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Family Report for: AcoC_BiotinLipoyl-ABH


Block X
Parent Family : Epoxide-hydrolase_like

This family groups proteins with an architecture composed of two or three domains: a Biotin_lipoyl domain, possibly a E3_binding domain and an alpha/beta hydrolase domain. PF00364. Biotin_lipoyl IPR000089. Biotin_lipoyl. Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme. PF02817. E3_binding. IPR004167. E3-bd. is a small domain of the E2 subunit of 2-oxo-acid dehydrogenases (not an alpha beta hydrolase) that is responsible for the binding of the E3 subunit. Here dihydrolipoamide acetyltransferase (acoC) from the 2,3-butanediol catabolic pathway: acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase. Transfer of thio acetate from Acetyl-CoA to N6-(dihydrolipoyl)lysine of an enzyme

PF12697 (Abhydrolase_6)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.
    Huang M, Oppermann FB, Steinbuchel A
    Ref: FEMS Microbiology Letters, 124:141, 1994 : PubMed


    Title: Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism
    Priefert H, Hein S, Krueger N, Zeh K, Schmidt B, Steinbuechel A
    Ref: Journal of Bacteriology, 173:4056, 1991 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in AcoC_BiotinLipoyl-ABH family (42)

No fragments
No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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