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Family Report for: ABHD16


Family ABHD16
Block X


This family consists of abhydrolase domain-containing protein 16 A (ABHD16A). Function of its members is unknown. However, ABHD16A contains transmembrane domain and is a potential multi-pass membrane protein. BAT5 (HLA-B-associated transcript 5). Savinainen et al. showed hydrolysis of medium-chain saturated (C14:0), long-chain unsaturated (C18:1, C18:2, C20:4) monoacylglycerols (MAGs) and 15-deoxy-12,14-prostaglandin J2-2-glycerol ester (15d-PGJ2-G). Only marginal diacylglycerol (DAG), triacylglycerol (TAG), or lysophospholipase activity PANTHER PTHR12277:SF54 There are two genes ABHD16 A and B in amniotes. Shan et al. identified a nonsense mutation in the bovine ABHD16B associated with male subfertility in Holstein cattle. ABHD16B is involved in lipid biosynthesis in testis and is crucial for fertilization. ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies (Lemire et al. 2021; Yahia et al. 2021; Miyake 2021)

1 Disease(s)

Interpro : IPR026604 (Abhydrolase domain-containing protein 16A ABHD16A)
Pdoc :
PFam :
Prints :
Prosite :
no EC number

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin : Text only/graphic display
Seed alignment with MAFFT : No colour/coloured with Mview
Alignment with MAFFT : No colour/coloured with Mview
Dendrogram : Graphical display, obtained with the dnd file produced by Clustalw
HMM profile : HMM profile

No Image

No Structure

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No Substrate

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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