Interpro : IPR001375 Peptidase_S9 , IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal , IPR031245 Dipeptidyl peptidase FAP FAP\/Dpf2
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00326 Peptidase_S9 , PF00930 DPPIV_N
Prints : No Print
EC Number : No EC Number
Title : Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target - Wang_2023_Science_381_eadd5787 |
Author(s) : Wang K , Zhang Z , Hang J , Liu J , Guo F , Ding Y , Li M , Nie Q , Lin J , Zhuo Y , Sun L , Luo X , Zhong Q , Ye C , Yun C , Zhang Y , Wang J , Bao R , Pang Y , Wang G , Gonzalez FJ , Lei X , Qiao J , Jiang C |
Ref : Science , 381 :eadd5787 , 2023 |
Abstract : Wang_2023_Science_381_eadd5787 |
ESTHER : Wang_2023_Science_381_eadd5787 |
PubMedSearch : Wang_2023_Science_381_eadd5787 |
PubMedID: 37535747 |
Gene_locus related to this paper: bactn-BT4193 |
Title : New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors - Cui_2022_Front.Pharmacol_13_1002871 |
Author(s) : Cui C , Tian X , Wei L , Wang Y , Wang K , Fu R |
Ref : Front Pharmacol , 13 :1002871 , 2022 |
Abstract : Cui_2022_Front.Pharmacol_13_1002871 |
ESTHER : Cui_2022_Front.Pharmacol_13_1002871 |
PubMedSearch : Cui_2022_Front.Pharmacol_13_1002871 |
PubMedID: 36172198 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Title : Structural basis of gating modulation of Kv4 channel complexes - Kise_2021_Nature__ |
Author(s) : Kise Y , Kasuya G , Okamoto HH , Yamanouchi D , Kobayashi K , Kusakizako T , Nishizawa T , Nakajo K , Nureki O |
Ref : Nature , : , 2021 |
Abstract : Kise_2021_Nature__ |
ESTHER : Kise_2021_Nature__ |
PubMedSearch : Kise_2021_Nature__ |
PubMedID: 34552243 |
Gene_locus related to this paper: human-DPP6 |
Title : A novel structure associated with aging is augmented in the DPP6-KO mouse brain - Lin_2020_Acta.Neuropathol.Commun_8_197 |
Author(s) : Lin L , Petralia RS , Lake R , Wang YX , Hoffman DA |
Ref : Acta Neuropathologica Commun , 8 :197 , 2020 |
Abstract : Lin_2020_Acta.Neuropathol.Commun_8_197 |
ESTHER : Lin_2020_Acta.Neuropathol.Commun_8_197 |
PubMedSearch : Lin_2020_Acta.Neuropathol.Commun_8_197 |
PubMedID: 33225987 |
Gene_locus related to this paper: human-DPP6 , mouse-DPP6 |
Title : A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice - Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
Author(s) : Berger JP , SinhaRoy R , Pocai A , Kelly TM , Scapin G , Gao YD , Pryor KAD , Wu JK , Eiermann GJ , Xu SS , Zhang X , Tatosian DA , Weber AE , Thornberry NA , Carr RD |
Ref : Endocrinol Diabetes Metab , 1 :e00002 , 2018 |
Abstract : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
ESTHER : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
PubMedSearch : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
PubMedID: 30815539 |
Gene_locus related to this paper: human-DPP4 |
Title : Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling - Rea_2017_Eur.J.Med.Chem_139_482 |
Author(s) : Rea D , Van Elzen R , De Winter H , Van Goethem S , Landuyt B , Luyten W , Schoofs L , Van der Veken P , Augustyns K , De Meester I , Fulop V , Lambeir AM |
Ref : Eur Journal of Medicinal Chemistry , 139 :482 , 2017 |
Abstract : Rea_2017_Eur.J.Med.Chem_139_482 |
ESTHER : Rea_2017_Eur.J.Med.Chem_139_482 |
PubMedSearch : Rea_2017_Eur.J.Med.Chem_139_482 |
PubMedID: 28826083 |
Gene_locus related to this paper: porgi-DPP |
Title : Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus - van Doremalen_2016_J.Virol_90_5499 |
Author(s) : van Doremalen N , Miazgowicz KL , Munster VJ |
Ref : J Virol , 90 :5499 , 2016 |
Abstract : van Doremalen_2016_J.Virol_90_5499 |
ESTHER : van Doremalen_2016_J.Virol_90_5499 |
