Arb2_FAM172A
Relationship
Comment
FAM172A plays an important role in the regulation of cotranscriptional alternative splicing by interacting with Ago2 (Argonaute-2) and Chd7. The FAM172A mutant mice display a complex phenotype mimicking both the major and minor features of CHARGE syndrome (Belanger et al.).Database
Interpro : IPR039929 Cotranscriptional regulator FAM172A , IPR019154 Arb2 domain
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF09757 Arb2
Prints : No Print
EC Number : No EC Number
References (9)
| Title : CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms - Belanger_2022_FASEB.J_36_e22176 |
| Author(s) : Belanger C , Cardinal T , Leduc E , Viger RS , Pilon N |
| Ref : FASEB Journal , 36 :e22176 , 2022 |
| Abstract : Belanger_2022_FASEB.J_36_e22176 |
| ESTHER : Belanger_2022_FASEB.J_36_e22176 |
| PubMedSearch : Belanger_2022_FASEB.J_36_e22176 |
| PubMedID: 35129866 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC - Xu_2020_Endocr.Relat.Cancer_27_657 |
| Author(s) : Xu PP , Zeng S , Xia XT , Ye ZH , Li MF , Chen MY , Xia T , Xu JJ , Jiao Q , Liu L , Li LX , Guo MG |
| Ref : Endocr Relat Cancer , 27 :657 , 2020 |
| Abstract : Xu_2020_Endocr.Relat.Cancer_27_657 |
| ESTHER : Xu_2020_Endocr.Relat.Cancer_27_657 |
| PubMedSearch : Xu_2020_Endocr.Relat.Cancer_27_657 |
| PubMedID: 33095186 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling - Chen_2020_Biol.Open_9_bio048462 |
| Author(s) : Chen Y , Liu P , Shen D , Liu H , Xu L , Wang J , Sun H , Wu H |
| Ref : Biol Open , 9 : , 2020 |
| Abstract : Chen_2020_Biol.Open_9_bio048462 |
| ESTHER : Chen_2020_Biol.Open_9_bio048462 |
| PubMedSearch : Chen_2020_Biol.Open_9_bio048462 |
| PubMedID: 31988090 |
| Gene_locus related to this paper: human-f172a |
| Title : The Effect of Protein FAM172A on Proliferation in HepG2 Cells and Investigation of the Possible Molecular Mechanism - Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083 |
| Author(s) : Zhao H , Wang Y , Liu Y , Hao X , Wei H , Xie W |
| Ref : Anal Cell Pathol (Amst) , 2019 :5901083 , 2019 |
| Abstract : Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083 |
| ESTHER : Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083 |
| PubMedSearch : Zhao_2019_Anal.Cell.Pathol.(Amst)_2019_5901083 |
| PubMedID: 31915594 |
| Gene_locus related to this paper: human-f172a |
| Title : Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome - Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| Author(s) : Belanger C , Berube-Simard FA , Leduc E , Bernas G , Campeau PM , Lalani SR , Martin DM , Bielas S , Moccia A , Srivastava A , Silversides DW , Pilon N |
| Ref : Proc Natl Acad Sci U S A , 115 :E620 , 2018 |
| Abstract : Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| ESTHER : Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| PubMedSearch : Belanger_2018_Proc.Natl.Acad.Sci.U.S.A_115_E620 |
| PubMedID: 29311329 |
| Gene_locus related to this paper: mouse-f172a , human-f172a |
| Title : Detection of FAM172A expressed in circulating tumor cells is a feasible method to predict high-risk subgroups of colorectal cancer - Cui_2017_Tumour.Biol_39_1010428317699126 |
| Author(s) : Cui CH , Chen RH , Zhai DY , Xie L , Qi J , Yu JL |
| Ref : Tumour Biol , 39 :1010428317699126 , 2017 |
| Abstract : Cui_2017_Tumour.Biol_39_1010428317699126 |
| ESTHER : Cui_2017_Tumour.Biol_39_1010428317699126 |
| PubMedSearch : Cui_2017_Tumour.Biol_39_1010428317699126 |
| PubMedID: 28618931 |
| Gene_locus related to this paper: human-f172a |
| Title : miR27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker - Liu_2017_Oncol.Rep_37_3554 |
| Author(s) : Liu W , Qian K , Wei X , Deng H , Zhao B , Chen Q , Zhang J , Liu H |
| Ref : Oncol Rep , 37 :3554 , 2017 |
| Abstract : Liu_2017_Oncol.Rep_37_3554 |
| ESTHER : Liu_2017_Oncol.Rep_37_3554 |
| PubMedSearch : Liu_2017_Oncol.Rep_37_3554 |
| PubMedID: 28440497 |
| Gene_locus related to this paper: human-f172a |
| Title : FAM172A modulates apoptosis and proliferation of colon cancer cells via STAT1 binding to its promoter - Qian_2016_Oncol.Rep_35_1273 |
| Author(s) : Qian K , Zhang J , Lu J , Liu W , Yao X , Chen Q , Lu S , Xiang G , Liu H |
| Ref : Oncol Rep , 35 :1273 , 2016 |
| Abstract : Qian_2016_Oncol.Rep_35_1273 |
| ESTHER : Qian_2016_Oncol.Rep_35_1273 |
| PubMedSearch : Qian_2016_Oncol.Rep_35_1273 |
| PubMedID: 26676844 |
| Gene_locus related to this paper: human-f172a |
| Title : FAM172A is a tumor suppressor in colorectal carcinoma - Cui_2016_Tumour.Biol_37_6501 |
| Author(s) : Cui C , Ye L , Huang Z , Huang S , Liu H , Yu J |
| Ref : Tumour Biol , 37 :6501 , 2016 |
| Abstract : Cui_2016_Tumour.Biol_37_6501 |
| ESTHER : Cui_2016_Tumour.Biol_37_6501 |
| PubMedSearch : Cui_2016_Tumour.Biol_37_6501 |
| PubMedID: 26637224 |
| Gene_locus related to this paper: human-f172a |
No structure scheme yet for this family
Genes Proteins in Arb2_FAM172A family (112)
Fragments of genes in Arb2_FAM172A family (74)
No fragment of genesNo substrate
No Inhibitor