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Cocaine_esterase

Relationship

Family: Cocaine_esterase

Block: X

Parent Family: Peptidase_S15

Comment

Contains also alpha-amino acid ester hydrolase (Beta-Lactam Acylase), glutaryl 7-aca acylases, antibiotic hydrolase, diester hydrolase. Able to perform both hydrolysis and synthesis of a variety of -amino -lactam antibiotics including (R)-ampicillin and cephalexin. The closest relatives is the S15 X-prolyl amino peptidase of Lactobacillus

Database

Interpro : IPR005674 CocE\/NonD hydrolase

PIRSF : PIRSF031658

Pdoc : No Pdoc

Pfam : PF02129 Peptidase_S15

Prints : No Print

EC Number : 3.1.1.43

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (3)

Title : Amino ester hydrolase from Xanthomonas campestris pv. campestris, ATCC 33913 for enzymatic synthesis of ampicillin - Blum_2010_J.Mol.Catal.B.Enzym_67_21
Author(s) : Blum JK , Bommarius AS
Ref : J Mol Catal B Enzym , 67 :21 , 2010
Abstract : Blum_2010_J.Mol.Catal.B.Enzym_67_21
ESTHER : Blum_2010_J.Mol.Catal.B.Enzym_67_21
PubMedSearch : Blum_2010_J.Mol.Catal.B.Enzym_67_21
PubMedID: 22087071
Gene_locus related to this paper: xanax-GAA

Title : Crystal structure of a bacterial cocaine esterase -
Author(s) : Larsen NA , Turner JM , Stevens J , Rosser SJ , Basran A , Lerner RA , Bruce NC , Wilson IA
Ref : Nat Struct Biol , 9 :17 , 2002
PubMedID: 11742345
Gene_locus related to this paper: rhosm-cocE

Title : Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1 - Bresler_2000_Appl.Environ.Microbiol_66_904
Author(s) : Bresler MM , Rosser SJ , Basran A , Bruce NC
Ref : Applied Environmental Microbiology , 66 :904 , 2000
Abstract : Bresler_2000_Appl.Environ.Microbiol_66_904
ESTHER : Bresler_2000_Appl.Environ.Microbiol_66_904
PubMedSearch : Bresler_2000_Appl.Environ.Microbiol_66_904
PubMedID: 10698749
Gene_locus related to this paper: rhosm-cocE

Structures (24)

Genes Proteins in Cocaine_esterase family (116)

Fragments of genes in Cocaine_esterase family (4)

Structures in Cocaine_esterase family (24)

Substrates in Cocaine_esterase family (7)

Inhibitors in Cocaine_esterase family (5)