ABHD16
Comment
This family consists of abhydrolase domain-containing protein 16 A (ABHD16A). Function of its members is unknown. However, ABHD16A contains transmembrane domain and is a potential multi-pass membrane protein. BAT5 (HLA-B-associated transcript 5). Savinainen et al. showed hydrolysis of medium-chain saturated (C14:0), long-chain unsaturated (C18:1, C18:2, C20:4) monoacylglycerols (MAGs) and 15-deoxy-12,14-prostaglandin J2-2-glycerol ester (15d-PGJ2-G). Only marginal diacylglycerol (DAG), triacylglycerol (TAG), or lysophospholipase activity PANTHER PTHR12277:SF54 There are two genes ABHD16 A and B in amniotes. Shan et al. identified a nonsense mutation in the bovine ABHD16B associated with male subfertility in Holstein cattle. ABHD16B is involved in lipid biosynthesis in testis and is crucial for fertilization. ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies (Lemire et al. 2021; Yahia et al. 2021; Miyake 2021). Substrates of ABHD include medium-chain saturated monoacylglycerols, 1-linoleylglycerol, 15-deoxy-delta12,14-prostaglandin J2-2-glycerol esterDatabase
Interpro : IPR026604 Abhydrolase domain-containing protein 16A ABHD16A
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (11)
| Title : Elucidating the Functional Role of Human ABHD16B Lipase in Regulating Triacylglycerol Mobilization and Membrane Lipid Synthesis in Saccharomyces cerevisiae - Narayanasamy_2023_Chem.Phys.Lipids__105353 |
| Author(s) : Narayanasamy R , Usharani D , Rajasekharan R |
| Ref : Chemistry & Physic of Lipids , :105353 , 2023 |
| Abstract : Narayanasamy_2023_Chem.Phys.Lipids__105353 |
| ESTHER : Narayanasamy_2023_Chem.Phys.Lipids__105353 |
| PubMedSearch : Narayanasamy_2023_Chem.Phys.Lipids__105353 |
| PubMedID: 37944658 |
| Gene_locus related to this paper: human-ABHD16B |
| Title : alpha\/beta-Hydrolase D16B Truncation Results in Premature Sperm Capacitation in Cattle - Shan_2022_Int.J.Mol.Sci_23_ |
| Author(s) : Shan S , Xu F , Hirschfeld M , Herrmann C , Schulze M , Sharifi AR , Hoelker M , Brenig B |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : Shan_2022_Int.J.Mol.Sci_23_ |
| ESTHER : Shan_2022_Int.J.Mol.Sci_23_ |
| PubMedSearch : Shan_2022_Int.J.Mol.Sci_23_ |
| PubMedID: 35887122 |
| Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B |
| Title : A homozygous ABHD16A variant causes a complex hereditary spastic paraplegia with developmental delay, absent speech, and characteristic face - Miyake_2021_Clin.Genet__ |
| Author(s) : Miyake N , Silva S , Troncoso M , Okamoto N , Andachi Y , Kato M , Iwabuchi C , Hirose M , Fujita A , Uchiyama Y , Matsumoto N |
| Ref : Clin Genet , : , 2021 |
| Abstract : Miyake_2021_Clin.Genet__ |
| ESTHER : Miyake_2021_Clin.Genet__ |
| PubMedSearch : Miyake_2021_Clin.Genet__ |
| PubMedID: 34866177 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies - Lemire_2021_Am.J.Hum.Genet__ |
| Author(s) : Lemire G , Ito YA , Marshall AE , Chrestian N , Stanley V , Brady L , Tarnopolsky M , Curry CJ , Hartley T , Mears W , Derksen A , Rioux N , Laflamme N , Hutchison HT , Pais LS , Zaki MS , Sultan T , Dane AD , Gleeson JG , Vaz FM , Kernohan KD , Bernard G , Boycott KM |
| Ref : American Journal of Human Genetics , : , 2021 |
| Abstract : Lemire_2021_Am.J.Hum.Genet__ |
| ESTHER : Lemire_2021_Am.J.Hum.Genet__ |
| PubMedSearch : Lemire_2021_Am.J.Hum.Genet__ |
| PubMedID: 34587489 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia - Yahia_2021_Front.Neurol_12_720201 |
