Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Thiohydrolase

Thiohydrolase



Relationship
Block X
Parent Family : Peptidase_S15

Comment
Under construction: extracted from Xaa-Pro-like_dom. Penicillium sp. Chain-fusing Polyketide Gregatin A GrgF belongs to this family.Thioesterase DcsB: A Polyketide Cyclase That Forms Medium-Ring Lactones. The nucleophile can be Ser as in beab2-j4wat9 (Beauveria bassiana (White muscardine disease fungus) thioesterase DcsB) or Cys as in pensq-GrgF (Penicillium sp. Chain-fusing Polyketide Gregatin A GrgF). The C115S mutant functions as a thioesterase, while losing the ability to perform chain fusion

Database
Sequences
Interpro
|
PIRSF
|
Pdoc
|
PFam
|
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: A Polyketide Cyclase That Forms Medium-Ring Lactones
    Gao DW, Jamieson CS, Wang G, Yan Y, Zhou J, Houk KN, Tang Y
    Ref: Journal of the American Chemical Society, 143:80, 2021 : PubMed

            

    Title: Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A
    Wang WG, Wang H, Du LQ, Li M, Chen L, Yu J, Cheng GG, Zhan MT, Hu QF and Matsuda Y <2 more author(s)>
    Ref: Journal of the American Chemical Society, 142:8464, 2020 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Thiohydrolase family (3)

Genes Proteins in Thiohydrolase family (182)

Fragments of genes in Thiohydrolase family (3)

No Substrate

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer