Carb_B_Chordata
Relationship
Comment
This family was extracted from the previous Carboxylesterase COesterase family. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10). Mammalian liver carboxylesterases (CESs; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals. CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol effluxDatabase
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : PDOC00112
Pfam : PF00135 COesterase
Prints : No Print
EC Number : 3.1.1.1
References (15)
| Title : Carboxylesterases in lipid metabolism: from mouse to human - Lian_2018_Protein.Cell_9_178 |
| Author(s) : Lian J , Nelson R , Lehner R |
| Ref : Protein Cell , 9 :178 , 2018 |
| Abstract : Lian_2018_Protein.Cell_9_178 |
| ESTHER : Lian_2018_Protein.Cell_9_178 |
| PubMedSearch : Lian_2018_Protein.Cell_9_178 |
| PubMedID: 28677105 |
| Gene_locus related to this paper: human-CES1 |
| Title : Nomenclature for alleles of the human carboxylesterase 1 gene - |
| Author(s) : Rasmussen HB , Madsen MB , Hansen PR |
| Ref : Pharmacogenet Genomics , 27 :78 , 2017 |
| PubMedID: 27831961 |
| Gene_locus related to this paper: human-CES1 |
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| Abstract : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| ESTHER : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427 |
| Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ |
| Ref : Mamm Genome , 21 :427 , 2010 |
| Abstract : Holmes_2010_Mamm.Genome_21_427 |
| ESTHER : Holmes_2010_Mamm.Genome_21_427 |
| PubMedSearch : Holmes_2010_Mamm.Genome_21_427 |
| PubMedID: 20931200 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
| Title : Genomic analysis of the carboxylesterases: identification and classification of novel forms - Williams_2010_Mol.Phylogenet.Evol_57_23 |
| Author(s) : Williams ET , Wang H , Wrighton SA , Qian YW , Perkins EJ |
| Ref : Mol Phylogenet Evol , 57 :23 , 2010 |
| Abstract : Williams_2010_Mol.Phylogenet.Evol_57_23 |
| ESTHER : Williams_2010_Mol.Phylogenet.Evol_57_23 |
| PubMedSearch : Williams_2010_Mol.Phylogenet.Evol_57_23 |
| PubMedID: 20510380 |
| Gene_locus related to this paper: macfa-a0a2k5uar1 |
| Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508 |
| Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : Molecular Pharmacology , 77 :508 , 2010 |
| Abstract : Hemmert_2010_Mol.Pharmacol_77_508 |
| ESTHER : Hemmert_2010_Mol.Pharmacol_77_508 |
| PubMedSearch : Hemmert_2010_Mol.Pharmacol_77_508 |
| PubMedID: 20051531 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterases: structure, function and polymorphism in mammals - Satoh_2010_J.Pestic.Sci_35_218 |
| Author(s) : Satoh T , Hosokawa M |
| Ref : Journal of Pesticide Science , 35 :218 , 2010 |
| Abstract : Satoh_2010_J.Pestic.Sci_35_218 |
| ESTHER : Satoh_2010_J.Pestic.Sci_35_218 |
| PubMedSearch : Satoh_2010_J.Pestic.Sci_35_218 |
| PubMedID: |
| Title : Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs - Hosokawa_2008_Molecules_13_412 |
| Author(s) : Hosokawa M |
| Ref : Molecules , 13 :412 , 2008 |
| Abstract : Hosokawa_2008_Molecules_13_412 |
| ESTHER : Hosokawa_2008_Molecules_13_412 |
| PubMedSearch : Hosokawa_2008_Molecules_13_412 |
| PubMedID: 18305428 |
| Title : Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun - Fleming_2007_Biochemistry_46_5063 |
| Author(s) : Fleming CD , Edwards CC , Kirby SD , Maxwell DM , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : Biochemistry , 46 :5063 , 2007 |
| Abstract : Fleming_2007_Biochemistry_46_5063 |
| ESTHER : Fleming_2007_Biochemistry_46_5063 |
| PubMedSearch : Fleming_2007_Biochemistry_46_5063 |
| PubMedID: 17407327 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structure, function and regulation of carboxylesterases - Satoh_2006_Chem.Biol.Interact_162_195 |
| Author(s) : Satoh T , Hosokawa M |
| Ref : Chemico-Biological Interactions , 162 :195 , 2006 |
| Abstract : Satoh_2006_Chem.Biol.Interact_162_195 |
| ESTHER : Satoh_2006_Chem.Biol.Interact_162_195 |
| PubMedSearch : Satoh_2006_Chem.Biol.Interact_162_195 |
| PubMedID: 16919614 |
| Title : Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 - Bencharit_2006_J.Mol.Biol_363_201 |
| Author(s) : Bencharit S , Edwards CC , Morton CL , Howard-Williams EL , Kuhn P , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 363 :201 , 2006 |
| Abstract : Bencharit_2006_J.Mol.Biol_363_201 |
| ESTHER : Bencharit_2006_J.Mol.Biol_363_201 |
| PubMedSearch : Bencharit_2006_J.Mol.Biol_363_201 |
| PubMedID: 16962139 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165 |
| Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 352 :165 , 2005 |
| Abstract : Fleming_2005_J.Mol.Biol_352_165 |
| ESTHER : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedSearch : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedID: 16081098 |
| Gene_locus related to this paper: human-CES1 |
| Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341 |
| Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR |
| Ref : Chemical Biology , 10 :341 , 2003 |
| Abstract : Bencharit_2003_Chem.Biol_10_341 |
| ESTHER : Bencharit_2003_Chem.Biol_10_341 |
| PubMedSearch : Bencharit_2003_Chem.Biol_10_341 |
| PubMedID: 12725862 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structural insights into CPT-11 activation by mammalian carboxylesterases - Bencharit_2002_Nat.Struct.Biol_9_337 |
| Author(s) : Bencharit S , Morton CL , Howard-Williams EL , Danks MK , Potter PM , Redinbo MR |
| Ref : Nat Struct Biol , 9 :337 , 2002 |
| Abstract : Bencharit_2002_Nat.Struct.Biol_9_337 |
| ESTHER : Bencharit_2002_Nat.Struct.Biol_9_337 |
| PubMedSearch : Bencharit_2002_Nat.Struct.Biol_9_337 |
| PubMedID: 11967565 |
| Gene_locus related to this paper: rabit-1cxes |
| Title : On the origins of esterases - Myers_1988_Mol.Biol.Evol_5_113 |
| Author(s) : Myers M , Richmond RC , Oakeshott JG |
| Ref : Molecular Biology Evolution , 5 :113 , 1988 |
| Abstract : Myers_1988_Mol.Biol.Evol_5_113 |
| ESTHER : Myers_1988_Mol.Biol.Evol_5_113 |
| PubMedSearch : Myers_1988_Mol.Biol.Evol_5_113 |
| PubMedID: 3163407 |
Structures (22)
Genes Proteins in Carb_B_Chordata family (543)
Fragments of genes in Carb_B_Chordata family (295)
Structures in Carb_B_Chordata family (22)Substrates in Carb_B_Chordata family (144)
Inhibitors in Carb_B_Chordata family (67)