PubMedSearch : van Doremalen_2016_J.Virol_90_5499 |
PubMedID: 27030263 |
Gene_locus related to this paper: human-DPP4 |
Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387 |
Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I |
Ref : Front Immunol , 6 :387 , 2015 |
Abstract : Waumans_2015_Front.Immunol_6_387 |
ESTHER : Waumans_2015_Front.Immunol_6_387 |
PubMedSearch : Waumans_2015_Front.Immunol_6_387 |
PubMedID: 26300881 |
Title : Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry - Song_2014_Virology_471-473C_49 |
Author(s) : Song W , Wang Y , Wang N , Wang D , Guo J , Fu L , Shi X |
Ref : Virology , 471-473C :49 , 2014 |
Abstract : Song_2014_Virology_471-473C_49 |
ESTHER : Song_2014_Virology_471-473C_49 |
PubMedSearch : Song_2014_Virology_471-473C_49 |
PubMedID: 25461530 |
Gene_locus related to this paper: human-DPP4 |
Title : Distribution, classification, domain architectures and evolution of prolyl oligopeptidases in prokaryotic lineages - Kaushik_2014_BMC.Genomics_15_985 |
Author(s) : Kaushik S , Sowdhamini R |
Ref : BMC Genomics , 15 :985 , 2014 |
Abstract : Kaushik_2014_BMC.Genomics_15_985 |
ESTHER : Kaushik_2014_BMC.Genomics_15_985 |
PubMedSearch : Kaushik_2014_BMC.Genomics_15_985 |
PubMedID: 25407321 |
Title : Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 - Lu_2013_Nature_500_227 |
Author(s) : Lu G , Hu Y , Wang Q , Qi J , Gao F , Li Y , Zhang Y , Zhang W , Yuan Y , Bao J , Zhang B , Shi Y , Yan J , Gao GF |
Ref : Nature , 500 :227 , 2013 |
Abstract : Lu_2013_Nature_500_227 |
ESTHER : Lu_2013_Nature_500_227 |
PubMedSearch : Lu_2013_Nature_500_227 |
PubMedID: 23831647 |
Gene_locus related to this paper: human-DPP4 |
Title : Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 - Wang_2013_Cell.Res_23_986 |
Author(s) : Wang N , Shi X , Jiang L , Zhang S , Wang D , Tong P , Guo D , Fu L , Cui Y , Liu X , Arledge KC , Chen YH , Zhang L , Wang X |
Ref : Cell Res , 23 :986 , 2013 |
Abstract : Wang_2013_Cell.Res_23_986 |
ESTHER : Wang_2013_Cell.Res_23_986 |
PubMedSearch : Wang_2013_Cell.Res_23_986 |
PubMedID: 23835475 |
Gene_locus related to this paper: human-DPP4 |
Title : Loss-of-function variation in the DPP6 gene is associated with autosomal dominant microcephaly and mental retardation - Liao_2013_Eur.J.Med.Genet_56_484 |
Author(s) : Liao C , Fu F , Li R , Yang WQ , Liao HY , Yan JR , Li J , Li SY , Yang X , Li DZ |
Ref : Eur Journal of Medical Genetics , 56 :484 , 2013 |
Abstract : Liao_2013_Eur.J.Med.Genet_56_484 |
ESTHER : Liao_2013_Eur.J.Med.Genet_56_484 |
PubMedSearch : Liao_2013_Eur.J.Med.Genet_56_484 |
PubMedID: 23832105 |
Gene_locus related to this paper: human-DPP6 |
Title : A Novel SUMO1-specific Interacting Motif in Dipeptidyl Peptidase 9 (DPP9) That Is Important for Enzymatic Regulation - Pilla_2012_J.Biol.Chem_287_44320 |
Author(s) : Pilla E , Moller U , Sauer G , Mattiroli F , Melchior F , Geiss-Friedlander R |
Ref : Journal of Biological Chemistry , 287 :44320 , 2012 |
Abstract : Pilla_2012_J.Biol.Chem_287_44320 |
ESTHER : Pilla_2012_J.Biol.Chem_287_44320 |
PubMedSearch : Pilla_2012_J.Biol.Chem_287_44320 |
PubMedID: 23152501 |
Gene_locus related to this paper: human-DPP9 |
Title : The dipeptidyl peptidase IV family in cancer and cell biology - Yu_2010_FEBS.J_277_1126 |
Author(s) : Yu DM , Yao TW , Chowdhury S , Nadvi NA , Osborne B , Church WB , McCaughan GW , Gorrell MD |
Ref : Febs J , 277 :1126 , 2010 |
Abstract : Yu_2010_FEBS.J_277_1126 |
ESTHER : Yu_2010_FEBS.J_277_1126 |
PubMedSearch : Yu_2010_FEBS.J_277_1126 |
PubMedID: 20074209 |
