Sci.U.S.A_91_2718 |
| PubMedID: 8146180 |
| Gene_locus related to this paper: human-LIPA |
Structures (3)
Genes Proteins in Acidic_Lipase family (672)
Fragments of genes in Acidic_Lipase family (83)
Structures in Acidic_Lipase family (3)Substrates in Acidic_Lipase family (38)
Inhibitors in Acidic_Lipase family (15)