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Family Report for: BCHE

BCHE



Relationship
Family BCHE
Block C
Parent Family : Cholinesterase

Comment
Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase. Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics.Various autosomal recessive mutations of the gene exist in human population
1 Risk(s) factors

1 Xenobiotic(s) sensitivity


Database
Sequences
Interpro
|
IPR000997 (Cholinesterase), IPR002018 (Carboxylesterase, type B)
PIRSF
|
Pdoc
|
PFam
|
PF00135 (COesterase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
2 more
    Title: Old and new questions about cholinesterases
    Massoulie J, Perrier N, Noureddine H, Liang D, Bon S
    Ref: Chemico-Biological Interactions, 175:30, 2008 : PubMed

            

    Title: Molecular and cellular biology of cholinesterases
    Massoulie J, Pezzementi L, Bon S, Krejci E, Vallette FM
    Ref: Prog Neurobiol, 41:31, 1993 : PubMed

            

    Title: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.
    Lockridge O
    Ref: Pharmacol Ther, 47:35, 1990 : PubMed

            

Other Papers


Structure scheme for BCHE

Structures in BCHE family (91)

Genes Proteins in BCHE family (91)

Fragments of genes in BCHE family (193)

Substrates of some enzymes in the BCHE family (46)

Inhibitors of some enzymes in the BCHE family (228)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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