Title : The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting beta-subunit of neuronal K(V)4.2 channels - Dougherty_2009_Channels.(Austin)_3_122 |
Author(s) : Dougherty K , Tu L , Deutsch C , Covarrubias M |
Ref : Channels (Austin) , 3 :122 , 2009 |
Abstract : Dougherty_2009_Channels.(Austin)_3_122 |
ESTHER : Dougherty_2009_Channels.(Austin)_3_122 |
PubMedSearch : Dougherty_2009_Channels.(Austin)_3_122 |
PubMedID: 19372736 |
Gene_locus related to this paper: human-DPP6 |
Title : The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26 - Davoodi_2007_Proteomics_7_2300 |
Author(s) : Davoodi J , Kelly J , Gendron NH , Mackenzie AE |
Ref : Proteomics , 7 :2300 , 2007 |
Abstract : Davoodi_2007_Proteomics_7_2300 |
ESTHER : Davoodi_2007_Proteomics_7_2300 |
PubMedSearch : Davoodi_2007_Proteomics_7_2300 |
PubMedID: 17549790 |
Title : The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices - Ghersi_2006_Cancer.Res_66_4652 |
Author(s) : Ghersi G , Zhao Q , Salamone M , Yeh Y , Zucker S , Chen WT |
Ref : Cancer Research , 66 :4652 , 2006 |
Abstract : Ghersi_2006_Cancer.Res_66_4652 |
ESTHER : Ghersi_2006_Cancer.Res_66_4652 |
PubMedSearch : Ghersi_2006_Cancer.Res_66_4652 |
PubMedID: 16651416 |
Title : Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis - Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
Author(s) : Rea D , Lambeir AM , Kumagai Y , De Meester I , Scharpe S , Fulop V |
Ref : Acta Crystallographica D Biol Crystallogr , 60 :1871 , 2004 |
Abstract : Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
ESTHER : Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
PubMedSearch : Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
PubMedID: 15388936 |
Gene_locus related to this paper: porgi-DPP |
Title : Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance - Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
Author(s) : Conarello SL , Li Z , Ronan J , Roy RS , Zhu L , Jiang G , Liu F , Woods J , Zycband E , Moller DE , Thornberry NA , Zhang BB |
Ref : Proc Natl Acad Sci U S A , 100 :6825 , 2003 |
Abstract : Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
ESTHER : Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
PubMedSearch : Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
PubMedID: 12748388 |
Gene_locus related to this paper: mouse-dpp4 |
Title : The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism - Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
Author(s) : Engel M , Hoffmann T , Wagner L , Wermann M , Heiser U , Kiefersauer R , Huber R , Bode W , Demuth HU , Brandstetter H |
Ref : Proc Natl Acad Sci U S A , 100 :5063 , 2003 |
Abstract : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
ESTHER : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
PubMedSearch : Engel_2003_Proc.Natl.Acad.Sci.U.S.A_100_5063 |
PubMedID: 12690074 |
Gene_locus related to this paper: pig-dpp4 |
Title : The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold - Hiramatsu_2003_Biochem.Biophys.Res.Commun_302_849 |
Author(s) : Hiramatsu H , Kyono K , Higashiyama Y , Fukushima C , Shima H , Sugiyama S , Inaka K , Yamamoto A , Shimizu R |
Ref : Biochemical & Biophysical Research Communications , 302 :849 , 2003 |
Abstract : Hiramatsu_2003_Biochem.Biophys.Res.Commun_302_849 |
ESTHER : Hiramatsu_2003_Biochem.Biophys.Res.Commun_302_849 |
PubMedSearch : Hiramatsu_2003_Biochem.Biophys.Res.Commun_302_849 |
PubMedID: 12646248 |
Gene_locus related to this paper: human-DPP4 |
Title : Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases - Qi_2003_Biochem.J_373_179 |
Author(s) : Qi SY , Riviere PJ , Trojnar J , Junien JL , Akinsanya KO |
