Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Cocaine_esterase

Cocaine_esterase



Relationship
Block X
Parent Family : Peptidase_S15

Comment
Contains also alpha-amino acid ester hydrolase (Beta-Lactam Acylase), glutaryl 7-aca acylases, antibiotic hydrolase, diester hydrolase. Able to perform both hydrolysis and synthesis of a variety of -amino -lactam antibiotics including (R)-ampicillin and cephalexin. The closest relatives is the S15 X-prolyl amino peptidase of Lactobacillus

Database
Sequences
Interpro
|
IPR005674 (CocE/NonD hydrolase)
PIRSF
|
Pdoc
|
PFam
|
PF02129 (Peptidase_S15)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: Amino ester hydrolase from Xanthomonas campestris pv. campestris, ATCC 33913 for enzymatic synthesis of ampicillin
    Blum JK, Bommarius AS
    Ref: J Mol Catal B Enzym, 67:21, 2010 : PubMed

            

    Title: Crystal structure of a bacterial cocaine esterase
    Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA
    Ref: Nat Struct Biol, 9:17, 2002 : PubMed

            

    Title: Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1
    Bresler MM, Rosser SJ, Basran A, Bruce NC
    Ref: Applied Environmental Microbiology, 66:904, 2000 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Cocaine_esterase family (23)

Genes Proteins in Cocaine_esterase family (138)

Fragments of genes in Cocaine_esterase family (4)

Substrates of some enzymes in the Cocaine_esterase family (7)

Inhibitors of some enzymes in the Cocaine_esterase family (5)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer