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Family Report for: Cholinesterase

Cholinesterase



Relationship
Block C
Children Family : ACHE, BCHE, Cholinesterase-like


Comment
Acetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly
1 Risk(s) factors

2 Xenobiotic(s) sensitivity


Database
Sequences
Interpro
|
IPR000997 (Cholinesterase), IPR002018 (Carboxylesterase, type B)
PIRSF
|
Pdoc
|
PFam
|
PF00135 (COesterase)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
1 more
    Title: Old and new questions about cholinesterases
    Massoulie J, Perrier N, Noureddine H, Liang D, Bon S
    Ref: Chemico-Biological Interactions, 175:30, 2008 : PubMed

            

    Title: The cholinesterases: from genes to proteins
    Taylor P, Radic Z
    Ref: Annual Review of Pharmacology & Toxicology, 34:281, 1994 : PubMed

            

    Title: Molecular and cellular biology of cholinesterases
    Massoulie J, Pezzementi L, Bon S, Krejci E, Vallette FM
    Ref: Prog Neurobiol, 41:31, 1993 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Cholinesterase family (406)

Genes Proteins in Cholinesterase family (1187)

Fragments of genes in Cholinesterase family (952)

Substrates of some enzymes in the Cholinesterase family (3)

Inhibitors of some enzymes in the Cholinesterase family (7)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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