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Family Report for: Cholesterol_esterase

Cholesterol_esterase



Relationship
Block C
Parent Family : Carboxylesterase

Comment
The human lactating mammary gland and pancreas produce a lipolytic enzyme, carboxyl-ester lipase, earlier called bile salt-stimulated lipase. Carboxyl-ester lipase is a major component of pancreatic juice and is responsible for the hydrolysis of cholesterol esters as well as a variety of other dietary esters. The enzyme is activated when mixed with bile salts, and plays an important role in the digestion of milk fat in newborn infants. This enzyme combines properties of esterases (activity on esters soluble in water) and lipases (activity on insoluble long chain acylglycerols) Numerous repeats at the c-term excluded in ESTHER (only n-term Pfam A COesterase 1 544)
1 Disease(s)


Database
Sequences
Interpro
|
IPR002018 (Carboxylesterase, type B), IPR033560 (Bile salt-activated lipase BAL)
PIRSF
|
Pdoc
|
PFam
|
PF00135 (COesterase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
3 more
    Title: Comparative Structures and Evolution of Vertebrate Carboxyl Ester Lipase (CEL) Genes and Proteins with a Major Role in Reverse Cholesterol Transport
    Holmes RS, Cox LA
    Ref: Cholesterol, 2011:781643, 2011 : PubMed

            

    Title: Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation
    Chen JC, Miercke LJ, Krucinski J, Starr JR, Saenz G, Wang X, Spilburg CA, Lange LG, Ellsworth JL, Stroud RM
    Ref: Biochemistry, 37:5107, 1998 : PubMed

            

    Title: The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism
    Wang X, Wang CS, Tang J, Dyda F, Zhang XC
    Ref: Structure, 5:1209, 1997 : PubMed

            

Other Papers


Structure scheme for Cholesterol_esterase

Structures in Cholesterol_esterase family (10)

Genes Proteins in Cholesterol_esterase family (128)

Fragments of genes in Cholesterol_esterase family (65)

Substrates of some enzymes in the Cholesterol_esterase family (13)

Inhibitors of some enzymes in the Cholesterol_esterase family (15)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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