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Family Report for: Aclacinomycin-methylesterase_RdmC

Aclacinomycin-methylesterase_RdmC



Relationship
Block X
Parent Family : Abhydrolase_6

Comment
PIRSF037216 Aclacinomycin methylesterase (RdmC) is one of the tailoring enzymes that modify the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species

Database
Sequences
Interpro
|
IPR000073 (Alpha/beta hydrolase fold-1)
PIRSF
|
Pdoc
|
PFam
|
PF12697 (Abhydrolase_6)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: Biochemical and Structural Insights into Enzymatic Depolymerization of Polylactic Acid and Other Polyesters by Microbial Carboxylesterases
    Hajighasemi M, Nocek BP, Tchigvintsev A, Brown G, Flick R, Xu X, Cui H, Hai T, Joachimiak A and Yakunin AF <3 more author(s)>
    Ref: Biomacromolecules, 17:2027, 2016 : PubMed

            

    Title: Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism
    Jansson A, Niemi J, Mantsala P, Schneider G
    Ref: Journal of Biological Chemistry, 278:39006, 2003 : PubMed

            

    Title: Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens
    Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P
    Ref: Biochimica & Biophysica Acta, 1480:191, 2000 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Aclacinomycin-methylesterase_RdmC family (2)

Genes Proteins in Aclacinomycin-methylesterase_RdmC family (213)

Fragments of genes in Aclacinomycin-methylesterase_RdmC family (2)

Substrates of some enzymes in the Aclacinomycin-methylesterase_RdmC family (2)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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