Carbon-carbon_bond_hydrolase
Relationship
Comment
2-hydroxymuconic semialdehyde hydrolase PIRSF037174. Members of this family are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, or HOPD hydrolase, the BphD protein of biphenyl degradation. BphD acts on the product of ring meta-cleavage by BphC. Many species carrying bphC and bphD are capable of degrading polychlorinated biphenyls as well as biphenyl itself (environmental pollutants: BP/PCB). 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. The purified enzyme is a dimeric protein requiring no cofactors for catalytic activityDatabase
Interpro : IPR000073 Alpha\/beta hydrolase fold-1 , IPR023791 2-hydroxy-6-oxononadienedioate\/2-hydroxy-6-oxononatrienedioate hydrolase , IPR017727 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, BphD
PIRSF : PIRSF037174 2-hydroxymuconic semialdehyde hydrolase
Pdoc : No Pdoc
Pfam : PF12697 Abhydrolase_6
Prints : No Print
EC Number : 3.7.1.8
References (10)
| Title : The Lid Domain of the MCP Hydrolase DxnB2 Contributes to the Reactivity toward Recalcitrant PCB Metabolites - Ruzzini_2013_Biochemistry_52_5685 |
| Author(s) : Ruzzini AC , Bhowmik S , Yam KC , Ghosh S , Bolin JT , Eltis LD |
| Ref : Biochemistry , 52 :5685 , 2013 |
| Abstract : Ruzzini_2013_Biochemistry_52_5685 |
| ESTHER : Ruzzini_2013_Biochemistry_52_5685 |
| PubMedSearch : Ruzzini_2013_Biochemistry_52_5685 |
| PubMedID: 23879719 |
| Gene_locus related to this paper: sphww-a5j2a5 |
| Title : Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism - Lack_2010_J.Biol.Chem_285_434 |
| Author(s) : Lack NA , Yam KC , Lowe ED , Horsman GP , Owen RL , Sim E , Eltis LD |
| Ref : Journal of Biological Chemistry , 285 :434 , 2010 |
| Abstract : Lack_2010_J.Biol.Chem_285_434 |
| ESTHER : Lack_2010_J.Biol.Chem_285_434 |
| PubMedSearch : Lack_2010_J.Biol.Chem_285_434 |
| PubMedID: 19875455 |
| Gene_locus related to this paper: myctu-Rv3569c |
| Title : The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization - Bhowmik_2007_J.Biol.Chem_282_36377 |
| Author(s) : Bhowmik S , Horsman GP , Bolin JT , Eltis LD |
| Ref : Journal of Biological Chemistry , 282 :36377 , 2007 |
| Abstract : Bhowmik_2007_J.Biol.Chem_282_36377 |
| ESTHER : Bhowmik_2007_J.Biol.Chem_282_36377 |
| PubMedSearch : Bhowmik_2007_J.Biol.Chem_282_36377 |
| PubMedID: 17932031 |
| Gene_locus related to this paper: burxl-bphD |
| Title : The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad - Horsman_2007_J.Biol.Chem_282_19894 |
| Author(s) : Horsman GP , Bhowmik S , Seah SY , Kumar P , Bolin JT , Eltis LD |
| Ref : Journal of Biological Chemistry , 282 :19894 , 2007 |
| Abstract : Horsman_2007_J.Biol.Chem_282_19894 |
| ESTHER : Horsman_2007_J.Biol.Chem_282_19894 |
| PubMedSearch : Horsman_2007_J.Biol.Chem_282_19894 |
| PubMedID: 17442675 |
| Gene_locus related to this paper: burxl-bphD |
| Title : Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway - Horsman_2006_Biochemistry_45_11071 |
| Author(s) : Horsman GP , Ke J , Dai S , Seah SY , Bolin JT , Eltis LD |
| Ref : Biochemistry , 45 :11071 , 2006 |
| Abstract : Horsman_2006_Biochemistry_45_11071 |
| ESTHER : Horsman_2006_Biochemistry_45_11071 |
| PubMedSearch : Horsman_2006_Biochemistry_45_11071 |
| PubMedID: 16964968 |
| Gene_locus related to this paper: burxl-bphD |
| Title : A series of crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with various cleavage products - Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491 |
| Author(s) : Fushinobu S , Jun SY , Hidaka M , Nojiri H , Yamane H , Shoun H , Omori T , Wakagi T |
| Ref : Biosci Biotechnol Biochem , 69 :491 , 2005 |
| Abstract : Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491 |
| ESTHER : Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491 |
| PubMedSearch : Fushinobu_2005_Biosci.Biotechnol.Biochem_69_491 |
| PubMedID: 15784976 |
| Gene_locus related to this paper: psefl-cumD |
| Title : Identification of a serine hydrolase as a key determinant in the microbial degradation of polychlorinated biphenyls - Seah_2000_J.Biol.Chem_275_15701 |
| Author(s) : Seah SY , Labbe G , Nerdinger S , Johnson MR , Snieckus V , Eltis LD |
| Ref : Journal of Biological Chemistry , 275 :15701 , 2000 |
| Abstract : Seah_2000_J.Biol.Chem_275_15701 |
| ESTHER : Seah_2000_J.Biol.Chem_275_15701 |
| PubMedSearch : Seah_2000_J.Biol.Chem_275_15701 |
| PubMedID: 10821847 |
| Gene_locus related to this paper: burxl-bphD |
| Title : The bphDEF meta-cleavage pathway genes involved in biphenyl\/polychlorinated biphenyl degradation are located on a linear plasmid and separated from the initial bphACB genes in Rhodococcus sp. strain RHA1 - Masai_1997_Gene_187_141 |
| Author(s) : Masai E , Sugiyama K , Iwashita N , Shimizu S , Hauschild JE , Hatta T , Kimbara K , Yano K , Fukuda M |
| Ref : Gene , 187 :141 , 1997 |
| Abstract : Masai_1997_Gene_187_141 |
| ESTHER : Masai_1997_Gene_187_141 |
| PubMedSearch : Masai_1997_Gene_187_141 |
| PubMedID: 9073078 |
| Gene_locus related to this paper: rhosp-bphd |
| Title : Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12 - Ferrandez_1997_J.Bacteriol_179_2573 |
| Author(s) : Ferrandez A , Garcia JL , Diaz E |
| Ref : Journal of Bacteriology , 179 :2573 , 1997 |
| Abstract : Ferrandez_1997_J.Bacteriol_179_2573 |
| ESTHER : Ferrandez_1997_J.Bacteriol_179_2573 |
| PubMedSearch : Ferrandez_1997_J.Bacteriol_179_2573 |
| PubMedID: 9098055 |
| Gene_locus related to this paper: ecoli-mhpc |
| Title : Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase - Lam_1997_Biochemistry_36_12242 |
| Author(s) : Lam WW , Bugg TD |
| Ref : Biochemistry , 36 :12242 , 1997 |
| Abstract : Lam_1997_Biochemistry_36_12242 |
| ESTHER : Lam_1997_Biochemistry_36_12242 |
| PubMedSearch : Lam_1997_Biochemistry_36_12242 |
| PubMedID: 9315862 |
| Gene_locus related to this paper: ecoli-mhpc |
Structures (47)
Genes Proteins in Carbon-carbon_bond_hydrolase family (334)
Fragments of genes in Carbon-carbon_bond_hydrolase family (10)
Structures in Carbon-carbon_bond_hydrolase family (47)Substrates in Carbon-carbon_bond_hydrolase family (23)
Inhibitors in Carbon-carbon_bond_hydrolase family (11)