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Family Report for: Arylacetamide_deacetylase

Arylacetamide_deacetylase



Relationship
Block H
Comment
AADAC Arylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. NCEH1 KIAA1363 AADACL1 NCEH1 neutral cholesterol ester hydrolase 1.is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated . Sequence similarities between hormone-sensitive lipase and prokaryotic enzymes was dicovered by Langin and Holm and Hemila et al.

Database
Sequences
Interpro
|
IPR017157 (Arylacetamide deacetylase), IPR013094 (Alpha/beta hydrolase fold-3)
PIRSF
|
Pdoc
|
PFam
|
PF07859 (Abhydrolase_3)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
3 more
    Title: Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer
    Wang Y, Fang T, Yin X, Zhang L, Zhang X, Zhang D, Zhang Y, Wang X, Wang H, Xue Y
    Ref: BMC Cancer, 22:635, 2022 : PubMed

            

    Title: Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
    Jiang J, Chen X, Zhong D
    Ref: Front Pharmacol, 8:846, 2017 : PubMed

            

    Title: Synthesis and function of hepatic very-low-density lipoprotein
    Gibbons GF, Wiggins D, Brown AM, Hebbachi AM
    Ref: Biochemical Society Transactions, 32:59, 2004 : PubMed

            

Other Papers


Structure scheme for Arylacetamide_deacetylase

No Structure yet in this family

Genes Proteins in Arylacetamide_deacetylase family (454)

Fragments of genes in Arylacetamide_deacetylase family (2)

Substrates of some enzymes in the Arylacetamide_deacetylase family (11)

Inhibitors of some enzymes in the Arylacetamide_deacetylase family (11)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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