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Family Report for: Carbon-carbon_bond_hydrolase

Carbon-carbon_bond_hydrolase



Relationship
Block X
Parent Family : Epoxide-hydrolase_like

Comment
2-hydroxymuconic semialdehyde hydrolase PIRSF037174. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself (environmental pollutants: BP/PCB). 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. The purified enzyme is a dimeric protein requiring no cofactors for catalytic activity

Database
Sequences
Interpro
|
IPR000073 (Alpha/beta hydrolase fold-1), IPR023791 (2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase), IPR017727 (2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, BphD)
PIRSF
|
Pdoc
|
PFam
|
PF12697 (Abhydrolase_6)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
7 more
    Title: The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad
    Horsman GP, Bhowmik S, Seah SY, Kumar P, Bolin JT, Eltis LD
    Ref: Journal of Biological Chemistry, 282:19894, 2007 : PubMed

            

    Title: Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway
    Horsman GP, Ke J, Dai S, Seah SY, Bolin JT, Eltis LD
    Ref: Biochemistry, 45:11071, 2006 : PubMed

            

    Title: A series of crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with various cleavage products
    Fushinobu S, Jun SY, Hidaka M, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T
    Ref: Biosci Biotechnol Biochem, 69:491, 2005 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Carbon-carbon_bond_hydrolase family (45)

Genes Proteins in Carbon-carbon_bond_hydrolase family (330)

Fragments of genes in Carbon-carbon_bond_hydrolase family (10)

Substrates of some enzymes in the Carbon-carbon_bond_hydrolase family (18)

Inhibitors of some enzymes in the Carbon-carbon_bond_hydrolase family (5)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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