Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Fungal_carboxylesterase_lipase

Fungal_carboxylesterase_lipase



Relationship
Block C
Parent Family : Carboxylesterase

Comment
This family was extracted from the previous Carboxylesterase COesterase family. Carboxylesterase, type B (COesterase) is very successful in fungi. Grouped with Lipase_3 in Family Fungal lipases in scop database. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10) LED_Database abH03 abH02. The presence of a water/lipid interface dramatically enhances the hydrolytic activity of lipases. The activation is associated with a conformational change. The Ser-His-Asp/Glu catalytic triad is occluded by a polypeptide flap (lid) and is not exposed to the solvent until the lid is open. A protein of this family lacking the catalytic serine is a dirigent protein which controls the stereoselectivity of multicopper oxidase(VdtB)-catalyzed phenol coupling in viriditoxin biosynthesis (Hu et al. 2019)

Database
Sequences
Interpro
|
IPR002018 (Carboxylesterase, type B)
PIRSF
|
Pdoc
|
PFam
|
PF00135 (COesterase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
10 more
    Title: Fungal Dirigent Protein Controls the Stereoselectivity of Multicopper Oxidase-Catalyzed Phenol Coupling in Viriditoxin Biosynthesis
    Hu J, Li H, Chooi YH
    Ref: Journal of the American Chemical Society, 141:8068, 2019 : PubMed

            

    Title: Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase
    Ghosh D, Wawrzak Z, Pletnev VZ, Li N, Kaiser R, Pangborn W, Jornvall H, Erman M, Duax WL
    Ref: Structure, 3:279, 1995 : PubMed

            

    Title: Insights into interfacial activation from an open structure of Candida rugosa lipase
    Grochulski P, Li Y, Schrag JD, Bouthillier F, Smith P, Harrison D, Rubin B, Cygler M
    Ref: Journal of Biological Chemistry, 268:12843, 1993 : PubMed

            

Other Papers



Structures in Fungal_carboxylesterase_lipase family (16)

Genes Proteins in Fungal_carboxylesterase_lipase family (4895)

Fragments of genes in Fungal_carboxylesterase_lipase family (1078)

Substrates of some enzymes in the Fungal_carboxylesterase_lipase family (20)

Inhibitors of some enzymes in the Fungal_carboxylesterase_lipase family (5)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer