ABHD10
Relationship
Comment
Abhydrolase domain-containing protein 10, Mycophenolic acid acyl-glucuronide esterase, mitochondrial. Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG Mycophenolic-acid-acyl-glucuronide). AcMPAG, may be an immunotoxic, and is deglucuronidated by ABBHD10. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 (Cao et al.). The name of this family should not be confounded with family Abhydrolase_10 which is quite far related and contains only sequences from bacteria and fungiDatabase
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (7)
| Title : ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 - Cao_2019_Nat.Chem.Biol_15_1232 |
| Author(s) : Cao Y , Qiu T , Kathayat RS , Azizi SA , Thorne AK , Ahn D , Fukata Y , Fukata M , Rice PA , Dickinson BC |
| Ref : Nat Chemical Biology , 15 :1232 , 2019 |
| Abstract : Cao_2019_Nat.Chem.Biol_15_1232 |
| ESTHER : Cao_2019_Nat.Chem.Biol_15_1232 |
| PubMedSearch : Cao_2019_Nat.Chem.Biol_15_1232 |
| PubMedID: 31740833 |
| Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
| Title : Role of Human Orphan Esterases in Drug-induced Toxicity - Fukami_2015_Yakugaku.Zasshi_135_1235 |
| Author(s) : Fukami T |
| Ref : Yakugaku Zasshi , 135 :1235 , 2015 |
| Abstract : Fukami_2015_Yakugaku.Zasshi_135_1235 |
| ESTHER : Fukami_2015_Yakugaku.Zasshi_135_1235 |
| PubMedSearch : Fukami_2015_Yakugaku.Zasshi_135_1235 |
| PubMedID: 26521872 |
| Gene_locus related to this paper: human-ABHD10 |
| Title : An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver - Ito_2014_Drug.Metab.Dispos_42_2109 |
| Author(s) : Ito Y , Fukami T , Yokoi T , Nakajima M |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :2109 , 2014 |
| Abstract : Ito_2014_Drug.Metab.Dispos_42_2109 |
| ESTHER : Ito_2014_Drug.Metab.Dispos_42_2109 |
| PubMedSearch : Ito_2014_Drug.Metab.Dispos_42_2109 |
| PubMedID: 25217485 |
| Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
| Title : Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone - Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| Author(s) : Lajkiewicz NJ , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF , Porco JA, Jr. |
| Ref : Journal of the American Chemical Society , 136 :2659 , 2014 |
| Abstract : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| ESTHER : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| PubMedSearch : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
| PubMedID: 24447064 |
| Gene_locus related to this paper: human-ABHD10 , human-ACOT1 , human-ACOT2 , human-CTSA , human-SCPEP1 , mouse-abhda |
| Title : Human alpha\/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver - Iwamura_2012_J.Biol.Chem_287_9240 |
| Author(s) : Iwamura A , Fukami T , Higuchi R , Nakajima M , Yokoi T |
| Ref : Journal of Biological Chemistry , 287 :9240 , 2012 |
| Abstract : Iwamura_2012_J.Biol.Chem_287_9240 |
| ESTHER : Iwamura_2012_J.Biol.Chem_287_9240 |
| PubMedSearch : Iwamura_2012_J.Biol.Chem_287_9240 |
| PubMedID: 22294686 |
| Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
| Title : Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition - Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| Author(s) : Zuhl AM , Mohr JT , Bachovchin DA , Niessen S , Hsu KL , Berlin JM , Dochnahl M , Lopez-Alberca MP , Fu GC , Cravatt BF |
| Ref : J Am Chem Soc , 134 :5068 , 2012 |
| Abstract : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| ESTHER : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| PubMedSearch : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
| PubMedID: 22400490 |
| Gene_locus related to this paper: human-ABHD10 |
| Title : The emerging role of human esterases - Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
| Author(s) : Fukami T , Yokoi T |
| Ref : Drug Metab Pharmacokinet , 27 :466 , 2012 |
| Abstract : Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
| ESTHER : Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
| PubMedSearch : Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
| PubMedID: 22813719 |
| Gene_locus related to this paper: human-ABHD10 |
Structures (1)
Genes Proteins in ABHD10 family (151)
Fragments of genes in ABHD10 family (11)
Structures in ABHD10 family (1)Substrates in ABHD10 family (5)
Inhibitors in ABHD10 family (5)