Ref : Biochemical Journal , 373 :179 , 2003 |
Abstract : Qi_2003_Biochem.J_373_179 |
ESTHER : Qi_2003_Biochem.J_373_179 |
PubMedSearch : Qi_2003_Biochem.J_373_179 |
PubMedID: 12662155 |
Gene_locus related to this paper: human-DPP8 , human-DPP9 , human-DPP10 , mouse-dpp9 , mouse-dpp10 |
Title : Crystal structure of human dipeptidyl peptidase IV\/CD26 in complex with a substrate analog - Rasmussen_2003_Nat.Struct.Biol_10_19 |
Author(s) : Rasmussen HB , Branner S , Wiberg FC , Wagtmann N |
Ref : Nat Struct Biol , 10 :19 , 2003 |
Abstract : Rasmussen_2003_Nat.Struct.Biol_10_19 |
ESTHER : Rasmussen_2003_Nat.Struct.Biol_10_19 |
PubMedSearch : Rasmussen_2003_Nat.Struct.Biol_10_19 |
PubMedID: 12483204 |
Gene_locus related to this paper: human-DPP4 |
Title : Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence - Kumagai_2000_Infect.Immun_68_716 |
Author(s) : Kumagai Y , Konishi K , Gomi T , Yagishita H , Yajima A , Yoshikawa M |
Ref : Infect Immun , 68 :716 , 2000 |
Abstract : Kumagai_2000_Infect.Immun_68_716 |
ESTHER : Kumagai_2000_Infect.Immun_68_716 |
PubMedSearch : Kumagai_2000_Infect.Immun_68_716 |
PubMedID: 10639438 |
Gene_locus related to this paper: porgi-DPP |
Title : Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 - Marguet_2000_Proc.Natl.Acad.Sci.U.S.A_97_6874 |
Author(s) : Marguet D , Baggio L , Kobayashi T , Bernard AM , Pierres M , Nielsen PF , Ribel U , Watanabe T , Drucker DJ , Wagtmann N |
Ref : Proc Natl Acad Sci U S A , 97 :6874 , 2000 |
Abstract : Marguet_2000_Proc.Natl.Acad.Sci.U.S.A_97_6874 |
ESTHER : Marguet_2000_Proc.Natl.Acad.Sci.U.S.A_97_6874 |
PubMedSearch : Marguet_2000_Proc.Natl.Acad.Sci.U.S.A_97_6874 |
PubMedID: 10823914 |
Title : Two highly conserved glutamic acid residues in the predicted beta propeller domain of dipeptidyl peptidase IV are required for its enzyme activity - Abbott_1999_FEBS.Lett_458_278 |
Author(s) : Abbott CA , McCaughan GW , Gorrell MD |
Ref : FEBS Letters , 458 :278 , 1999 |
Abstract : Abbott_1999_FEBS.Lett_458_278 |
ESTHER : Abbott_1999_FEBS.Lett_458_278 |
PubMedSearch : Abbott_1999_FEBS.Lett_458_278 |
PubMedID: 10570924 |
Title : Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans - Beauvais_1997_Infect.Immun_65_3042 |
Author(s) : Beauvais A , Monod M , Wyniger J , Debeaupuis JP , Grouzmann E , Brakch N , Svab J , Hovanessian AG , Latge JP |
Ref : Infect Immun , 65 :3042 , 1997 |
Abstract : Beauvais_1997_Infect.Immun_65_3042 |
ESTHER : Beauvais_1997_Infect.Immun_65_3042 |
PubMedSearch : Beauvais_1997_Infect.Immun_65_3042 |
PubMedID: 9234752 |
Gene_locus related to this paper: aspfu-DPP4 |
Title : Direct association of adenosine deaminase with a T cell activation antigen, CD26 - Kameoka_1993_Science_261_466 |
Author(s) : Kameoka J , Tanaka T , Nojima Y , Schlossman SF , Morimoto C |
Ref : Science , 261 :466 , 1993 |
Abstract : Kameoka_1993_Science_261_466 |
ESTHER : Kameoka_1993_Science_261_466 |
PubMedSearch : Kameoka_1993_Science_261_466 |
PubMedID: 8101391 |
Title : Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum - Mentlein_1993_Eur.J.Biochem_214_829 |
Author(s) : Mentlein R , Gallwitz B , Schmidt WE |
Ref : European Journal of Biochemistry , 214 :829 , 1993 |
Abstract : Mentlein_1993_Eur.J.Biochem_214_829 |
ESTHER : Mentlein_1993_Eur.J.Biochem_214_829 |
PubMedSearch : Mentlein_1993_Eur.J.Biochem_214_829 |
PubMedID: 8100523 |
Structures (182)
Genes Proteins in DPP4N_Peptidase_S9 family (829)
Fragments of genes in DPP4N_Peptidase_S9 family (13)
Structures in DPP4N_Peptidase_S9 family (182)Substrates in DPP4N_Peptidase_S9 family (14)
Inhibitors in DPP4N_Peptidase_S9 family (157)