Family Report for: Duf_1023

This family has been recognized as alpha/beta hydrolase by Zheng et al. . Pfam family DUF1023 consists entirely of uncharacterized proteins generated by sequencing the genomes of Actinobacteria (Zheng et al 2005) Genomic context suggests that they may function as lipases, controlling the concentration of their putative phospholipid substrates. Most sequences include long n-terminal low complexity region not included here.

Title: Protein domain of unknown function DUF1023 is an alpha/beta hydrolase
Zheng M, Ginalski K, Rychlewski L, Grishin NV
Ref: Proteins, 59:1, 2005 : PubMed
Abstract


ESTHER: Zheng_2005_Proteins_59_1
PubMedSearch: Zheng 2005 Proteins 59 1
PubMedID: 15688435

Abstract

Pfam family DUF1023 consists entirely of uncharacterized proteins generated by sequencing the genomes of Actinobacteria (Bateman A., et al., Nucleic Acids Res. 2004;32 Database issue:D138-141.) Utilizing sequence similarity detection methods, we infer homology between DUF1023 and alpha/beta hydrolases. DUF1023 proteins conserve the core secondary structures in alpha/beta hydrolase fold, and share similar catalytic machinery as that of alpha/beta hydrolases. We predict DUF1023 spatial structure and deduce that they function as hydrolases utilizing catalytic Ser-His-Asp triad with the serine as a nucleophile.