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Family Report for: Homoserine_transacetylase

Homoserine_transacetylase



Relationship
Block X
Parent Family : Abhydrolase_6

Comment
Homoserine acetyltransferase (homoserine transacetylase; EC: 2.3.1.31) catalyses the first step unique to methionine biosynthesis, converting L-homoserine to O-acetyl-L-homoserine using acetyl-CoA as an acetyl group donor. This enzyme is unique to fungi and some bacteria. This enzyme regulates homoserine in a number of biosynthetic pathways, making it vital to cell growth and viability. The biosynthesis of methionine in particular has been shown to be susceptible to small-molecule inhibition in fungi and is consequently a good candidate for antifungal agents PIRSF000443. A subset of this family was shown by Toelzer et al. to be esterases and unable to bind acetyl-CoA and was extracted as a new family (Homoserine_transacetylase_like_est)

Database
Sequences
Interpro
|
IPR008220 (Homoserine/serine acetyltransferase MetX-like HAT_MetX-like), IPR000073 (Alpha/beta hydrolase fold-1)
PIRSF
|
Pdoc
|
PFam
|
PF00561 (Abhydrolase_1)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
1 more
    Title: Catalytic mechanism of fungal homoserine transacetylase
    Nazi I, Wright GD
    Ref: Biochemistry, 44:13560, 2005 : PubMed

            

    Title: Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Haemophilus influenzae met2-encoded homoserine transacetylase
    Born TL, Franklin M, Blanchard JS
    Ref: Biochemistry, 39:8556, 2000 : PubMed

            

    Title: The MET2 gene of Saccharomyces cerevisiae: molecular cloning and nucleotide sequence
    Langin T, Faugeron G, Goyon C, Nicolas A, Rossignol JL
    Ref: Gene, 49:283, 1986 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Homoserine_transacetylase family (14)

Genes Proteins in Homoserine_transacetylase family (427)

Fragments of genes in Homoserine_transacetylase family (1)

Substrates of some enzymes in the Homoserine_transacetylase family (4)

Inhibitors of some enzymes in the Homoserine_transacetylase family (2)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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