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Family Report for: Arb2_domain

Arb2_domain



Relationship
Block X
Parent Family : Arb2

Comment
This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae was published (Shen et al.) and from Saccharomyces pombe (Job et al.)

Database
Sequences
Interpro
|
IPR019154 (Arb2 domain)
PIRSF
|
Pdoc
|
PFam
|
PF09757 (Arb2)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules
    Job G, Brugger C, Xu T, Lowe BR, Pfister Y, Qu C, Shanker S, Banos Sanz JI, Partridge JF, Schalch T
    Ref: Mol Cell, 62:207, 2016 : PubMed

            

    Title: Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae
    Shen H, Zhu Y, Wang C, Yan H, Teng M, Li X
    Ref: Sci Rep, 6:33905, 2016 : PubMed

            

    Title: Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast
    Buker SM, Iida T, Buhler M, Villen J, Gygi SP, Nakayama J, Moazed D
    Ref: Nat Struct Mol Biol, 14:200, 2007 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Arb2_domain family (2)

Genes Proteins in Arb2_domain family (297)

Fragments of genes in Arb2_domain family (5)

No Substrate

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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