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Family Report for: Carb_B_Chordata


Carb_B_Chordata



Relationship
Block C
Parent Family : Carboxylesterase


Comments

This family was extracted from the previous Carboxylesterase COesterase family. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10). Mammalian liver carboxylesterases (CESs; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals. CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux



1 Risk(s) factors


1 Xenobiotic(s) sensitivity
CES-1 deficiency in gene_locus human-CES1 with OMIM 114835.


Database
Sequences
Interpro : IPR002018 (Carboxylesterase, type B)
PFam : PF00135 (COesterase)
Prints :
EC at KEGG : 3.1.1.1
EC at EXPASY : 3.1.1.1
Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin : Text only/graphic display
Seed alignment with MAFFT : No colour/coloured with Mview
Alignment with MAFFT : No colour/coloured with Mview
Dendrogram : Graphical display, obtained with the dnd file produced by Clustalw
HMM profile : HMM profile







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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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