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Family Report for: ABHD8


Family ABHD8
Block X
Parent Family : Epoxide-hydrolase_like

This family was initially included in the Epoxide_hydrolase family but the active site nucleophile is a Serine. The vertebrate proteins present a long desordered N-terminal sequence. Could represent a breast-ovarian cancer susceptibility locus.

IPR000639 (Epoxide hydrolase-like)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts
    Guyatt AL, Brennan RR, Burrows K, Guthrie PAI, Ascione R, Ring SM, Gaunt TR, Pyle A, Cordell HJ and Rodriguez S <3 more author(s)>
    Ref: Hum Genomics, 13:6, 2019 : PubMed


    Title: Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
    Yang Y, Wu L, Shu X, Lu Y, Shu XO, Cai Q, Beeghly-Fadiel A, Li B, Ye F and Long J <90 more author(s)>
    Ref: Cancer Research, 79:505, 2019 : PubMed


    Title: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
    Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q and Gayther SA <272 more author(s)>
    Ref: Nat Commun, 7:12675, 2016 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in ABHD8 family (135)

Fragments of genes in ABHD8 family (28)

No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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