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Family Report for: Duf_1749

Duf_1749



Relationship
Family Duf_1749
Block X
Comment
Grundlingern et al. show that Aspergillus fumigatus AFUA_3G03390 gene product, SidJ (aspfu-q4wf56) is involved in hydrolysis of siderophore fusarinine C. It is the first functionally characterized member of the family. Structure of siderophore esterase AfSidJ from Aspergillus fumigatus is described by Ecker et al.. A structure of a protein of unknown fucntion is also available (2Q0X) Merritt et al. . However this protein is only representative of trypanosomatid members of this sequence family as these proteins lack some if not all of the catalytic triad residues. Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria. (Not to be cofounded with SidJ Calmodulin-dependent glutamylase from Legionella pneumophila)

Database
Sequences
Interpro
|
IPR013744 (Fusarinine C esterase sidJ)
PIRSF
|
Pdoc
|
PFam
|
PF08538 (DUF1749)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases
    Ecker F, Haas H, Groll M, Huber EM
    Ref: Angew Chem Int Ed Engl, 57:14624, 2018 : PubMed

            

    Title: Aspergillus fumigatus SidJ Mediates Intracellular Siderophore Hydrolysis
    Grundlinger M, Gsaller F, Schrettl M, Lindner H, Haas H
    Ref: Applied Environmental Microbiology, 79:7534, 2013 : PubMed

            

    Title: Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function
    Merritt EA, Holmes M, Buckner FS, Van Voorhis WC, Quartly E, Phizicky EM, Lauricella A, Luft J, DeTitta G and Hol WG <2 more author(s)>
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 64:474, 2008 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Duf_1749 family (2)

Genes Proteins in Duf_1749 family (104)

Fragments of genes in Duf_1749 family (4)

Substrates of some enzymes in the Duf_1749 family (1)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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