| Author(s) : Yahia A , Elsayed LEO , Valter R , Hamed AAA , Mohammed IN , Elseed MA , Salih MA , Esteves T , Auger N , Abubaker R , Koko M , Abozar F , Malik H , Adil R , Emad S , Musallam MA , Idris R , Eltazi IZM , Babai A , Ahmed EAA , Abd Allah ASI , Mairey M , Ahmed A , Elbashir MI , Brice A , Ibrahim ME , Ahmed AE , Lamari F , Stevanin G |
| Ref : Front Neurol , 12 :720201 , 2021 |
| Abstract : Yahia_2021_Front.Neurol_12_720201 |
| ESTHER : Yahia_2021_Front.Neurol_12_720201 |
| PubMedSearch : Yahia_2021_Front.Neurol_12_720201 |
| PubMedID: 34489854 |
| Gene_locus related to this paper: human-ABHD16A |
| Title : Mapping the neuroanatomy of ABHD16A-ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC - Singh_2020_Biochemistry_59_2299 |
| Author(s) : Singh S , Joshi A , Kamat SS |
| Ref : Biochemistry , 59 :2299 , 2020 |
| Abstract : Singh_2020_Biochemistry_59_2299 |
| ESTHER : Singh_2020_Biochemistry_59_2299 |
| PubMedSearch : Singh_2020_Biochemistry_59_2299 |
| PubMedID: 32462874 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A |
| Title : Association of alpha\/beta-Hydrolase D16B with Bovine Conception Rate and Sperm Plasma Membrane Lipid Composition - Shan_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Shan S , Xu F , Bleyer M , Becker S , Melbaum T , Wemheuer W , Hirschfeld M , Wacker C , Zhao S , Schutz E , Brenig B |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : Shan_2020_Int.J.Mol.Sci_21_ |
| ESTHER : Shan_2020_Int.J.Mol.Sci_21_ |
| PubMedSearch : Shan_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 31963602 |
| Gene_locus related to this paper: bovin-ABHD16B , human-ABHD16B , mouse-Abhd16b |
| Title : The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids - Shanbhag_2020_J.Membr.Biol_253_381 |
| Author(s) : Shanbhag K , Mhetre A , Khandelwal N , Kamat SS |
| Ref : J Membr Biol , 253 :381 , 2020 |
| Abstract : Shanbhag_2020_J.Membr.Biol_253_381 |
| ESTHER : Shanbhag_2020_J.Membr.Biol_253_381 |
| PubMedSearch : Shanbhag_2020_J.Membr.Biol_253_381 |
| PubMedID: 32767057 |
| Title : Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease - Xu_2018_Open.Biol_8_ |
| Author(s) : Xu J , Gu W , Ji K , Xu Z , Zhu H , Zheng W |
| Ref : Open Biol , 8 : , 2018 |
| Abstract : Xu_2018_Open.Biol_8_ |
| ESTHER : Xu_2018_Open.Biol_8_ |
| PubMedSearch : Xu_2018_Open.Biol_8_ |
| PubMedID: 29794032 |
| Gene_locus related to this paper: human-ABHD16A , human-ABHD16B |
| Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164 |
| Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF |
| Ref : Nat Chemical Biology , 11 :164 , 2015 |
| Abstract : Kamat_2015_Nat.Chem.Biol_11_164 |
| ESTHER : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedID: 25580854 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a |
| Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869 |
| Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT |
| Ref : PLoS ONE , 9 :e109869 , 2014 |
| Abstract : Savinainen_2014_PLoS.One_9_e109869 |
| ESTHER : Savinainen_2014_PLoS.One_9_e109869 |
| PubMedSearch : Savinainen_2014_PLoS.One_9_e109869 |
| PubMedID: 25290914 |
| Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a |
No structure scheme yet for this family
Genes Proteins in ABHD16 family (142)
Fragments of genes in ABHD16 family (26)
No fragment of genesSubstrates in ABHD16 family (3)
Inhibitors in ABHD16 family (5)