CIB-CCG1-interacting-factor-B
Relationship
Comment
Alpha/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). Dorz1 (ABHD14A,ABHEA) was identified and characterized as one of the most significantly down-regulated genes in Zic1-deficient cerebellum (Zic1: zinc finger protein that controls vertebrate neural development) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum has also been released. ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues (Rajendran et al. 2020): lysine deacetylaseDatabase
Interpro : IPR026764 Alpha\/beta hydrolase domain containing protein 14B
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12695 Abhydrolase_5
Prints : No Print
EC Number : No EC Number
References (5)
| Title : Identification of sequence determinants for the ABHD14 enzymes - Vaidya_2023_Proteins__ |
| Author(s) : Vaidya K , Rodrigues G , Gupta S , Devarajan A , Yeolekar M , Madhusudhan MS , Kamat SS |
| Ref : Proteins , : , 2023 |
| Abstract : Vaidya_2023_Proteins__ |
| ESTHER : Vaidya_2023_Proteins__ |
| PubMedSearch : Vaidya_2023_Proteins__ |
| PubMedID: 37974539 |
| Gene_locus related to this paper: human-ABHD14A , human-CIB |
| Title : A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals - Rajendran_2022_J.Biol.Chem_298_102128 |
| Author(s) : Rajendran A , Soory A , Khandelwal N , Ratnaparkhi G , Kamat SS |
| Ref : Journal of Biological Chemistry , 298 :102128 , 2022 |
| Abstract : Rajendran_2022_J.Biol.Chem_298_102128 |
| ESTHER : Rajendran_2022_J.Biol.Chem_298_102128 |
| PubMedSearch : Rajendran_2022_J.Biol.Chem_298_102128 |
| PubMedID: 35700823 |
| Gene_locus related to this paper: human-CIB |
| Title : Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme - Rajendran_2020_Biochemistry_59_183 |
| Author(s) : Rajendran A , Vaidya K , Mendoza J , Bridwell-Rabb J , Kamat SS |
| Ref : Biochemistry , 59 :183 , 2020 |
| Abstract : Rajendran_2020_Biochemistry_59_183 |
| ESTHER : Rajendran_2020_Biochemistry_59_183 |
| PubMedSearch : Rajendran_2020_Biochemistry_59_183 |
| PubMedID: 31478652 |
| Gene_locus related to this paper: human-CIB |
| Title : The crystal structure of CCG1\/TAF(II)250-interacting factor B (CIB) - Padmanabhan_2004_J.Biol.Chem_279_9615 |
| Author(s) : Padmanabhan B , Kuzuhara T , Adachi N , Horikoshi M |
| Ref : Journal of Biological Chemistry , 279 :9615 , 2004 |
| Abstract : Padmanabhan_2004_J.Biol.Chem_279_9615 |
| ESTHER : Padmanabhan_2004_J.Biol.Chem_279_9615 |
| PubMedSearch : Padmanabhan_2004_J.Biol.Chem_279_9615 |
| PubMedID: 14672934 |
| Gene_locus related to this paper: human-CIB |
| Title : Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse - Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57 |
| Author(s) : Hoshino J , Aruga J , Ishiguro A , Mikoshiba K |
| Ref : Brain Research Mol Brain Res , 120 :57 , 2003 |
| Abstract : Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57 |
| ESTHER : Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57 |
| PubMedSearch : Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57 |
| PubMedID: 14667578 |
| Gene_locus related to this paper: human-ABHD14A , mouse-Dorz1 |
Structures (2)
Genes Proteins in CIB-CCG1-interacting-factor-B family (92)
Fragments of genes in CIB-CCG1-interacting-factor-B family (8)
Structures in CIB-CCG1-interacting-factor-B family (2)Substrates in CIB-CCG1-interacting-factor-B family (2)
No Inhibitor