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Family Report for: DPP4N_Peptidase_S9

DPP4N_Peptidase_S9



Relationship
Block X
Parent Family : Peptidase_S9

Comment
Dipeptidyl petidase IV related proteins (EC 3.4.14.5) (DPP IV) important for the activation or inactivation of extracellular endocrine paracrine and autocrine peptides. DPPIV is synonymous with CD26 (important in HIV infection). Some members lack active serine and are probably not enzymes. The prototype structure has a 8-bladed beta-propeller N-terminal domain which guide substrates to the active site and a transmembrane segment. DPP4 is a cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. The novel emerging coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) binds cells through DPP4. Mutations in the DPP6 gene are linked to autosomal dominant mental retardation.(Liao et al 2013). The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting beta-subunit of neuronal K(V)4.2 channels. Structures of the complex are available (Kise et al.)
4 Disease(s)
Hatipoglu syndrome from mutation Q851X_human-DPP9 in gene_locus human-DPP9.


Database
Sequences
Interpro
|
IPR001375 (Peptidase_S9), IPR002469 (Peptidase S9B, dipeptidylpeptidase IV N-terminal), IPR031245 (Dipeptidyl peptidase FAP FAP/Dpf2)
PIRSF
|
Pdoc
|
PFam
|
PF00326 (Peptidase_S9), PF00930 (DPPIV_N)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
25 more
    Title: Structural basis of gating modulation of Kv4 channel complexes
    Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O
    Ref: Nature, :, 2021 : PubMed

            

    Title: A novel structure associated with aging is augmented in the DPP6-KO mouse brain
    Lin L, Petralia RS, Lake R, Wang YX, Hoffman DA
    Ref: Acta Neuropathologica Commun, 8:197, 2020 : PubMed

            

    Title: Loss-of-function variation in the DPP6 gene is associated with autosomal dominant microcephaly and mental retardation
    Liao C, Fu F, Li R, Yang WQ, Liao HY, Yan JR, Li J, Li SY, Yang X, Li DZ
    Ref: Eur Journal of Medical Genetics, 56:484, 2013 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in DPP4N_Peptidase_S9 family (179)

Genes Proteins in DPP4N_Peptidase_S9 family (829)

Fragments of genes in DPP4N_Peptidase_S9 family (13)

Substrates of some enzymes in the DPP4N_Peptidase_S9 family (13)

Inhibitors of some enzymes in the DPP4N_Peptidase_S9 family (133)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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